Clinical Trials on Monogenic Diseases

Total 376648 results

University Hospital, Montpellier
ABM Industries

Unknown

NIPD of CFTC by WGA Coupled to Mini-exome Sequencing (DIAFEXOME)

Monogenic Diseases

France
Kunling Shen
Shengjing Hospital; Xinhua Hospital, Shanghai Jiao Tong University School of... and other collaborators

Recruiting

Registry Study on Respiratory Monogenic Diseases in Chinese Children

Monogenic Diseases

China
Apteeus

Enrolling by invitation

Development of In Vitro Functional Assays From Primary Cells of Patients With Monogenic Diseases (OPERANDO)

Monogenic Disorders

France
Chinese Academy of Medical Sciences, Fuwai Hospital

Unknown

Genetic Testing of Monogenic Hypertension in Chinese Population

Monogenic Hypertension

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Real-life Evaluation of WEGOVY (Semaglutide) Treatment in Adults With Monogenic Obesity (ObGeSema) (ObGeSema)

Monogenic Obesity

France
University Hospital, Bordeaux

Not yet recruiting

Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity (OBEGENE)

Monogenic Obesity

France
Children's Hospital of Fudan University

Recruiting

Monogenic Lupus in Childhood Onset Systemic Lupus Erythematosus

Systemic Lupus Erythematosus | Monogenic Lupus

China
University Hospital, Bordeaux

Not yet recruiting

Genetic Research of Monogenic Obesity in a Pediatric Cohort With Severe and Early Onset Obesity (GENOBE) (GENOBE)

Monogenic Obesity | Non Syndromic Obesity

France
University of Chicago

Completed

Incretin Regulation of Insulin Secretion in Monogenic Diabetes

Monogenic Diabetes

United States
Joslin Diabetes Center

Enrolling by invitation

Oral Hypoglycemic Therapy for Monogenic Variant Carriers of the Joslin Medalist Study

Type 1 Diabetes | Monogenic Diabetes

United States
Assistance Publique - Hôpitaux de Paris

Completed

Predisposition Genes in Monogenic Diabetes (DIAMONO) (DIAMONO)

Non Autoimmune Monogenic Diabetes
United Arab Emirates University

Not yet recruiting

Identifying Maturity-onset Diabetes of the Young in Emirati Patients

Maturity-onset Diabetes of the Young | MODY | Monogenic Diabetes
AHEPA University Hospital

Unknown

Molecular Pathways Involved in the Pathogenesis and Behavior of Mesenchymal Phosphaturic Tumors Causing Oncogenic Osteomalacia

Tumor Induced Oncogenic Osteomalacia

Greece
National Institute of Dental and Craniofacial Research...

Completed

Catheterization to Locate Mesenchymal Tumors in Patients With Tumor-Induced Osteomalacia or Oncogenic Osteomalacia

Neoplasms | Osteomalacia

United States
Regeneron Pharmaceuticals

Available

Expanded Access to REGN4461 for Patients With Lipodystrophy or Monogenic Obesity With Complications of Leptin Deficiency or Deficient Leptin Signaling

Partial Lipodystrophy | Generalized Lipodystrophy | Monogenic Obesity Due to LEP or LEPR Loss of Function
CASI Pharmaceuticals, Inc.

Completed

A Phase 1 Study of MKC-1 in Patients With Refractory Hematologic Malignancies

Myelodysplasia | Hematological Malignancies | Agnogenic Myeloid Metaplasia

Canada
Dana-Farber Cancer Institute
Massachusetts General Hospital; Novartis; Brigham and Women's Hospital

Completed

A Study of Gleevec in Patients With Idiopathic Myelofibrosis or Chronic Myelomonocytic Leukemia (CMML)

Myelofibrosis | Chronic Myelomonocytic Leukemia | Myeloid Metaplasia | Agnogenic Myeloid Metaplasia

United States
Peking Union Medical College Hospital

Unknown

68Ga-DOTATATE PET/CT in Oncogenic Osteomalacia

Oncogenic Osteomalacia | Mesenchymal Tumor

China
National Institute of Dental and Craniofacial Research...

Terminated

BGJ398 for the Treatment of Tumor-Induced Osteomalacia

Oncogenic Osteomalacia | Tumor-Induced Osteomalacia

United States
M.D. Anderson Cancer Center
Novartis

Completed

PTK 787 and Gleevec in Patients With AML, AMM, and CML-BP

Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | Agnogenic Myeloid Metaplasia

United States
Guang Ning

Recruiting

China Diabetes Registry by Metabolic Management Center (CDR-MMC)

Type 2 Diabetes Mellitus | Type1 Diabetes Mellitus | Monogenetic Diabetes | Pancreatogenic Diabetes | Drug-Induced Diabetes Mellitus | Other Forms of Diabetes Mellitus

China
Johns Hopkins University
Massachusetts General Hospital; Washington University School of Medicine; Emory... and other collaborators

Completed

Answer ALS: Individualized Initiative for ALS Discovery (AnswerALS)

Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Primary Lateral Sclerosis | Progressive Muscular Atrophy | Healthy Controls | Flail Arm ALS | Monomelic Amyotrophy | Asymptomatic ALS Gene Carriers

United States
M.D. Anderson Cancer Center
Novartis

Completed

RAD001 in Relapsed or Refractory AML, ALL, CML in Blastic-Phase, Agnogenic Myeloid Metaplasia, CLL, T-Cell Leukemia, or Mantle Cell Lymphoma

Leukemia | Myelofibrosis | Mantle Cell Lymphoma

United States
M.D. Anderson Cancer Center
Bristol-Myers Squibb

Completed

Dasatinib as Therapy for Myeloproliferative Disorders (MPDs)

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Polycythemia Vera | Myelofibrosis | Leukemia, Myelomonocytic, Chronic | Hypereosinophilic Syndrome | Mastocytosis | Agnogenic Myeloid Metaplasia

United States
McGill University Health Centre/Research Institute...

Recruiting

Monogenic Diabetes Misdiagnosed as Type 1 (ADDAM)

Diabetes Mellitus, Type 1 | Wolfram Syndrome | Neonatal Diabetes | Monogenic Diabetes | Maturity-onset Diabetes in the Young (MODY) | Wolcott-Rallison Syndrome | Mitochondrial Diabetes

Canada
UK Kidney Association

Recruiting

National Registry of Rare Kidney Diseases (RaDaR)

Vasculitis | AL Amyloidosis | Tuberous Sclerosis | Fabry Disease | Cystinuria | Focal Segmental Glomerulosclerosis | IgA Nephropathy | Bartter Syndrome | Pure Red Cell Aplasia | Membranous Nephropathy | Atypical Hemolytic Uremic Syndrome | Autosomal Dominant Polycystic Kidney Disease | Cystinosis | Nephronophthisis | BK Nephropathy and other conditions

United Kingdom
University of Michigan
National Institutes of Health (NIH); National Institute of Dental and Craniofacial...

Completed

The Importance of Periostin in Periodontal Health and Disease

Periodontal Disease | Non-diseased Patients

United States
Yonsei University

Active, not recruiting

Low-Density Lipoprotein Cholesterol-targeting Statin Therapy Versus the Intensity-based Statin Therapy in Patients With Coronary Artery Disease (LODESTAR)

Coronary Artery Diseasse

Korea, Republic of
Gangnam Severance Hospital

Recruiting

Prevalence of Marginal Ulcer After PPPD and Preventive Effect of Proton Pump Inhibitor in Korea: A Prospective Multicenter Study

Pancretic Dissease (Benign/Malignancy) | BIle Duct Diseae(Benign/Malignancy) | Ampulla of Vater Disease (Benign/Malignancy)

Korea, Republic of
Eisai Co., Ltd.

Completed

Post-marketing Surveillance of Donepezil Hydrochloride Investigation of the Safety and Effectiveness of Combination Therapy of Donepezil Hydrochloride and Memantine Hydrochloride in Patients With Alzheimer's Disease

Alzheimer's Desease

Japan
Central Hospital, Nancy, France
Institut Régional de Médecine Physique et de Réadaptation

Unknown

Interest of Hydrophysiotherapy Care in Parkinson Disease's Motor and Non-motor Symptoms (THERMAPARK)

Interest of Hydrophysiotherapy Care in Parkinson Disease's Non-motor Symptoms
McMaster Children's Hospital
St. Justine's Hospital

Completed

PediCRaFT: Pediatric Crohn's Disease Fecal Transplant Trial (PediCRaFT)

Inflammatory Bowel Diseases | Crohn Disease | Colitis | Pediatric Crohns Disease

Canada
First Affiliated Hospital of Wenzhou Medical University

Completed

Tongue Image Database and Diagnostic Model for Digestive Tract Disease Diagnosis

Liver Diseases | Small Bowel Disease | Colorectal Disease | Gastric Diseases | Digestive Tract Diseases

China
Academisch Medisch Centrum - Universiteit van Amsterdam...
Celltrion

Recruiting

inDuctIon tREatment With subCuTaneous Infliximab for Crohn's Disease (DIRECTCD)

Bowel Disease | Inflammatory Disease | Disease Crohn

Netherlands
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Raynaud's Treatment Study (RTS)

Heart Diseases | Cardiovascular Diseases | Vascular Diseases | Raynaud's Disease
The Second Hospital of Nanjing Medical University
Air Force Military Medical University, China

Recruiting

Standardized Fecal Microbiota Transplantation for Crohn&Apos;s Diseases

Inflammatory Bowel Disease | Crohn's Diseases

China
First Affiliated Hospital of Harbin Medical University

Unknown

"Air Assisted"Water Injection Colonoscopy in Experienced Endoscopists

Colon Disease; | Rectal Disease

China
National Institutes of Health Clinical Center (CC)

Completed

Translational Development of Photon-counting CT Imaging

Vascular Diseases | Cancer | Metabolic Bone Disease | Inflammatory Disease

United States
Fondazione IRCCS Policlinico San Matteo di Pavia
University of Pavia

Recruiting

Calcific Aortic Valve Disease:the Role of Bacteria as Trigger of a Chronic Inflammation

Calcific Aortic Valve Diasease

Italy
University of Bern
Merck Sharp & Dohme LLC; University Hospital, Basel, Switzerland; University... and other collaborators

Completed

Significance of Ficolin 2 in the Determination of Serological Activity in Chronic Inflammatory Bowel Disease

Crohn Disease

Switzerland
Children's Hospital Los Angeles

Completed

FMT in Pediatric Crohn's Disease (FMTPCD)

Crohn Disease | Pediatric Crohns Disease

United States
Ryazan State Medical University

Completed

Chronic Obstructive Pulmonary Disease in Combination With Atherosclerosis (Clinical and Biochemical Study)

Chronic Obstructive Pulmonary Disease | Peripheral Artery Disease

Russian Federation
Facet Biotech

Completed

A Humanized Anti-Interferon-γ Monoclonal Antibody (HuZAF) for Moderate to Severe Crohn's Disease

Crohn's Disease | Colitis | Digestive System Disease | Gastrointestinal Disease | Intestinal Disease

United States, Canada
First Affiliated Hospital of Harbin Medical University

Unknown

Water Injection Colonoscopy vs Air Insufflation Colonoscopy in Experienced Endoscopists

Colon Disease; | Rectal Disease;

China
Direct Biologics, LLC

Recruiting

Study of ExoFlo for the Treatment of Medically Refractory Crohn's Disease

Inflammatory Bowel Diseases | Crohn Disease

United States
University of North Carolina, Chapel Hill
University of Amsterdam; Crohn's and Colitis Foundation

Recruiting

Personalized AZithromycin/metronidAZole Therapy in Pediatric Crohn's Disease (CD) (PAZAZ)

Crohn Disease | Pediatric Crohns Disease

Netherlands, United States, Canada, Israel
Pharmbio Korea Co., Ltd.

Completed

Safety and Efficacy of PBK-1701TC for Bowel Cleansing Before Colonoscopy

Colonic Diseases | Digestive System Disease | Gastrointestinal Disease | Intestinal Disease

Korea, Republic of
Klinikum Westbrandenburg GmbH

Unknown

TOPIT; Trough Level Optimized Pediatric Inflammatory Bowel Disease Therapy: A Multicenter Study Comparing Effectiveness of Trough Level Optimized Infliximab Maintenance Therapy With Standard Dosing Regimen of Pediatric Patients With Crohn's Disease (TOPIT)

Pediatric Crohns Disease
Konkuk University Medical Center

Completed

Effect of Anesthetics on CD39 and CD73 After Open-heart Surgery

Valvular Heart Disease | Aortic Disease

Korea, Republic of
Sheikh Zayed Federal Postgraduate Medical Institute
Higher Education Commission (Pakistan)

Completed

Influence of Periodontal Treatment on Systemic Inflammatory Mediators (Perio-CHD)

Coronary Heart Disease | Periodontal Disease

Pakistan

Clinical Trials on Monogenic Diseases

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