Clinical Trials on High LDL-c

Total 4665 results

Merck Sharp & Dohme LLC

Completed

Effect of Statins on Lipid Levels Following the First Acute Coronary Event (MK-0000-204) (REMAINS)

Dyslipidemias | Hypercholesterolemia | Hypertriglyceridemia | High LDL-C | Low HDL-C
University of Manitoba
The Association of Rehabilitation Medicine in Manitoba

Completed

Omega-3 Supplementation for Tetraplegics With Poor Cholesterol Levels

Spinal Cord Injury | Tetraplegia | Quadraplegia | Low HDL-c | High LDL-c

Canada
Alnylam Pharmaceuticals

Completed

Trial to Evaluate Safety and Tolerability of ALN-PCS02 in Subjects With Elevated LDL-Cholesterol (LDL-C)

Elevated LDL-Cholesterol (LDL-C)

United Kingdom
Ikaria Bioscience Pty Ltd

Recruiting

Adult Subjects With Elevated Low-Density Lipoprotein-Cholesterol to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects

To Reduce the LDL-C Level in Hypercholesteremia Adult Patients | Combination for Subgroup High LDL-c Patients With Other Comorbidities

Australia
Texas A&M University

Completed

Impact of Beef's Unique Food Matrix on Human Health

Cholesterol, LDL | Cholesterol, HDL | Research Subjects

United States
Danone Japan

Completed

"A Clinical Study for Evaluating the Effect of a Plant Sterol-enriched Fermented Dairy Product on Blood Lipoprotein Profile in Japanese Adults"

Subjects With High LDL-Cholesterol

Japan
University Rovira i Virgili
Universitat de Lleida; Ministerio de Ciencia e Innovación, Spain

Unknown

Red-fleshed Apple as a Novel Anthocyanin-biofortified Food to Improve Cardiometabolic Risk Factors. (AppleCor)

High LDL-cholesterol Levels

Spain
Haisco Pharmaceutical Group Co., Ltd.

Completed

Ascending Single-Dose and Multiple-Dose Study to Evaluate HSK31679 in Healthy Subjects and Subjects With Elevated LDL-C

Healthy | Elevated LDL-C

China
Universiteit Antwerpen

Completed

the Effect of a Red Rice Nutrition Supplement on Cholesterol Levels

Cholesterol Level | HDL Level | LDL Level | TG Level

Belgium
Ethical Naturals, Inc.
KGK Science Inc.

Completed

Pilot Study to Evaluate the Effect of ENI Patented Whole Grape Extract on Antioxidant Status

High Oxidation Stress | Oxidized LDL Level

Canada
Perrigo CSCI
Analyze & Realize

Recruiting

Effects of Arterin Cholesterol for Reduction of Lipid Levels

Blood Cholesterol Lowers | LDL-C

Germany
Iuliu Hatieganu University of Medicine and Pharmacy

Completed

Comparing a Low-GI Nutrigenetic and Ketogenic Diet for Weight Loss With 18 Month Follow-up (LOWGI_GENE)

Weight Loss | Glucose, High Blood | LDL Hyperlipoproteinemia | HDL | Triglycerides High
Yonsei University

Completed

The Effectiveness of Plant Stanols as Ester on Change in Blood Cholesterol Level

LDL-cholesterol Level 130-159mg/dL
Arizona State University
North American Millers Association - Corn Division

Completed

Corn and Heart Health Study (CHS)

Gut Microbiome | Cholesterol, LDL | Cholesterol, HDL

United States
Yonsei University

Not yet recruiting

Low- and Moderate-intensity Statin and Clinical Outcome of Primary Prevention in Individuals Aged >75 Years: the SCOPE-75 RCT Study

Healthy Elderly Individuals With High LDL-cholesterol or Risk of Cardiovascular Disease

Korea, Republic of
Dhurakij Pundit University

Not yet recruiting

Effects of Phytoestrogen From Pueraria Mirifica in Improvement of Serum Lipid Parameters in Postmenopausal Women

Dyslipidemias | Hypercholesterolemia | Hypertriglyceridemia | Postmenopausal Symptoms | Hyper-LDL-cholesterolemia | Hypo HDL Cholesterolaemia
Ramathibodi Hospital
AstraZeneca

Unknown

Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level

Systemic Lupus Erythematosus | High LDL Cholesterol Level

Thailand
Ikaria Bioscience Pty Ltd
SHANGHAI RONA Therapeutics Co.,Ltd.

Not yet recruiting

the Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects in Adult Subjects With Elevated LDL-C

To Reduce the LDL-C Level in Hypercholesteremia Patients
LIB Therapeutics LLC
Medpace, Inc.

Completed

Study to Evaluate Efficacy and Safety of LIB003 in Patients on Lipid-Lowering Therapy Needing Additional LDL-C Reduction

LDL Cholesterol

United States
China Medical University Hospital

Unknown

A Study Using L5 as a Risk Factor of Cardiovascular (CV) Disease in Chronic Renal and Dialytic Patients (L5)

Cardiovascular Disease | Chronic Kidney Disease Patients | Hemodialytic Patients | High LDL Level | High L5 Level

Taiwan
Universidad de Granada
University of Copenhagen; University of Oxford; Harvard University; University... and other collaborators

Recruiting

Cardiovascular Risk Prevention With a Mediterranean Dietary Pattern Reduced in Saturated Fat (CADIMED)

LDL Cholesterol

Spain
Uppsala University
Dalarna County Council, Sweden

Completed

Effectiveness of Written Dietary Advice on Lipoproteins - a Pragmatic Randomized Controlled Trial (MYDICLIN)

Cholesterol, LDL

Sweden
Unity Health Toronto

Unknown

Effect of Viscous Soluble Fibers on Serum Cholesterol Levels (CHOL-META)

LDL Cholesterol

Canada
University of Texas Southwestern Medical Center
Merck Sharp & Dohme LLC; Donald W. Reynolds Foundation

Completed

Comparison of Efficacy and Safety of Ezetimibe or Statin Monotherapy to Co-Administration of Both

Cholesterol, LDL

United States
Ferrer Internacional S.A.

Terminated

Pharmacodynamic Clinical Trial of Cardiovascular Polypill on LDL Cholesterol

Elevated LDL Cholesterol

Spain
Ferrer Internacional S.A.

Terminated

A Pharmacodynamic Study to Evaluate the Effect of a Fixed Dose Combination Pill on Low Density Lipoprotein (LDL) Cholesterol

Elevated LDL Cholesterol

United States
LIB Therapeutics LLC
Medpace, Inc.

Active, not recruiting

Study of Efficacy and Safety of LIB003 in Patient With CVD on Statins Requiring Additional LDL-C Reduction (LIBerate-CVD)

Cardiovascular Diseases | Hyper-LDL-cholesterolemia

United States
Biosearch S.A.

Completed

Evaluation of a Probiotic on LDL-cholesterol Levels

Cardiovascular Diseases | LDL-cholesterol

Spain
Almond Board of California
KGK Science Inc.

Completed

Investigating the Dose Response of an Almond-enriched Diet on Optimizing HDL-C in a Population With Hypercholesterolemia

Hypercholesterolemia | HDL-C

Canada
AstraZeneca

Terminated

JUPITER - Crestor 20mg Versus Placebo in Prevention of Cardiovascular (CV) Events

Elevated High-sensitivity C-Reactive Protein (hsCRP)

United States, Brazil, Bulgaria, Poland, Russian Federation, South Africa, United Kingdom, Germany, Estonia, Romania, Denmark, Netherlands, Norway, Canada, Mexico, Belgium, Israel, Puerto Rico, Colombia, Argentina, Venezuela, Panama, Urugu... and more
Otsuka Pharmaceutical Co., Ltd.

Active, not recruiting

A Long-term Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia

Hyper-low-density Lipoprotein (LDL) Cholesterolemia

Japan
Fazer Group
Nokia Technologies Oy; Nightingale Health Oy; Tekes - the Finnish Funding Agency... and other collaborators

Completed

Dietary Intervention With Brain-friendly Diet (BRAVE)

Cognitive Performance | Physiological Stress | LDL Cholesterol

Finland
Hadassah Medical Organization

Unknown

Aerobic Exercise Training & the Autonomic System In Patients After Myocardial Infarction or Stroke

HR Vaiability, Aerobic Physical Fitness,Blood Pressure, Blood Sugar Level, Blood HDL, LDL

Israel
Otsuka Pharmaceutical Co., Ltd.

Completed

A Confirmatory Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia

Hyper-low-density Lipoprotein (LDL) Cholesterolemia

Japan
Jordan Collaborating Cardiology Group
The Cardiovascular Academy Group of the JCS; The Jordan Cardiac Society (JCS); Istishari Hospital Department of Clinical Research

Terminated

Cardiovascular Risk Categories and Attaining LDL-C Targets in Middle Eastern Adults Aged 30-55 Years of Age (CREATE)

Atherosclerotic Cardiovascular Risk | Low-density-lipoprotein (LDL) Cholesterol

Jordan
Maastricht University Medical Center

Not yet recruiting

Current Practice of Patients Undergoing C-arm Procedures at the Operating Department

Types of C-arm Procedures Included | Low Complex (Lower & Upper Extremities) | High Complex (Lower Extremities & Spinal Cord)
Cothera Bioscience, Inc

Recruiting

Sepantronium Bromide for the Treatment of High-grade B-cell Lymphoma

Lymphoma, B-Cell | Lymphoma, Large B-Cell, Diffuse | Lymphatic Diseases | Burkitt Lymphoma | High-grade B-cell Lymphoma | C-MYC/BCL6 Double-Hit High-Grade B-Cell Lymphoma | C-MYC/BCL2 Double-Hit High-Grade B-Cell Lymphoma | Lymphoma, High-Grade | C-Myc Gene Rearrangement

Korea, Republic of, China
St. Boniface Hospital
Agriculture and Agri-Food Canada

Active, not recruiting

Flax Muffins and Cholesterol Lowering

Above Optimal Plasma LDL Concentrations

Canada
Northwestern University
Agency for Healthcare Research and Quality (AHRQ)

Completed

Reducing Disparities in Primary Prevention of Cardiovascular Disease

Cardiovascular Diseases | Cholesterol, LDL

United States
S.LAB (SOLOWAYS)
Center of New Medical Technologies; Triangel Scientific

Completed

Evaluating the Impact of Omega-3 Fatty Acid Supplementation (Soloways™) on Lipid Profiles in Adults With PPARG Polymorphisms (SOLIPARG)

LDL Hyperlipoproteinemia | Low-Density-Lipoprotein-Type [LDL] Hyperlipoproteinemia | Triglyceride Storage Type I or II Disease

Russian Federation
Tung Wah College

Enrolling by invitation

Cardioprotective and Mental Health Benefits of the MIND Diet Combined With Forest Bathing

Elevated LDL Cholesterol

Hong Kong
PepsiCo Global R&D
Glycemic Index Laboratories, Inc

Completed

Oat and Cholesterol

Elevated LDL Cholesterol

Canada
Nordic Pharma, USA
Nutrasource Pharmaceutical and Nutraceutical Services, Inc.

Completed

Safety and Efficacy of a Natural Health Product in Reducing Cholesterol and Triglyceride Levels.

Triglycerides | LDL Cholesterol

Canada
Newcastle University

Unknown

Effects of Quinoa Consumption on Markers of Cardiovascular Risk and Gastrointestinal Health

Change in Fasting Plasma LDL-cholesterol Concentration After the Consumption of Quinoa

United Kingdom
United Arab Emirates University
Mohammed Bin Rashid University of Medicine and Health Sciences

Completed

Effects of a Workplace Exercise Intervention on Cardio-Metabolic Health

Cardiovascular Risk Factor | Pre Diabetes | High Blood Pressure | Elevated LDL Cholesterol

United Arab Emirates
Szeged University

Unknown

Pulmonary Arterial Pressure Response During Exercise (PAPCOPDHS)

Healthy Subjects | COPD Patients | Semi-supine Echo (SSE) | Flow-mediated Vasodilatation (FMD) | High Sensitive C-reactive Protein (hsCRP)

Hungary
Novartis Pharmaceuticals

Completed

Safety, Pharmacokinetics and Pharmacodynamics of LGT209 in Healthy Volunteers With Elevated Cholesterol and in Hypercholesterolemic Patients Treated With Statins

Hypercholesterolemia | LDL Cholesterol

United States
Dexa Medica Group

Withdrawn

DLBS1449 in Diabetic Patients With Low HDL

Diabetic Patients | Low HDL-cholesterol (< 35 mg/dL) | Lifestyle Intervention for at Least 1 Month

Indonesia
Azienda Ospedaliera Brotzu
University of Cagliari

Completed

Cheese Intake,CLA and Hypercholesterolemia (CASU)

Modifications of LDL Cholesterol | Modifications of Enocannabinoid Levels

Italy
Osaka University
Merck Sharp & Dohme LLC

Unknown

Relationship Between CETP Deficiency and Atherosclerosis in Patients With Hyperalphalipoproteinemia (INFINITY)

Hyper-LDL-cholesterolemia | Low CETP Activity | CETP Deficiency | Hyperalphalipoproteinemia | High Level of Remnant Cholesterol

Japan

Clinical Trials on High LDL-c

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Senegal

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Rare Diseases

Drug Interventions

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