Clinical Trials on Hepatic Surgery

Total 9106 results

Huazhong University of Science and Technology

Completed

MASIMO Radical 7 and Laboratory Measurement

Major Hepatic Surgery

China
Kasr El Aini Hospital

Recruiting

Erector Spinae Plane Block Versus Subcostal Transversus Abdominis Plane Block in Open Liver Resection Surgery

Analgesia | Hepatic Resection Surgery

Egypt
Sahlgrenska University Hospital, Sweden

Completed

Optimization of Hepatic Hemodynamics During Liver Surgery

Liver Surgery | Portal Blood Pressure | Hepatic Hemodynamics
H. Lundbeck A/S

Completed

Pharmacokinetics Properties of Single Oral Dosing of Lu AE58054 in Subjects With Hepatic Impairment (Mild and Moderate) and in Healthy Subjects

Heptic Impairment

Germany
Sahlgrenska University Hospital, Sweden

Completed

Inflammation and Organ Impact During Hepatic Surgery

Hepatic Surgery

Sweden
Centre hospitalier de l'Université de Montréal...
University of Alberta; McGill University Health Centre/Research Institute of... and other collaborators

Completed

Intraoperative Hemodynamic Management and Postoperative Outcomes in Liver Transplantation (ELIPTO-2)

Liver Diseases | Liver Failure | Surgery | Surgery--Complications | Transplant; Failure, Liver

Canada
Imperial College London
Royal Brompton & Harefield NHS Foundation Trust

Completed

Haemostatic Markers in Cardiopulmonary Bypass

Cardiopulmonary Bypass Surgery | Unfractionated Heparin

United Kingdom
National Central University

Completed

Autonomic Modulation After Spinal Anesthesia With Depth of Anesthesia and Vital Signs.

Participants Scheduled for Surgery Under Spinal Anesthesia Without Impairment of Renal, Hepatic, Cardiac or Respiratory Function

Taiwan
Kartal Kosuyolu Yuksek Ihtisas Education and Research...

Completed

The Investigation of the Causes of Hepatic Dysfunction in the Postoperative Period During Open-heart Surgeries

Surgery | Hepatic Impairment | Cardiac Disease | Hyperbilirubinemia
Massachusetts General Hospital
GlaxoSmithKline

Terminated

Significance of Antibodies to Heparin/Platelet Factor 4 Complex in Vein Graft Patency and Potential Role of Argatroban for Prevention of Vein Graft Occlusion

Coronary Artery Bypass Graft Surgery | Presence of Heparin/Platelet Factor 4 Antibody

United States
Dongguan HEC TaiGen Biopharmaceuticals Co., Ltd.
Peking University People's Hospital

Completed

To Evaluate Efficacy and Safety in TG-2349 Combination With DAG181 (± Ribavirin) in HCV Genotype I Infected Patients

Cirrhosis | Chronic Hepatics C Virus (HCV) Genotype 1 | Non-Cirrhotic | Treatment naïve

China
Semmelweis University Heart and Vascular Center
Semmelweis University

Recruiting

The Role and Dynamics of Liver Dysfunction in Patients Undergoing Cardiac Surgery

Heart Failure | Cardiac Surgery | Hepatic Impairment

Hungary
Karolinska University Hospital
Karolinska Institutet

Unknown

Adjusted Calculation of Heparin and Protamin Dosing and Correlation With Postoperative Bleeding and Transfusions

Bleeding | Cardiac Surgery | Heparin | Transfusion | Protamine Sulfate

Sweden
University Hospital Hradec Kralove
University Hospital Pilsen

Completed

Effect of Fluid Challenge on Glycocalyx

Sepsis | Septic Shock | Surgery | Endothelial Dysfunction | Anesthesia

Czechia
Novartis Pharmaceuticals

Completed

Evaluation of Hepatic Function Impairment on the Pharmacokinetics of LEE011

Normal Hepatic Function | Impaired Hepatic Function

United States
Novartis Pharmaceuticals

Completed

Effect of Hepatic Impairment on LDE225..

Normal Hepatic Function | Impaired Hepatic Function

Belgium, Germany, Israel, Bulgaria, United States
Novartis Pharmaceuticals

Completed

Effect of Hepatic Impairment on LDK378 Pharmacokinetics

Normal Hepatic Function | Impaired Hepatic Function

United States
GlycoMimetics Incorporated

Completed

A Study to Evaluate the Effect of IV Doses of Rivipansel in Subjects With Moderate Hepatic Impairment and in Healthy Subjects With Normal Hepatic Function

Moderate Hepatic Impairment | Normal Hepatic Function

United States
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Investigate the Effect of Severely Diminished Liver Function on the Metabolism, Safety, and Tolerability of a Single Oral Dose of Enzalutamide in Men

Severe Hepatic Impairment | Normal Hepatic Function

Bulgaria
Pfizer

Completed

Pharmacokinetics Of Orally Administered Fx-1006A In Subjects With Hepatic Dysfunction

Mild Hepatic Dysfunction | Moderate Hepatic Dysfunction

South Africa
Hong Kong Children's Hospital

Recruiting

Ultrasound Measurements of Hepatic Vasculatures and Hepatic Doppler Assessment of Healthy Children

Portal Vein | Hepatic Veins | Hepatic Artery | Liver Circulation

Hong Kong
Pfizer

Recruiting

A Study to Learn About the Study Medicine (Called Lorlatinib) in People With Liver Dysfunction

Healthy Volunteers | Moderate Hepatic Impairment | Severe Hepatic Impairment

United States
Western University, Canada
Valeo Pharma Inc

Not yet recruiting

Prolonged Hypercoagulability Following Major Liver Resection for Malignancy (PRIORITY)

Thrombosis | Hepatic Disease | Surgery-Complications | Hypercoagulability

Canada
Taichung Veterans General Hospital

Recruiting

The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery

Cardiopulmonary Bypass | Heparin | Surgery, Cardiac | Tranxemic Acid | Activated Clotting Time

Taiwan
Assistance Publique - Hôpitaux de Paris

Unknown

Patients' Outcome With Severe or Fulminant Hepatic Insufficiency, Hospitalized in the Public Hospitals of Paris (DEVINHEF)

Fulminating Hepatic Failure

France
Eisai Inc.

Completed

A Pharmacokinetic and Safety Study of E7080 in Subjects With Mild (10 mg), Moderate (10 mg), and Severe Hepatic Impairment (5 mg) and Normal Hepatic Function (10 mg)

Hepatic Impairment | Hepatic Function

United States
Wenzhou Medical University

Unknown

ABMSC Infusion Through Hepatic Artery in Portal Hypertension Surgery for the Treatment of Liver Cirrhosis

Liver Cirrhosis | Surgery | Portal Hypertension | Hepatic Decompensation

China
Gianluca Costa

Recruiting

Laparoscopic Versus Open Repair of Peptic Ulcer Perforation (LOREPUP)

Emergencies | Surgery | Peptic Ulcer Perforation

Italy
Hospices Civils de Lyon
Sanofi; Bioaster; BioMérieux

Completed

REAnimation Low Immune Status Markers (REALISM)

Septic Shock | Severe Trauma | Severe Burn | Major Surgery

France
Agios Pharmaceuticals, Inc.

Completed

A Pharmacokinetic Study of Mitapivat in Participants With Moderate Hepatic Impairment Compared to Matched Healthy Control Participants With Normal Hepatic Function

Moderate Hepatic Impairment

United States
Vital Therapies, Inc.

Completed

Phase 2 Evaluation of the ELAD System in the Management of Acute Liver Failure

Fulminant Hepatic Failure

United States
Vital Therapies, Inc.

Withdrawn

Safety and Efficacy of the Extracorporeal Liver Assist Device (ELAD®) In Patients With Fulminant Hepatic Failure (FHF) (ELAD)

Fulminant Hepatic Failure

United States
Bausch Health Americas, Inc.

Terminated

Steady-State Pharmacokinetics of Rifaximin 550 mg Tablets in Healthy and Hepatically Impaired Subjects

Severe Hepatic Impairment

United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Effects of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine

Hepatic Impairment | Normal Hepatic Function

United States
Cardiox Corporation

Terminated

Liver Function Assessment - Feasibility and Dosing Study

Hepatic Failure
Merck Sharp & Dohme LLC

Completed

Belzutifan (MK-6482) Hepatic Impairment Study (MK-6482-020)

Moderate Hepatic Impairment

United States
EQRx International, Inc.

Completed

An Open-Label, Single-Dose, Parallel-Group Study of the Pharmacokinetics and Safety of EQ143

Severe Hepatic Impairment

United States
Pfizer

Completed

Evaluate Severe Hepatic Impairment on Dacomitinib PK

Severe Hepatic Impairment

United States
Takeda

Completed

Pharmacokinetics, Safety and Tolerability of Vortioxetine in Normal Hepatic Function or Severe Hepatic Impairment

Severe Hepatic Impairment

United States
University Hospital, Strasbourg, France

Recruiting

Hydrodissection of the Hepatoduodenal Ligament (Duodenal)

Hepatic Lesions

France
Rennes University Hospital

Completed

Pharmacogenetic Study of Tacrolimus in Hepatic Transplant (CYPTAC'H)

Hepatic Transplantation

France
Maastricht University

Completed

Liver Glycogen Dynamics (LGD)

Hepatic Glycogen

Netherlands
Shire

Completed

Pharmacokinetics (PK) of 20 mg Teduglutide in Participants With Moderately Impaired Hepatic Function Compared to Healthy Participants

Hepatic Impairment

United States
University of Michigan Rogel Cancer Center

Completed

Assessment Of Liver Function in Patients Undergoing Hepatic Irradiation (IC-Green)

Hepatic Irradiation

United States
Assiut University

Unknown

Implication of Fluid Strategies Upon Hepatic Outcome in Hepatobiliary Surgery

Hepatic Complication
Novartis Pharmaceuticals

Completed

Pharmacokinetic Study of Icenticaftor in Participants With Hepatic Impairment

Hepatic Failure

United States
Daiichi Sankyo, Inc.

Completed

A Study of Quizartinib Pharmacokinetics in Participants With Moderate Hepatic Impairment

Hepatic Impairment | Moderate Impaired Hepatic Function

United States
Mitsubishi Tanabe Pharma Corporation

Completed

PK Study in Subjects With Severe Hepatic Impairment (MCI-186-E05 HP)

Healthy | Severe Hepatic Impairment

Czechia, Hungary, Slovakia
University of Colorado, Denver

Active, not recruiting

Hepatic Mitochondrial Function in Youth (MANGO)

Obesity | Bariatric Surgery Candidate | Adolescent Obesity | Hepatic Steatosis

United States
Jazz Pharmaceuticals

Completed

Assessment of the Single Dose Pharmacokinetics and Tolerability of Sativex in Patients With Impaired Hepatic Function and Healthy Patients

Hepatic Impairment

United States

Clinical Trials on Hepatic Surgery

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