Clinical Trials on PKLR Variants

Total 154 results

National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease

Sickle Cell | PKLR Variants | Adenosine Triphosphate Activities

United States
Stanford University

Recruiting

CYP2C19 Variants and Limonene Metabolism

CYP2C19 Genetic Variants

United States
Sohag University

Recruiting

Prevalence of Anatomical Variants of Dural Sinuses by MRV Evaluation in Sohag

Anatomical Variants of Dural Sinuses by MRV

Egypt
Sohag University

Recruiting

Prevalence of Anatomical Variants of Dural Sinuses by Magnetic Resonance Venography Evaluation in Sohag

Anatomical Variants of Dural Sinuses by Magnetic Resonance Venography

Egypt
Hospices Civils de Lyon

Recruiting

Protection Response to Cellular Stress in BPAN's Patient Study (REP-BPAN)

Children and Adults With BPAN Carrying Pathogenic Variants of WDR45

France
National Human Genome Research Institute (NHGRI)

Enrolling by invitation

Reverse Phenotyping Core

Harboring of Unexpected Genetic Variant

United States
Karl Landsteiner Institute for Systematics in General...

Completed

CYP2D6 Polymorphism in Patients of General Practice in Austria

Disorder Due Cytochrome P450 CYP2D6 Variant

Austria
University of Sao Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo

Completed

Pharmacogenetic and Pharmacokinetics of Naproxen and Associated Naproxen-esomeprazole

Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant | Poor Metabolizer Due to Cytochrome p450 CYP2C19 Variant

Brazil
Cleveland Medical Devices Inc
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Self Abrading Rapidly Applied Electrode Validation (SARA)

ELECTROENCEPHALOGRAPHIC VARIANT PATTERN 1 (Disorder)

United States
University of Groningen
ZonMw: The Netherlands Organisation for Health Research and Development

Completed

Cytochrome P450-2D6 Screening Among Elderly Using Antidepressants (CYSCE) (CYSCE)

Depressive Disorder | Depression | Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant | Ultrarapid Metabolizer Due to Cytochrome P450 CYP2D6 Variant | Intermediate Metabolizer Due to Cytochrome P450 CYP2D6 Variant

Netherlands
Stanford University
AstraZeneca

Terminated

Durvalumab and Standard Chemotherapy Before Surgery in Treating Patients With Variant Histology Bladder Cancer

Bladder Adenocarcinoma | Bladder Mixed Adenocarcinoma | Bladder Squamous Cell Carcinoma | Infiltrating Bladder Urothelial Carcinoma With Giant Cells | Infiltrating Bladder Urothelial Carcinoma, Nested Variant | Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant | Bladder Urothelial... and other conditions

United States
Centre Hospitalier Universitaire de Saint Etienne

Recruiting

CT Features of Interrupted Inferior Vena Cava With Azygous Continuation

Anatomical Variant of the Inferior Vena Cava

France
Korea Otsuka Pharmaceutical Co., Ltd.

Completed

Evaluate the Efficacy and Safety of Pletaal (Cilostazol) in Subjects With Vasospastic Angina (STELLA)

Variant Angina

Korea, Republic of
Samsung Medical Center

Unknown

The Effect of Sarpogrelate and High Dose Statin on the Reduction of Coronary Spasm

Variant Angina

Korea, Republic of
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Pemetrexed and Avelumab in Treating Patients With MTAP-Deficient Metastatic Urothelial Cancer

Metastatic Urothelial Carcinoma | Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant | Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant | Infiltrating Bladder Urothelial Carcinoma With Glandular Differentiation | Infiltrating Bladder Urothelial Carcinoma With Squamous... and other conditions

United States
Mohammed VI University Hospital

Not yet recruiting

PLR in a Good Helath After 24 Week of Preganancy

Cardiac Output, High | ITV Sosu Aortique | PLR
Seoul National University Hospital

Unknown

ANti-Oxidant in Variant Angina (ANOVA) Trial

Variant Angina

Korea, Republic of
Seung-Jung Park
CardioVascular Research Foundation, Korea

Withdrawn

BVS Implantation in Patients With Variant Angina and MODerate Coronary Artery Disease (BIVA-pilot)

Angina Pectoris, Variant

Korea, Republic of
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Glofitamab With Obinutuzumab, Venetoclax, and Lenalidomide for the Treatment of Patients With Newly Diagnosed High Risk Mantle Cell Lymphoma

Mantle Cell Lymphoma | Blastoid Variant Mantle Cell Lymphoma | Pleomorphic Variant Mantle Cell Lymphoma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Ibrutinib, Rituximab, and Consolidation Chemotherapy in Treating Young Patients With Newly Diagnosed Mantle Cell Lymphoma

Mantle Cell Lymphoma | Blastoid Variant Mantle Cell Lymphoma | Pleomorphic Variant Mantle Cell Lymphoma

United States
Maastricht University Medical Center
RWTH Aachen University

Unknown

Atrial Fibrillation Ablation Registry (AFAB)

Atrial Fibrillation (Paroxysmal) | Atrial Fibrillation Recurrent | Atrial Fibrillation Common Gene Variants

Netherlands
Genelex Corporation

Completed

Drug & Gene Interaction Risk Analysis With & Without Genetic Testing Among Patients Undergoing MTM

Drug Metabolism, Poor, CYP2D6-RELATED | Drug Metabolism, Poor, CYP2C19-RELATED | Cytochrome P450 CYP2D6 Enzyme Deficiency | Cytochrome P450 CYP2C9 Enzyme Deficiency | Cytochrome P450 CYP2C19 Enzyme Deficiency | Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant | CYP2D6 Polymorphism | Ultrarapid... and other conditions

United States
The First Affiliated Hospital of Zhejiang Chinese...

Completed

A Retrospective Study on the Differentiation Between Cough Variant Asthma and Chronic Cough

Asthma

China
Genelex Corporation
University of Utah

Completed

YouScript IMPACT Registry (IMPACT)

Drug Interaction Potentiation | Adverse Drug Events | Adverse Drug Reactions | Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant | Drug Metabolism, Poor, CYP2D6-RELATED | Drug Metabolism, Poor, CYP2C19-RELATED | Cytochrome P450 Enzyme Deficiency | Cytochrome P450 CYP2D6 Enzyme Deficiency | Cytochrome... and other conditions

United States
Genelex Corporation
Harding University

Completed

Pharmacogenetic Testing Among Home Health Patients

Drug Interaction Potentiation | Adverse Drug Events | Adverse Drug Reactions | Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant | Poor Metabolizer Due to Cytochrome p450 CYP2C19 Variant | Drug Metabolism, Poor, CYP2D6-RELATED | Drug Metabolism, Poor, CYP2C19-RELATED | Cytochrome P450 Enzyme... and other conditions

United States
Massachusetts General Hospital
National Institute on Deafness and Other Communication Disorders (NIDCD)

Recruiting

TMS for the Treatment of Primary Progressive Aphasia

Logopenic Variant Primary Progressive Aphasia | Non-fluent Variant Primary Progressive Aphasia | Semantic Variant Primary Progressive Aphasia

United States
National Institute of Allergy and Infectious Diseases...

Completed

Collection of Blood From Persons With Hemoglobin and Erythrocyte Polymorphisms for Laboratory Malaria Research

Hemoglobin Mutations | Erythrocyte Variants

United States
University Hospital, Lille
France Alzheimer

Not yet recruiting

Social & Affective Cognition in Alzheimer's Disease & Associated Disorders (SOCIALIZE)

Alzheimer's Disease | Frontotemporal Degeneration (Semantic & Behavioral Variants)
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Venetoclax and Acalabrutinib in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma

Recurrent Mantle Cell Lymphoma | CD20 Positive | Refractory Mantle Cell Lymphoma | Blastoid Variant Mantle Cell Lymphoma | CCND1 Protein Overexpression | CD5 Positive | FCER2 Negative | Pleomorphic Variant Mantle Cell Lymphoma | t(11;14)(q13;q32)

United States
Soleno Therapeutics, Inc.

Not yet recruiting

An Open-Label Study of Diazoxide Choline in Patients With Genetic Obesities

SH2B1 Deficiency Obesity | Obesity Associated With PCSK1 Mutation (rs6232 Variant) | SIM1 Deficiency Obesity
Yanling Wei

Not yet recruiting

Clinical Study of Selective Fecal Microbiota Transplantation in the Treatment of Irritable Bowel Syndrome.

Irritable Bowel Syndrome Variant of Childhood
NHS National Waiting Times Centre Board
British Heart Foundation; University of Glasgow; NHS Greater Clyde and Glasgow; Chief Scientist Office of the Scottish Government

Active, not recruiting

Coronary Microvascular Function and CT Coronary Angiography (CorCTCA) (CorCTCA)

Angina, Stable | Angina Pectoris, Variant | Microvascular Angina

United Kingdom
Mayo Clinic

Recruiting

Assessment of Hyperphosphorylated Tau PET Binding in Primary Progressive Aphasia and Frontotemporal Dementia (SLD3)

Primary Progressive Aphasia | Behavioral Variant of Frontotemporal Dementia | Frontotemporal Dementia, Behavioral Variant

United States
Translational Research Center for Medical Innovation...
Okayama University; Japanese Gynecologic Oncology Group (JGOG)

Recruiting

Prospective Cohort Study of Germline Variant Carriers With BRCA1 or BRCA2

Fallopian Tube Carcinoma | Peritoneal Carcinoma | Ovarian Carcinoma | BRCA1 and/or BRCA2 Variant Carriers

Japan
University of Utah
National Cancer Institute (NCI)

Recruiting

Tremelimumab + Durvalumab(MEDI4736)+ Belinostat in ARID1A Mutated Cancer Focus on Urothelial Carcinoma (RESOLVE)

Metastatic Urothelial Carcinoma | Locally Advanced Urothelial Carcinoma | Unresectable Urothelial Carcinoma | Infiltrating Urothelial Carcinoma, Sarcomatoid Variant

United States
University Hospital, Lille

Unknown

Neurophysiological Correlates of Cognitive Tasks in Healthy Volunteers -WP3 P003 (PharmacogWP3)

Alzheimer Disease | ELECTROENCEPHALOGRAPHIC VARIANT PATTERN 1 (Disorder)

France
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer That Cannot Be Treated With Cisplatin-Based Therapy Before Surgery

Hydronephrosis | Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant | Stage III Bladder Urothelial Carcinoma AJCC v6 and v7 | Stage III Renal Pelvis Cancer AJCC v7 | Stage III Ureter Cancer AJCC v7 | Stage III Urethral Cancer AJCC v7 | Stage IV Renal Pelvis Cancer AJCC v7 | Stage IV... and other conditions

United States
The First Affiliated Hospital of Zhejiang Chinese...
Xin Hua Hospital of Zhejiang Province; Hangzhou Hospital of Traditional Chinese... and other collaborators

Recruiting

Multicenter Clinical Study on the Optimal Treatment Protocol and Outcome of Cough Variant Asthma With Chinese and Western Medicine

Cough Variant Asthma

China
Dong-A University

Unknown

Multidetector Coronary CT In Vasospastic Angina

Vasospastic Angina

Korea, Republic of
Shanghai Jiao Tong University School of Medicine

Unknown

Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA)

Cough Variant Asthma

China
AstraZeneca

Completed

Non-Interventional Study of Cough Variant Asthma Treatment With Pulmicort®Respules® in Children Outpatients (PUL NIS)

Cough Variant Asthma

China
Robert Bosch Gesellschaft für Medizinische Forschung...

Completed

Influence of Pharmacogenetic Factors, Paroxetine and Clarithromycin on Pharmacokinetics of Clomiphene

Anovulation | Cytochrome P450 CYP3A Enzyme Deficiency | Disorder Due Cytochrome P450 CYP2D6 Variant

Germany
Luzerner Kantonsspital

Unknown

Angina in Non Coronary Artery Disease (HeartQuest)

Angina Pectoris | Angina Pectoris, Variant | Microvascular Angina

Switzerland
Samsung Medical Center

Unknown

Efficacy Study of Atorvastatin to Treat Variant Angina (ESAVA)

Angina Pectoris, Variant

Korea, Republic of
Chang Gung Memorial Hospital

Completed

Toll-like Receptor 2 Gene Polymorphism, Serum Cytokines and Susceptibility to Disease Severity or Treatment Response of Pulmonary Tuberculosis

Pulmonary Tuberculosis | Genetic Variants of Host | Immune Response of Host

Taiwan
KK Women's and Children's Hospital
Singapore University of Technology and Design

Unknown

Acoustic Analytic Apps for Smart Telehealth Screening - Creating a Big Data

Cough | URTI | Cough Variant Asthma | Cough; Bronchial, With Grippe or Influenza

Singapore
Ege University

Completed

Vestibular Rehabilitation in Patients With Vestibular Migraine

Vestibular Migraine | Vestibular Disorder | Migraine Variant
Brigham and Women's Hospital
Biohaven Pharmaceuticals, Inc.

Completed

Effect of Verdiperstat on Microglial Activation in Well-characterized MSA Patients

Multiple System Atrophy | Multiple System Atrophy, Parkinson Variant (Disorder) | Multiple System Atrophy, Cerebellar Variant | Multiple System Atrophy (MSA) With Orthostatic Hypotension

United States
Tongji Hospital

Recruiting

A Multi-Omics Study of Vasospastic Angina (KIVAM)

Vasospastic Angina

China
Korea Otsuka Pharmaceutical Co., Ltd.

Completed

A Therapeutic Confirmatory Study to Evaluate the Efficacy and Safety of Cilostazol in Subjects With Vasospastic Angina (STELLA)

Vasospastic Angina

Korea, Republic of

Clinical Trials on PKLR Variants

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Peru

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

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