Clinical Trials on PNH

Total 201 results

CARE Pharma Shanghai Ltd.

Completed

Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of a Single Ascending Dose (SAD) of CAN106 Administered Intravenously (IV) in Healthy Subjects

PNH

Singapore
Astellas Pharma Inc

Completed

Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch (LIFT)

or Peripheral Nerve Injury (PNI) | Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN)

Belgium, Czechia, Denmark, Ireland, Norway, Slovakia, United Kingdom
CARE Pharma Shanghai Ltd.

Recruiting

A Study on the Safety, Tolerability, Efficacy, Pharmacokinetics and Pharmacodynamics of CAN106 in Subjects With PNH

Hemolysis | PNH

China
Apellis Pharmaceuticals, Inc.

Active, not recruiting

Pegcetacoplan Long Term Safety and Efficacy Extension Study

PNH

United States, France, Germany, Canada, United Kingdom, Belgium, Hong Kong, Japan, Singapore, Thailand, Russian Federation, Serbia, Australia, Bulgaria, Spain, Malaysia, Korea, Republic of, Colombia, Mexico, Peru, Philippines
Handok Inc.

Completed

A Retrospective Chart Review Study to Evaluate the Impact of Eculizumab in Korean PNH Patients

PNH

Korea, Republic of
Focus Medical, LLC

Completed

Evaluation of the Effectiveness of the PiQo4 System for Reduction of Infra-orbital Pigmentation

POH

United States
United Therapeutics

Withdrawn

Dose Escalation, MTD, Safety and PK Study of a Single Dose SC Injection of TransCon PEG Treprostinil in Healthy Male Volunteers

PAH

United States
Mahidol University

Unknown

The Use of Sunscreen Starting on the First Day After Ablative Fractional Skin Resurfacing

PIH

Thailand
The Third Xiangya Hospital of Central South University

Recruiting

Effects of Repeated Intravenous Anesthesia With Propofol on the Postoperative Neurological Function of Patients Undergoing Hysteroscopic Surgery

Anesthesia | PND

China
Astellas Pharma Europe Ltd.

Completed

A Study to Compare QUTENZA With Pregabalin for the Treatment of Peripheral Neuropathic Pain (PNP) After 8 Weeks of Treatment (ELEVATE)

Non-diabetic Painful Peripheral Polyneuropathy | Postherpetic Neuralgia (PHN) | Peripheral Nerve Injury (PNI)

Armenia, Austria, Belarus, Belgium, Bulgaria, Czechia, Finland, France, Germany, Greece, Hungary, Italy, Poland, Portugal, Romania, Russian Federation, Slovakia, Slovenia, Spain, Sweden, Turkey, United Kingdom
AZ Delta
Alexion

Completed

Retrospective Chart Review Screening Algorithm to Assess the Prevalence of PNH-clones

Thrombosis | PNH

Belgium
Actelion

Active, not recruiting

Clinical Study to Compare the Efficacy and Safety of Macitentan and Tadalafil Monotherapies With the Corresponding Fixed-dose Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH) (A DUE)

Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)

United States, Japan, Taiwan, Turkey, Canada, China, Germany, Spain, Italy, Malaysia, Hungary, Russian Federation, Brazil, Australia, Bulgaria, Czechia, Mexico, Poland, South Africa
Takeda

Completed

Adherence to PTH(1-84) Treatment (FP-002-IM)

Clinical Use of PTH(1-84)

Denmark
Technische Universität Dresden
GWT-TUD GmbH

Recruiting

COMPERA / COMPERA-KIDS (COMPERA)

Pulmonary Arterial Hypertension (PAH) | Pulmonary Hypertension (PH)

Germany, Belgium, Italy, Switzerland
Merz Therapeutics GmbH

Recruiting

A Clinical Trial to Investigate Efficacy and Safety of NT 201 Injections Compared With Placebo Injections in Participants Aged 18 Years and Older With Chronic Nerve Pain After Shingles or Nerve Injury (PaiNT)

Moderate to Severe Chronic Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN) or Peripheral Nerve Injury

Bulgaria, Germany, Poland, France, Hungary, Spain
Shenzhen Second People's Hospital

Recruiting

The Effects of Different Anesthesia Methods on Perioperative Neurocognitive Disorders in the Elderly

PND

China
Handok Inc.

Unknown

Observational of PNH Type Cells in Korean Patients With Bone Marrow Failure Syndrome and Having Hemolytic PNH (OPENK)

PNH
Westat
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Safety and Immunogenicity of Anti-Pneumococcal Vaccines in HIV-Infected Pregnant Women

PNC Vaccine | HIV-infected Pregnant Women

Brazil
Universidad Tecnologica de Mexico

Completed

Comparison of Salivary pH After Consuming Milk of Origin Vegetable vs Cow's Milk in Children

pH

Mexico
ResQ Medical Ltd

Not yet recruiting

Safety and Effectiveness of the Alma System in Treating Primary Postpartum Hemorrhage ("Alma system")

PPH | Postpartum Hemorrhage \(PPH\) | Postpartum Hemorrhage \(Primary\)

Kenya
Novartis Pharmaceuticals

Completed

Proof of Concept Study to Assess the Efficacy, Safety and Pharmacokinetics of LFG316 in Patients With Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Nocturnal Hemoglobinuria PNH

Lithuania, Japan, Czechia
Ra Pharmaceuticals

Completed

Phase 2 Safety and Efficacy Study of Zilucoplan (RA101495) to Treat PNH Patients Who Have an Inadequate Response to Eculizumab

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United States
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

Study of Danicopan in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United Kingdom, New Zealand, Korea, Republic of, Italy
AKARI Therapeutics

Completed

Treating Paroxysmal Nocturnal Haemoglobinuria Patients With rVA576 (CAPSTONE)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Kazakhstan, Lithuania, Sri Lanka
Alexion Pharmaceuticals

Terminated

Safety and Pharmacokinetics of TT30 in Subjects With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United States, Czech Republic, Italy, Poland, United Kingdom
Trace Minerals
Citruslabs

Active, not recruiting

A Clinical Trial to Evaluate the Efficacy of ConcenTrace to Buffer pH Levels Within the Body.

pH

United States
Alexion Pharmaceuticals

Completed

Open-label, Multiple Ascending Dose Study of Ravulizumab (ALXN1210) in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria | PNH

Korea, Republic of, Canada, France, Germany, Spain, Taiwan, United Kingdom
Apellis Pharmaceuticals, Inc.

Completed

A Phase IIa Study to Assess the Safety, Efficacy, and Pharmacokinetics of Subcutaneously Administered Pegcetacoplan (APL-2) in Subjects With PNH

PNH

Serbia, Bulgaria
Alexion Pharmaceuticals

Completed

Paroxysmal Nocturnal Hemoglobinuria Human Anti-Human Antibodies Study

Paroxysmal Nocturnal Hemoglobinuria | PNH

Australia, France, United Kingdom, Belgium, Germany, Netherlands, Ireland, United States, Switzerland, Italy
Assiut University

Not yet recruiting

Protocols for Prevention of PPH During CS in High Risk Group

Atonic PPH
The Cleveland Clinic

Withdrawn

Biomarkers in Pulmonary Arterial Hypertension Treated With Nilotinib

PAH

United States
BioCryst Pharmaceuticals

Active, not recruiting

A Long Term Safety Study of BCX9930 in Subjects With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria | PNH

United Kingdom, Austria, South Africa
Alexion Pharmaceuticals

Completed

Dose-Escalation Study of ALXN1210 IV in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

PNH

Korea, Republic of, Australia
Bambino Gesù Hospital and Research Institute

Active, not recruiting

Anti-CD19 CAR T Cells in Pediatric Patients Affected by Relapsed/Refractory CD19+ ALL and NHL

CD19-ALL | CD19-LNH

Italy
Alexion

Completed

ALXN1210 Versus Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United States, Korea, Republic of, Canada, France, Germany, Spain, United Kingdom, Japan, Australia, Italy, Netherlands
Ra Pharmaceuticals

Completed

Phase 2 Safety and Efficacy Study of Zilucoplan (RA101495) to Treat PNH Patients

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United Kingdom, Australia, Canada, Denmark, Finland, Germany, Hungary, New Zealand
Alnylam Pharmaceuticals

Completed

A Phase 1/2 Study of an Investigational Drug, ALN-CC5, in Healthy Adult Volunteers and Patients With PNH

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Spain, United Kingdom
Bo Wang,MD

Unknown

The Application of Rapid PTH Test Paper in Operation of Hyperparathyroidism

Hyperthyroidism | Thyroidectomy | PTH | Immunochromatographic

China
Alexion

Active, not recruiting

Study of the Oral Factor D (FD) Inhibitor ALXN2050 in PNH Patients as Monotherapy

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United Kingdom, Italy, Canada, Korea, Republic of, New Zealand, Spain, Turkey
Alexion

Completed

ALXN1210 (Ravulizumab) Versus Eculizumab in Complement Inhibitor Treatment-Naïve Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Belgium, France, Italy, Japan, Spain, Taiwan, United Kingdom, United States, Canada, Czechia, Germany, Sweden, Singapore, Korea, Republic of, Russian Federation, Austria, Poland, Argentina, Australia, Brazil, Estonia, Malaysia, Mexico, Thaila... and more
Apellis Pharmaceuticals, Inc.

Completed

A Phase I Study to Assess the Safety of Pegcetacoplan (APL-2) as an Add-On to Standard of Care in Subjects With PNH

Paroxysmal Nocturnal Hemoglobinuria (PNH)

United States
Haisco Pharmaceutical Group Co., Ltd.

Completed

The Drug-drug Interaction of HSK16149 Capsule With Probenecid Tablets or Cimetidine Tablets in Healthy Subjects

PHN - Post-Herpetic Neuritis

China
The Cleveland Clinic

Completed

Pulmonary Hypertension and Imatinib

PAH

United States
Apellis Pharmaceuticals, Inc.

Recruiting

A Study of Pegcetacoplan in Pediatric Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Paroxysmal Nocturnal Hemoglobinuria (PNH) | Paroxysmal Hemoglobinuria

Malaysia, United States, Czechia, France, Netherlands, Serbia, Spain, Thailand, United Kingdom
Takeda

Withdrawn

Magnesium Pantoprazole 20mg b.i.d. vs Magnesium Pantoprazole 40mg q.d. on Intragastric Acid Inhibition

Gastric pH Control

Mexico
University of Hohenheim
Universität Tübingen

Completed

Increasing the Oral Bioavailability of 6-prenylnaringenin by Micellar Solubilization

Safety of Native vs. Micellar 6-PN After Oral Intake | Pharmacokinetics of Native vs. Micellar 6-PN After Oral Intake | PBMC Activity After Native vs. Micellar 6-PN Oral Intake

Germany
Azienda Policlinico Umberto I

Unknown

Clinical Management of Childhood Intestinal Lymphoid Nodular Hyperplasia

Intestinal LNH

Italy
University of Vienna

Unknown

Influence of a Bitter Compound and Bittermasking Compound on Gastric pH

Change of Gastric pH

Austria
United Therapeutics

Completed

Safety, Tolerability, and Pharmacokinetics of Oral Treprostinil in Pediatric PAH Patients Aged 7 to 17 Years

PAH

United States
Dexa Medica Group

Completed

Efficacy and Safety of DLBS2411 in Healthy Volunteers

Gastric pH Regulation in Healthy Volunteers

Indonesia

Clinical Trials on PNH

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