Clinical Trials on Hypophosphatasia

Total 131 results

University Hospital, Clermont-Ferrand
DiaSorin ; Saluggia, Italia

Completed

Study of the Inappropriate Secretion of FGF23 in Patients Followed in Hospital in a Context of Hypophosphatemia (IFEH)

Hypophosphatemia Without Immediate Anteriority | Unexplained Hypophosphatemia

France
University of Strathclyde

Unknown

Investigating a New Way of Giving Medicine to Newborn and Preterm Babies

Osteopenia of Prematurity | Hypophosphataemia

United Kingdom
University Hospital, Geneva

Completed

Newborn Phosphocalcic Metabolism After Intravenous Iron Administration During Pregnancy

Iron Induced Hypophosphatemia

Switzerland
Alexion

Enrolling by invitation

Registry of Patients With Hypophosphatasia

Hypophosphatasia (HPP)

France, Poland, United Kingdom, Germany, Spain, Saudi Arabia, United States, Canada, Russian Federation, Australia, Italy
Kyowa Kirin Pharmaceutical Development Ltd

Completed

A UK Multicentre, Health-Related Quality of Life Study for Children and Adolescents With XLH

X-Linked Hypophosphataemia

United Kingdom
Hvidovre University Hospital
Odense University Hospital

Active, not recruiting

Evaluation of Bone Architecture and Bone Strength in Adults With Hypophosphatasia (HPP) (BABS)

Hypophosphatasia (HPP)

Denmark
Alexion Pharmaceuticals

Completed

Safety Study of Human Recombinant Tissue Non-Specific Alkaline Phosphatase Fusion Protein Asfotase Alfa in Adults With Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Canada
Alexion Pharmaceuticals

Completed

A Retrospective Study of the Natural History of Patients With Severe Perinatal and Infantile Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Taiwan, United Kingdom, Australia, Canada, Germany, Spain
Alexion Pharmaceuticals

Completed

Safety and Efficacy of Asfotase Alfa in Juvenile Patients With Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Canada
Alexion Pharmaceuticals

Completed

Extension Study of Protocol ENB-006-09 - Study of Asfotase Alfa in Children With Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Canada
Alexion Pharmaceuticals

Completed

Retrospective, Non-interventional Natural History of Patients With Juvenile-onset Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, France, United Kingdom, Canada, Netherlands, Russian Federation, Turkey, Australia
Alexion Pharmaceuticals

Completed

Safety and Efficacy Study of Asfotase Alfa in Severely Affected Infants With Hypophosphatasia (HPP)

Hypophosphatasia (HPP)

United States, Canada, United Arab Emirates, United Kingdom
Ayman Anis Metry

Completed

Hypophosphatemia Deleteriously Affects Outcome of Septic Shock Patients Admitted to ICU

Effect of Hypophosphatemia on Septic Patients

Egypt
Kyowa Kirin, Inc.
Kyowa Kirin Co., Ltd.

Completed

Long-Term Extension Study of KRN23 in Adult Subjects With X-Linked Hypophosphatemia (XLH)

X-Linked Hypophosphatemia

United States
Kyowa Kirin Co., Ltd.

Active, not recruiting

Study to Assess the Safety, Pharmacokinetics and Efficacy of KRN23 in Pediatric Chinese Patients With XLH

X-linked Hypophosphatemia (XLH)

China
Kyowa Kirin Pharmaceutical Development Ltd

Active, not recruiting

Registry for Patients With X-Linked Hypophosphatemia (XLH Registry)

X-Linked Hypophosphatemia

Spain, Italy, United Kingdom, France, Belgium, Denmark, Germany, Hungary, Portugal, Norway, Switzerland, Israel, Netherlands, Czechia, Bulgaria, Sweden, Slovenia, Ireland, Latvia, Slovakia
Kyowa Kirin Pharmaceutical Development Ltd

Recruiting

A Study to Describe the Lived Experience of XLH for Adolescents at End of Skeletal Growth

X-Linked Hypophosphatemia

France, Netherlands, United Kingdom
Kyowa Kirin, Inc.
Kyowa Kirin Co., Ltd.

Completed

Efficacy and Safety of Burosumab (KRN23) Versus Oral Phosphate and Active Vitamin D Treatment in Pediatric Patients With X Linked Hypophosphatemia (XLH)

X-Linked Hypophosphatemia

Korea, Republic of, Canada, United States, Australia, Japan, United Kingdom, Sweden
Rijnstate Hospital

Completed

FGF-23 Suppressibility by Calcitonin

Hypophosphatemia

Netherlands
Wuerzburg University Hospital
Kyowa Kirin, Inc.

Active, not recruiting

Burden of Disease and Functional Impairment in XLH (IdeFIX)

X Linked Hypophosphatemia

Germany
Kyowa Kirin, Inc.

Completed

Study of the Safety, Pharmacodynamics (PD) and Efficacy of KRN23 in Children From 1 to 4 Years Old With X-linked Hypophosphatemia (XLH)

X-Linked Hypophosphatemia

United States
Kyowa Kirin Co., Ltd.

Active, not recruiting

Study to Assess the Safety, Pharmacokinetics and Efficacy of KRN23 in Adult Chinese Patients With XLH

X-linked Hypophosphatemia (XLH)

China
Laura Tosi
Children's National Research Institute; Ultragenyx Pharmaceutical Inc

Active, not recruiting

Burosumab for CSHS

Cutaneous Skeletal Hypophosphatemia Syndrome (CSHS) | Epidermal Nevus Syndrome

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Prevention of Spontaneous Dental Abscesses in Children With X-linked Hypophosphatemia : a RCT (PRADEX)

X-linked Hypophosphatemia (XLH)
Kyowa Kirin Co., Ltd.

Active, not recruiting

Study of Longitudinal Observation for Patient With X-linked Hypophosphatemic Rickets/Osteomalacia in Collaboration With Asian Partners (SUNFLOWER)

X-Linked Hypophosphatemia

Japan
University of Aarhus

Completed

Characterising Pain, QoL, Body Composition, Arterial Stiffness, Muscles and Bones in Adult Persons With XLH and Healthy Controls

X-linked Hypophosphatemia | Hereditary Hypophosphatemia

Denmark
Kyowa Kirin Pharmaceutical Development Ltd

Active, not recruiting

Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of Burosumab in Patients Less Than 1 Year of Age

X-linked Hypophosphatemia (XLH)

Sweden, Spain, United Kingdom, Italy, Austria, France
University of Tartu

Recruiting

Validation of the GIDS and Description of Phosphate Disorders (GUTPHOS)

Hypophosphatemia | Organ Dysfunction Scores

Estonia
University Hospital, Brest

Completed

Hypophosphatemia as a Predictive Marker of Mortality During Sepsis in ICU (PORPOISE-REA)

Infection | Hypophosphatemia

France
Assistance Publique - Hôpitaux de Paris

Recruiting

Dental Implants in Patients With X-linked Hypophosphatemia (IMPLANTS-XLH)

X-linked Hypophosphatemia

France
Wuerzburg University Hospital
Kyowa Kirin, Inc.

Completed

Anti-FGF23 (Burosumab) in Adult Patients With XLH (BurGER)

X-linked Hypophosphatemia

Germany
Hospices Civils de Lyon

Completed

X-linked Hypophosphatemia and FGF21 (XLH 21)

X-linked Hypophosphatemia

France
Kyowa Hakko Kirin Pharma, Inc.
Kyowa Kirin Co., Ltd.

Completed

A Repeated Study of KRN23 in Adults With X-Linked Hypophosphatemia

X-linked Hypophosphatemia

United States, Canada
Peking Union Medical College Hospital

Unknown

Using Different Doses of Active Vitamin D Combined With Neutral Phosphate in Children With X-linked Hypophosphatemia

X-linked Hypophosphatemia

China
Kyowa Kirin, Inc.
Kyowa Kirin Co., Ltd.

Completed

Study of KRN23 in Adults With X-linked Hypophosphatemia (XLH)

X-linked Hypophosphatemia

United States, Korea, Republic of, Japan, Ireland, United Kingdom, France, Italy
Kyowa Kirin, Inc.
Kyowa Kirin Co., Ltd.

Completed

Study of KRN23 (Burosumab), a Recombinant Fully Human Monoclonal Antibody Against Fibroblast Growth Factor 23 (FGF23), in Pediatric Subjects With X-linked Hypophosphatemia (XLH)

X-linked Hypophosphatemia

Netherlands, United States, United Kingdom, France
Kyowa Kirin Pharmaceutical Development Ltd

Completed

Study of the Anti-FGF23 Antibody, Burosumab, in Adults With XLH

X-linked Hypophosphatemia

United Kingdom, France, Ireland, Italy
Kyowa Hakko Kirin Pharma, Inc.

Completed

A Study of KRN23 in X-linked Hypophosphatemia

X-linked Hypophosphatemia

United States
Montefiore Medical Center

Terminated

Using Cinacalcet to Treat the Hypophosphatemia of Early Kidney Transplant

Renal Transplant | Hypophosphatemia

United States
Alexion Pharmaceuticals, Inc.

Recruiting

Phase 3 Study of ALXN1850 in Pediatric Participants With HPP Previously Treated With Asfotase Alfa (CHESTNUT)

Hypophosphatasia

United States, Japan, Italy, Turkey, Australia, Germany, United Kingdom, Argentina, France, Canada, India
Alexion Pharmaceuticals, Inc.

Not yet recruiting

Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia (RESTORE)

Hypophosphatasia
Alexion

Recruiting

A Prospective Sub-Study of the Global Hypophosphatasia Registry

Hypophosphatasia

United States
Children's Mercy Hospital Kansas City

Recruiting

United States Hypophosphatasia Molecular Research Center

Hypophosphatasia

United States
Sheffield Teaching Hospitals NHS Foundation Trust
National Institute for Health Research, United Kingdom; Alexion Pharmaceuticals...

Completed

Characterisation of Adult-Onset Hypophosphatasia

Hypophosphatasia

United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield

Active, not recruiting

The PORTRAIT Study (PORTRAIT)

Hypophosphatasia

United Kingdom
Duke University

Recruiting

Natural History Study of Patients With Hypophosphatasia (HPP) (NatHisHPP)

Hypophosphatasia

United States
Ultragenyx Pharmaceutical Inc
Novartis; Mereo BioPharma

Completed

Dose Escalation Study to Evaluate the Safety and Tolerability of Multiple Infusions of BPS804 in Adults With Hypophosphatasia (HPP)

Hypophosphatasia

Germany
Dr. Lothar Seefried
Alexion Pharmaceuticals

Completed

Evaluate and Monitor Physical Performance of Adults Treated With Asfotase Alfa for Hypophosphatasia (EmPATHY)

Hypophosphatasia

Germany
CENTOGENE GmbH Rostock
Alexion Pharmaceuticals

Completed

Unraveling Genetics of HypoPhosPhatasia (HPP Genetics)

Hypophosphatasia

Germany
Alexion Pharmaceuticals

Completed

Pharmacokinetic and Dose Response Study of Asfotase Alfa in Adult Patients With Pediatric-Onset Hypophosphatasia (HPP)

Hypophosphatasia

United States, Germany

Clinical Trials on Hypophosphatasia

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Spain

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