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Clinical Trials on Oropharyngeal Neoplasms

Total 310 results

NCT04541355

Not yet recruiting

Sodium Thiosulfate for the Prevention of Ototoxicity in Patients With Locally Advanced Squamous Cell Cancer of the Head and Neck Undergoing Chemoradiation With Cisplatin

Conditions: Clinical Stage III Human Papillomavirus (HPV)-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Locally Advanced Head and Neck Squamous Cell Carcinoma; Locally Advanced Hypopharyngeal Squamous Cell Carcinoma; Locally Advanced Laryngeal Squamous Cell Carcinoma; Locally Advanced Oral Cavity Squamous Cell Carcinoma; Locally Advanced Oropharyngeal Squamous Cell Carcinoma; Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Stage III Hypopharyngeal Carcinoma AJCC v8; Stage III Laryngeal Cancer AJCC v8; Stage III Lip and Oral Cavity Cancer AJCC v8; Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IV Hypopharyngeal Carcinoma AJCC v8; Stage IV Laryngeal Cancer AJCC v8; Stage IV Lip and Oral Cavity Cancer AJCC v8; Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IVA Hypopharyngeal Carcinoma AJCC v8; Stage IVA Laryngeal Cancer AJCC v8; Stage IVA Lip and Oral Cavity Cancer AJCC v8; Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IVB Hypopharyngeal Carcinoma AJCC v8; Stage IVB Laryngeal Cancer AJCC v8; Stage IVB Lip and Oral Cavity Cancer AJCC v8; Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IVC Hypopharyngeal Carcinoma AJCC v8; Stage IVC Laryngeal Cancer AJCC v8; Stage IVC Lip and Oral Cavity Cancer AJCC v8; Stage IVC Oropharyngeal (p16-Negative) Carcinoma AJCC v8
NCT04533750

Not yet recruiting

Testing the Addition of M3814 (Peposertib) to Radiation Therapy for Patients With Advanced Head and Neck Cancer Who Cannot Take Cisplatin

Conditions: Advanced Head and Neck Squamous Cell Carcinoma; Advanced Hypopharyngeal Squamous Cell Carcinoma; Advanced Laryngeal Squamous Cell Carcinoma; Advanced Oral Cavity Squamous Cell Carcinoma; Advanced Oropharyngeal Squamous Cell Carcinoma; Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Stage III Hypopharyngeal Carcinoma AJCC v8; Stage III Laryngeal Cancer AJCC v8; Stage III Lip and Oral Cavity Cancer AJCC v8; Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IVA Hypopharyngeal Carcinoma AJCC v8; Stage IVA Laryngeal Cancer AJCC v8; Stage IVA Lip and Oral Cavity Cancer AJCC v8; Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IVB Hypopharyngeal Carcinoma AJCC v8; Stage IVB Laryngeal Cancer AJCC v8; Stage IVB Lip and Oral Cavity Cancer AJCC v8; Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8
NCT04508829

Recruiting

Anti-EGFR Therapy With IMRT Concurrent Chemoradiotherapy in Locally Advanced OPC With Induced Chemotherapy Resistance

Conditions: Oropharyngeal Carcinoma
NCT04502407

Not yet recruiting

Trial of De-Intensified Post-operative Chemoradiation Following Robotic Surgery for HPV-positive Oropharyngeal Cancer

Conditions: HPV Positive Oropharyngeal Squamous Cell Carcinoma
NCT04498221

Not yet recruiting

Lymphatic Mapping Of Oropharyngeal Cancer

Conditions: Oropharyngeal Cancer
NCT04489212

Not yet recruiting

Study of Mucosal Sparing Adjuvant Radiotherapy After Surgical Exploration in HPV+ Head and Neck Cancer of Unknown Primaries

Conditions: Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Head and Neck Carcinoma of Unknown Primary; Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
NCT04444869

Not yet recruiting

Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal Cancer

Conditions: Cancer of the Head and Neck; Oropharynx Cancer; HPV Positive Oropharyngeal Squamous Cell Carcinoma; Throat Carcinoma
NCT04440618

Recruiting

Prevalence of Obstructive Sleep Apnea Hypopnea Syndrome (OSAHS) Following Squamous Cell Carcinomas of the Oropharynx Treatment by Combined Chemoradiotherapy

Conditions: Obstructive Sleep Apnea-hypopnea; Oropharyngeal Cancer
NCT04432597

Recruiting

HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers

Conditions: HPV Positive Cancer; Vulvar, Vaginal, Penile, Rectal Cancer; Anal Cancer; Oropharyngeal Cancer; Cervical Cancer
NCT04398524

Not yet recruiting

A Phase II Study of Cemiplimab and ISA101b in Patients With Recurrent/Metastatic HPV16 Positive OPC

Conditions: Squamous Cell Carcinoma of the Oropharynx
NCT04359199

Not yet recruiting

QUantitative Assessment of Swallowing After Radiation (QUASAR)

Conditions: Head and Neck Cancer; Dysphagia; Oropharyngeal Dysphagia; Oropharynx Cancer; Oropharynx Squamous Cell Carcinoma
NCT04287868

Recruiting

Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies

Conditions: Cervical Cancer; HPV Cancers; Anal Cancer; Oropharyngeal Cancer; Vulvar, Vaginal, Penile, Rectal Cancer
NCT04277858

Recruiting

Neoadjuvant Chemotherapy and Transoral Robotic Surgery for Oropharyngeal Cancer.

Conditions: Oropharynx Cancer; Tonsil Cancer; Throat Cancer; Base of the Tongue Carcinoma
NCT04266093

Enrolling by invitation

Gene Therapy Follow up for Subjects Previously Enrolled in NCI Genitourinary Malignancies Branch or Experimental Transplantation and Immunology Branch Studies

Conditions: Cervical Intraepithelial Neoplasia; Cervical Neoplasms; Oropharyngeal Neoplasms; Squamous Intraepithelial Lesions of the Cervix; Hematologic Malignacies
NCT04251949

Not yet recruiting

Evaluation of the Photobiomodulation Using LED Lamp for Curative Treatment of Radio-induced Mucositis.

Conditions: Oral Cancer; Oropharyngeal Cancer
NCT04222543

Recruiting

Imaging of Tumour Microenvironment in Patients With Oropharyngeal Head and Neck Squamous Cell Carcinoma Using RGD PET/CT Imaging

Conditions: Oropharyngeal Squamous Cell Carcinoma
NCT04220749

Recruiting

Radiotherapy vs. Trans-Oral Surgery for HPV-Negative Oropharyngeal Squamous Cell Carcinoma

Conditions: Head and Neck Cancer; Oropharyngeal Squamous Cell Carcinoma
NCT04189003

Active, not recruiting

Molecular Signatures of HPV+ ORL Cancers (OROPAP)

Conditions: Oropharyngeal Cancer; Human Papillomavirus-Related Carcinoma
NCT04189107

Recruiting

Postoperative Pain, Why Still in Hospital and DAOH Following TORS for SCCUP

Conditions: Analgesia; Surgery; Cancer of Head and Neck; Oropharyngeal Cancer; Carcinoma of Unknown Primary; Pain, Postoperative; Postoperative Pain
NCT04178174

Recruiting

Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer

Conditions: Head and Neck Cancer; Oropharynx Cancer; Human Papilloma Virus
NCT04162873

Recruiting

Celecoxib Through Surgery and Radiation Therapy for the Treatment of Advanced Head and Neck Cancer

Conditions: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Nasal Cavity and Paranasal Sinus Carcinoma; Oral Cavity Carcinoma; Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Recurrent Hypopharyngeal Carcinoma; Recurrent Laryngeal Carcinoma; Recurrent Nasal Cavity and Paranasal Sinus Carcinoma; Recurrent Oral Cavity Carcinoma; Recurrent Oropharyngeal Carcinoma; Stage III Hypopharyngeal Carcinoma AJCC v8; Stage III Laryngeal Cancer AJCC v8; Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IV Hypopharyngeal Carcinoma AJCC v8; Stage IV Laryngeal Cancer AJCC v8; Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IVA Hypopharyngeal Carcinoma AJCC v8; Stage IVA Laryngeal Cancer AJCC v8; Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IVB Hypopharyngeal Carcinoma AJCC v8; Stage IVB Laryngeal Cancer AJCC v8; Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IVC Hypopharyngeal Carcinoma AJCC v8; Stage IVC Laryngeal Cancer AJCC v8; Stage IVC Oropharyngeal (p16-Negative) Carcinoma AJCC v8
NCT04151134

Recruiting

Evaluation of Tongue Base MucOsectomy & Step sErial Sectioning

Conditions: Squamous Cell Carcinoma of the Oropharynx
NCT04151264

Not yet recruiting

Influence of the "Hypotension Probability Index" on Intraoperative and Postoperative Hypotension in ENT- and OM-Surgery

Conditions: Hypotension; ENT Disease; Acute Kidney Injury; Anesthesia
NCT04140513

Not yet recruiting

Digital PET Scan for the Prediction of Outcomes in Patients With Locally Advanced Oropharyngeal Cancer

Conditions: Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Locally Advanced Oropharyngeal Squamous Cell Carcinoma; Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8
NCT04124198

Recruiting

Quality of Life After Primary TORS vs IMRT for Patients With Early-stage Oropharyngeal Squamous Cell Carcinoma

Conditions: Oropharynx Cancer; Oropharynx Squamous Cell Carcinoma; Carcinoma, Squamous Cell; Carcinoma; Oropharyngeal Neoplasms; Neoplasms, Squamous Cell; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Pharyngeal Neoplasms Malignant and Unspecified; Otorhinolaryngologic Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Otorhinolaryngologic Diseases; Pharyngeal Diseases; Papillomavirus Infections; Virus Diseases; DNA Virus Infections; Tumor Virus Infections; Quality of Life
NCT04116047

Recruiting

CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)

Conditions: Oropharyngeal Cancer
NCT04112940

Active, not recruiting

Physiological Flow of Liquids in Head and Neck Cancer Patients: A Pilot Study

Conditions: Deglutition Disorders; Oropharynx Cancer
NCT04106362

Recruiting

Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With HPV Positive, KRAS-Variant Stage III-IV Oropharyngeal Squamous Cell Carcinoma

Conditions: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; KRAS Protein Variant; Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
NCT04104945

Not yet recruiting

p16+ Oropharyngeal Cancer Radiation Optimization Trial Reducing Elective Treatment Volumes (PROTEcT)

Conditions: Squamous Cell Carcinoma of the Oropharynx
NCT04085120

Recruiting

Ropivacaine/Dexamethasone and 10% Lignocaine Injection in GPN Block for Intractable Cancer Pain

Conditions: Cancer, Oropharynx; Pain, Intractable; Cancer Pain
NCT04044950

Withdrawn

A Phase II Study of Neoadjuvant E7 TCR T Cell Immunotherapy for Borderline Resectable and Unresectable Stage I HPV-Associated Oropharyngeal Cancer

Conditions: Papillomavirus Infections; Oropharyngeal Neoplasms
NCT04019548

Recruiting

Assessment of Swallowing Function and Quality of Life in Oropharyngeal Cancer Patients Treated by Chemo-radiotherapy

Conditions: Oropharyngeal Cancer
NCT04015336

Recruiting

E7 TCR Cell Induction Immunotherapy for Stage II and Stage III HPV-Associated Oropharyngeal Cancer

Conditions: Papillomavirus Infections; Oropharyngeal Neoplasms
NCT04012502

Recruiting

De-escalation Protocols in HPV-related Oropharyngeal Carcinoma in Chinese Populations

Conditions: Oropharyngeal Carcinoma; De-escalation
NCT04001413

Recruiting

Therapy for High-Risk HPV 16-Positive Oropharynx Cancer Patients

Conditions: HPV Positive Oropharyngeal Squamous Cell Carcinoma; Oropharynx Cancer; HPV-Related Carcinoma
NCT03952585

Recruiting

De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage, HPV-Positive, Non-Smoking Associated Oropharyngeal Cancer

Conditions: Basaloid Squamous Cell Carcinoma; Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Oropharyngeal Squamous Cell Carcinoma; Papillary Squamous Cell Carcinoma; Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
NCT03935672

Not yet recruiting

PEARL PET-based Adaptive Radiotherapy Clinical Trial

Conditions: Oropharyngeal Cancer
NCT03890783

Recruiting

Functional Results of Soft Palate Free Flap Reconstruction

Conditions: Oropharyngeal Cancer; Palate Free Flap Reconstruction
NCT03875716

Recruiting

Study of Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma

Conditions: Head and Neck Cancer
NCT03874572

Active, not recruiting

Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth

Conditions: Xerostomia Due to Radiotherapy; Hyposalivation; Xerostomia; Oropharynx Cancer; Salivary Gland Diseases; Dry Mouth; Mesenchymal Stem Cells; Mesenchymal Stromal Cells; Stem Cells
NCT03838263

Recruiting

Feasibility and Tolerance of Nivolumab Neoadjuvant Immunotherapy in High Risk HPV Driven Oropharynx Cancer

Conditions: Oropharynx Cancer
NCT03829033

Recruiting

Photon Therapy Versus Proton Therapy in Early Tonsil Cancer.

Conditions: Tonsil Cancer
NCT03829722

Recruiting

Radiotherapy, Carboplatin/Paclitaxel and Nivolumab for High Risk HPV-related Head and Neck Cancer

Conditions: Oropharynx Squamous Cell Carcinoma
NCT03822897

Recruiting

De-Escalation Radiotherapy in Patients With Low-Risk HPV-Related Oropharyngeal Squamous Cell Carcinoma

Conditions: Oropharyngeal Cancer
NCT03811015

Recruiting

Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer

Conditions: Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
NCT03799445

Recruiting

Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma

Conditions: Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Human Papillomavirus Positive Oropharyngeal Squamous Cell Carcinoma; Oropharyngeal Basaloid Carcinoma; Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Posterior Tongue Squamous Cell Carcinoma; Soft Palate Squamous Cell Carcinoma; Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7; Tonsillar Squamous Cell Carcinoma
NCT03777384

Recruiting

EValuating the Safety Of De-escaLated Head and Neck Irradiation in HPV positivE Oropharynx Cancer in Non-smokers/Minimal Smokers

Conditions: Oropharyngeal Cancer
NCT03737968

Not yet recruiting

Window of Opportunity Trial of Durvalumab (MEDI4736) or Durvalumab/Tremelimumab as Neoadjuvant Chemotherapy to Identify Immune Dynamics in Surgically Resectable Head and Neck Cancer Patients.

Conditions: Stage II-IVB Operable HNSCC Oral Cavity; Hypopharynx; Oropharynx; Larynx
NCT03735745

Recruiting

Transdisciplinary Oral/Oropharyngeal Cancer Research & Care in Head and Neck Cancer (TORCH)

Conditions: Head and Neck Cancer
NCT03729518

Recruiting

TORS De-Intensification Protocol Version 2.0: Dose and Volume Reduction in the Neck

Conditions: Oropharyngeal Cancer; Squamous Cell Carcinoma; Human Papilloma Virus

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Clinical Trials on Oropharyngeal Neoplasms