Clinical Trials on Epileptic Encephalopathy of Unindentified Genetic Origin

Total 30 results

Centre Hospitalier Universitaire Dijon

Completed

Evaluation of the Diagnostic Contribution of High-throughput Exome Sequencing for Patients With Convulsive Encephalopathy of Unknown Etiology: Pilot Study to Improve Genetic Counselling (SHD-EE)

Epileptic Encephalopathy of Unindentified Genetic Origin

France
Boston Children's Hospital

Recruiting

Genetics of Epilepsy and Related Disorders

Epilepsy | Dravet Syndrome | Infantile Spasms | Epileptic Encephalopathy | Ohtahara Syndrome | Early Myoclonic Epileptic Encephalopathy | PCDH19-related Epilepsy and Related Conditions | KCNQ2-Related Epileptic Encephalopathy | Epilepsy of Infancy With Migrating Focal Seizures (Disorder)

United States
University College Cork

Completed

eegCap Application in Paediatrics wiTh redUced GCS in REsus (CAPTURE)

Epilepsy | Status Epilepticus | Altered Level of Consciousness | Non-epileptic Seizures | Encephalopathy

Ireland
Zogenix, Inc.
Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc.

Active, not recruiting

A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut Syndrome

Dravet Syndrome | Epileptic Encephalopathy | Lennox Gastaut Syndrome

United States, Australia, Belgium, Canada, Denmark, France, Germany, Italy, Mexico, Netherlands, Poland, Spain, Sweden, United Kingdom
Longboard Pharmaceuticals

Completed

Study to Investigate LP352 in Subjects With Developmental and Epileptic Encephalopathies (PACIFIC)

Dravet Syndrome | Lennox Gastaut Syndrome | Developmental and Epileptic Encephalopathy

United States, Australia
Longboard Pharmaceuticals

Recruiting

Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy

Dravet Syndrome | Lennox-Gastaut Syndrome | Developmental and Epileptic Encephalopathy

United States, Australia
Northwell Health
Medtronic

Terminated

Long-term Cardiac Monitoring in Epilepsy (LOOP)

Generalized Epilepsy | Intractable Epilepsy | Focal Epilepsy | Epileptic Encephalopathy | Lennox Gastaut Syndrome | Symptomatic Epilepsy

United States
Longboard Pharmaceuticals

Available

Intermediate-Size Expanded Access Protocol (EAP) for LP352

Dravet Syndrome | Lennox Gastaut Syndrome | Developmental and Epileptic Encephalopathies

United States
University Hospital, Strasbourg, France

Unknown

Interest of High-throughput Sequencing of RNAs for the Diagnosis of Heterogeneous Genetic Diseases

DNA Sequencing | Diagnosis of Genetic Diseases of Heterogeneous Origin

France
Takeda
Ovid Therapeutics Inc.

Completed

A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic Encephalopathies (ELEKTRA)

Epilepsy | Dravet Syndrome | Lennox-Gastaut Syndrome

United States, Canada, Israel, Poland, Spain, Australia, China, Portugal
Nantes University Hospital

Completed

Neurological Fate, Prematurity and Genetic Susceptibility Factors (GENIMOC)

Polymorphism, Restriction Fragment Length | Premature | Infertility of Cervical Origin

France
University of Southern California

Recruiting

Trazodone vs. Quetiapine for the Treatment of ICU Delirium (TQDelirium)

Delirium | Treatment Side Effects | Morality | Delirium in Old Age | Psych | Delirium of Mixed Origin | Delirium Confusional State | Delirium, Sepsis Associated

United States
Universiteit Antwerpen
University Hospital, Antwerp

Recruiting

Gait in Rare Diseases (GAGA)

Tuberous Sclerosis | STXBP1 Encephalopathy With Epilepsy

Belgium
PTC Therapeutics

Completed

A Study to Evaluate Efficacy and Safety of Vatiquinone for Treating Mitochondrial Disease in Participants With Refractory Epilepsy (MIT-E)

Mitochondrial Diseases | Drug Resistant Epilepsy | Leigh Disease | Leigh Syndrome | Mitochondrial Encephalopathy (MELAS) | Pontocerebellar Hypoplasia Type 6 (PCH6) | Alpers Disease | Alpers Syndrome

United States, Spain, United Kingdom, Canada, France, Italy, Poland, Sweden, Japan
University of California, San Francisco
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Epilepsy Phenome/Genome Project (EPGP)

Epilepsy | Infantile Spasms | Lennox-Gastaut Syndrome | Polymicrogyria | Localization-related Epilepsy | Periventricular Heterotopias

United States, Argentina, Australia
Protecting Brains Saving Futures

Not yet recruiting

Protecting Brains and Saving Futures - the PBSF Protocol (PBSF)

Brain Injuries | Intraventricular Hemorrhage | Congenital Heart Disease | Hypoxic-Ischemic Encephalopathy | Newborn Morbidity | Inborn Errors of Metabolism | Extracorporeal Membrane Oxygenation Complication | Respiratory Complication | Hemodynamic Instability | Nosocomial Infection | Neonatal Seizure | Brain... and other conditions

Brazil
Jazz Pharmaceuticals

Recruiting

Assessment of Potential for Chronic Liver Injury in Participants Treated With Epidiolex (Cannabidiol) Oral Solution

Tuberous Sclerosis Complex | Dravet Syndrome | Lennox Gastaut Syndrome

United States
NYU Langone Health

Withdrawn

Turmeric as Treatment in Epilepsy

Epilepsy | Tuberous Sclerosis | Dravet Syndrome | Focal Seizures | Lennox-Gastaut Syndrome

United States
National Human Genome Research Institute (NHGRI)

Recruiting

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Metabolic Disease | Purine-Pyrimidine Metabolism | AICDA, OMIM *605257, Immunodeficiency With Hyper-IgM, Type 2; HIGM2 | UNG, OMIM *191525, Hyper-IgM Syndrome 5 | NT5C3A<TAB>, OMIM *606224, Anemia, Hemolytic, Due to UMPH1 Deficiency | UMPS, OMIM *613891, Orotic Aciduria | DHODH, OMIM *126064,... and other conditions

United States
University College Cork

Not yet recruiting

Assessment of Diastolic Function During the Transitional Period and Infancy Using Serial Echocardiography (DiFuSE)

Gestational Diabetes | Neonatal Encephalopathy | Diastolic Dysfunction | Trisomy 21 | Transient Tachypnea of the Newborn | Small for Gestational Age at Delivery

Ireland
Jazz Pharmaceuticals

Recruiting

Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) in Children With Tuberous Sclerosis Complex (TSC), Dravet Syndrome (DS), or Lennox-Gastaut Syndrome (LGS) Who Experience Inadequately-controlled Seizures

Seizure in Participants With Tuberous Sclerosis Complex | Seizure in Participants With Dravet Syndrome | Seizure in Participants With Lennox-Gastaut Syndrome

United States
Wayne State University
Blue Cross Blue Shield of Michigan Foundation

Unknown

Timing of Acute Palliative Care Consultation in Critically Ill Patients

Multiple Sclerosis | Sepsis | Hepatic Encephalopathy | Parkinson's Disease | Dementia | Multiple Organ Failure | Chronic Kidney Disease Stage 5 | Solid Organ Cancer | End Stage Chronic Obstructive Airways Disease | In-Hospital Cardiac Arrest | End Stage Cardiac Failure

United States
University of Aberdeen

Not yet recruiting

ORCHARD- Optimising Home Assessment of Rural Patients (ORCHARD)

Cancer | Sickle Cell Disease | Immunosuppression | Inborn Errors of Metabolism | Organ Transplant | COPD Asthma
MD Stem Cells

Recruiting

Neurologic Stem Cell Treatment Study (NEST)

Stroke | Nervous System Diseases | Diabetic Neuropathies | Neurodegenerative Diseases | Cognitive Impairment | Amyotrophic Lateral Sclerosis | Dementia | Neurological Disorders | Alzheimer Disease | ALS | Traumatic Brain Injury | Cerebral Infarction | Lewy Body Disease | Cerebral Hemorrhage | Frontotemporal Dementia | Progressive... and other conditions

United States, United Arab Emirates
Chinese University of Hong Kong

Recruiting

Safety and Efficacy of Fecal Microbiota Transplantation

Alcohol Dependence | Multiple Sclerosis | Obesity | Diabetes Mellitus | Hepatic Encephalopathy | Irritable Bowel Syndrome | Constipation | Celiac Disease | Crohn Disease | Ulcerative Colitis | Liver Disease | Idiopathic Thrombocytopenic Purpura | Clostridium Difficile Infection | Alopecia | Autism | Multiple Organ Dysfunction... and other conditions

Hong Kong
OMNI Medical Services, LLC
OMNI Medical Services Inc

Recruiting

Outcomes Mandate National Integration With Cannabis as Medicine (OMNI-Can)

Depression | COVID-19 | Epilepsy | Multiple Sclerosis | Glaucoma | Cancer | Covid19 | Chronic Pain | Parkinson Disease | Inflammatory Bowel Diseases | Hepatitis C | Insomnia | HIV/AIDS | Amyotrophic Lateral Sclerosis | Fibromyalgia | Anxiety | Bipolar Disorder | Seizures | Crohn Disease | Traumatic Brain Injury | Ulcerative Colitis | Sickle... and other conditions

United States
Cure CMD

Recruiting

Congenital Muscle Disease Study of Patient and Family Reported Medical Information (CMDPROS)

Emery-Dreifuss Muscular Dystrophy | Congenital Myasthenic Syndrome | Limb-Girdle Muscular Dystrophy | Congenital Muscular Dystrophy With ITGA7 (Integrin Alpha-7) Deficiency | Alpha-Dystroglycanopathy (Congenital Muscular Dystrophy and Abnormal Glycosylation of Dystroglycan With Severe Epilepsy) and other conditions

United States
Sanguine Biosciences

Recruiting

A Single-Site Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives

Heart Diseases | Stroke | Lymphoma | Multiple Sclerosis | Kidney Diseases | Diabetes | Leukemia | Age-Related Macular Degeneration | Cancer | Arthritis | Schizophrenia | Thyroid Diseases | Parkinson Disease | Hepatitis | Vasculitis | Psoriasis | Asthma | Amyloidosis | Fibromyalgia | Graves Disease | Alzheimer Disease | Celiac Disease | Cirr... and other conditions

United States
Centre Hospitalier Régional de la Citadelle
Sanofi; Takeda; University of Liege; Orchard Therapeutics; Centre Hospitalier Universitaire... and other collaborators

Recruiting

Baby Detect : Genomic Newborn Screening

Congenital Adrenal Hyperplasia | Hemophilia A | Hemophilia B | Mucopolysaccharidosis I | Mucopolysaccharidosis II | Cystic Fibrosis | Alpha 1-Antitrypsin Deficiency | Sickle Cell Disease | Fanconi Anemia | Chronic Granulomatous Disease | Wilson Disease | Severe Congenital Neutropenia | Ornithine Transcarbamylase... and other conditions

Belgium
RTI International
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Enrolling by invitation

Early Check: Expanded Screening in Newborns

Primary Hyperoxaluria Type 3 | Diabetes Mellitus | Hemophilia A | Hemophilia B | Hereditary Fructose Intolerance | Cystic Fibrosis | Factor VII Deficiency | Phenylketonurias | Sickle Cell Disease | Dravet Syndrome | Duchenne Muscular Dystrophy | Prader-Willi Syndrome | Fragile X Syndrome | Chronic Granulomatous Disease and other conditions

United States

Clinical Trials on Epileptic Encephalopathy of Unindentified Genetic Origin

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CROs in Senegal

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