Clinical Trials on Alzheimer Disease 2 Due to Apoe4 Isoform

Total 825 results

University of Kansas Medical Center
National Institute on Aging (NIA)

Completed

Dementia Risk and Dynamic Response to Exercise (DYNAMIC)

Healthy Aging | Alzheimer Disease 2 Due to Apoe4 Isoform

United States
National Taiwan Normal University

Completed

Acute Exercise on Neurocognitive Function Among Adults With/Without Generic Risk of AD

Alzheimer Disease 2 Due to Apoe4 Isoform

Taiwan
Yu-Hsiang Wu
Vanderbilt University Medical Center; National Institute on Deafness and Other...

Recruiting

Hearing Aid and Individuals With Cognitive Disorders

Alzheimer Disease 2 Due to Apoe4 Isoform | Presbycusis, Bilateral

United States
University College, London
Washington University School of Medicine; University of Washington; Alzheimer... and other collaborators

Not yet recruiting

A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK (NIO-SILK)

Alzheimer Disease | Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 1 (Disorder) | Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 2 (Disorder) | Autosomal Dominant Alzheimer Disease Due to Mutation of Amyloid Precursor Protein (Disorder)
Douglas Mental Health University Institute
Johns Hopkins University; McGill University

Completed

Randomized Trial of Low-dose Naproxen in Cognitively Intact Persons at Risk of Alzheimer's Dementia

Alzheimer Disease | Cognitive Decline Due to Alzheimer Disease | Mild Cognitive Impairment Due to Alzheimer Disease

Canada
University of the Balearic Islands
Fundació d'investigació Sanitària de les Illes Balears; Consorcio Centro de...

Recruiting

Biomarkers of Cognitive Impairment in Blood Cells (COGNIMARK)

Mild Cognitive Impairment Due to Alzheimer's Disease | Dementia Due to Alzheimer's Disease (Disorder)

Spain
Vivoryon Therapeutics N.V.
Amsterdam UMC, location VUmc; Nordic Bioscience A/S

Completed

A Study to Evaluate Safety and Tolerability of Different Doses and Efficacy of PQ912 in Subjects With MCI and Mild AD (VIVIAD)

Early Alzheimers Disease | Mild Cognitive Impairment Due to AD

Netherlands, Spain, Denmark, Germany, Poland
South London and Maudsley NHS Foundation Trust

Enrolling by invitation

UK Based Remote Brain Health Clinic (BHC) for Patients With Mild Cognitive Impairment (MCI) (BHC)

Mild Cognitive Impairment | Mild Cognitive Impairment Due to Alzheimer's Disease

United Kingdom
Charite University, Berlin, Germany
Berlin Institute of Health; Federal Agency for Disruptive Innovation - SPRIN-D

Completed

Evaluation of Safety of Contraloid Acetate in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease

Mild Cognitive Impairment Due to Alzheimer's Disease

Germany
Takeda
Zinfandel Pharmaceuticals Inc.

Terminated

Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone in Delaying Its Onset (TOMMORROW)

Mild Cognitive Impairment Due to Alzheimer's Disease

United States, Germany, Switzerland, United Kingdom, Australia
PRInnovation GmbH
Julius Clinical; Federal Agency for Disruptive Innovation - SPRIN-D; Priavoid

Recruiting

Study to Assess Safety and Efficacy of PRI-002 in Patients With MCI to Mild Dementia Due to Alzheimer's Disease (AD) (PRImus-AD)

Mild Cognitive Impairment Due to Alzheimer's Disease | Alzheimer's Disease, Early Onset

Spain, Italy, Germany, Netherlands, Czechia, France, Poland
Biogen

Recruiting

A Study to Learn About the Safety of BIIB080 and Whether it Can Improve Symptoms of Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild AD Dementia Between 50 to 80 Years of Age (CELIA)

Mild Cognitive Impairment Due to Alzheimer's Disease | Alzheimer's Disease Dementia

Belgium, United States, Australia, Italy, Spain, Denmark, United Kingdom, Czechia, France, Poland, Germany, Canada, Japan, Finland, Switzerland, Netherlands, Sweden
Central Hospital, Nancy, France

Recruiting

Altered Respiratory Compliance Under Invasive Mechanical Ventilation in SARS-CoV-2 & Development of Respiratory Sequels (COMPLI-QUO)

Respiratory Compliance | ARDS Due to Disease Caused by SARS Co-V-2 | Sequels of COVID

France
Regenera Pharma Ltd

Completed

A Clinical Study Evaluating the Efficacy and Safety of RPh201 Treatment in Individuals With Alzheimer's Disease With or Without Coexisting Cerebrovascular Disease

Mild to Moderate Dementia Due to Alzheimer's Disease | With or Without Coexisting Cerebrovascular Disease

Canada
Novartis Pharmaceuticals

Completed

Observation of Treatment Patterns With Lucentis in Approved Indications (OCEAN)

Neovascular AMD, Visual Impairment Due to DME, Visual Impairment Due to Macular Oedema Secondary to Branch or Central RVO, Visual Impairment Due to CNV

Germany
APRINOIA Therapeutics, LLC

Active, not recruiting

Evaluation of [18F]APN-1607 PET Uptake in Alzheimer's Disease Patients Compared With Healthy Subjects

Healthy Volunteers | Alzheimer's Disease | Mild Cognitive Impairment Due to Alzheimer's Disease

United States
APRINOIA Therapeutics

Recruiting

[18F]APN-1607 PET in Subjects With AD Compared to HC

Healthy Volunteers | Alzheimer's Disease | Mild Cognitive Impairment Due to Alzheimer's Disease

China
Centers for Medicare and Medicaid Services/ Coverage...

Recruiting

Medicare Anti-Aβ mAb Coverage With Evidence Development (CED) Study

Mild Alzheimer's Disease | Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease

United States
Douglas Mental Health University Institute
McGill University; Weston Brain Institute

Completed

Dosage and Efficacy of Probucol-induced apoE to Negate Cognitive Deterioration (DEPEND)

Mild Cognitive Impairment Due to Alzheimer Disease | Age-related Cognitive Decline | Dementia of the Alzheimer Type

Canada
Takeda

Terminated

AD-4833/TOMM40_303 Extension Study of the Safety and Efficacy of Pioglitazone to Slow Cognitive Decline in Participants With Mild Cognitive Impairment Due to Alzheimer Disease

Mild Cognitive Impairment Due to Alzheimer's Disease

United States, Australia, United Kingdom, Switzerland
Kepler University Hospital

Completed

Prediction of Conversion From Vv-ECMO to Va-ECMO in COVID-19 Patients (ECMOPred-vvva)

ARDS Due to Disease Caused by SARS Co-V-2

Austria
The First Hospital of Jilin University

Completed

Clinical Effects of Sivelestat Sodium on Improving ARDS in Patients With COVID-19

ARDS Due to Disease Caused by SARS Co-V-2

China
Prehospital Center, Region Zealand

Not yet recruiting

Patients Treated by the Danish Emergency Medical Services Following Non-drowning Water Rescues From 2016 to 2023 (RESCUE)

Drowning | Drowning, Near | Submersion | Submersion - Accidental | Submersion or Drowning Due to Being Washed Overboard | Submersion or Drowning Due to Being Thrown Overboard | Submersion or Drowning Due to Ship Sinking, Water Skier Injured | Submersion or Drowning Due to Boat Submerging, Swimmer... and other conditions

Denmark
Medical College of Wisconsin
National Institute on Aging (NIA)

Completed

Network-Level Mechanisms for Preclinical Alzheimer's Disease Development

APOE 4

United States
University of Texas Southwestern Medical Center

Completed

Clinical Trial of Lamotrigine to Reverse Cognitive Impairment in Chronic Corticosteroid-Treated Patients

Memory Impairment Due to Corticosteroid Use | Hypomania Due to Corticosteroid Use | Hippocampal Atrophy Due to Corticosteroid

United States
Mansoura University

Active, not recruiting

Management of Distally Extension Maxillary Atrophied Ridge With Two Different Minimal Invasive Treatment Modalities

Partial Edentulism Class 2 Due to Periodontal Disease

Egypt
Orthocare Innovations, LLC
National Institute on Disability, Independent Living, and Rehabilitation...

Recruiting

mGain - sEMG-based Gamified Therapy for Improved Upper Limb Rehabilitation

Stroke | Upper Limb Amputation | Upper Limb Weakness Due to Central Neurologic Injury | Upper Limb Weakness Due to Peripheral Neurologic Injury | Upper Limb Weakness Due to Nerve Reconstruction | Upper Limb Weakness Due to Tendon Transfer Surgery

United States
Bedford Hospital NHS Trust

Unknown

Finger-prick Autologous Blood (FAB) for Use in Dry Mouth

Xerostomia | Xerostomia Due to Radiotherapy | Xerostomia Due to Hyposecretion of Salivary Gland
Minia University

Completed

Role of Helicobacter Pylori in Microalbuminuria

Microalbuminuria Due to Type 2 Diabetes Mellitus

Egypt
Tianjin Medical University Cancer Institute and...

Recruiting

Minimally Invasive Intrathoracic Esophagogastric Side to Side Anastomosis vs. End to Side Anastomosis

Epiphora Due to Insufficient Drainage, Left Side | Epiphora Due to Insufficient Drainage, Right Side

China
Hospital Universitario Dr. Jose E. Gonzalez

Completed

Fecal Microbiota Transplantation as a Therapeutic Strategy in the Progression of Chronic Kidney Disease

Chronic Kidney Disease Due to Hypertension | Chronic Kidney Disease Due to Type 2 Diabetes Mellitus

Mexico
Johns Hopkins University

Completed

CGM Use in Children With Type 2 Diabetes (IMPaCT2)

Type 2 Diabetes | Hyperglycemia Due to Type 2 Diabetes Mellitus

United States
Assistance Publique - Hôpitaux de Paris

Completed

Capacity Assessment in Persons With Alzheimer's Disease (MACAP)

Alzheimer's Disease | Capacity to Consent to Treatment | Capacity to Vote | Capacity to Design a Proxy

France
Cognito Therapeutics, Inc.

Recruiting

A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (Hope Study, CA-0011) (Hope)

Cognitive Impairment | Dementia | Alzheimer Disease | Mild Cognitive Impairment | Cognitive Decline | Alzheimer Disease, Early Onset | Alzheimer Disease, Late Onset | MCI | Dementia Alzheimers | Mild Dementia | Dementia of Alzheimer Type | Cognitive Impairment, Mild | Alzheimer Disease 1 | Dementia, Mild | Alzheimer... and other conditions

United States
Pain Concern
The Thistle Foundation; Health and Social Care Alliance Scotland (the ALLIANCE) and other collaborators

Completed

Supporting Self-management of Chronic Pain

Chronic Pain | Chronic Pain Syndrome | Chronic Pain, Widespread | Chronic Pain Due to Trauma | Chronic Pain Due to Malignancy (Finding) | Chronic Pain Due to Injury | Chronic Pain Post-Procedural | Chronic Pain Hip

United Kingdom
Aphios

Not yet recruiting

Study of APH-1105 in Patients With Mild to Moderate Alzheimer's Disease

Dementia | Alzheimer Disease 1 | Alzheimer Disease 2 | Alzheimer Disease 3
Medivation, Inc.
Pfizer

Terminated

A Safety and Efficacy Study Evaluating Dimebon (Latrepirdine) in Patients With Moderate to Severe Alzheimer's Disease (CONTACT)

Moderate to Severe Alzheimer

Chile, United Kingdom
Michael von Wolff
University of Bern

Not yet recruiting

Impact of Gonadotoxic Therapies on Fertility (FertiTOX)

Cancer | Fertility Issues | Effects of Immunotherapy | Toxicity Due to Chemotherapy | Toxicity Due to Radiotherapy | Fertility Preservation
Alkahest, Inc.

Completed

A Randomized Study to Assess the Safety of GRF6019 Infusions in Subjects With Mild to Moderate Alzheimer's Disease

Alzheimer Disease | Mild to Moderate Alzheimer Disease

United States
Samsung Medical Center

Unknown

Study on the Effect of Transcranial Magnetic Stimulation in Mild to Moderate Alzheimer's Disease

Mild to Moderate Alzheimer Disease

Korea, Republic of
Ain Shams University

Recruiting

Carnitine Supplementation in Pediatric Hemodialysis Patients

Carnitine Deficiency Due to Hemodialysis

Egypt
Chang Gung Memorial Hospital

Completed

Replacement of Lamivudine by Telbivudine to Improve Renal Function

Virus Diseases | Disorder Related to Transplantation | Injury Due to Exposure to External Cause
Shanghai Greenvalley Pharmaceutical Co., Ltd.

Completed

An Efficacy and Safety Study of Sodium Oligo-mannurarate (GV-971) Capsule for the Treatment of Alzheimer's Disease

Cognitive Impairment | Mild to Moderate Alzheimer Disease

China
Regenera Pharma Ltd
Syneos Health

Completed

A Randomized SAD and MAD Study Evaluating the Safety and Tolerability of RPh201 in Healthy Subjects and in Adults With Alzheimer's Disease

Healthy Volunteers | Moderate to Severe Alzheimer Patients

Canada
Neuromed IRCCS

Completed

Supplementation With Dietary Anthocyanins and Side Effects of Radiotherapy for Breast Cancer (ATHENA)

Toxicity Due to Radiotherapy

Italy
Hyundai Pharmaceutical Co., LTD.

Recruiting

BPDO-1603 Intervention Trial in Patients With Moderate-to-severe Alzheimer's Disease

Moderate-to-severe Alzheimer's Disease

Korea, Republic of
GemVax & Kael

Active, not recruiting

GV1001 Subcutaneous(SC) for the Treatment of Mild to Moderate Alzheimer's Disease (AD)

Mild to Moderate Alzheimer's Disease

Spain, United States, Netherlands, Poland
Danyang Huichuang Medical Equipment Co., Ltd.
First Affiliated Hospital of Chongqing Medical University; Rehabilitation Hospital...

Enrolling by invitation

Efficacy and Safety of Near Infrared Light Therapy for Alzheimer's Disease

Mild to Moderate Alzheimer's Disease

China
Novartis Pharmaceuticals

Completed

NextStep:Study to Evaluate Safety,Efficacy & Tolerability of Rivastigmine Patch in Mild to Moderate Alzheimer's Patients. (ENA1stepswitch)

Mild to Moderate Alzheimer's Disease

Japan
Eisai Inc.
Pfizer

Completed

The Effectiveness And Safety Of Donepezil Hydrochloride (E2020) In Subjects With Mild To Severe Alzheimer's Disease Residing In An Assisted Living Facility

Mild to Severe Alzheimer's Disease

United States

Clinical Trials on Alzheimer Disease 2 Due to Apoe4 Isoform

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