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Clinical Trials on Diffuse Intrinsic Pontine Glioma

Total 112 results

NCT05843253

Not yet recruiting

Study of Ribociclib and Everolimus in HGG and DIPG

Glioblastoma | Glioblastoma Multiforme | High Grade Glioma | Anaplastic Astrocytoma | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | WHO Grade III Glioma | Metastatic Brain Tumor | WHO Grade IV Glioma
NCT05839379

Not yet recruiting

Targeted Pediatric High-Grade Glioma Therapy

Glioblastoma | Glioblastoma Multiforme | High Grade Glioma | Anaplastic Astrocytoma | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | WHO Grade III Glioma | Metastatic Brain Tumor | WHO Grade IV Glioma
NCT05768880

Recruiting

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma | Refractory Primary Malignant Central Nervous System Neoplasm | Recurrent CNS Tumor, Adult | Recurrent, CNS Tumor, Childhood
NCT05762419

Recruiting

FUS Etoposide for DMG - A Feasibility Study

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant
NCT05717699

Recruiting

Oncolytic Virus Ad-TD-nsIL12 for Progressive Pediatric Diffuse Intrinsic Pontine Glioma

Diffuse Intrinsic Pontine Glioma | Adverse Drug Event | Oncolytic Virus
NCT05717712

Recruiting

Oncolytic Virus Ad-TD-nsIL12 for Primary Pediatric Diffuse Intrinsic Pontine Glioma

Diffuse Intrinsic Pontine Glioma | Adverse Drug Event | Oncolytic Virus
NCT05630209

Recruiting

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG

Brain Tumor
NCT05615623

Recruiting

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG

Brain Tumor
NCT05500508

Recruiting

Oral AMXT 1501 Dicaprate in Combination With IV DFMO

Melanoma | Cervical Cancer | Cancer | Breast Cancer | Head and Neck Cancer | Gastric Cancer | Colorectal Cancer | Esophageal Cancer | Solid Tumor | Endometrial Cancer
NCT05476939

Recruiting

Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0 (BIOMEDE 2)

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant
NCT05298995

Not yet recruiting

GD2-CAR T Cells for Pediatric Brain Tumours

High Grade Glioma | Medulloblastoma, Childhood | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma | Embryonal Tumor | Brain Tumor Adult | Brain Tumor, Pediatric
NCT05278208

Recruiting

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors or Meningiomas Expressing SST2A

High Grade Glioma | Medulloblastoma | Meningioma | Anaplastic Ependymoma | Recurrent Malignant Glioma | Recurrent Medulloblastoma | Refractory Malignant Glioma | Refractory Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Recurrent Primary Central Nervous System Neoplasm
NCT05123534

Recruiting

A Phase 2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 Type 2.0 in Patients With DIPG

Diffuse Intrinsic Pontine Glioma
NCT05099003

Recruiting

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Glioblastoma | Malignant Glioma | Anaplastic Astrocytoma | Anaplastic Astrocytoma, Not Otherwise Specified | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | Glioblastoma, Not Otherwise Specified
NCT05096481

Not yet recruiting

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

High Grade Glioma | Recurrent Medulloblastoma | Diffuse Intrinsic Pontine Glioma
NCT05009992

Recruiting

Combination Therapy for the Treatment of Diffuse Midline Gliomas

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent Diffuse Intrinsic Pontine Glioma | Recurrent Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent WHO Grade III Glioma | WHO Grade III Glioma
NCT04978727

Recruiting

A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Glioblastoma Multiforme | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Ependymoma | Anaplastic Oligodendroglioma | Diffuse Intrinsic Pontine Glioma | High-grade Astrocytoma NOS
NCT04943848

Recruiting

rHSC-DIPGVax Plus Checkpoint Blockade for the Treatment of Newly Diagnosed DIPG and DMG

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant
NCT04870944

Recruiting

CBL0137 for the Treatment of Relapsed or Refractory Solid Tumors, Including CNS Tumors and Lymphoma

Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Recurrent Lymphoma | Recurrent Malignant Solid Neoplasm | Recurrent Osteosarcoma | Refractory Osteosarcoma | Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent Diffuse Intrinsic Pontine Glioma | Metastatic Malignant Neoplasm in the Central Nervous System | Recurrent Primary Malignant Central Nervous System Neoplasm
NCT04837547

Recruiting

PEACH TRIAL- Precision Medicine and Adoptive Cellular Therapy (PEACH)

Neuroblastoma | Diffuse Intrinsic Pontine Glioma
NCT04771897

Recruiting

A Study of BXQ-350 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) or Diffuse Midline Glioma (DMG) (KONQUER)

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant
NCT04758533

Recruiting

Clinical Trial to Assess the Safety and Efficacy of AloCELYVIR With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) in Combination With Radiotherapy or Medulloblastoma in Monotherapy (AloCELYVIR)

Diffuse Intrinsic Pontine Glioma | Medulloblastoma, Childhood, Recurrent
NCT04749641

Recruiting

Neoantigen Vaccine Therapy Against H3.3-K27M Diffuse Intrinsic Pontine Glioma (ENACTING)

Diffuse Intrinsic Pontine Glioma
NCT04670016

Recruiting

HRQL and Symptom Assessment for Patients With DIPG or Recurrent and Re-irradiated Brain Tumours and Their Caregivers

Radiation Toxicity | Radiation Exposure | DIPG | Brain Tumor, Pediatric, Recurrent | Brain Tumor, Pediatric | Brain Tumor, DIPG
NCT04655404

Recruiting

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

High Grade Glioma | Diffuse Intrinsic Pontine Glioma
NCT04532229

Recruiting

Nimotuzumab in Combined With Chemoradiotherapy to Treat the Newly Diagnosed Diffuse Intrinsic Pontine Glioma in Children

Diffuse Intrinsic Pontine Glioma
NCT04264143

Recruiting

CED of MTX110 Newly Diagnosed Diffuse Midline Gliomas

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma | Diffuse Pontine and Thalamic Gliomas
NCT04250064

Recruiting

A Study of Low Dose Bevacizumab With Conventional Radiotherapy Alone in Diffuse Intrinsic Pontine Glioma (LoBULarDIPG)

DIPG
NCT04238819

Recruiting

A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma

Relapsed Solid Tumor | Refractory Solid Tumor
NCT04196413

Recruiting

GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG)

Glioma of Spinal Cord | Glioma of Brainstem
NCT04185038

Recruiting

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Glioma | Ependymoma | Medulloblastoma, Childhood | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma | Central Nervous System Tumor | Germ Cell Tumor | Atypical Teratoid/Rhabdoid Tumor | Primitive Neuroectodermal Tumor | Choroid Plexus Carcinoma
NCT04099797

Recruiting

C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)

High Grade Glioma | Diffuse Intrinsic Pontine Glioma | Embryonal Tumor | Ependymal Tumor
NCT04049669

Recruiting

Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPG

Glioblastoma | Ependymoma | Medulloblastoma | Diffuse Intrinsic Pontine Glioma
NCT03709680

Recruiting

Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors

Ewing Sarcoma | Medulloblastoma | Rhabdoid Tumor | Neuroblastoma | Solid Tumors | Rhabdomyosarcoma | Diffuse Intrinsic Pontine Glioma
NCT03605550

Recruiting

A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

High Grade Glioma | Diffuse Intrinsic Pontine Glioma
NCT03598244

Recruiting

Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors

Recurrent Malignant Glioma | Recurrent Medulloblastoma | Refractory Malignant Glioma | Refractory Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Recurrent Primary Central Nervous System Neoplasm | Refractory Primary Central Nervous System Neoplasm | Refractory Diffuse Intrinsic Pontine Glioma
NCT03396575

Recruiting

Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) (BRAVO)

Brain Stem Glioma | Diffuse Intrinsic Pontine Glioma (DIPG)
NCT03243461

Recruiting

International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013) (HIT-HGG-2013)

Diffuse Intrinsic Pontine Glioma | Gliomatosis Cerebri | Glioblastoma WHO Grade IV | Diffuse Midline Glioma Histone 3 K27M WHO Grade IV | Anaplastic Astrocytoma WHO Grade III
NCT03126266

Recruiting

Re-Irradiation of Progressive or Recurrent DIPG

Recurrent or Progressive Diffuse Intrinsic Pontine Glioma
NCT03101813

Recruiting

International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | Diffuse Midline Glioma
NCT02992015

Recruiting

Gemcitabine in Newly-Diagnosed Diffuse Intrinsic Pontine Glioma

Diffuse Intrinsic Pontine Glioma
NCT02644460

Recruiting

Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors (AflacST1501)

Diffuse Intrinsic Pontine Glioma | Brain Tumor, Recurrent | Solid Tumor, Recurrent | Neuroblastoma, Recurrent, Refractory | Ewing Sarcoma, Recurrent, Refractory | Rhabdomyosarcoma, Recurrent, Refractory | Osteosarcoma, Recurrent, Refractory | Rhabdoid Tumor, Recurrent, Refractory
NCT02359565

Recruiting

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

Lynch Syndrome | Malignant Glioma | Recurrent Childhood Ependymoma | Recurrent Medulloblastoma | Refractory Ependymoma | Refractory Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Refractory Diffuse Intrinsic Pontine Glioma | Recurrent Brain Neoplasm | Refractory Brain Neoplasm
NCT01837862

Recruiting

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

Glioblastoma Multiforme | Gliosarcoma | Anaplastic Astrocytoma | Pleomorphic Xanthoastrocytoma | Pilocytic Astrocytoma | Diffuse Intrinsic Pontine Glioma | Low-grade Glioma | DIPG | Brainstem Glioma | Optic Nerve Glioma
NCT01106794

Recruiting

Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma

Diffuse Intrinsic Pontine Glioma | Brainstem Glioma
NCT03841435

Completed

Hypofractionated Radiotherapy for Recurrent DIPG

Recurrent Diffuse Intrinsic Pontine Glioma
NCT05518838

Available

Expanded Access to OKN-007 for Patients With Diffuse Midline Glioma, H3 K27-altered

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant
NCT03893487

Active, not recruiting

Fimepinostat in Treating Brain Tumors in Children and Young Adults (PNOC016)

Recurrent Glioblastoma | Recurrent Malignant Glioma | Recurrent Medulloblastoma | Diffuse Intrinsic Pontine Glioma | Recurrent Anaplastic Astrocytoma
NCT01445288

Completed

Exploratory Study of Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors

Ependymoma | Medulloblastoma | PNET | Diffuse Intrinsic Pontine Glioma | Germinoma
NCT03416530

Active, not recruiting

ONC201 in Pediatric H3 K27M Gliomas

Diffuse Intrinsic Pontine Glioma | Glioma, Malignant

Clinical Trials on Diffuse Intrinsic Pontine Glioma

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