Clinical Trials on Dysmetabolic Iron Overload Syndrome

Total 272 results

Rennes University Hospital

Completed

A Prospective, Mono-center, Interventional Study Evaluating the Effect of One Year Initial Care by Hygieno-dietary Advices With or Without Phlebotomy on Glycemia After at Least 5 Years in Patients With Dysmetabolic Iron Overload Syndrome (EvoHSD)

Dysmetabolic Iron Overload Syndrome

France
University Hospital, Clermont-Ferrand
Institut National de la Recherche Agronomique

Unknown

MEPHISTO (Macrophage Phenotype In Metabolic Syndrome With Iron Overload) (MEPHISTO)

Metabolic Syndrome X | Dysmetabolic Iron Overload Syndrome

France
University Hospital, Clermont-Ferrand

Completed

Effects of Polyphenols on Iron Absorption in Iron Overload Disorders. (POLYFER)

Polyphenols | Iron Absorption | Dysmetabolic Iron Overload Syndrome | Genetic Hemochromatosis

France
Rennes University Hospital

Terminated

Rare Iron Overloads Except C282Y Homozygosity : Description and Characterization. (HEPCIDEF)

Rare Iron Overloads Except C282Y Homozygosity

France
University Hospital, Lille

Terminated

Respiratory Variations for Assessing Blood Withdrawal 2 (ReVAs2)

Obese | Hyperferritinemia | Dysmetabolic Syndrome

France
Novartis Pharmaceuticals

Terminated

Myelodysplastic Syndrome (MDS) Gastrointestinal (GI) Tolerability Study (MACS1574)

Myelodysplastic Syndrome | Transfusional Iron Overload

Spain, France, Italy, South Africa
Rennes University Hospital

Completed

Analysis of the Modulation of Serum Hepcidin Level in Response to Iron Oral Intake: Potential Interest for the Differential Diagnosis Between Ferroportin Disease and Dysmetabolic Hepatosiderosis.

Diagnosis | Hemochromatosis, Type 4 | Ferroportin Disease | Dysmetabolic Hepatosiderosis

France
Novartis Pharmaceuticals

Completed

Extension Study of Iron Chelation Therapy With Deferasirox in Patients With Transfusional Iron Overload

Transfusional Iron Overload

Italy
ApoPharma

Completed

Active Drug Surveillance Program of Ferriprox Use

Transfusional Iron Overload

Egypt, Cyprus, Oman, Saudi Arabia, Turkey
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Deferasirox in Patients With Myelodysplastic Syndrome and Transfusion-dependent Iron Overload

Myelodysplastic Syndromes | Transfusion Dependent Iron Overload

Germany
Sheba Medical Center
Hadassah Medical Organization; Kaplan Medical Center; Tel Aviv Medical Center; Ziv...

Completed

Effect of Deferiprone on Oxidative-Stress and Iron-Overload in Low Risk Transfusion-Dependent MDS Patients

Myelodysplastic Syndrome With Low-grade Lesions | Iron Overload Due to Repeated Red Blood Cell Transfusions

Israel
Novartis Pharmaceuticals

Completed

Study to Assess Iron Chelation Therapy in Patients With Chronic Iron Overload (EXCALIBUR)

Chronic Iron Overload

Germany
Novartis Pharmaceuticals

Not yet recruiting

Survey to Assess Physicians' Knowledge of Exjade Posology and Biological Monitoring Recommendations as Described in the Educational Materials

Chronic Iron Overload
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Deferasirox in Combination With Deferoxamine Followed by Deferasirox Monotherapy in Severe Cardiac Iron Overload (HYPERION)

Cardiac Iron Overload

Taiwan, Egypt, Thailand, Turkey, United Kingdom, Italy, Canada, Greece
Assiut University

Unknown

Platelet Changes in Cases of Iron Overload(IO)

Platelet Changes in Cases of Iron Overload
ApoPharma

Completed

Safety and Acceptability of Deferiprone Delayed Release Tablets in Patients With Systemic Iron Overload (TWICE)

Iron Overload Due to Repeated Red Blood Cell Transfusions

United States, Canada, Greece, Italy
Assiut University

Unknown

Platelet Changes in Cases of Chronic Iron Over Load

Platelet Changes in Cases of Iron Overload
Shire

Terminated

Study for Transfusionally Iron Overloaded Children, Adolescents and Adults Using FBS0701 (SSP-004184)

Iron Overload Due to Repeated Red Blood Cell Transfusions

Canada, United States, Thailand, Italy, United Kingdom
Wolfson Medical Center
Hadassah Medical Organization; Tel-Aviv Sourasky Medical Center; Sheba Medical... and other collaborators

Completed

Evaluation the Effect of Exjade on Oxidative Stress in Low Risk Myelodysplastic Syndrome Patients With Iron Over Load

Myelodysplastic Syndrome

Israel
Shire

Terminated

Pharmacokinetics of SSP-004184 in the Treatment of Chronic Iron Overload Requiring Chelation Therapy

Iron Overload Due to Repeated Red Blood Cell Transfusions

United States, Canada, Lebanon, Italy, Egypt
Rennes University Hospital

Completed

Evaluation of MRI Sequences in Hepatic Overload (HEPAT_MR)

Iron and Fat Hepatic Overload

France
Fondazione Italiana Sindromi Mielodisplastiche-ETS

Terminated

Early and Low Dose Deferasirox (3.5 mg/kg FCT) to Suppress NTBI and LPI as Early Intervention to Prevent Tissue Iron Overload in Lower Risk MDS

Myelodysplastic Syndromes

Italy
Novartis Pharmaceuticals

Completed

Study of Deferasirox for Treatment of Transfusional Iron Overload in Myelodysplastic Patients

Iron Overload | Myelodysplastic Syndrome

United States, Canada
Rennes University Hospital

Completed

Comparison of the Variability of Hepatic Load Quantification in Iron and Fat Estimated by MRI at 1.5 and 3 Tesla (HEMOCOMPARE)

Iron Hepatic Overload | Fat Hepatic Overload

France
Novartis Pharmaceuticals

Completed

Study for the Treatment of Transfusional Iron Overload in Myelodysplastic Patients

Myelodysplastic Syndromes | Iron Overload

United States
Zealand University Hospital

Completed

Iron Overload and Transient Elastography in Patients With Myelodysplastic Syndrome

Myelodysplastic Syndrome

Denmark
Novartis Pharmaceuticals

Completed

Safety and Efficacy of Deferasirox in Patients With Transfusion Dependent Iron Overload - a Non-comparative Extension Study

Liver Iron Overload

Italy
University of Pisa
IRCCS Burlo Garofolo; University of Genova

Recruiting

Risk Factors and Measures to Prevent Liver and Pancreas Complications in Pediatric Patients After HSCT

Iron Overload

Italy
University of Utah

Terminated

The Iron Content of Ferritin in Serum and Urine of Children With High Serum Ferritin Levels

Iron Overload

United States
Andrea Kew

Completed

Safety and Efficacy of Iron Reduction by Phlebotomy

Iron Overload

Canada
Novartis Pharmaceuticals

Completed

Open-Label Single-Arm Pilot Study in Adult Allogeneic Hematopoietic Stem Cell Transplant Recipients With Transfusional Iron Overload

Iron Overload

Spain
The University of Texas Health Science Center at...
Abfero Pharmaceuticals, Inc

Suspended

Safety of SP-420 in the Treatment of Transfusional Iron Overload

Iron Overload

United States
Northwell Health
Novartis

Completed

Iron Overload in Pediatric Oncology Patients

Iron Overload

United States
GE Healthcare

Completed

Non-invasive Quantification of Liver Iron With MRI

Iron Overload

United States
Sheba Medical Center

Unknown

Fetal Parenchymatic Evaluation (Liver, Spleen) Using T2* Sequences

Iron Overload

Israel
Novartis Pharmaceuticals

Completed

Extended Evaluation of Deferasirox Film-coated Tablet (FCT) Formulation

Chronic Iron Overload

Austria, Italy, Greece
Rennes University Hospital

Unknown

Study of the Effects of Muscular Activity on Iron Metabolism

Iron Overload | Iron Deficiency

France
Assiut University

Completed

Evaluation of Hepatic Affection in Hemodialysis Patients With Iron Overload in Assiut University Hospital

Hepatic Injury

Egypt
Annamalai University

Unknown

Safety of Various Mode of Delivery of Iron Supplement on Iron Toxicity Markers in Preschool Children

Iron Overload | Oxidative Stress

India
Consorzio per Valutazioni Biologiche e Farmacologiche
European Commission

Completed

Efficacy/Safety Study of Deferiprone Compared to Deferasirox in Paediatric Patients

Chronic Iron Overload

Italy, United Kingdom, Egypt, Greece, Cyprus, Albania, Tunisia
Novartis Pharmaceuticals

Completed

A Study Assessing the Efficacy and Safety of Deferasirox in Patients With Transfusion-dependent Iron Overload

Transfusion-dependent Iron Overload

Egypt, Greece, Hong Kong, Taiwan, Germany, United Kingdom, Belgium, Italy, Spain, France, Israel, Korea, Republic of, Turkey, China, Australia, Denmark, Austria, Switzerland, Netherlands, South Africa, Lebanon, Malaysia, Thailand
Consorzio per Valutazioni Biologiche e Farmacologiche
European Commission

Completed

Pharmacokinetic Study of Deferiprone in Paediatric Patients (DEEP-1)

Chronic Iron Overload

Italy, Cyprus, Egypt
University of Wisconsin, Madison
National Institute for Biomedical Imaging and Bioengineering (NIBIB)

Recruiting

Fully Automated High-Throughput Quantitative MRI of the Liver

Healthy | Iron Overload | Liver Fat

United States
Novartis Pharmaceuticals

Completed

A Protocol to Allow Treatment With ICL670 for Patients With or at Risk of Life-threatening Complications of Transfusional Iron Overload Who Are Unable to Tolerate Other Iron Chelators Because of Documented Severe Toxicity

Transfusional Iron Overload

United States, Greece, Italy
ApoPharma

Completed

Safety and Efficacy of Ferriprox™ (Deferiprone) Oral Solution in Iron Overloaded Pediatric Patients

Iron Overload

Egypt, Indonesia, Malaysia
Peking Union Medical College Hospital
Novartis

Unknown

Study of MRI Monitoring in Patients With Aplastic Anemia and Low or Int-1 Risk of MDS Complicated With Iron Overload

Iron Overload | Aplastic Anemia | Dysmyelopoietic Syndromes
HaEmek Medical Center, Israel

Unknown

Iron Metabolism in Small Pre Term Newborns

Iron Overload | Preterm | Iron Metabolism

Israel
Cornell University

Recruiting

Heme and Non-heme Iron Intakes, Gut Microbiota, and Influence on Host Iron Absorption (FeMicrobiome)

Iron Overload | Anemia, Iron Deficiency

United States
Cornell University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National...

Active, not recruiting

Ethnic Differences in Iron Absorption (FeGenes) (FeGenes)

Iron Overload | Anemia, Iron Deficiency

United States
McMaster University

Withdrawn

Validation of a Point-of-care Device Measuring Ferritin With Capillary Blood (FerPOC)

Iron-deficiency | Iron Overload | Anemia, Iron Deficiency

Clinical Trials on Dysmetabolic Iron Overload Syndrome

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