Clinical Trials on Molecular Mechanisms of Pharmacological Action

Total 282 results

Balance Therapeutics

Completed

A Study to Investigate the Mass Balance of BTD-001 (HV103)

Molecular Mechanisms of Pharmacological Action

United Kingdom
University of Malaya
Ministry of Health, Malaysia

Unknown

Pharmacometabolomics of Andrographis Paniculata And Metformin In Healthy Volunteers Under Fasting Condition

Pharmacokinetics | Molecular Mechanisms of Pharmacological Action

Malaysia
Takeda

Completed

A Phase 1 Positron Emission Tomography Study to Measure Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935

Epilepsy, Molecular Mechanisms of Pharmalogical Action, Protective Agents

United States
University of Oxford

Completed

Effects of Seven Day Prucalopride Administration in Healthy Volunteers

Mental Disorders | Depressive Disorder | Depression | Mood Disorders | Molecular Mechanisms of Pharmacological Action | Cognition | Antidepressive Agents

United Kingdom
University of Oxford

Completed

Effects of Acute Prucalopride Administration in Healthy Volunteers

Depressive Disorder | Depression | Mood Disorders | Molecular Mechanisms of Pharmacological Action | Mental Disorder | Cognition | Antidepressive Agents

United Kingdom
University of Oxford
University of Bath

Unknown

Citalopram and Self Emotional Processing

Depressive Disorder | Depression | Molecular Mechanisms of Pharmacological Action | Mental Disorder | Cognition | Antidepressive Agents

United Kingdom
Fudan University

Not yet recruiting

The Maintenance Treatment of Apatinib/Capecitabine Versus Observation in Advanced Gastric Cancer

Neoplasms | Stomach Neoplasms | Gastrointestinal Neoplasms | Digestive System Neoplasms | Stomach Diseases | Molecular Mechanisms of Pharmacological Action | Capecitabine | Apatinib
Second Affiliated Hospital of Wenzhou Medical University

Unknown

Acceptable Hemodynamic Changes in Dexmedetomidine for Single Intravenous Bolus Injection

Mental Disorders | Pathologic Processes | Postoperative Complications | Delirium | Neurocognitive Disorders | Dexmedetomidine | Molecular Mechanisms of Pharmacological Action | Physiological Effects of Drugs | Analgesics | Hypnotics and Sedatives

China
Centre for Addiction and Mental Health

Completed

Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence

Smoking Cessation | Tobacco Smoking | Tobacco Use Disorder | Substance Use Disorders | Molecular Mechanisms of Pharmacological Action | Tobacco Dependence | Physiological Effects of Drugs

Canada
Luye Pharma Group Ltd.

Completed

Study to Evaluate the PK Profiles of LY03010 in Patients With Schizophrenia or Schizoaffective Disorder

Mental Disorders | Psychotic Disorders | Mood Disorders | Schizophrenia | Schizophrenia Spectrum and Other Psychotic Disorders | Molecular Mechanisms of Pharmacological Action | Tranquilizing Agents | Physiological Effects of Drugs | Psychotropic Drugs | Antipsychotic Agents | Neurotransmitter Agents | Central...

United States
Luye Pharma Group Ltd.

Completed

Relative Bioavailability of LY03010 Compared to Listed Drug

Mental Disorders | Psychotic Disorders | Mood Disorders | Schizophrenia | Molecular Mechanisms of Pharmacological Action | Tranquilizing Agents | Physiological Effects of Drugs | Psychotropic Drugs | Antipsychotic Agents | Central Nervous System Depressants | Neurotransmitter Agents | Schizophrenia Spectrum

United States
Sichuan Cancer Hospital and Research Institute

Recruiting

TACE, Sorafenib and PD-1 Monoclonal Antibody in the Treatment of HCC

Liver Diseases | Digestive System Neoplasms | Liver Neoplasms | Hepatocellular Carcinoma | Antineoplastic Agents | Molecular Mechanisms of Pharmacological Action | Protein Kinase Inhibitors | Sorafenib

China
Sunnybrook Health Sciences Centre
University Health Network, Toronto; McMaster University; London Health Sciences...

Recruiting

Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients (CODEX)

Mental Disorders | Nervous System Diseases | Neurologic Manifestations | Delirium | Confusion | Neurobehavioral Manifestations | Neurocognitive Disorders | Cognitive Dysfunction | Dexmedetomidine | Molecular Mechanisms of Pharmacological Action | Signs and Symptoms | Physiological Effects of Drugs | Analgesics,... and other conditions

Canada
Tianjin Medical University General Hospital

Not yet recruiting

Propranolol on Post Stroke Immune Status and Infection

Cardiovascular Diseases | Stroke | Cerebrovascular Disorders | Brain Diseases | Central Nervous System Diseases | Nervous System Diseases | Ischemic Stroke | Molecular Mechanisms of Pharmacological Action | Physiological Effects of Drugs | Propranolol | Immunologic Factors | Beta Blocker

China
Guizhi Du

Recruiting

The Effects of General Anesthetics on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and Mechanism Involved

Colorectal Cancer Metastatic | Survival Rate | General Anesthetics Toxicity | Lymphocyte Destruction | Molecular Mechanism of Pharmacological Action

China
Brigham and Women's Hospital
Harvard Medical School (HMS and HSDM)

Recruiting

Revisiting the Mechanism of the Anti-inflammatory Effect of Colchicine

Colchicine Mechanism of Action

United States
National Cancer Institute, Slovakia
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in Refractory Testicular Germ Cell Cancer.

Neoplasms | Gonadal Disorders | Neoplasms, Germ Cell and Embryonal | Testicular Neoplasms | Testicular Diseases | Antineoplastic Agents | Molecular Mechanisms of Pharmacological Action

Slovakia
Universidad Nacional de Salta
Fundacion Mundo Sano

Not yet recruiting

Pharmacokinetics and Excretion of Albendazole and Its Metabolites in Saliva

Pharmacological Action
Federal State Budgetary Scientific Institution,...
The League of Clinical Research, Russia; Institute of Biomedical Chemistry,...

Completed

"Corticoid-16" in Long Term When Administered Systemically in Patients in Routine Medical Practice

Pharmacological Action
Masaryk Hospital Usti nad Labem

Unknown

PARADOX - the Incidence of Paradoxical Reactions in Pediatric Patients Premedicated With Midazolam (PARADOX)

Pharmacological Action

Czechia
Ervin Taso
University of Belgrade

Completed

Dental Restorations Effect on Oxidative Status of the Gingival Crevicular Fluid

Pharmacological Action

Serbia
Tianjin Medical University General Hospital

Recruiting

Efficacy and Safety of Liposomal Bupivacaine Under ERAS Concept for Postoperative Analgesia of Ultrasound-Guided QLB in Gynecologic Laparoscopic Patients: A Randomized, Single-blind, Active-Controlled Clinical Study

Pharmacological Action

China
Qin Zhang

Recruiting

Ulinastatin Improves and Prevents Cardiac Dysfunction Induced by Cardiopulmonary Bypass

Pharmacological Action

China
Food and Nutrition Research Institute, Philippines
Ateneo de Manila University; De La Salle Medical and Health Sciences Institute

Active, not recruiting

Exploratory Pharmacokinetic Study of Virgin Coconut Oil (VCO)

Pharmacological Action

Philippines
Fudan University
Shanghai First Maternity and Infant Hospital; Women and children's hospital...

Unknown

Comparison of Epidural Labor Analgesia With Dexmedetomidine or Sufentanil

Pharmacological Action

China
Kolding Sygehus

Unknown

Pharmacokinetic Study of Paracetamol. (Para1523)

Pharmacological Action

Denmark
California Pacific Medical Center Research Institute

Completed

Role of Serotonin in Acute and Subacute MDMA Effects

MDMA Mechanism of Action

United States
Celularity Incorporated

Terminated

Natural Killer Cell (CYNK-001) IV Infusion or IT Administration in Adults With Recurrent GBM (CYNK001GBM01)

Glioblastoma Multiforme | Molecular Mechanisms of Pharmacological Action | Giant Cell Glioblastoma | Astrocytoma, Grade IV | Physiological Effects of Drugs | Peripheral Nervous System Agents | Analgesics | Analgesics, Non-narcotic | Cyclophosphamide | Immunosuppressive Agents | Immunologic Factors | Antiviral... and other conditions

United States
King Faisal Specialist Hospital & Research Center
King AbdulAziz City for Science and Technology

Completed

Measuring Placebo Effect by Elimination and Investigating Mechanism of Action

Placebo Effect | Placebo Mechanisms of Action

Saudi Arabia
Zealand University Hospital
University of Copenhagen

Unknown

Test of a New Gel-based Colon Cleansing Agent Compared to Moviprep

Pharmacological Action

Denmark
Maimonides Medical Center

Recruiting

Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome (PWS-GXR)

Aggression | Behavioral Symptoms | Pathologic Processes | Nervous System Diseases | Obesity | Neurologic Manifestations | Neurobehavioral Manifestations | Congenital Abnormalities | Overnutrition | Nutrition Disorders | Genetic Diseases, Inborn | Intellectual Disability | Self-Injurious Behavior | Abnormalities, Multiple and other conditions

United States
Emad Abdel Aal Saliem

Completed

Intravitreal Triamcinolone and Moxifloxacin Injection After Cataract Surgery

Pharmacological Action

Egypt
AstraZeneca

Completed

A Phase I Study in Healthy Volunteers to Assess the Effect of Cytochrome3A4 (CYP3A4) Inhibitors (Diltiazem and Itraconazole) on the Pharmacokinetics (PK) of AZD3293 and the Effects of AZD3293 on the Pharmacokinetics of Midazolam, a Cytochrome 3A4 and Cytochrome 3A5 (CYP3A4/CYP3A5) Substrate (AZD3293DDI)

Healthy Volunteers | Pharmacologic Action

United States
Vivoryon Therapeutics N.V.
Covance

Completed

Effects of PQ912 on the Pharmacokinetics of Midazolam and Omeprazole

Healthy Volunteers | Pharmacologic Action

United Kingdom
Karen Hoejmark Hansen

Completed

The Effect of Tranexamic Acid. A Randomised Study of Patients Undergoing Elective Lumbar Spine Surgery.

Pharmacological Action

Denmark
Xiaoxiang Chen

Unknown

Efficacy and Safety of Niraparib Combined With Bevacizumab in Platinum Refractory/Resistant Recurrent Ovarian Cancer (AVANIRA3)

Neoplasms | Neoplasms by Histologic Type | Urogenital Neoplasms | Neoplasms by Site | Carcinoma | Neoplasms, Glandular and Epithelial | Genital Neoplasms, Female | Endocrine System Diseases | Ovarian Diseases | Adnexal Diseases | Gonadal Disorders | Endocrine Gland Neoplasms | Ovarian Neoplasms | Fallopian Tube Neoplasms and other conditions

China
National Aeronautics and Space Administration (NASA)

Completed

Optimize Astronaut Sleep Medication Efficacy and Individual Effects

Sleep | Cognition | Pharmacologic Actions
University of Maryland, Baltimore

Completed

Low-Dose Galantamine to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine (GalaNic)

Basic Science Study of the Mechanisms of Attentional Enhancement by Compounds Acting on the Nicotinic Receptor

United States
National Liver Institute, Egypt
Pharco Pharmaceuticals

Unknown

Safety and Efficacy of Gratisovir (Sofosbuvir)- Ribavirin Therapy in Pediatric Patients

Pharmacological Action

Egypt
Walter Reed Army Institute of Research (WRAIR)

Completed

Genetic Variability in CYP2D6 in U.S Active Duty Population

Pharmacologic Action

United States
AstraZeneca

Completed

Relative Bioavailability Study to Assess Two Solid Formulations Compared to an Oral Solution of AZD3293 in Healthy Male and Non-Fertile Female Subjects (BA)

Healthy Volunteers | Pharmacologic Action

United States
Silesian Centre for Heart Diseases
Medical Research Agency, Poland

Not yet recruiting

Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)

Heart Failure | Breast Cancer | Breast Diseases | Cardiotoxicity | Molecular Mechanisms of Pharmacological Action | Angiotensin Receptor Antagonists | Neoplasm, Breast | Cardiac Toxicity | Angiotensin II Type 1 Receptor Blockers | Cancer, Therapy-Related | Antihypertensive Agents | Sacubitril/Valsartan | Cancer...

Poland
CardioDex
Sheba Medical Center

Withdrawn

Hemostatic Closure of Femoral Artery Access Site, Using the QuickClose Design 9 System

Coagulation | Therapeutic Uses | Pharmacologic Actions

Israel
Ain Shams University

Not yet recruiting

Assessment of Rituximab Therapeutic Response Versus Conventional Treatment

Pharmacological Action
Rambam Health Care Campus

Completed

The Effect Methylphenidate Hydrochloride on Pain and Auditory Sensitivity in Healthy Subjects

Pharmacological Action (PA)

Israel
University of Alberta

Recruiting

Diagnostic and Therapeutic Applications in Microarrays in Organ Transplantation

Validation Study of Molecular Diagnostic System | Development of Reporting System for Molecular Diagnosis | Incorporate Molecular Diagnosis Into Diagnostic Standards

United States, Switzerland, Austria, Croatia, Slovenia, Canada, Czechia, France, Germany, Ireland, Korea, Republic of, Poland, Spain, United Kingdom
Jaseng Medical Foundation

Recruiting

Ultrasound Guiding Pharmacopuncture Therapy for Supraspinatus Tendinopathy

Pharmacological Action

Korea, Republic of
Profil Institut für Stoffwechselforschung GmbH
Merck Sharp & Dohme LLC

Completed

Sitagliptin and the Risk for Hypoglycaemia in Type 2 Diabetes Patients

Pharmacological Action

Germany
Zhonghua Chen,MD
China (Zhejiang) Health technology RESEARCH and development and transformation...

Recruiting

Effect of Ultrasound-guided Left Stellate Ganglion Block on Rapid Recovery in Patients With Liver Lobectomy and Its Mechanism

Left Stellate Ganglion Block on Rapid Recovery | Possible Molecular Mechanism of Left Stellate Ganglion Block

China
Dr. Lutfi Kirdar Kartal Training and Research Hospital

Not yet recruiting

Postoperative Pain in Laparoscopic Radical Prostatectomy Surgery With Tranexamic Acid: Analgesia? Hiperalgesia?

Pharmacological Action

Clinical Trials on Molecular Mechanisms of Pharmacological Action

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