Clinical Trials on Meningeal Neoplasms

Total 106339 results

Central Hospital, Nancy, France

Recruiting

Clinical, Radiological, Histologic and Molecular Features of a Cohort of Melanocytic Tumors of the Central Nervous System (MelaMen)

Meningeal Melanocytoma | Meningeal Melanomatosis | Meningeal Melanocytosis | Meningeal Melanoma

France
National Cancer Institute (NCI)

Completed

Phase I Study of Intrathecal Mafosfamide

Lymphoma | Leukemia | Meningeal Neoplasm

United States
University of Aarhus

Recruiting

Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis (CSI ProLong)

Leptomeningeal Metastasis

Denmark
Dartmouth-Hitchcock Medical Center

Completed

Circulating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Metastasis (LM)

Leptomeningeal Metastasis

United States
Cancer Institute and Hospital, Chinese Academy...

Completed

Tomotherapy for Leptomeningeal Metastases

Leptomeningeal Metastasis

China
Plus Therapeutics

Recruiting

Intraventricular Administration of Rhenium-186 NanoLiposome for Leptomeningeal Metastases (ReSPECT-LM)

Leptomeningeal Metastasis

United States
The First Hospital of Jilin University

Completed

Concurrent Involved-field Radiotherapy and Intrathecal Chemotherapy for Leptomeningeal Metastases From Solid Tumors

Leptomeningeal Metastasis

China
The First Hospital of Jilin University
The Second Hospital of Hebei Medical University; Second Affiliated Hospital... and other collaborators

Recruiting

Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis

Leptomeningeal Metastasis

China
The First Hospital of Jilin University

Completed

Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors

Leptomeningeal Metastasis

China
The First Hospital of Jilin University
The Second Hospital of Hebei Medical University; Second Affiliated Hospital... and other collaborators

Active, not recruiting

Intrathecal Pemetrexed for Leptomeningeal Metastasis

Leptomeningeal Metastases

China
Memorial Sloan Kettering Cancer Center
Fred Hutchinson Cancer Center

Active, not recruiting

Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors

Leptomeningeal Metastases

United States
Memorial Sloan Kettering Cancer Center
Center for Experimental Therapeutics; F.M. KIRBY FOUNDATION

Recruiting

A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis

Leptomeningeal Metastases

United States
Memorial Sloan Kettering Cancer Center

Completed

Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases

Leptomeningeal Metastases

United States
Y-mAbs Therapeutics

Withdrawn

177Lu-DTPA-Omburtamab Radioimmunotherapy for Leptomeningeal Metastasis From Solid Tumors (Breast, NSCLC, Malignant Melanoma)

Solid Tumor, Adult | Leptomeningeal Metastasis

United States, United Kingdom
Baylor College of Medicine
GlaxoSmithKline

Completed

Phase 1 Intrathecal Topotecan for Neoplastic Meningitis (PBTC-019)

Neoplastic Meningitis

United States
M.D. Anderson Cancer Center
Schering-Plough; Enzon Pharmaceuticals, Inc.

Terminated

DepoCyt Plus Temozolomide in Patients With Neoplastic Meningitis

Neoplastic Meningitis

United States
West China Hospital

Not yet recruiting

Immune Checkpoint Inhibitors Intrathecal Injection in Patients With Leptomeningeal Metastases in NSCLC

NSCLC Associated With Leptomeningeal Metastases
Massachusetts General Hospital
Merck Sharp & Dohme LLC

Terminated

Pembrolizumab And Lenvatinib In Leptomeningeal Metastases

Solid Tumor | Solid Tumor, Adult | Leptomeningeal Metastasis

United States
M.D. Anderson Cancer Center
Genentech, Inc.

Completed

A Pilot Study of Bevacizumab for Neoplastic Meningitis

Neoplastic Meningitis

United States
Baylor College of Medicine
National Cancer Institute (NCI); Mayo Clinic; University of Pittsburgh; Brown University and other collaborators

Terminated

Intrathecal Gemcitabine to Treat Neoplastic Meningitis, IT Gemcitabine

Neoplasms | Meningitis

United States
Guangzhou Medical University

Recruiting

Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor Receptor Mutation-Positive Non-Small-cell Lung Cancer

Leptomeningeal Metastasis

China
Baylor College of Medicine

Completed

Intrathecal Mafosfamide

Malignant Meningeal Neoplasms

United States
Massachusetts General Hospital
Bristol-Myers Squibb

Completed

Ipilimumab and Nivolumab in Leptomeningeal Metastases

Leptomeningeal Carcinomatosis

United States
Hui Bu

Unknown

Different Dose of Methotrexate for the Treatment of Meningeal Carcinomatosis

Meningeal Carcinomatosis
The First Hospital of Jilin University

Completed

Intrathecal Pemetrexed for Recurrent Leptomeningeal Metastases From Non-small Cell Lung Cancer

Leptomeningeal Metastases

China
Hui Bu

Not yet recruiting

Efficacy and Safety of Durvalumab in Non-Small Cell Lung Cancer With Leptomeningeal Metastasis

Leptomeningeal Metastasis | Durvalumab
Second Affiliated Hospital of Nanchang University
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Not yet recruiting

Almonertinib With Bevacizumab for EGFR-Mutant NSCLC Patients With Leptomeningeal Metastasis (ATTRACT)

NSCLC | EGFR Activating Mutation | Leptomeningeal Metastasis

China
Hebei Medical University

Recruiting

Clinical Observation of ICI Combined With Recombinant Human Endostatin on Leptomeningeal Metastasis of Lung Cancer

Leptomeningeal Metastasis | Immune Checkpoint Inhibitor | Endostatin

China
The Netherlands Cancer Institute

Unknown

Clinical and Pharmacological Study With 2B3-101 in Patients With Breast Cancer and Leptomeningeal Metastases

Meningeal Carcinomatosis

Netherlands
H. Lee Moffitt Cancer Center and Research Institute
Bayer

Terminated

Depocyt® With Sorafenib in Neoplastic Meningitis

Neoplastic Meningitis

United States
Memorial Sloan Kettering Cancer Center
Kazia Therapeutics

Active, not recruiting

GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases

Brain Metastases | Leptomeningeal Metastasis

United States
Centre Oscar Lambret

Withdrawn

Analyses of Exosomes in the Cerebrospinal Fluid for Breast Cancer Patients With Suspicion of Leptomeningeal Metastasis.

Breast Cancer | Leptomeningeal Metastasis

France
Centre Oscar Lambret

Completed

Interest of Intrathecal Chemotherapy With Liposomal Cytarabine (DepoCyte®) in Meningeal Metastasis of Breast Cancer (DEPOSEIN)

Breast Cancer | Leptomeningeal Metastases

France
Pacira Pharmaceuticals, Inc

Completed

DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor

Meningeal Neoplasms

United States, Canada
Mundipharma Research Limited

Completed

Study to Demonstrate the Safety of WBR Administered at the Same Time as Intrathecal Liposomal Cytarabine (DepoCyte®) Versus Intrathecal Liposomal Cytarabine (DepoCyte®) Administered After WBR for the Treatment of Solid Tumour Neoplastic Meningitis in Patients With or Without Brain Metastasis.

Brain Metastases | Solid Tumour Neoplastic Meningitis

Austria, Germany
The Netherlands Cancer Institute

Completed

Circulating Tumor Cells and Cytology in Cerebrospinal Fluid of Patients Clinically Suspected for Leptomeningeal Metastases

Meningeal Carcinomatosis

Netherlands
University of Virginia

Terminated

BATs in Patients With Breast Cancer and Leptomeningeal Metastases

Breast Cancer Female | Leptomeningeal Metastases

United States
Reata, a wholly owned subsidiary of Biogen

Terminated

A Safety Study of RTA 744 in Recurrent, Progressive or Refractory Neoplastic Meningitis (LMD)

Leptomeningeal Carcinomatosis

United States
Hui Bu

Recruiting

Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung Cancer

Lung Cancer | Leptomeningeal Metastasis

China
Henan Cancer Hospital

Recruiting

A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY)

NSCLC | Brain Metastases | Leptomeningeal Metastasis

China
UNICANCER
Seagen Inc.

Recruiting

Capecitabine, Tucatinib, and Intrathecal Trastuzumab for Breast Cancer Patients With Leptomeningeal Disease (ETIC-LM)

HER2-positive Metastatic Breast Cancer | Leptomeningeal Disease | Leptomeningeal Metastasis

France
National Taiwan University Hospital
Chang Gung Memorial Hospital; Taipei Veterans General Hospital, Taiwan; Taichung...

Completed

Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis

Breast Neoplasms | Brain Metastases | Leptomeningeal Metastasis

Taiwan
Dartmouth-Hitchcock Medical Center
National Cancer Institute (NCI)

Terminated

Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or Lymphoma

Brain Tumors | Central Nervous System Tumors | Leptomeningeal Metastases

United States
Fudan University

Recruiting

Intrathecal Chemotherapy Through Ommaya Reservoir Upon Her-2 Negative Breast Cancer With Leptomeningeal Metastasis

HER2-negative Breast Cancer | Leptomeningeal Metastasis

China
Biocept, Inc.
ICON plc

Terminated

A Therapy Treatment Response Trial in Patients With Leptomeningeal Metastases ((LM) Using CNSide (FORESEE)

Breast Cancer | Non-Small Cell Lung Cancer | Leptomeningeal Disease | Leptomeningeal Metastasis | Leptomeningeal Neoplasms

United States
TYK Medicines, Inc

Active, not recruiting

Study of TY-9591 in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR Mutation

NSCLC | Brain Metastases | EGFR Activating Mutation | Leptomeningeal Metastasis

China
Institut Curie
Centre Leon Berard; Institut Bergonié; Hoffmann-La Roche; University Hospital,... and other collaborators

Completed

Intrathecal Trastuzumab Administration in Metastatic Breast Cancer Patients Developing Carcinomatous Meningitis (HIT)

Metastatic Breast Cancer | Carcinomatous Meningitis

France
Guangzhou Medical University

Not yet recruiting

Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib.

Leptomeningeal Metastasis
University Hospital, Bonn
Mundipharma Research GmbH & Co KG

Terminated

A Clinical Trial to Assess the Safety & Efficacy of the Treatment of Patients With Metastasis From Malignant Melanoma - Treatment Consists of the Substances Lomustine (Capsules) & Cytarabine (Injected Into an Area Near the Spinal Cord), Accompanied by Radiotherapy of the Brain

Leptomeningeal Metastasis From Malignant Melanoma

Germany
University Hospital Tuebingen

Recruiting

Intrathecal Application of PD1 Antibody in Metastatic Solid Tumors With Leptomeningeal Disease (IT-PD1/ NOA 26) (IT-PD1)

Leptomeningeal Disease

Germany

Clinical Trials on Meningeal Neoplasms

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Sri Lanka

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations