Clinical Trials on Malignant Brain Neoplasm

Total 128502 results

University of Chicago
Stand Up To Cancer

Recruiting

Novel Outreach Methods to Increase Enrollment to Early Phase Clinical Trials

Cancer | Malignant Neoplasm | Malignancy

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Low Dose Versus Standard Dose Dexamethasone for Reduction of Swelling in Patients With Primary or Metastatic Brain Tumors

Metastatic Malignant Neoplasm in the Brain | Malignant Brain Neoplasm | Recurrent Malignant Brain Neoplasm

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

CAR T Cells After Lymphodepletion for the Treatment of IL13Rα2 Positive Recurrent or Refractory Brain Tumors in Children

Malignant Brain Neoplasm | Recurrent Malignant Brain Neoplasm | Refractory Malignant Brain Neoplasm

United States
Royal Marsden NHS Foundation Trust
University College London Hospitals; University of Southampton; St George's University... and other collaborators

Completed

Information Needs Around Parenteral nUTrition in Cancer (INPUT)

Neoplasms | Cancer | Tumor | Malignant Neoplasm | End Stage Cancer | Malignancy | Terminal Cancer

United Kingdom
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

DECT in Imaging Patients With Solid Organ Cancer With Intracranial Metastasis

Malignant Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
Jonsson Comprehensive Cancer Center

Withdrawn

Stereotactic Radiation Therapy Before Surgery for the Treatment of Resectable Brain Metastases

Brain Tumor | Malignant Neoplasm, Brain

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases

Malignant Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
Emory University
National Cancer Institute (NCI)

Recruiting

Radiosurgery Before Surgery for the Treatment of Brain Metastases

Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
Emory University
National Cancer Institute (NCI)

Not yet recruiting

Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases

Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Dual Time Point FDG PET/MRI Scan in Improving the Imaging Cancer Patients With Brain Metastases

Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...
National Cancer Institute (NCI)

Recruiting

Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery

Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
National Cancer Institute (NCI)

Active, not recruiting

Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
Novelwise Pharmaceutical Corporation

Recruiting

NBM-BMX Administered Orally to Patients With Solid Tumors or Newly Diagnosed Glioblastoma

Malignant Neoplasm | Malignant Neoplasm of Brain

Taiwan
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases

Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm

United States
Emory University
National Cancer Institute (NCI); National Institutes of Health (NIH)

Completed

Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases

Metastatic Malignant Neoplasm in the Brain | Invasive Malignant Neoplasm

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Dasatinib, Temsirolimus, and Cyclophosphamide in Treating Patients With Advanced, Recurrent, or Refractory Solid Tumors

Advanced Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Recurrent Brain Neoplasm | Refractory Brain Neoplasm

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Novel MRI Techniques for the Characterization and Treatment Assessment of High Grade Brain Lesions

Lymphoma | Brain Neoplasm | Metastatic Malignant Neoplasm in the Brain | Recurrent Malignant Brain Neoplasm

United States
Ohio State University Comprehensive Cancer Center

Recruiting

Neuropsychological Care for Maintaining Quality of Life After Radiation Therapy in Patients With Brain Metastases

Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain

United States
City of Hope Medical Center
National Cancer Institute (NCI); California Institute for Regenerative Medicine...

Recruiting

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

Breast Cancer | HER2-positive Breast Cancer | Malignant Neoplasm | Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm in the Leptomeninges

United States
Sameek Roychowdhury
National Cancer Institute (NCI)

Withdrawn

Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers

Locally Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | ALK Gene Mutation | Metastatic Malignant Neoplasm in the Brain | Advanced Malignant Neoplasm | ALK Fusion Protein Expression | Metastatic Malignant Neoplasm in the Central Nervous System | ROS1 Gene Mutation | ALK Gene... and other conditions

United States
Cancer Research UK
Royal Marsden NHS Foundation Trust; Hoffmann-La Roche; University of Manchester; University of Birmingham

Recruiting

DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Teenage/Young Adults and Paediatric Patients With ROS1 Gene Fusion-positive Cancers. (DETERMINE)

Glioma | Melanoma | Neoplasms by Histologic Type | Lymphoproliferative Disorders | Neoplasms by Site | Cancer | Brain Neoplasms | Solid Tumor | Malignant Neoplasm | Malignancy | Haematological Malignancy

United Kingdom
Case Comprehensive Cancer Center

Completed

18F-Fluciclovine PET to Distinguish Tumor Progression From Radiation Necrosis

Secondary Malignant Neoplasm of Brain and Cerebral Meninges

United States
Northwestern University
National Cancer Institute (NCI)

Withdrawn

Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis

Breast Carcinoma | Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm in the Leptomeninges

United States
University of Illinois at Chicago
Millennium Pharmaceuticals, Inc.

Completed

Phase I Study of MLN8237 and Pazopanib in Patients With Solid Tumors

Melanoma | Head and Neck Neoplasms | Malignant Neoplasm of Breast | Malignant Neoplasm of Thorax | CNS Malignancy | Malignant Neoplasm of Gastrointestinal Tract | Genitourinary Neoplasms Malignancy and Gender Unspecified

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Pro-Active Genetic Testing in Patients With Solid Tumors, Inherit Study

Malignant Solid Neoplasm | Breast Carcinoma | Digestive System Neoplasm | Skin Carcinoma | Malignant Female Reproductive System Neoplasm | Metastatic Malignant Neoplasm of Unknown Primary | Malignant Head and Neck Neoplasm | Malignant Brain Neoplasm | Malignant Central Nervous System Neoplasm | Malignant... and other conditions

United States
Albert Einstein College of Medicine
National Cancer Institute (NCI)

Terminated

Anti-NY ESO-1 mTCR Peripheral Blood Lymphocytes

Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm | HLA-A2 Positive Cells Present

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Muscadine Grape Skin Extract in Treating Patients With Malignancy That Is Metastatic or Cannot Be Removed by Surgery

Metastatic Malignant Neoplasm | Unresectable Malignant Neoplasm | Advanced Malignant Neoplasm

United States
University of California, San Francisco
Gilead Sciences

Suspended

Magrolimab in Children and Adults With Recurrent or Progressive Malignant Brain Tumors (PNOC025)

Brain Cancer | Malignant Brain Tumor | Brain Tumor Adult | Recurrent Brain Tumor | Progressive Malignant Brain Tumor | Brain Tumor, Pediatric

United States
OHSU Knight Cancer Institute
National Cancer Institute (NCI); Oregon Health and Science University

Terminated

Ferumoxytol- and Gadolinium-Labeled MRI in Measuring Tumors Before or After Treatment in Patients With Primary or Metastatic Brain Tumors

Metastatic Malignant Neoplasm in the Brain | Primary Brain Neoplasm

United States
ABM Therapeutics Shanghai Company Limited

Recruiting

A Study of ABM-1310 in Patients With BRAF V600-Mutant Relapsed and Drug Resistant Primary Malignant Brain Tumors

Primary Malignant Brain Tumor

China
Jonsson Comprehensive Cancer Center

Terminated

Quantifying Oxygen Utilization of Tumors Using Oxygen-Enhanced Molecular MRI

Malignant Brain Neoplasm

United States
OHSU Knight Cancer Institute
National Cancer Institute (NCI); Oregon Health and Science University; Weill...

Recruiting

Feasibility of FMISO in Brain Tumors

Malignant Brain Neoplasm

United States
University Hospital, Lille
Ministry of Health, France

Terminated

Rates DMBT1 ( Glycoprotein) in Sputum of CF Patients With Pseudomonas Aeruginosa (DMBT1)

Malignant Brain Tumor

France
M.D. Anderson Cancer Center
National Cancer Institute (NCI); University of Houston

Recruiting

Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors

Brain Neoplasm | Metastatic Malignant Neoplasm in the Brain | Recurrent Brain Neoplasm

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Active, not recruiting

Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease

Metastatic Malignant Neoplasm in the Brain

United States, Canada
University of Washington
National Cancer Institute (NCI)

Completed

18F-FLT PET/CT in Measuring Cell Proliferation in Patients With Brain Tumors

Metastatic Malignant Neoplasm in the Brain | Recurrent Brain Neoplasm | Primary Brain Neoplasm

United States
Lucid Lane, Inc
M.D. Anderson Cancer Center

Recruiting

Digital and Behavioral Tele-Health Tapering Program for Lowering Dependence on Opioids in Patients Undergoing Surgery

Malignant Solid Neoplasm | Malignant Thoracic Neoplasm | Malignant Head and Neck Neoplasm | Malignant Abdominal Neoplasm

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Blood Brain Barrier Differences in Patients With Brain Tumors Undergoing Surgery

Metastatic Malignant Neoplasm in the Brain | Recurrent Brain Neoplasm | Central Nervous System Neoplasm | Localized Brain Neoplasm

United States
Vanderbilt University Medical Center
University of Alabama at Birmingham; Emory University; H. Lee Moffitt Cancer... and other collaborators

Terminated

Risk Factors for Adult-Onset Brain Tumors

Brain Neoplasms, Benign | Brain Neoplasms, Malignant | Brain Neoplasm, Primary

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies

Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Liver | Metastatic Malignant Neoplasm in the Lung

United States
National Cancer Institute (NCI)

Active, not recruiting

Trametinib and Navitoclax in Treating Patients With Advanced or Metastatic Solid Tumors

Refractory Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Immunotherapy (Nivolumab With or Without Ipilimumab) in Patients With Advanced Solid Cancers That Have Changes in the Following Genes: PIK3CA and PTEN

Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States, Canada
National Cancer Institute (NCI)

Active, not recruiting

Testing the Sequential Combination of the Anti-cancer Drugs Olaparib Followed by Adavosertib (AZD1775) in Patients With Advanced Solid Tumors With Selected Mutations and PARP Resistance, STAR Study

Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
M.D. Anderson Cancer Center

Recruiting

Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology

Metastatic Malignant Neoplasm in the Brain | Central Nervous System Neoplasm | Leptomeningeal Neoplasm | Primary Brain Neoplasm

United States
M.D. Anderson Cancer Center

Active, not recruiting

Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors

Refractory Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Eli Lilly and Company; Genentech, Inc.; Kazia... and other collaborators

Recruiting

Genetic Testing in Guiding Treatment for Patients With Brain Metastases

Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain | NTRK Family Gene Mutation | CDK Gene Mutation | PI3K Gene Mutation | ROS1 Gene Mutation | KRAS G12C Mutation

United States
Darell D. Bigner, MD, PhD
National Institute of Neurological Disorders and Stroke (NINDS)

Terminated

Study of Immunotoxin, MR1-1 (MR1-1)

Supratentorial Malignant Brain Tumor

United States
National Cancer Institute (NCI)

Recruiting

Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and M1774 for Advanced Solid Tumors

Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States

Clinical Trials on Malignant Brain Neoplasm

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