Clinical Trials on Metformin Associated Lactic Acidosis

Total 60 results

Central Hospital, Nancy, France

Recruiting

Study of Metformin Overdose (METINFO)

Metformin Associated Lactic Acidosis

France
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...

Completed

Study On the Role of Mitochondrial Dysfunction in the Pathogenesis of Metformin-associated Lactic Acidosis

Lactic Acidosis | Metformin

Italy
Humanitas Hospital, Italy

Recruiting

Metformin in Diabetic Patients Undergoing Coronary Angiography (NO-STOP)

Coronary Artery Disease | Diabetes Mellitus | Contrast-induced Nephropathy | Lactic Acidosis With Diabetes Mellitus | Metformin Associated Lactic Acidosis

Italy
University of Florida

Completed

Pharmacotoxicology of Trichloroethylene Metabolites

Congenital Lactic Acidosis

United States
National Institute of Environmental Health Sciences...

Completed

Dichloroacetate Kinetics, Metabolism and Toxicology

Lactic Acidosis

United States
Central South University

Completed

Glucose-insulin-potassium Therapy Improves Lactic Acidosis in Liver Transplantation (GIK)

Liver Transplantation

China
Tri-Service General Hospital

Completed

Nitroglycerin Infusion During Cardiac Surgery

Lactic Acidosis | Blood Glucose, High

Taiwan
University of Florida

No longer available

Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Expanded Access (CLA)

Mitochondrial Enzyme Deficiencies

United States
Fayoum University

Withdrawn

Remote Ischemic Preconditioning During Cardiopulmonary Bypass (RIPC)

Lactic Acidosis

Egypt
Shahid Beheshti University of Medical Sciences

Completed

Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media

Diabetes Mellitus | Lactic Acidosis

Iran, Islamic Republic of
Duke University

Withdrawn

The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression

Hypoxia | Lactic Acidosis

United States
Makerere University

Completed

Effect of Blood Storage Age on the Resolution of Lactic Acidosis in Children With Severe Malarial Anemia at Mulago Hospital

Compare Blood Age for Transfusion

Uganda
University Hospital of Split

Completed

Study of Blood Lactate Levels in Patients Treated With Antipsychotics

Movement Disorders | Lactic Acidosis

Croatia
Changi General Hospital

Completed

The Threshold of Serum Anion Gap as a Screening Tool for Organic Acidosis

Critical Illness | Metabolic Acidosis | Anion Gap Acidosis | Lactic Acidosis | Keto Acidosis | Acid Base Disorder

Singapore
Asan Medical Center

Terminated

Lactic Acidosis During Entecavir(ETV)Treatment (ETV)

Lactic Acidosis
National Taiwan University Hospital

Recruiting

Investigation of the Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions

Peripheral Neuropathy | Lactic Acidosis | Myelosuppression

Taiwan
University of California, San Diego

Completed

Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia

Lactic Acidosis

United States
University of Florida

Completed

Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis

Lactic Acidosis
Sangart

Withdrawn

Phase 2c Dose Comparison Study of MP4OX in Trauma

Trauma | Hemorrhagic Shock | Lactic Acidosis

New Zealand, United Kingdom, Israel, France, Switzerland, Australia, Belgium, Brazil, Germany, Norway, South Africa
Stanford University

Completed

Lactic Acidosis During and After Seizures

Epilepsy

United States
New York Institute of Technology

Completed

Whole Body Periodic Acceleration on Blood Lactate and Recovery

Acidosis, Lactic

United States
University of British Columbia
GlaxoSmithKline; CIHR Canadian HIV Trials Network

Completed

D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE)

Acidosis, Lactic

Canada
Vapotherm, Inc.
Auburn University

Active, not recruiting

Wingate-type Exercise Test to Evaluate the Effect of High Velocity Therapy on Recovery Sensation and Blood Lactate Decline

Exercise | Recovery | Dyspnea | Breathlessness | Muscle | Lactic Acidosis

United States
Skane University Hospital

Completed

Metformin Treatment, Renal Function and Lactic Acidosis

Type 2 Diabetes Mellitus

Sweden
The Cleveland Clinic

Withdrawn

Thiamine Supplementation in Patients With Septic Shock

Septic Shock | Shock, Septic | Lactic Acidosis | Thiamine Deficiency

United States
Beth Israel Deaconess Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest

Shock | Cardiac Arrest | Lactic Acidosis | Thiamin Deficiency

United States
Queen's University
Ontario HIV Treatment Network

Completed

Lactate Metabolism Study in HIV Infected Persons

HIV Infections | Lipodystrophy | AIDS | Lactic Acidosis

Canada
University of Florida

Completed

Prevention of Dichloroacetate Toxicity

Chronic Disease | Acidosis, Lactic

United States
Sangart

Completed

Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients

Shock, Hemorrhagic | Acidosis, Lactic | Shock, Traumatic

Norway, Singapore, Israel, France, United Kingdom, Germany, Switzerland, Australia, Brazil, South Africa, New Zealand, Colombia, Austria, Spain
Sangart

Completed

Phase IIa Study of MP4OX in Traumatic Hemorrhagic Shock Patients

Shock, Hemorrhagic | Acidosis, Lactic | Shock, Traumatic

France, United Kingdom, South Africa, Germany
Tisento Therapeutics
Children's Hospital of Philadelphia

Terminated

Phase 2a Study of IW-6463 in Adults Diagnosed With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS)

MELAS

United States
Medical University of Vienna

Completed

Preoperative Parenteral Thiamine Supplementation in Patients Undergoing Heart Surgery

Heart Failure | Acidosis, Lactic | Thiamine Deficiency

Austria
Khondrion BV
Julius Clinical; ProPharma Group; Certara

Completed

The KHENEREXT Study

Mitochondrial Diseases | Mitochondrial DNA tRNALeu(UUR) m.3243A<G Mutation | Maternally Inherited Diabetes and Deafness (MIDD) | Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke Like Episodes (MELAS) | Chronic Progressive External Ophthalmoplegia (CPEO)

Netherlands, Denmark, United Kingdom, Germany
Glasgow Royal Infirmary

Completed

Alcohol: Thiamine and or Magnesium 1 (AToM1)

Magnesium Deficiency | Alcohol Withdrawal | Lactic Acidosis | Vitamin B1 Deficiency | Wernicke Encephalopathy

United Kingdom
National Center for Research Resources (NCRR)
University of California, San Diego

Completed

Study of the Metabolism of Pyruvate and Related Problems in Patients With Lactic Acidemia

MELAS Syndrome | Lactic Acidosis | Mitochondrial Myopathy

United States
Michio Hirano
Santhera Pharmaceuticals

Completed

Study of Idebenone in the Treatment of Mitochondrial Encephalopathy Lactic Acidosis & Stroke-like Episodes (MELAS)

MELAS Syndrome

United States
Jesús González de la Aleja Tejera

Completed

Glutamine Supplement in MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes) Syndrome

MELAS Syndrome

Spain
Rigshospitalet, Denmark
University College, London

Enrolling by invitation

EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV (EuroSIDA)

End Stage Liver Disease | Cardiovascular Diseases | Fractures, Bone | Diabetes Mellitus | Renal Insufficiency | Hepatitis B | Hepatitis C | Kidney Failure, Chronic | Proteinuria | HIV | Coinfection | Acidosis, Lactic | AIDS

Spain, Switzerland, Germany, United Kingdom, Austria, Sweden, Finland, Israel, Denmark, France, Italy, Iceland, Belgium, Slovakia, Norway, Lithuania, Portugal, Poland, Croatia, Czechia, Greece, Hungary, Luxembourg, Argentina, Belarus, Bosnia... and more
Mayo Clinic
National Cancer Institute (NCI)

Terminated

Nivolumab in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma

Blastic Plasmacytoid Dendritic Cell Neoplasm | HTLV-1 Infection | Recurrent Mycosis Fungoides | Refractory Mycosis Fungoides | Refractory Angioimmunoblastic T-cell Lymphoma | Hepatosplenic T-Cell Lymphoma | Recurrent Adult T-Cell Leukemia/Lymphoma | Refractory Anaplastic Large Cell Lymphoma | Recurrent... and other conditions

United States
UK Kidney Association

Recruiting

National Registry of Rare Kidney Diseases (RaDaR)

Vasculitis | AL Amyloidosis | Tuberous Sclerosis | Fabry Disease | Cystinuria | Focal Segmental Glomerulosclerosis | IgA Nephropathy | Bartter Syndrome | Pure Red Cell Aplasia | Membranous Nephropathy | Atypical Hemolytic Uremic Syndrome | Autosomal Dominant Polycystic Kidney Disease | Cystinosis | Nephronophthisis | BK Nephropathy and other conditions

United Kingdom
Mayo Clinic
National Cancer Institute (NCI)

Completed

Salvia Hispanica Seed in Reducing Risk of Disease Recurrence in Patients With Non-Hodgkin Lymphoma

Diffuse Large B-Cell Lymphoma | Splenic Marginal Zone Lymphoma | Mantle Cell Lymphoma | Mycosis Fungoides | Sezary Syndrome | Lymphoplasmacytic Lymphoma | Anaplastic Large Cell Lymphoma | Blastic Plasmacytoid Dendritic Cell Neoplasm | Primary Effusion Lymphoma | Adult T-Cell Leukemia/Lymphoma | Post-Transplant... and other conditions

United States
National Cancer Institute (NCI)

Completed

Vorinostat and Decitabine in Treating Patients With Advanced Solid Tumors or Relapsed or Refractory Non-Hodgkin's Lymphoma, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, or Chronic Myelogenous Leukemia

Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent... and other conditions

Canada
University of Medicine and Dentistry of New Jersey
National Cancer Institute (NCI)

Withdrawn

Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With High-Risk Hematologic Malignancies

Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent... and other conditions

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Cyclophosphamide for Prevention of Graft-Versus-Host Disease After Allogeneic Peripheral Blood Stem Cell Transplantation in Patients With Hematological Malignancies

Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma and other conditions

United States
University of Chicago
National Cancer Institute (NCI)

Completed

Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent... and other conditions

United States
Case Comprehensive Cancer Center

Completed

Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell... and other conditions

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse... and other conditions

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic Malignancies

Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult... and other conditions

United States, Germany, Italy
Fred Hutchinson Cancer Research Center/University...
National Cancer Institute (NCI)

Completed

Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications

Depression | Fatigue | Primary Myelofibrosis | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone... and other conditions

United States
Martin, Paul
National Cancer Institute (NCI)

Completed

Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer

Primary Myelofibrosis | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma and other conditions

United States

Clinical Trials on Metformin Associated Lactic Acidosis

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