Clinical Trials on NTRK1 Fusion Positive

Total 8091 results

University of California, San Francisco

Terminated

Capmatinib, Ceritinib, Regorafenib, or Entrectinib in Treating Patients With BRAF/NRAS Wild-Type Stage III-IV Melanoma

ALK Fusion Protein Expression | Stage III Cutaneous Melanoma | Stage IIIA Cutaneous Melanoma | Stage IIIB Cutaneous Melanoma | Stage IIIC Cutaneous Melanoma | Stage IV Cutaneous Melanoma | ROS1 Fusion Positive | BRAF wt Allele | Invasive Skin Melanoma | MET Fusion Gene Positive | NRAS wt Allele | NTRK1 Fusion... and other conditions

United States
Centre Leon Berard

Recruiting

Real Word European Registry of NTRK Fusions and Other Rare Actionable Fusions (TRacKING) (TRacKING)

Cancer | Cancer Metastatic | ALK Fusion Protein Expression | FGFR2 Gene Translocation | FGFR3 Gene Translocation | NTRK Family Gene Mutation | Gene Fusion | ROS1 Gene Translocation | NTRK Gene Fusion Overexpression | ATIC-ALK Fusion Protein Expression | BCR-FGFR1 Fusion Protein Expression | COL1A1-PDGFB Fusion... and other conditions

France, Denmark, Netherlands, Austria, Germany, Italy, United Kingdom, Czechia, Poland, Slovenia, Spain
Bayer

Completed

A Study to Test the Safety of the Investigational Drug Larotrectinib in Adults That May Treat Cancer

Solid Tumors Harboring NTRK Fusion

United States
Bayer

Approved for marketing

Expanded Access to Provide Larotrectinib for the Treatment of Cancers With a NTRK Gene Fusion

Tumors Harboring NTRK Fusion
Bayer

Completed

A Study Called VICTORIA to Learn More About How Well Larotrectinib Works in Adults With TRK Fusion-positive Cancer by Comparing Larotrectinib Data From Clinical Studies With Data of Other Treatments From Actual Practice

Solid Tumors Harboring NTRK Fusion

United States
Bayer

Completed

Study to Compare How the Body Absorbs, Distributes and Excretes the Drug Selitrectinib (BAY2731954) Given as Two Different Tablet Formulations or as Liquid Formulations Including the Effect of Food on the Absorption, Distribution or Excretion of the Different Formulations in Healthy Participants

Solid Tumors Harboring NTRK Fusion

United States
Bayer

Completed

Study in Healthy Adult Male Participants to Gather Information How the Human Body Absorbs, Distributes and Excretes the Study Drug Selitrectinib Including the Effect of the Interaction of Food With the Study Drug on the Human Body

Solid Tumors Harboring NTRK Fusion

Germany
Jiangsu vcare pharmaceutical technology co., LTD

Completed

Food Effect Study on the Pharmacokinetics of VC004 Capsules in Healthy Adult Subjects

Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion

China
Hoffmann-La Roche

No longer available

Expanded Access to Entrectinib for Cancers With NTRK1/2/3, ROS1, or ALK Gene Fusions

Cancers With NTRK, ROS1, or ALK Gene Fusions

United States
Bayer

No longer available

Expanded Access to Provide Selitrectinib for the Treatment of Cancers With a NTRK Gene Fusion

Solid Tumors Harboring NTRK Fusion
Bayer

Recruiting

Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body (ON-TRK)

Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion

United States, Austria, Denmark, Germany, Italy, Norway, Spain, United Kingdom, Brazil, Russian Federation, Switzerland, Taiwan, Canada, China, Australia, Greece, Belgium, Sweden, Korea, Republic of, France, Argentina, Finland, Ireland and more
Pacira Pharmaceuticals, Inc

Completed

Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL, EXPAREL Admixed With Bupivacaine HCl vs. Bupivacaine HCl Administered as Combined Sciatic and Saphenous Nerve Blocks for Postsurgical Analgesia in Subjects Undergoing Lower Extremity Surgeries (STRIDE)

Bunion | Midfoot Fusion | Total Ankle Arthroplasty | Lower Extremity Surgery | Metatarsophalangeal Fushion | Hindfoot Fushion

United States
Bayer

Completed

A Study to Test the Safety of the Investigational Drug Selitrectinib in Children and Adults That May Treat Cancer

Solid Tumors Harboring NTRK Fusion

United States, Belgium, Italy, Germany, Australia, Spain, Singapore, Denmark, France, Ireland
Jiangsu Simcere Pharmaceutical Co., Ltd.

Recruiting

An Open Label, Multi-center, Phase I Clinical Study to Evaluate the Safety, Effectiveness and Pharmacokinetic Characteristics of SIM1803-1A in Patients With Locally Advanced/Metastatic Solid Tumors With NTRK, ROS1 or ALK Gene Fusion Mutations.

Advanced or Metastatic Solid Tumors With NTRK, ROS1 or ALK Gene Fusion

China
Bayer

Active, not recruiting

A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children (SCOUT)

Solid Tumors Harboring NTRK Fusion

United States, China, Poland, Australia, Germany, Japan, Canada, Italy, Czechia, Spain, Turkey, United Kingdom, Sweden, Netherlands, France, Switzerland, Korea, Republic of, Denmark, Ireland, Israel, Ukraine
Beijing InnoCare Pharma Tech Co., Ltd.

Recruiting

A Phase 2 Study of ICP-723 in Patients With Advanced Solid Tumors or Primary Central Nervous System Tumors

Advanced Solid Tumors Harboring NTRK Fusion | Primary Central Nervous System Tumors Harboring NTRK Fusion

China
Bayer

Completed

An Observational Study to Learn More About NTRK Gene Fusion Positive in Solid Tumor in Japan

Advanced or Recurrent Solid Tumor Harboring an NTRK Gene Fusion

Japan
Addario Lung Cancer Medical Institute

Completed

ALCMI-006: A Prospective Biospecimen Collection Study From Patients With ROS1-Fusion Positive Tumors

ROS1-fusion Positive Tumor

United States
Bayer

Recruiting

NTRK Gene Fusion - Positive Advanced or Recurrent Solid Tumors, a Rare Cancer Caused by Specific Changes in the Genes

Advanced or Recurrent Solid Tumor Harboring an NTRK Gene Fusion

Japan
Pacira Pharmaceuticals, Inc

Withdrawn

Phase 3, Randomized, Double Blinded, Active Controlled, Multicenter Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of EXPAREL Admixed With Bupi vs. Bupi Only Administered as Combined Sciatic and Adductor Canal Nerve Block for Postsurgical Analgesia in Lower Extremity Surgeries (STRIDE)

Bunion | Metatarsophalangeal Fusion | Midfoot Fusion | Hindfoot Fusion | Total Ankle Arthroplasty | Forefoot Surgery
Bayer

Active, not recruiting

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors (NAVIGATE)

Solid Tumors Harboring NTRK Fusion

United States, Korea, Republic of, China, Japan, India, Turkey, Portugal, Spain, France, Taiwan, Czechia, Sweden, Brazil, Denmark, Singapore, Argentina, Germany, Ireland
Duke University

Completed

Impact of Body Habitus (Arm Span and Abdominal Girth) on Activities of Daily Living (ADL) (ADL)

Spinal Fusion | Activities of Daily Living Following Complex Spinal Fusions

United States
Bayer

Completed

A Study Called EPI VITRAKVI to Compare Treatment Results in Patients With Infantile Fibrosarcoma (IFS), a Type of Connective Soft Tissue Cancer, Who Received a Treatment Called Larotrectinib From a Study Called SCOUT With Patient Data From an External Database (EPI VITRAKVI)

Locally Advanced or Metastatic Infantile Fibrosarcoma Harboring an NTRK Gene Fusion | Infantile Fibrosarcoma

France
Plexxikon

Terminated

Phase 1 Study of PLX7486 as Single Agent in Patients With Advanced Solid Tumors

Solid Tumor | Tenosynovial Giant Cell Tumor | Tumors of Any Histology With Activating Trk (NTRK) Point or NTRK Fusion Mutations

United States
Massachusetts Eye and Ear Infirmary
National Eye Institute (NEI)

Completed

Understanding Visual Confusion Using Stereoscopic Displays

Diplopia | Binocular Vision Suppression | Binocular; Fusion, With Defective Stereopsis | Monocular Diplopia

United States
Hoffmann-La Roche

Recruiting

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK Fusion-Positive Solid or CNS Tumors

ALK Fusion-positive Solid or CNS Tumors

United States, Korea, Republic of, China, Spain, Canada, United Kingdom, Australia, Denmark, France, Italy, Germany
National Taiwan University Hospital

Terminated

Clinical and Biomechanics Research in Core Muscles After Lumbar Fusion Surgery

Lumbar Fusion | Lumbar Spinal Fusion Surgery

Taiwan
iOMEDICO AG
Roche Pharma AG

Active, not recruiting

Registry for Molecular Testing, Treatment and Outcome of Patients With Solid Tumors Harboring a NTRK Gene Fusion (REALTRK)

NTRK Family Gene Mutation

Switzerland, Germany
Sewon Cellontech Co., Ltd.

Unknown

Efficacy and Safety of SurgiFill™ on Spinal Fusion

Spinal Fusion Acquired | Fusion of Spine (Disease)

Korea, Republic of
University of Pittsburgh

Not yet recruiting

The Effect of AR in Patient Pre-operative Education

Transforaminal Lumbar Interbody Fusion | Anterior Cervical Discectomy and Fusion

United States
Xtant Medical
RTI Surgical

Recruiting

Prospective SPINE Registry (SPINE)

Joint Diseases | Musculoskeletal Diseases | Spinal Stenosis | Fusion of Spine | Spine | Spinal Fusion | Spinal Disease | Spinal Instability | Sacroiliac; Fusion | Fusion of Joint | Sacroiliac

United States, Spain, Germany
AXIS Spine Center- a division of Northwest Specialty...
IDAHO PANHANDLE HEALTH DISTRICT

Recruiting

Pre-Operative Ketamine Infusion for Post Operative Pain Control After Revision Spinal Surgery (KIPSs)

Cervical Fusion | Fusion of Spine | Lumbar Fusion | Revision Spine Surgery

United States
Oregon Health and Science University

Not yet recruiting

Steroids After Spine Fusion Surgery

Spine Fusion

United States
Chi Mei Medical Hospital

Active, not recruiting

Evaluation of Treatment Effect of Minimally Invasive Spinal Fusion Surgery

Spinal Fusion
Exela Pharma Sciences, LLC.

Terminated

Efficacy and Safety of Tranexamic Acid in Spinal Fusion Surgery

Spinal Fusion

United States
Gia Dinh People Hospital

Completed

The Efficacy of Postoperative Analgesia of Gabapentin Plus Nefopam in the Spinal Surgery

Spinal Fusion

Vietnam
Mayo Clinic

Completed

Thromboelastography-Guided Fluid Management in Spinal Surgery

Spinal Fusion

United States
George Papanicolaou Hospital

Completed

SSEP Fluctuations Due to Dexmedetomidine During Posterior Spine Fusion

Spinal Fusion
BioAlpha Inc.

Unknown

The Clinical Study of Novosis in Posterolateral Fusion

Posterolateral Fusion

Korea, Republic of
OrthoGeorgia
Baxter Healthcare Corporation

Unknown

A Retrospective Study of Actifuse Synthetic Bone Graft Versus Other Bone Graft Substitutes in Patients Requiring Lumbar Fusion

Lumbar Fusion

United States
Sameek Roychowdhury
National Cancer Institute (NCI)

Withdrawn

Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers

Locally Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | ALK Gene Mutation | Metastatic Malignant Neoplasm in the Brain | Advanced Malignant Neoplasm | ALK Fusion Protein Expression | Metastatic Malignant Neoplasm in the Central Nervous System | ROS1 Gene Mutation | ALK Gene... and other conditions

United States
AO Foundation, AO Spine

Not yet recruiting

Durability of Suppl. Rod Constructs-SuppleMentAry Rod Technique for Long-segment Posterior Instrumented Spinal Fusions

Spinal Fusion

United States
M.C. Kruyt, MD, PhD
Kuros BioSciences B.V.

Active, not recruiting

MagnetOs™ Granules vs. Autograft in Instrumented Posterolateral Spinal Fusion (MaxA)

Spinal Fusion

Netherlands
Augmedics

Completed

Pedicle Screw Placement With XVS

Spine Fusion

Israel
Sunnybrook Health Sciences Centre
Medtronic Sofamor Danek

Completed

A Study on the Use of a Brace Following Low Back Surgery

Lumbar Fusion

United States
Montefiore Medical Center

Terminated

Evaluating the Role of Pregabalin in Reducing Opioid Requirement in Spinal Fusion Surgeries of Two or More Vertebrae

Spinal Fusion

United States
University of Washington
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Completed

Understanding Non-Response in Spine Fusion Surgery

Spine Fusion

United States
Taipei Veterans General Hospital, Taiwan

Completed

Risk Factors of Second Surgery for Adjacent Segment Disease Following Anterior Cervical Discectomy and Fusion (2nd ACDF)

Spinal Fusion

Taiwan
Assiut University

Unknown

Minimally Invasive Versus Open Transforaminal Lumbar Interbody Fusion

Spinal Fusion
Hadassah Medical Organization

Unknown

GO-LIF With Percutaneous Facet Fusion

Lumbar Fusion

Israel

Clinical Trials on NTRK1 Fusion Positive

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