Clinical Trials on Metabolic Detoxication, Phase I

Total 410 results

University Hospital, Basel, Switzerland

Completed

Pharmacokinetic Study to Characterize Phenotyping Metrics of the "Basel" Cocktail After CYP Induction or Inhibition

Metabolic Detoxication, Phase I

Switzerland
Factors Group of Nutritional Companies Inc.
Isura

Completed

Metabolic Differences Between Dihydroberberine and Micellar Berberine

Phase I and Phase II Metabolites of Berberine

Canada
Bayer

Completed

Study in Postmenopausal Women to Investigate the Drug-drug Interaction (DDI) Between Itraconazole(ITZ) and Orally Administered Vilaprisan; Absolute Bioavailability Using Intravenous Microtracer Dose of [14C]Vilaprisan

Clinical Trial, Phase I

United Kingdom
Bayer

Completed

Drug-drug Interaction Study: Influence of Vilaprisan on Pharmacodynamics (PD) and Pharmacokinetics (PK) of a Combined Oral Contraceptive (COC)

Clinical Trial ,Phase I

Germany
Bayer

Completed

Study in Healthy Young Women to Investigate the Pharmacodynamics, Pharmacokinetics and Safety of Vilaprisan

Clinical Trial, Phase I

Germany
Bayer

Completed

Rogaratinib (BAY1163877) Human Mass Balance Study

Pharmacokinetics | Clinical Trial, Phase I

Netherlands
Bayer

Completed

First in Human Study in Healthy Volunteers to Investigate the Safety, Tolerability and Pharmacokinetics of BAY1214784

Clinical Trials, Phase I as Topic

Germany
Bayer

Completed

BAY 1902607: Single Dose Escalation, Safety and Tolerability, Pharmacokinetics, Bioavailability, Food Effect

Clinical Trials, Phase I as Topic

Germany
Bayer

Completed

First in Human Study to Investigate the Safety and Tolerability, Pharmacokinetics, Itraconazole Drug-drug-interaction and Food Effect of BAY1817080

Clinical Trials, Phase I as Topic

Germany
Isofol Medical AB

Completed

Study Evaluating ECG Effects, Safety, Tolerability and Pharmacokinetics of Single Doses of Modufolin (Arfolitixorin) in Healthy Volunteers Tetrahydrofolate in Healthy Male Volunteers

Phase I Study in Healthy Volunteers to Evaluate ECG Effect

Sweden
Alvotech Swiss AG

Completed

AVT03 With Xgeva in Healthy Male Subjects

This is a Phase I Study Conducted in Healthy Volunteers

United Kingdom, South Africa, Poland
Federal University of Mato Grosso
Univag Centro Universitário

Recruiting

Metabolic Effects of Whey Protein Supplementation After Fasting in Volunteers

Insulin Resistance | Ketosis | Acute-Phase Response

Brazil
Federal University of Mato Grosso

Completed

Preoperative Feeding With a Whey Protein Plus Carbohydrate Drink on the Acute Phase Response and Insulin Resistance

Insulin Resistance | Acute Phase Response

Brazil
Bayer

Completed

Renal Impairment Study

Clinical Trial, Phase I

Germany
Peking University Third Hospital

Not yet recruiting

Pravastatin Reduces Acute Phase Response of Zoledronic Acid

Postmenopausal Osteoporosis
Samsung Medical Center

Terminated

Phase I/II Study of Neoadjuvant Chemoradiotherapy With S-1/ Oxaliplatin in Patients With Gastric Cancer: Randomized Phase II Study of S-1/RT vs. S-1/Oxaliplatin/RT

Phase I: To Determine the Maximum Tolerated Dose (MTD) | Phase II: To Assess the Pathologic CR Rate and Feasibility Following Neoadjuvant Chemoradiation Therapy With S1/Oxaliplatin

Korea, Republic of
University of Pisa

Completed

Acute-phase Response & Periodontal Treatment in Diabetes Affected Patients (PERIO-DIA)

Diabetes | Periodontitis

Italy
Genzyme, a Sanofi Company

Recruiting

Mucopolysaccharidosis I (MPS I) Registry

Mucopolysaccharidosis I (MPS I)

Croatia, Argentina, Australia, Belgium, Denmark, France, Hong Kong, India, Indonesia, Italy, Korea, Republic of, Kuwait, Lebanon, Malaysia, Pakistan, Philippines, Poland, Saudi Arabia, Singapore, Slovakia, Taiwan, Thailand, United Kingdom and more
REGENXBIO Inc.

Active, not recruiting

RGX-111 Gene Therapy in Patients With MPS I

Hurler Syndrome | Hurler-Scheie Syndrome | Mucopolysaccharidosis Type I (MPS I)

United States, Brazil, Israel
Sanofi

Completed

A Study to Assess the Safety of Myozyme® and of Aldurazyme® in Male and Female Participants of Any Age Group With Pompe Disease or With Mucopolysaccharidosis Type I (MPS I) in a Home-care Setting (HomERT)

Pompe Disease | Mucopolysaccharidosis Type I (MPS I)

Italy
Han Yaling, MD

Recruiting

The Impact of Phase I Cardiac Rehabilitation on the Prognosis of AMI Patients After PCI (AID)

Acute Myocardial Infarction | Phase I Cardiac Rehabilitation

China
Shanghai Vitalgen BioPharma Co., Ltd.

Recruiting

A Study to Evaluate the Tolerability, Safety and Efficacy of VGM-R02b

Glutaric Acidemia Type I | Glutaric Aciduria Type I

China
University of Pisa

Completed

Acute-phase Response & Periodontal Treatment in Obese Patients (PERIO-OBESE)

Obesity | Periodontal Diseases

Italy
Sohag University

Recruiting

Evaluation of Health Related Quality of Life in Patients With Intoxication-type Inherited Metabolic Diseases in Sohag University Hospital

Intoxication-type Inherited Metabolic Diseases

Egypt
Mackay Memorial Hospital
Sanofi Taiwan Co. Ltd

Recruiting

The Intensively Follow-up Examinations for Asymptomatic MPS I Infants in Taiwan

MPS I

Taiwan
Hadassah Medical Organization
Oramed Pharmaceutical Inc.

Completed

Effectiveness of Oral Insulin in Unstable Type 1 Diabetes Patients

Brittle Type I Diabetes Mellitus

Israel
West China Hospital

Recruiting

A Clinical Study Evaluating the Safety, Tolerability, and Initial Efficacy of JWK008 in Patients With Mucopolysaccharidosis Type I

Mucopolysaccharidosis Type I

China
Swiss Federal Institute of Technology
Addis Ababa University; HarvestPlus

Unknown

Iron Status in Infants in Ethiopia.

Iron-deficiency | Iron Deficiency Anemia | Aluminium Intoxication

Switzerland, Ethiopia
University of Pennsylvania
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Recruiting

Effect of Nutritional Ketosis on Alcohol Metabolism (KAM)

Alcohol Drinking | Magnetic Resonance Imaging | Ketoses, Metabolic | Ketogenic Dieting | Alcohol Intoxication

United States
Cinnagen

Completed

Efficacy and Safety of YW17 (Laronidase-CinnaGen) Compared to Aldurazyme® in MPS I Patients

Mucopolysaccharidosis Type 1

Iran, Islamic Republic of
Sangamo Therapeutics

Terminated

Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-318 in Subjects With MPS I

MPS I

United States
Sanofi

Completed

A Study to Evaluate Absolute Bioavailability, Absorption, Metabolism, and Excretion of Genz-112638 in Healthy Male Participants

Gaucher's Disease Type I
Nemours Children's Clinic
Thrasher Research Fund

Completed

Glutamine and Insulin Sensitivity in Type I Diabetes

Type I Diabetes Mellitus

United States
IRCCS San Raffaele
Fondazione Telethon

Active, not recruiting

Gene Therapy With Modified Autologous Hematopoietic Stem Cells for the Treatment of Patients With Mucopolysaccharidosis Type I, Hurler Variant (TigetT10_MPSIH)

Mucopolysaccharidosis IH

Italy
CENTOGENE GmbH Rostock

Withdrawn

Biomarker for Hurler Disease (BioHurler) (BioHurler)

Metabolism, Inborn Errors | Mucopolysaccharidosis Type I | Gargoylism

Germany, India, Sri Lanka, Egypt
University of Minnesota
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National... and other collaborators

Completed

MRS to Determine Neuroinflammation and Oxidative Stress in MPS I

Mucopolysaccharidosis Type I

United States
Novartis Pharmaceuticals

Terminated

Extension to a Randomized, Double-blind, Placebo Controlled Study of LCQ908 in Subjects With Familial Chylomicronemia Syndrome.

Familial Chylomicronemia Syndrome (FCS) (HLP Type I)

South Africa, Germany, United Kingdom, France, United States, Canada, Netherlands
Masonic Cancer Center, University of Minnesota

Recruiting

Evaluation of Intravenous Laronidase Pharmacokinetics Before and After Hematopoietic Cell Transplantation in Patients With Mucopolysaccharidosis Type IH.

Mucopolysaccharidosis Type I | Hematopoietic Cell Transplantation

United States
AstraZeneca

Active, not recruiting

Study of Acalabrutinib in Chinese Adult Subjects With Relapsed or Refractory Mantle Cell Lymphoma, Chronic Lymphocytic Leukemia or Other B-cell Malignancies

Phase I: Relapsed or Refractory B-cell Malignancies | Phase II Cohort A: Relapsed or Refractory Mantle Cell Lymphoma | Phase II Cohort B: Relapsed or Refractory Chronic Lymphocytic Leukemia

China
Centre Hospitalier Universitaire, Amiens

Active, not recruiting

Analysis of Disturbances in Neurofluid Dynamics in Type I Chiari Malformations (NEUROFLUX-C)

Cerebrospinal Fluid | Phase Contrast MRI | Type I Chiari Malformation | Cerebral Hemodynamic | Craniospinal Hydrodynamic

France
Masonic Cancer Center, University of Minnesota

Completed

Stem Cell Transplantation for Hurler

Mucopolysaccharidosis I | Mucopolysaccharidosis VI | Mannosidosis | Mucolipidosis Type II (I-cell Disease)

United States
AZ-VUB
Novo Nordisk A/S

Completed

Prevention of Clinical Onset of Type 1 Diabetes in High Risk First Degree Relatives

Diabetes, Type I

Belgium
Karolinska University Hospital
AstraZeneca

Unknown

Diabetes Type 1, Treatment Study Atacand/Placebo After Kidney Biopsy

Diabetes, Type I

Sweden
Vardalinstitutet The Swedish Institute for Health...
Lund University Hospital; Sahlgren´s University Hospital

Unknown

Childhood Diabetes

Diabetes, Type I

Sweden
Sanofi

Completed

12 Week,Comparing Safety of HMR1964 & Insulin Aspart Used in Continuous Subcutaneous Infusion in Type 1 Diabetes.

Diabetes, Type I

Germany, Netherlands, France
Masonic Cancer Center, University of Minnesota

Terminated

Laronidase (Aldurazyme TM) Enzyme Replacement Therapy With Hematopoietic Stem Cell Transplant for Hurler Syndrome

Hurler Syndrome | Mucopolysaccharidosis Type IH | MPS I

United States
Sanofi

Active, not recruiting

Safety and Efficacy of Eliglustat With or Without Imiglucerase in Pediatric Patients With Gaucher Disease (GD) Type 1 and Type 3 (ELIKIDS)

Gaucher's Disease Type III | Gaucher's Disease Type I

Canada, Argentina, France, Italy, Japan, Russian Federation, Spain, Sweden, Turkey, United Kingdom
University Health Network, Toronto
Princess Margaret Hospital, Canada; Ontario Institute for Cancer Research

Completed

Feasibility Study of Genomic Profiling Methods and Timing in Tumor Samples

Breast Cancer | Colorectal Cancer | Metastatic | Gynecological Cancer | Melanoma Cancer | Eligible for Phase I or Phase II Study

Canada
Amsterdam Molecular Therapeutics
ICON plc

Terminated

Duration of Effect of Alipogene Tiparvovec Treatment, Which Was Administered in Other Studies

Hyperlipoproteinemia Type I

Canada
University of Texas Southwestern Medical Center

Completed

Orlistat for the Treatment of Type I Hyperlipoproteinemia (T1HLP)

Hypertriglyceridemia | Hyperlipoproteinemia Type I

United States

Clinical Trials on Metabolic Detoxication, Phase I

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