Clinical Trials on Congenital Fibrinogen Deficiency

Total 17479 results

Octapharma

Completed

Study to Assess the Efficacy, Safety and Pharmacokinetic of Octafibrin in Paediatric Subjects With Fibrinogen Deficiency

Congenital Fibrinogen Deficiency

India, Iran, Islamic Republic of, Lebanon
Octapharma

Completed

Efficacy and Safety Study of Octafibrin for On-demand Treatment of Acute Bleeding and to Prevent Bleeding During and After Surgery

Congenital Fibrinogen Deficiency

United States, Bulgaria, India, Iran, Islamic Republic of, Lebanon, Russian Federation, Saudi Arabia, Turkey, United Kingdom
Octapharma

Recruiting

Safety and Efficacy of Fibryga in Congenital Fibrinogen Deficiency

Congenital Fibrinogen Deficiency

Germany
Octapharma

Completed

Pharmacokinetic, Efficacy, and Safety Study of Octafibrin Compared to Haemocomplettan/Riastap

Congenital Fibrinogen Deficiency | Afibrinogenemia

Iran, Islamic Republic of, United States, Bulgaria, India, Switzerland, United Kingdom
CSL Behring

Completed

An Observational Cohort Study of the Safety and Efficacy of Fibrinogen Concentrate, Human (FCH) in Subjects With Congenital Fibrinogen Deficiency

Congenital Fibrinogen Deficiency

United States, Canada
Hospital Clinic of Barcelona
University of Barcelona

Completed

Pharmacokinetic Model of Fibrinogen Plasma Levels After Fibrinogen Administration (PKMF)

Fibrinogen; Deficiency, Acquired | PHARMACOKINETICS

Spain
University Health Network, Toronto

Completed

FIBrinogen REplenishment in Surgery (FIBRES)

Deficiency; Fibrinogen, Acquired

Canada
Laboratoire français de Fractionnement et de Biotechnologies

Completed

Human Fibrinogen Concentrate (FGTW) in Pediatric Patients With Congenital Fibrinogen Deficiency

Hypofibrinogenemia, Congenital | Afibrinogenemia, Congenital

France, Lebanon, Morocco, Turkey
Biotest
Accovion GmbH; ICON plc; SYNLAB Analytics and Services Germany GmbH; Phoenix Clinical... and other collaborators

Completed

Pharmacokinetic, Efficacy and Safety of BT524 in Patients With Congenital Fibrinogen Deficiency

Congenital Afibrinogenemia | Congenital Hypofibrinogenemia

Bulgaria, Egypt, Germany, Lebanon, Tunisia
Isala
CSL Behring

Completed

Haemocomplettan® P During Elective Complex Cardiac Surgery

Fibrinogen Deficiency in Complex Cardiac Surgery

Netherlands
University Hospital Inselspital, Berne

Completed

Kinetics of Plasma Fibrinogen in Cardiac Surgery

Fibrinogens, Abnormal

Switzerland
Royal College of Surgeons, Ireland
Enterprise Ireland; Dublin City University

Unknown

F-Point Validation Study (F-Point)

Low Fibrinogen

Ireland
Société Française d'Anesthésie et de Réanimation
Keyrus Biopharma

Unknown

Observational Study About the Use of Fibrinogen in Adult Cardiac Surgery

Cardiac Surgery | Extracorporeal Circulation | Fibrinogen
UCSF Benioff Children's Hospital Oakland
University of California, San Francisco

Completed

Pediatric ACEs Screening and Resiliency Study (PEARLS)

Inflammatory Response | Self-regulation | Fibrinogen Abnormality | Telomere Length, Mean Leukocyte | Atopic | Acute Infection

United States
CSL Behring

Completed

Human Fibrinogen - Pharmacokinetics

Fibrinogen Deficiency

United States, Italy
University of Sao Paulo General Hospital

Completed

Early Administration of Fibrinogen in Polytraumatized Patients With Hypofibrinogenemia: a Randomized Feasibility Trial

Trauma | Bleeding Disorder | Fibrinogen; Deficiency, Acquired

Brazil
CSL Behring

Withdrawn

Fibrinogen Concentrate (Human) - Efficacy and Safety Study

Afibrinogenemia | Hypofibrinogenemia | Fibrinogen Deficiency
Centers for Disease Control and Prevention

Completed

Limb Loss Self-Management Program

Congenital or Acquired Limb Deficiency

United States
Assiut University

Not yet recruiting

Cystatin D Fibrinogen Like Protein 1

Fibrinogen Like Protein 1
QOL Medical, LLC

Completed

Adult Pilot Study for Reference Ranges and Optimal Cut-offs for the Sucrose Challenge Test and Sucrose Breath Test

Congenital Sucrase-Isomaltase Deficiency

United States
National Cardiovascular Center Harapan Kita Hospital...

Unknown

Thiamine Influenced on Substrate Energy Effectiveness in Indonesian Children Undergoing Cardiopulmonary Bypass

Cardiopulmonary Bypass | Congenital Heart Disease | Thiamine Deficiency

Indonesia
Children's Hospital of Eastern Ontario
McGill University; Ottawa Hospital Research Institute; The Ottawa Hospital; Children...

Completed

Prevention of Vitamin D Deficiency Following Pediatric CHD Surgery: a Phase II Dose Evaluation Randomized Controlled Trial Comparing Usual Care With a High Dose Pre-operative Supplementation Regimen Based on the Institute of Medicine Daily Upper Tolerable Intake Level (HICCUPS 2)

Vitamin D Deficiency | Heart Defects, Congenital | Thoracic Surgery | Pediatric Disorders

Canada
Queen Fabiola Children's University Hospital

Recruiting

Iron Deficiency in Pediatric Heart Surgery

Iron Deficiency Anemia | Congenital Heart Disease in Children | Cardiac Surgical Procedures | Iron Deficiencies

Belgium
University of Minnesota

Recruiting

Treatment of LSCD With DM

Limbal Stem-cell Deficiency | Congenital Aniridia

United States
Northwestern University

Completed

The Effects of Metreleptin in Congenital Leptin Deficiency

Congenital Leptin Deficiency (Disorder)

United States
QOL Medical, LLC
Johns Hopkins University; Massachusetts General Hospital; Baylor College of Medicine and other collaborators

Completed

Congenital Sucrase-Isomaltase Deficiency (CSID) Genetic Prevalence Study (GPS) (CSID GPS)

Congenital Sucrase-isomaltase Deficiency (CSID)

United States
Istanbul University

Completed

Evaluation of Relationship Between Preoperative Fibrinogen/Albumin Ratio and Morbidity After Hip Fracture Operations

Hip Fractures | Elderly | Fibrinogen | Albumin | Scoring Systems | Preoperative Risk Prediction

Turkey
Maggie's Pearl, LLC

Active, not recruiting

Oral Epalrestat Therapy in Pediatric Subjects With PMM2-CDG

Pmm2-CDG | Phosphomannomutase 2 Deficiency | Phosphomannomutase 2 Congenital Disorder of Glycosylation | Phosphomannomutase II Congenital Disorder of Glycosylation | Phosphomannomutase II Deficiency

United States
Pfizer

Completed

Post-Marketing Surveillance To Observe Safety And Efficacy Of Xyntha Solofuse Prefilled Syringe

Factor VIII Deficiency, Congenital | Hemophilia A, Congenital | Factor 8 Deficiency, Congenital | Autosomal Hemophilia A | Classic Hemophilia
Angel Augusto Perez Calatayud
Grupo Mexicano para el Estudio de la Medicina Intensiva

Completed

Patient Blood Management for Massive Obstetric Hemorrhage

Post Partum Hemorrhage | Transfusion Related Complication | Fibrinogenolysis; Hemorrhage | Fibrinogen; Deficiency, Acquired | Massive Hemorrhage

Mexico
University of Alberta

Withdrawn

Initiation of Resuscitation While Attached to the Cord With Congenital Heart Disease (INSPIRE-CHD)

Hypoplastic Left Heart Syndrome | Congenital Heart Defect | TGA - Transposition of Great Arteries | Congential Absence of Heart Structure | Congenital Malformation of Heart, Unspecified | Hypoplastic Right Heart Syndrome | Congential Malformations of Aortic Valve | Congential Malformations of Great...

Canada
Universitas Sumatera Utara

Not yet recruiting

The Role of Thiamine After Transcatheter Closure in Children With Left-to-Right Shunt Congenital Heart Disease

Atrial Septal Defect | Congenital Heart Disease | Patent Ductus Arteriosus | Ventricular Septal Defect | Thiamine Deficiency

Indonesia
QOL Medical, LLC

Recruiting

7-Day Trial of Sucraid for Alleviating CSID Symptoms in Subjects With Low, Moderate, and Normal Sucrase Levels

Congenital Sucrase-Isomaltase Deficiency | CSID | Sucrase Isomaltase Deficiency

United States
University of Alabama at Birmingham

Completed

Feasibility, Acceptability and Directional Signal Effect on Blood Folate Levels of Iodized Salt Fortified With Folic Acid: Clinical Study (FASALT)

Folic Acid Deficiency | Neural Tube Defects | Fortification

United States
Octapharma

Recruiting

Efficacy of Atenativ in Patients With Congenital Antithrombin Deficiency Undergoing Surgery or Delivery

Congenital Antithrombin Deficiency

Spain, United States, Italy, France, Hungary, Austria, Germany, United Kingdom
Kyowa Hakko Kirin UK, Ltd.

Completed

A Study of KW-3357 in Congenital Antithrombin Deficiency

Congenital Antithrombin Deficiency

France, Germany, Italy, Sweden, United Kingdom
University of Sao Paulo
CSL Behring

Completed

Fibrinogen Concentrate In Children After Cardiac Surgery (FiCCS)

Blood Coagulation Disorders | Cardiac Surgical Procedures | Fibrinogen | Cryoprecipitate

Brazil
Cure CMD
Congenital Muscle Disease International Registr

Withdrawn

LAMA2-related Muscular Dystrophy Brain Study

LAMA2-MD (Merosin Deficient Congenital Muscular Dystrophy, MDC1A)

United States
The University of Hong Kong
Queen Mary Hospital, Hong Kong

Not yet recruiting

Effect of Folic Acid Supplementation in Pregnant Women Having Thalassaemia Trait

Thalassemia | Folic Acid Deficiency Anemia
Novo Nordisk A/S

Completed

Observational Study on Safety and Efficacy of NovoSeven® in Subjects With Congenital FVII Deficiency

Congenital Bleeding Disorder | Congenital FVII Deficiency

Japan
Novo Nordisk A/S

Enrolling by invitation

A Study of Safety and Effectiveness of NovoThirteen® (rFXIII) During Treatment of Congenital FXIII Deficiency in Japan

Congenital Bleeding Disorder | Congenital FXIII Deficiency

Japan
Novo Nordisk A/S

Completed

Use of rFXIII in Treatment of Congenital FXIII Deficiency, a Prospective Multi-centre Observational Study (mentor™6)

Congenital Bleeding Disorder | Congenital FXIII Deficiency

Spain, United States, Canada, Italy, United Kingdom, Hungary
Novo Nordisk A/S

Completed

Safety and Efficacy of Monthly Replacement Therapy With Recombinant Factor XIII (rFXIII) in Paediatric Subjects With Congenital Factor XIII A-subunit Deficiency (mentor™5)

Congenital Bleeding Disorder | Congenital FXIII Deficiency

United Kingdom, Israel, United States
Novo Nordisk A/S

Completed

Safety of a Single Intravenous Dose of Recombinant Factor XIII in Children With Congenital FXIII A-subunit Deficiency (mentor™4)

Congenital Bleeding Disorder | Congenital FXIII Deficiency

United States, Israel, United Kingdom
Novo Nordisk A/S

Completed

Safety and Pharmacokinetics of Recombinant Factor XIII in Healthy Volunteers

Healthy | Congenital Bleeding Disorder | Congenital FXIII Deficiency

United Kingdom
Novo Nordisk A/S

Completed

Safety and Pharmacokinetics of Recombinant Factor XIII Administration in Healthy Volunteers

Healthy | Congenital Bleeding Disorder | Congenital FXIII Deficiency

United Kingdom
Novo Nordisk A/S

Completed

Safety of Monthly Recombinant Factor XIII Replacement Therapy in Subjects With Congenital Factor XIII Deficiency: An Extension to Trial F13CD-1725 (mentor™2)

Congenital Bleeding Disorder | Congenital FXIII Deficiency

France, United States, Israel, Spain, Switzerland, Germany, Canada, Japan, United Kingdom, Italy, Finland, Austria
Novo Nordisk A/S

Completed

Treatment of Congenital Factor VII Deficiency (F7CONDEF)

Congenital Bleeding Disorder | Congenital FVII Deficiency

Slovakia, Israel, Spain, India, Iran, Islamic Republic of, Pakistan, Turkey, Germany, Serbia, Italy, Greece, Thailand, France, United States, Hong Kong, Venezuela
Hydrocephalus and Neuroscience Institute

Completed

Salt-FA to Increase Folate Levels

Folic Acid Deficiency | Neural Tube Defects | Spina Bifida | Anencephaly-Spina Bifida

United States
University Hospital, Grenoble

Not yet recruiting

Technical Feasibility Study of Ultrasound Muscle Imaging in Antenatal Ultrasound (FetUS)

Arthrogryposis Multiplex Congenita (AMC)

Clinical Trials on Congenital Fibrinogen Deficiency

Sponsors and Collaborators

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CROs in Spain

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Drug Interventions

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