Clinical Trials on Anal Dysplasia

Total 2489 results

ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Active, not recruiting

Cisplatin and Fluorouracil Compared With Carboplatin and Paclitaxel in Treating Patients With Inoperable Locally Recurrent or Metastatic Anal Cancer (InterAACT)

Anal Squamous Cell Carcinoma | Anal Basaloid Carcinoma | Anal Canal Cloacogenic Carcinoma | Metastatic Anal Canal Carcinoma | Recurrent Anal Canal Carcinoma | Stage IIIB Anal Canal Cancer | Stage IV Anal Canal Cancer

United States
National Cancer Institute (NCI)

Active, not recruiting

Nivolumab With or Without Ipilimumab in Treating Patients With Refractory Metastatic Anal Canal Cancer

Anal Canal Squamous Cell Carcinoma | Metastatic Anal Canal Carcinoma | Stage IV Anal Canal Cancer AJCC v6 and v7

United States, Canada
Sun Yat-sen University

Enrolling by invitation

Neoadjuvant PD-1 Blockade Combined With Chemotherapy Followed by Concurrent Immunoradiotherapy for Locally Advanced Anal Canal Squamous Carcinoma Patients

Anal Canal Cancer | Anal Squamous Cell Carcinoma | Anal Cancer | Anal Canal Cancer Stage I | Anal Canal Cancer Stage II | Anal Canal Cancer Stage III

China
Anandasabapathy, Sharmila, M.D.

Terminated

Evaluation of a Low-Cost High Resolution Microendoscope for the Detection of Lower Gastrointestinal Neoplasia

Colon Polyps | Anal Dysplasia | Colonic Dysplasia

United States
University of Roma La Sapienza

Unknown

Application of Oral Bacteriotherapy to Promote Anal HPV Clearance in HIV Positive Individuals (HPVinHIV)

HIV | Anal Dysplasia

Italy
Laser Surgery Care
QIAGEN Gaithersburg, Inc

Completed

Hybrid Capture 2 Human Papiloma Virus (HPV) High-Risk Anal DNA Test

Anal Cancer | Anal Canal HPV Infection Diagnosis | Anal Dysplasia Diagnosis

United States
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study

Anal Basaloid Carcinoma | Anal Canal Cloacogenic Carcinoma | Anal Canal Squamous Cell Carcinoma | Anal Margin Squamous Cell Carcinoma | Stage I Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8

United States
Sixth Affiliated Hospital, Sun Yat-sen University

Recruiting

Chemoradiotherapy Combined With or Without PD-1 Blockade in Anal Canal Squamous Carcinoma Patients

Anal Canal Cancer | Anal Squamous Cell Carcinoma | Anal Cancer | Anal Canal Cancer Stage III

China
Mansoura University

Completed

Idiopathic Hypertensive Anal Canal: a Place of Internal Sphincterotomy

Hypertensive Anal Canal

Egypt
Dr. Danielle Vicus

Recruiting

Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer. (Vulvar-AIN)

Cervical Cancer | Vulvar Cancer | Anal Cancer | Cervical Dysplasia | HPV-Related Anal Squamous Cell Carcinoma | Anal Dysplasia | Vulvar Dysplasia

Canada
AHS Cancer Control Alberta

Unknown

A Phase II Study to Assess Acute Toxicity and Quality of Life of Patients With Carcinoma of the Anal Canal Receiving Chemotherapy and Radiation Using Helical Tomotherapy

Anal Canal Cancer

Canada
United States Naval Medical Center, San Diego

Withdrawn

Anal Dysplasia Study of Men Who Have Sex With Men Living With HIV

HIV | Human Papilloma Virus | Anal Dysplasia

United States
Abramson Cancer Center of the University of Pennsylvania

Withdrawn

PDT Plus Vitamin D3 for Anal Dysplasia

Carcinoma in Situ | Anal Dysplasia

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

HPV Vaccine Therapy in Interrupting Progression in Patients With High-Grade Vulvar or Anal Lesions

High Grade Anal Canal Intraepithelial Neoplasia | High Grade Vulvar Squamous Intraepithelial Lesion

United States
Dr. Te Vuong
YM BioSciences

Terminated

Nimotuzumab With Radiotherapy in the Treatment of Anal Canal Cancers

Squamous Cell Carcinoma of Anal Canal

Canada
Centre Francois Baclesse
Accuray Incorporated

Active, not recruiting

Study of SIB-IMRT in Combination With 5-FU and Mitomycin-C Among Patients With Locally Advanced Anal Canal Cancer: Efficacy, Safety and Quality of Life (CANAL-IMRT-01)

Locally Advanced Anal Canal Cancer

France
Institut Cancerologie de l'Ouest

Completed

Medico-economic Evaluation Comparing Intensity-Modulated Radiation Therapy (IMRT) Performed by Helical Tomotherapy and Dynamic Arc Therapy in Prostate, Cervical and Anal Canal Cancers (RCMI PELVIS)

Cervical Cancer | Prostate Cancer | Anal Canal Cancers

France
Gangnam Severance Hospital

Completed

Effectiveness and Safety in Administrating CNU® Capsule to Refractory Functional Dyspepsia Patients

Dyspepsia | Biliary Dysplasia

Korea, Republic of
Johns Hopkins University
University of Wisconsin, Madison; Frantz Viral Therapeutics, LLC

Completed

Intra-Anally Administered Artesunate in Patients With High-Grade Anal Intraepithelial Neoplasia (AIN 2/3) (ART-AIN)

Precancerous Conditions | Human Papilloma Virus | Anal Dysplasia | HPV-Related Anal Intraepithelial Neoplasia | AIN2/3 | Artesunate | Alternative Treatment

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: a Feasibility Trial

Stage III Anal Cancer AJCC v8 | Anal Canal Squamous Cell Carcinoma | Stage IIB Anal Cancer AJCC v8 | Stage IIIA Anal Cancer AJCC v8 | Stage IIIB Anal Cancer AJCC v8 | Stage IIIC Anal Cancer AJCC v8 | Stage I Anal Cancer AJCC v8 | Stage II Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8

United States
Centre Hospitalier Universitaire de Besancon

Completed

Evaluation of Immune Response Against Human Papillomavirus (HPV)in Patients With Metastatic Cancer of the Anal Canal (Epitopes-HPV01)

Metastatic Anal Canal Cancer | Human Papillomavirus

France
The HIV Netherlands Australia Thailand Research...
Chulalongkorn University; Thai Red Cross AIDS Research Centre; South East Asia... and other collaborators

Completed

HPV in Adolescents

HPV Infection | Cervical/Anal Dysplasia

Thailand
Centre Hospitalier Universitaire de Besancon

Withdrawn

Immunomonitoring and Biomarker Research in Patients With Squamous Cell Anal Carcinoma (LAND)

Anal Canal Cancer

France
University Health Network, Toronto
Merck Sharp & Dohme LLC; Canadian Institutes of Health Research (CIHR); Ontario... and other collaborators

Terminated

The HPV-SAVE Study Team: HPV Screening and Vaccine Evaluation in Men Who Have Sex With Men (HPV-SAVE)

Anal Cancer | Human Papillomavirus | Anal Dysplasia

Canada
AHS Cancer Control Alberta

Recruiting

Inguinal Node Sparing Radiotherapy For Patients With Early Stage Anal Cancer (INSPIRE)

Anal Canal Cancer

Canada
National Cancer Institute (NCI)

Recruiting

EA2176: Phase 3 Clinical Trial of Carboplatin and Paclitaxel +/- Nivolumab in Metastatic Anal Cancer Patients

Anal Canal Cloacogenic Carcinoma | Metastatic Anal Squamous Cell Carcinoma | Recurrent Anal Squamous Cell Carcinoma | Stage III Anal Cancer AJCC v8 | Stage IV Anal Cancer AJCC v8 | Unresectable Anal Squamous Cell Carcinoma | Anal Basaloid Squamous Cell Carcinoma

United States
David Finch
Lancashire Teaching Hospitals NHS Foundation Trust

Not yet recruiting

COrSIcA: Disease Measurement

Anal Intraepithelial Neoplasia | Anal High-grade Squamous Intraepithelial Lesion | Anal HSIL
National Cancer Institute (NCI)
Canadian Cancer Trials Group

Active, not recruiting

Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer

Anal Canal Cloacogenic Carcinoma | Stage III Anal Cancer AJCC v8 | Anal Margin Squamous Cell Carcinoma | Stage IIB Anal Cancer AJCC v8 | Anal Basaloid Squamous Cell Carcinoma

United States, Canada
Massachusetts General Hospital
National Cancer Institute (NCI)

Unknown

Concurrent Chemoradiation + 5-FU + Mitomycin-C in Anal Carcinoma

Carcinoma of the Anal Canal

United States
National Cancer Institute (NCI)

Recruiting

Therapy Adapted for High Risk and Low Risk HIV-Associated Anal Cancer

HIV Infection | Anal Squamous Cell Carcinoma | Anal Canal Cloacogenic Carcinoma | Stage III Anal Cancer AJCC v8 | Stage III Rectal Cancer AJCC v8 | Stage II Rectal Cancer AJCC v8 | Anal Margin Squamous Cell Carcinoma | AIDS-Related Anal Carcinoma | Rectal Squamous Cell Carcinoma | Stage I Anal Cancer AJCC... and other conditions

United States
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of Arkansas; The Emmes Company, LLC; AIDS and Cancer Specimen Resource

Active, not recruiting

Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection

HIV Infection | Anal Squamous Cell Carcinoma | Stage 0 Anal Canal Cancer | Stage I Anal Canal Cancer

United States
Instituto do Cancer do Estado de São Paulo

Completed

A Study of Substitution of 5-FU (Fluorouracil) by Capecitabine in Scheme of Chemo-radiotherapy in Patients With Squamous Cell Carcinoma of the Anal Canal.

Anal Canal Cancer.

Brazil
Centre Hospitalier Universitaire Vaudois

Terminated

Phase II Study of Concomitant Intensity-modulated Radiotherapy Combined to Capecitabine, Mitomycin and Panitumumab in Patients With Stage II-IIIB Squamous-cell Carcinoma of the Anal Canal

Carcinoma of Anal Canal

Switzerland
Centre Hospitalier Universitaire de Besancon

Completed

Clinical and Biological Interest of Taxanes in Advanced Squamous Cell Anal Carcinoma (Epitopes-HPV02)

Anal Canal Carcinoma

France
Incyte Corporation

Completed

A Study of INCMGA00012 in Squamous Carcinoma of the Anal Canal Following Platinum-Based Chemotherapy (POD1UM-202)

Squamous Cell Carcinoma of Anal Canal

Spain, United Kingdom, United States, Germany, Belgium, France, Denmark, Italy, Norway
Boehringer Ingelheim

Withdrawn

A Study to Test BI 754091 Alone or in Combination With BI 836880 in People Who Have Advanced Anal Cancer

Anal Canal Squamous Cell Carcinoma

Korea, Republic of
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

4-Point Therapy Response Score With PET/CT for Anal Squamous Cell Cancer

Anal Squamous Cell Carcinoma | Stage III Anal Cancer AJCC v8 | Stage IIB Anal Cancer AJCC v8 | Stage IIIA Anal Cancer AJCC v8 | Stage IIIB Anal Cancer AJCC v8 | Stage IIIC Anal Cancer AJCC v8 | Stage I Anal Cancer AJCC v8 | Stage II Anal Cancer AJCC v8 | Stage IIA Anal Cancer AJCC v8 | Stage 0 Anal Cancer...

United States
The Cleveland Clinic
Bard Ltd

Completed

Comparative Study Between Two Fecal Management Systems

Anal Erosion

United States
Hospices Civils de Lyon

Completed

Assessment of the Predictive Value of the Acetic Acid Test in Surgery Condition for the Detection of Dysplastic Lesions in Patients With Anal Condylomatosis

Anal Condyloma

France
University Hospitals Cleveland Medical Center

Completed

A Randomized Trial of Surgical Treatments for Vulvar and Vaginal Dysplasia

Vaginal Dysplasia | Vulvar Dysplasia

United States
Grupo Espanol Multidisciplinario del Cancer Digestivo
Hoffmann-La Roche

Recruiting

Tiraglolumab Atezolizumab and Chemoradiotherapy in Localized Anal Carcinoma (TIRANUS) (TIRANUS)

Squamous Cell Carcinoma of the Anal Canal

Spain
University Health Network, Toronto
Canadian Foundation for AIDS Research (CANFAR); Ontario HIV Treatment Network

Completed

Screening for HIV-Associated Anal Cancer (TRACE)

HIV Infections | Papillomavirus Infections | Anal Cancer | Anal Dysplasia

Canada
Hvidovre University Hospital

Unknown

Ultrasound Guided Lateral Sphincterotomy: Long Term Results

Focus: Anal Incontinence After Lateral Sphincterotomy for Chronic Anal Fissure

Denmark
Sixth Affiliated Hospital, Sun Yat-sen University
Guangdong Provincial Hospital of Traditional Chinese Medicine; Cancer Institute... and other collaborators

Unknown

"Cross" Closure for Reconstructing the Perineal Wound of Abdominoperineal Resection (CCRPWAR)

Rectal Cancer | Anal Canal Cancer
RDD Pharma Ltd

Completed

An Open Label Study to Examine the Effect of Coated Nifedipine Suppositories on Anal Pressure in Healthy Subjects

Anal Resting Pressure

Israel
Poitiers University Hospital

Recruiting

Reproducibility of External Anal Sphincter Elastic Properties Assessment Using Elastography During Pregnancy (SEA ELASTO 1)

Obstetric Anal Sphincter Injury

France
Frantz Viral Therapeutics, LLC
University of California, San Francisco; Laser Surgery Care; Amarex CRO; Anal Dysplasia...

Active, not recruiting

Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL (anal HSIL HIV-)

HPV Infection | Anal Dysplasia | Anal High Grade Squamous Intraepithelial Lesion | Anal Precancerous Condition | AIN 2/3 | HPV Disease

United States
Incyte Corporation

Active, not recruiting

Carboplatin-paclitaxel With Retifanlimab or Placebo in Participants With Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (POD1UM-303/InterAACT 2).

Squamous Cell Carcinoma of the Anal Canal

United States, Italy, Spain, United Kingdom, Australia, France, Germany, Sweden, Japan, Norway, Belgium, Denmark, Puerto Rico
Institut Paoli-Calmettes

Completed

Interstitial Brachytherapy Boost for Treatment of Anal Canal Cancers, Comparison of Two Dose Rates (BOOST-CA)

Anal Canal Cancer

France
Northwell Health
Mayo Clinic; NinePoint Medical

Completed

Volumetric Laser Endomicroscopy With Intelligent Real-time Image Segmentation (IRIS)

Barrett's Esophagus Without Dysplasia | Barrett's Esophagus With Dysplasia | Barrett's Esophagus With Low Grade Dysplasia | Barrett's Esophagus With High Grade Dysplasia | Barrett's Esophagus With Dysplasia, Unspecified

United States

Clinical Trials on Anal Dysplasia

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