Clinical Trials on Mitochondrial Alteration

Total 623 results

Children's Hospital of Philadelphia
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

National CounterACT Initiative

Mitochondrial Alteration

United States
University of Sao Paulo

Completed

Mitochondrial Energy Metabolism in Obese Women

Obesity | Physical Activity | Metabolism Disorder | Mitochondrial Alteration

Brazil
Naestved Hospital
University of Southern Denmark; Region Zealand

Completed

NeoThyr - the Role of Mitochondria-dysfunction in Newborns of Mothers With Autoimmune Thyroid Disease

Subclinical Hypothyroidism | Autoimmune Thyroid Disease | Alteration of Mitochondrial Membrane

Denmark
Mclean Hospital
Yale University; University of Lausanne

Not yet recruiting

MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction

Cognitive Impairment | Schizophrenia and Related Disorders | Mitochondrial Alteration

United States, Switzerland
University of Washington
American Heart Association

Completed

Nicotinamide Riboside in LVAD Recipients (PilotNR-LVAD)

Heart Failure，Congestive | Mitochondrial Alteration | Heart Failure New York Heart Association Class IV

United States
The Hospital for Sick Children

Completed

A Single Case Study of Hypermetabolism

Hypermetabolism Due to Defect in Mitochondria | Luft Disease

Canada
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge; Medical Research Council Mitochondrial Biology Unit

Completed

Nicotinamide Riboside and Mitochondrial Biogenesis

Mitochondrial Diseases | Mitochondrial Myopathies | Progressive External Ophthalmoplegia | Progressive Ophthalmoplegia | Progressive; Ophthalmoplegia, External | Mitochondria DNA Deletion | MELAS

United Kingdom
BioMed Valley Discoveries, Inc

Terminated

Study of Ulixertinib for Patients With Advanced Malignancies Harboring MEK or Atypical BRAF Alterations

Advanced Solid Tumor | MAP2K1 Gene Mutation | BRAF Gene Mutation | MEK Mutation | BRAF Gene Alteration | MEK Alteration | MAP2K1 Gene Alteration | MAP2K2 Gene Mutation | MAP2K2 Gene Alteration

United States
Slovak Academy of Sciences
Comenius University

Completed

Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance (MS-MIDY)

Multiple Sclerosis | Mitochondrial Alteration

Slovakia
University Hospital Heidelberg
German Cancer Research Center

Completed

Mitochondrial Effects of C18:0 Supplementation in Humans

Type2 Diabetes | Fatty Acid Deficiency | Alteration of Mitochondrial Membrane

Germany
Danone Asia Pacific Holdings Pte, Ltd.

Completed

Effect of Birth on Immunological Parameters in Cord Blood

Immunologic Activity Alteration
University Hospital, Clermont-Ferrand

Recruiting

High Intensity Interval Training and Muscle Adaptations During PR (MITOXITRAIN)

Pulmonary Disease, Chronic Obstructive | Oxygen Deficiency | Mitochondrial Alteration

France
Cairo University

Unknown

Assessment of Pubertal Growth Spurt in Growing Girls Using Middle Phalynx Finger and Correlate With Mandibular Second Molar

Growth Alteration

Egypt
United States Army Research Institute of Environmental...
United States Department of Defense

Completed

Efficacy of a Once Daily Calcium and Vitamin D Fortified Food Product to Improve Bone Microarchitecture

Dietary Modification | Bone Alteration

United States
National Taiwan University Hospital

Completed

Cognitive Effects of Tai Chi Chuan in Healthy Older Adults and Older Adults

Alteration of Cognitive Function

Taiwan
Northumbria University

Completed

The Effect of Breakfast Size Prior to Morning Exercise on Cognition, Mood and Appetite in Habitually Active Women

Alteration of Cognitive Function

United Kingdom
Stealth BioTherapeutics Inc.

Active, not recruiting

Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD) (NuPower)

Mitochondrial Diseases | Mitochondrial Myopathies | Mitochondrial Complex I Deficiency | Mitochondrial Pathology | Mitochondrial DNA Depletion | Mitochondrial DNA Mutation | Mitochondrial DNA Deletion | Mitochondrial Metabolism Defect

Spain, United States, Italy, Netherlands, Australia, Germany, Hungary, New Zealand, Norway, United Kingdom
Ramathibodi Hospital

Completed

Mallampati Score Before and After Cesarean Delivery (MSBAC)

Alteration of Modified Mallampati Score
University of California, Irvine
Beckman Laser Institute University of California Irvine; Unilever R&D

Completed

Assessing the Effects of Tretinoin Cream on Human Skin With Optical Imaging Technologies

Collagen Fibril Alteration

United States
University of Sao Paulo

Unknown

Study of Digestive Tolerance of Orange Juice With Fibers

Digestive Alteration [PE]

Brazil
University of Nottingham

Withdrawn

The Impact of Covid-19 on Skeletal Muscle

Covid19 | Muscle Loss | Mitochondrial Alteration

United Kingdom
McGill University Health Centre/Research Institute...

Recruiting

Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome (dC-dT-MDS)

Mitochondrial Diseases | Mitochondrial Encephalomyopathy | Mitochondrial Encephalopathy | Mitochondrial DNA Depletion | Mitochondrial Metabolism Disorders

Canada
Stealth BioTherapeutics Inc.

Completed

Safety, Tolerability, Efficacy of MTP-131 for Treatment of Mitochondrial Disease in Subjects From the MMPOWER Study (MMPOWER-2)

Primary Mitochondrial Disease

United States
Hitit University

Completed

Intubation Tube Applications on Voice Performance in Early Postoperative Period

Intubation Complication | Voice Alteration

Turkey
University of Florida

Completed

Physiologic Effects of Topiramate on Cognition

Alteration of Cognitive Function
Stealth BioTherapeutics Inc.

Terminated

Open-Label Extension Trial to Characterize the Long-term Safety and Tolerability of Elamipretide in Subjects With Genetically Confirmed Primary Mitochondrial Myopathy (PMM)

Primary Mitochondrial Disease

United States
Children's Hospital of Philadelphia
University of Pennsylvania; United Mitochondrial Disease Foundation (UMDF)

Recruiting

Mitochondrial Myopathy Rating Scale

Primary Mitochondrial Disease

United States
Rigshospitalet, Denmark
University of Copenhagen

Recruiting

Human Mitochondrial Stress-driven Obesity Resistance (MITO-OB-RES)

Mitochondrial Diseases | Mitochondrial Myopathies | Mitochondrial Disorder

Denmark
Khondrion BV
Radboud University Medical Center

Completed

The KHENERGY Study (KHENERGY)

Mitochondrial Diseases | Mitochondrial Myopathies | MELAS | Mitochondrial Encephalomyopathies | MIDD

Netherlands
Minovia Therapeutics Ltd.

Not yet recruiting

A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion

Primary Mitochondrial Diseases

Israel
Newcastle-upon-Tyne Hospitals NHS Trust
Newcastle University

Completed

A Study of Bezafibrate in Mitochondrial Myopathy

Mitochondrial Diseases

United Kingdom
Massachusetts General Hospital

Completed

Defining 31Phosphorous Magnetic Resonance Spectroscopy Characteristics in Patients With Mitochondrial Myopathy

Mitochondrial Disease

United States
Reata, a wholly owned subsidiary of Biogen
AbbVie

Completed

RTA 408 Capsules in Patients With Mitochondrial Myopathy - MOTOR

MItochondrial Myopathies

United States, Denmark
University Hospital, Bordeaux

Recruiting

Mitochondrial Disease-associated ImmunoDeficiencies (MitoID)

Mitochondrial Disorders

France
Rigshospitalet, Denmark
University of Copenhagen

Recruiting

Mitochondrial Dysfunctions Driving Insulin Resistance (MITO-DYS-IR)

Mitochondrial Diseases | Mitochondrial Myopathies | Mitochondrial Disorders

Denmark
Rigshospitalet, Denmark
University of Copenhagen

Recruiting

Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance (EX-MITO-DYS-IR)

Mitochondrial Diseases | Mitochondrial Myopathies | Mitochondrial Disorders

Denmark
Children's Hospital of Philadelphia
National Institute of Neurological Disorders and Stroke (NINDS)

Recruiting

Validation of Oxygen Nanosensor in Mitochondrial Myopathy

Mitochondrial Diseases | Mitochondrial Myopathies

United States
Children's Hospital of Philadelphia
United States Department of Defense

Recruiting

Applying pGz in Mitochondrial Disease

Mitochondrial Diseases | Mitochondrial Myopathies

United States
Reneo Pharma Ltd

Terminated

An Open Label, Long Term Safety Study of REN001 in Primary Mitochondrial Myopathy Patients (Stride Ahead)

Primary Mitochondrial Myopathy

Spain, Australia, Belgium, Denmark, Canada, United Kingdom, France, Germany, Hungary, Italy, Netherlands, New Zealand
Cristina Domínguez González

Recruiting

Natural History in Primary Mitochondrial Myopathies (NHPMM)

Primary Mitochondrial Myopathies

Spain
Stealth BioTherapeutics Inc.

Completed

Safety, Tolerability, and Efficacy of MTP-131 for the Treatment of Mitochondrial Myopathy (MMPOWER)

Mitochondrial Myopathy

United States
The Emmes Company, LLC
United Mitochondrial Disease Foundation; PolG Foundation Mito Australia

Recruiting

Mitochondrial Video Assessment Source Material Study

PolG, Primary Mitochondrial Myopathy

United States
Children's Hospital of Philadelphia
National Institute of Neurological Disorders and Stroke (NINDS); North American...

Recruiting

Promoting Resilience in Stress Management (PRISM) and Clinical-focused Narrative (CFN) Pilot in Adults With Primary Mitochondrial Disease (PMD).

Mitochondrial Diseases | Mitochondrial Myopathies | MELAS | Mitochondrial Encephalomyopathies | MERRF

United States
Ajou University School of Medicine

Completed

Cognitive Health Promotion Project in the Community

Dietary Modification | Alteration of Cognitive Function
Reneo Pharma Ltd

Completed

An Efficacy and Safety Study of 24 Week Treatment With Mavodelpar (REN001) in Primary Mitochondrial Myopathy Patients (STRIDE)

Primary Mitochondrial Myopathy

United States, Spain, Australia, France, United Kingdom, New Zealand, Denmark, Norway, Czechia, Belgium, Canada, Germany, Hungary, Italy, Netherlands
Stealth BioTherapeutics Inc.

Terminated

A Trial to Evaluate Safety and Efficacy of Elamipretide Primary Mitochondrial Myopathy Followed by Open-Label Extension (MMPOWER-3)

Primary Mitochondrial Myopathy

United States, Germany, Canada, Italy, United Kingdom, Denmark, Hungary
Reneo Pharma Ltd

Terminated

A Study of the Safety of REN001 in Patients With Primary Mitochondrial Myopathy

Primary Mitochondrial Myopathy

United Kingdom
Radboud University Medical Center

Completed

DINAMITE Study Nutritional State and Effect Diet in Mitochondrial Disease (DINAMITE)

Mitochondrial Disorders
Hoffmann-La Roche

No longer available

Expanded Access to RXDX-105 for Cancers With RET Alterations

Cancers With RET Alterations

United States
Al-Azhar University

Completed

Perforated Barrier Membranes Maintain Physiologic Gingival Crevicular Fluid Growth Factor Levels

Vascular Endothelial Growth Factor Overexpression | Membrane Alteration

Egypt

Clinical Trials on Mitochondrial Alteration

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Azerbaijan

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Rare Diseases

Drug Interventions

Dietary Supplements

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