Clinical Trials on Elevated Lp(a)

Total 5058 results

Xention Ltd

Completed

A Study on the Effects of TA-8995 on Lp(a) in Subjects With Elevated Lp(a)

Elevated Lp(a)

Denmark
Silence Therapeutics plc
Medpace, Inc.

Completed

Study to Investigate Safety, Tolerability, PK and PD Response of SLN360 in Subjects With Elevated Lipoprotein(a)

Dyslipidemias | Hyperlipidemias | Elevated Lp(a)

United States, Australia, United Kingdom, Netherlands
Novartis Pharmaceuticals

Not yet recruiting

Lp(a) Lowering Study of Pelacarsen (TQJ230) in US Black/African American and Hispanic Participants With Elevated Lp(a) and Established ASCVD

Elevated Lp(a) and Established Atherosclerotic Cardiovascular Disease
Eli Lilly and Company

Recruiting

A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)

Elevated Lp(a) | Atherosclerotic Cardiovascular Disease (ASCVD)

Taiwan, United States, Spain, Argentina, China, Italy, Australia, France, Canada, Japan, Belgium, Denmark, Germany, Hungary, Israel, Austria, Korea, Republic of, Brazil, Mexico, Netherlands, Romania, United Kingdom, Greece, Czechia, India, Slovak... and more
Technische Universität Dresden
Kaneka Pharma Europe N.V.

Recruiting

Effect of Lipoprotein(a) Elimination by Lipoprotein Apheresis on Cardiovascular Outcomes (MultiSELECt)

Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia

Germany
Ionis Pharmaceuticals, Inc.

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISIS-APO(a)Rx in Participants With High Lipoprotein(a)

Elevated Lipoprotein(a)

Netherlands, United Kingdom, Denmark, Germany, Canada
Changi General Hospital

Not yet recruiting

Elevated Lipoprotein(a) in Hospital Staff (LPACO)

Cardiovascular Diseases | Hypercholesterolemia | Lipoprotein Types--Lp System Lp(A) Hyperlipoproteinemia

Singapore
Ionis Pharmaceuticals, Inc.
Akcea Therapeutics

Completed

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS APO(a)-LRx in Healthy Volunteers With Elevated Lipoprotein(a)

Elevated Lipoprotein(a)

Canada
Amgen

Completed

A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Olpasiran in Chinese Participants With Elevated Serum Lipoprotein(a)

Elevated Serum Lipoprotein(a)

Hong Kong
Charite University, Berlin, Germany

Unknown

Evaluation of the Effect of NICOtinic Acid (Niacin) on Elevated Lipoprotein(a) Levels (NICOLa Study) (NICOLa)

Elevated Lipoprotein(a) Levels

Germany
Akcea Therapeutics

Completed

Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Warfarin

Cardiovascular Diseases | Elevated Lipoprotein(a)

Canada
Akcea Therapeutics

Completed

Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Clopidogrel

Cardiovascular Diseases | Elevated Lipoprotein(a)

Canada
Fresenius Medical Care Deutschland GmbH

Completed

Safety and Efficacy of the DALI LDL-adsorber and MONET Lipoprotein Filter (LINET)

Hypercholesterolemia, Familial | LIPOPROTEIN TYPES--Lp SYSTEM Lp(a) HYPERLIPOPROTEINEMIA

Germany
Akcea Therapeutics
Ionis Pharmaceuticals, Inc.

Completed

Phase 2 Study of ISIS 681257 (AKCEA-APO(a)-LRx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular Disease

Cardiovascular Disease | Elevated Lipoprotein(a)

United States, Canada, Denmark, Germany, Netherlands
University of Zurich

Unknown

Lichen Planus Mucosae at USZ, Efficacy of Oral Alitretinoin

Lichen Planus (LP)

Switzerland
School of Medicine. National University of Cuyo

Recruiting

Argentine Registry of Lp(a) (GAELpa)

Cardiovascular Diseases | Hypertension | Hypercholesterolemia | Diabete Type 2 | Lp(A)

Argentina
Standard Process Inc.
Nutrasource Pharmaceutical and Nutraceutical Services, Inc.

Completed

Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels (SAH)

Elevated S-adenosylhomocysteine

United States
Ferrer Internacional S.A.

Terminated

Pharmacodynamic Clinical Trial of Cardiovascular Polypill on LDL Cholesterol

Elevated LDL Cholesterol

Spain
Mati Therapeutics Inc.

Completed

Safety and Intraocular Lowering Effect of Delivery of Travoprost Evolute® in Subjects With Elevated Intraocular Pressure

Elevated Intraocular Pressure (IOP)

United States
Texas A&M University

Unknown

Cholesterol and Statin in Healthy Adults

Elevated HMB Excretion

United States
Clinical Life Sciences Ltd.

Completed

Effect of Plant Stanol Esters on Blood Lipids

Elevated Blood Lipids

Finland
Tasso Inc.

Recruiting

ALT Routinely Recorded Remotely: A Comparator Study of Liver Function Tests Using the Tasso+ to Venipuncture. (ARRR)

Elevated Alanine Transaminase (ALT)

United States
Novozymes A/S
Universidad Iberoamericana A.C., Mexico; Linus Biotechnology Inc

Completed

Effect of Lactobacillus Plantarum DSM 33464 on Blood Lead Levels in Young Women of Child-bearing Age

Elevated Blood Lead Levels

Mexico
University Hospital, Montpellier

Completed

Pulmonary Vein Diameter and Collapsibility Measured by TEE to Predict Elevated Left Atrial Pressure in Cardiac Surgery (POGETO)

Elevated Left Atrial Pressure

France
University of Chicago

Recruiting

Impact of Anti-inflammatory Medications in Patients With Elevated Serum Prostate-specific Antigen

Elevated Serum PSA

United States
Ferrer Internacional S.A.

Terminated

A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Low Density Lipoprotein (LDL) Cholesterol

Elevated LDL Cholesterol

United States
Brooke Army Medical Center

Unknown

The Effect of Gait Training Using Virtual Reality and Real-Time Feedback on Physiological and Functional Gait Performance in Persons With a Traumatic Lower Extremity Amputation (VRVO2)

Elevated Metabolic Cost

United States
ProgenaBiome

Recruiting

A Pilot Study to Explore the Role of Gut Flora in Elevated Cholesterol

Cholesterol, Elevated | Elevated Cholesterol

United States
Syneos Health
SynerK Pharmatech (Suzhou) Limited

Recruiting

Dose Escalation of SNK-396 in Participants With Elevated Low-Density Lipoprotein Cholesterol

Elevated Low-Density Lipoprotein Cholesterol

Australia
Alnylam Pharmaceuticals

Completed

Trial to Evaluate Safety and Tolerability of ALN-PCS02 in Subjects With Elevated LDL-Cholesterol (LDL-C)

Elevated LDL-Cholesterol (LDL-C)

United Kingdom
Haisco Pharmaceutical Group Co., Ltd.

Completed

Ascending Single-Dose and Multiple-Dose Study to Evaluate HSK31679 in Healthy Subjects and Subjects With Elevated LDL-C

Healthy | Elevated LDL-C

China
Novozymes A/S
Beijing Children's Hospital; Chengdu Women's and Children's Central Hospital; Beijing Clinical Service Center and other collaborators

Completed

A Trial to Evaluate the Efficacy and Safety of Lactobacillus Plantarum DSM 33464 on Blood Lead Levels in Children

Elevated Blood Lead Levels

China
Aga Khan University
Pakistan Science Foundation

Completed

Lead Detoxifying Effects of Ascorbic Acid Among School Going Adolescents of Karachi- A Cluster Randomized Control Trial (LDVC)

Elevated Blood Lead Levels
Nonin Medical, Inc

Completed

Dysfunctional Hemoglobin CO-ox

Elevated Levels of Carboxyhemoglobin

United States
University of Chicago

Terminated

Randomized Trial of Ciprofloxacin Versus Observation for Men With Elevated Prostate Specific Antigen (PSA)

Elevated Prostate Specific Antigen

United States
Ionis Pharmaceuticals, Inc.
Akcea Therapeutics

Completed

Safety, Tolerability, PK, and Pharmacodynamics(PD) of IONIS APOCIII-LRx in Healthy Volunteers With Elevated Triglycerides

Elevated Triglycerides (TG)

Canada
Shire

Completed

A Double-Blind Multi-Dose Tolerability and Pharmacokinetic Study of Teduglutide

Pharmacokinetics and Safety of Elevated Doses

United States
Amgen

Withdrawn

An Interventional Study to Evaluate the Effect of Ivabradine on Exercise Capacity in Heart Transplant Recipients

Heart Transplantation, Elevated Resting Heart Rate
University of Malaya

Completed

Comparison of Bed up Head Elevated Intubation Position With Glidescope Assisted Tracheal Intubation

Bed up Head Elevated Intubation Position

Malaysia
Zimmer Biomet

Unknown

An MRI Investigation of Soft Tissues in Total Hip Arthroplasty (MoM_MRI)

Tissue Reaction | Elevated Blood Ion Levels

United States
Nonin Medical, Inc
University of California, San Francisco

Completed

Dysfunctional Hemoglobin

Elevated Levels of Carboxyhemoglobin and Methemoglobin

United States
National Taiwan University Hospital

Unknown

Investigation of Human Alpha-fetoprotein Genes

Elevated or Normal Alpha-fetoprotein Patients

Taiwan
Leiden University Medical Center

Completed

EEG Theta-Beta Ratio Neurofeedback-training (TBR-NFT)

Elevated EEG Theta/Beta Ratio
Unilever R&D

Completed

Efficacy Study on the Lipid-lowering Effect of Plant Sterols and Fish Oil

Healthy | Mildly Elevated Cholesterol Levels

Sweden
University Health Network, Toronto

Completed

Optic Nerve Sheath Diameter in Patients With Intracranial Pathology

Elevated Intracranial Pressure (ICP)

Canada
China National Center for Cardiovascular Diseases

Not yet recruiting

24 Versus 12-Month Dual Antiplatelet Therapy After Drug-Eluting Stent in Patients With Elevated Lipoprotein(a) Levels (DAPT-Lp(a))

Coronary Artery Disease | Dual Antiplatelet Therapy | Elevated Lipoprotein(a) Level | Drug-Eluting Stent

China
Lashmi Venkatraghavan
University Health Network, Toronto

Completed

Optic Nerve Sheath Diameter (ONSD) With the Raised PCO2 and Internal Jugular Venous Occlusion

Elevated Intracranial Pressure (ICP)

Canada
Mahidol University

Completed

Factors Associated With Post-induction Hypotension in iNPH Patient Undergoing VP and LP Shunt

The iNPH Patients Scheduled for VP or LP Shunt Procedures

Thailand
V.A. Nasonova Research Institute of Rheumatology...
AstraZeneca

Not yet recruiting

Evaluation of Type I IFN Level and Disease Activity in SLE Patients

Elevated Level of IFN Type I in SLE Patients
University of Cologne

Completed

Comparing Eye Pressure Using Maximal Tolerated Local Therapy or Systemic Acetazolamide

Control of Elevated Eye Pressure by Local and Systemic Therapy

Germany

Clinical Trials on Elevated Lp(a)

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