Clinical Trials on Patients With Impaired Hepatic Function

Total 1794 results

Astellas Pharma Inc

Completed

Pharmacokinetics Study in Patients With Impaired Hepatic Function

Patients With Impaired Hepatic Function

Japan
Novartis Pharmaceuticals

Completed

Evaluation of Hepatic Function Impairment on the Pharmacokinetics of LEE011

Normal Hepatic Function | Impaired Hepatic Function

United States
Novartis Pharmaceuticals

Completed

Effect of Hepatic Impairment on LDE225..

Normal Hepatic Function | Impaired Hepatic Function

Belgium, Germany, Israel, Bulgaria, United States
NGM Biopharmaceuticals, Inc

Completed

Study of Aldafermin (NGM282) in Participants With Impaired Hepatic Function

Impaired Hepatic Function

United States
Tetraphase Pharmaceuticals, Inc.

Completed

A Phase 1, Open-Label Study to Assess the Single-Dose Pharmacokinetics of Eravacycline in Subjects With Impaired Hepatic Function and Healthy Subjects

Impaired Hepatic Function

United States
Taiho Oncology, Inc.

Completed

Evaluating Patients With Impaired Hepatic Function

Impaired Hepatic Function

United States
Alexion

Recruiting

Study of ALXN2050 in Participants With Hepatic Impairment

Healthy | Impaired Hepatic Function

United States
Astellas Pharma Inc

Completed

Pharmacokinetics Study in Patients With Impaired Renal Function and Subjects With Normal Renal Function

Patients With Impaired Renal Function

Japan
Novartis Pharmaceuticals

Completed

Effect of Hepatic Impairment on LDK378 Pharmacokinetics

Normal Hepatic Function | Impaired Hepatic Function

United States
Astellas Pharma Inc

Completed

ASP8825 - Pharmacokinetics Study in Patients With Impaired Renal Function and Haemodialysis

Patients With Impaired Renal Function and Haemodialysis

Japan
UCB Biopharma S.P.R.L.

Terminated

A Pharmacokinetic Study of Padsevonil in Study Participants With Either Normal or Moderately Impaired Hepatic Function

Impaired Hepatic Function | Healthy Study Participants

United States
Daiichi Sankyo, Inc.

Completed

A Study of Quizartinib Pharmacokinetics in Participants With Moderate Hepatic Impairment

Hepatic Impairment | Moderate Impaired Hepatic Function

United States
Jiangsu HengRui Medicine Co., Ltd.

Unknown

A Study to Evaluate the Pharmacokinetics of Apatinib in Subjects With Impaired Renal Function

Subjects With Impaired Renal Function and Healthy Subjects
Yonsei University

Recruiting

Cost-Effectiveness of Spyglass Direct Visualization System Facilitated Management for the Patients With Intrahepatic Bile Duct Stone and/or Large Extrahepatic Bile Duct Stone

Patients With Large or Impacted Intra- or Extra-hepatic Bile Duct Stone

Korea, Republic of
Taisho Pharmaceutical Co., Ltd.

Completed

A Pharmacokinetic Study of TS-142 in Patients With Hepatic Impairment

Patients With Mild or Moderate Hepatic Impairment

Japan
Englewood Hospital and Medical Center

Withdrawn

Neuropsychological Testing Using Mobile Devices

Inpatients With Normal Neurological Function

United States
Novartis Pharmaceuticals

Terminated

An Open-label, Dose Escalation Multi-center Study in Patients With Advanced Cancer to Determine the Infusion Rate Effect of ASA 404 With Paclitaxel Plus Carboplatin Regimen or Docetaxel on the Pharmacokietics of Free and Total ASA404

Metastatic Cancer With Impaired Renal Function | Metastatic Cancer With Normal Renal Function

Belgium
Universidad Antonio de Nebrija

Completed

Cervical Functionality and Posture (CERFUPOS) (CERFUPOS)

People With Impaired Motor Function in the Cervical Region

Spain
Stanford University

Terminated

Quality of Life in Adults Impaired Functioning - A Randomized Controlled Trial of Bidet vs Usual Toileting

Toileting in Adults With Impaired Functional Status | Caregiver Burden for Those Who Care for Adults With Impaired Functional Status | UTI in Adults With Impaired Functional Status

United States
Nektar Therapeutics

Completed

A Study in Cancer Patients With Hepatic Impairment to Evaluate the Pharmacokinetics and Safety of NKTR-102 (Etirinotecan Pegol)

Advanced or Metastatic Solid Tumors in Patients With Hepatic Impairment

United States
Genta Incorporated

Completed

Pharmacokinetic Study of Genasense in Subjects With Normal Renal Function, Mildly Impaired Renal Function, and Moderately Impaired Renal Function

Normal Renal Function | Mildly Impaired Renal Function | Moderately Impaired Renal Function

United States
Repros Therapeutics Inc.

Completed

Evaluate the Safety and PK of Proellex® in Female Patients With Impaired Hepatic Function and Healthy Adults

Impaired Liver Function

United States
National Taiwan University Hospital

Unknown

Evaluation of ELISA Assay on Human Papilloma Viruses (HPV) Infection Population

Patient With Invasive Cervical Carcinoma | Patient With CIN Lesion | Patient With HPV Infected Patients Without Histopathologic Lesion | Normal Populations.

Taiwan
Royal Devon and Exeter NHS Foundation Trust
University of Exeter

Completed

Increasing Mitochondrial Function on Skeletal Muscle Performance in Older Men (Rejuvenate)

Impaired Mitochondrial Function, Muscle Performance

United Kingdom
University of Leicester
National Institute for Health Research, United Kingdom

Completed

Developing Imaging And plasMa biOmarkers iN Describing Heart Failure With Preserved Ejection Fraction (DIAMONDHFpEF) (DIAMONDHFpEF)

Patients With Heart Failure and Preserved Ejection Fraction - HFpEF | Patients With Heart Failure With Reduced Ejection Fraction - HFrEF | Healthy Controls Group - Age and Sex-matched
Tel-Aviv Sourasky Medical Center

Unknown

The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers (Nanoexposure)

Inadequate or Impaired Respiratory Function
Sanofi

Completed

A Pharmacokinetic and Tolerability Study of Fexinidazole in a Single Oral Dose in Adult Participants With Mild and Moderate Hepatic Impairment

Hepatic Function Abnormal

Bulgaria, France
Sanofi

Completed

Study to Assess the Plasma Concentration of Tolebrutinib Given as a Tablet to Adult Participants With Mild Hepatic Impairment Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Belgium
Sanofi

Terminated

Pharmacokinetics of Amcenestrant in Female Hepatic Impaired Participants as Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

Korea, Republic of, Germany
Sanofi

Completed

A Study in Adults to Investigate the Impact of Mild, Moderate, and Severe Hepatic Impairment on Pharmacokinetics of Venglustat Compared to Participants With Normal Hepatic Function

Hepatic Function Abnormal

United States, Germany
Stealth BioTherapeutics Inc.

Completed

A Phase 1 Study Investigating the Safety and Pharmacokinetics of Repeat-dose Intravenous Infusion of MTP-131 in Subjects With Impaired Renal Function

Normal and Impaired Renal Function

United States
Klinikum Ludwigshafen

Completed

Influence of of a Lipid Emulsion on Inflammatory Response and Hepatic Function

Inflammatory Response | Hepatic Function

Germany
University of Exeter
Royal Devon and Exeter NHS Foundation Trust

Terminated

Assessing the Effects of Increased Mitochondrial Function Exercise Training on Muscle Performance (Rejuvenate2)

Impaired Mitochondrial Function, Muscle Performance

United Kingdom
University of Regensburg

Completed

CNI-free de Novo Protocol in Patients Undergoing Liver Transplantation With Renal Impairment (PATRON07)

End Stage Liver Disease | Impaired Renal Function

Germany
Centre Hospitalier Universitaire de Besancon

Terminated

CoSeal in Liver and Biliary Surgery in Prevention of Denovo Hepatic Adhesion (COLIBIS)

Patient With Hepatic Metastasis

France
Klinikum Ludwigshafen
Universitätsmedizin Mannheim

Completed

Inhalative Sedation in ICU With Sevoflurane Via Anaesthetic Conserving Device Compared to Propofol

Renal Function | Hepatic Function | Recovery From Sedation | Cardioprotection | Sevoflurane Consumption
Eisai Inc.

Completed

A Pharmacokinetic and Safety Study of E7080 in Subjects With Mild (10 mg), Moderate (10 mg), and Severe Hepatic Impairment (5 mg) and Normal Hepatic Function (10 mg)

Hepatic Impairment | Hepatic Function

United States
Universidade Metodista de Piracicaba

Completed

Positive Airway Pressure Versus Breathing Exercises With Load Inspiratory in Patients Undergoing Bariatric Surgery

Inadequate or Impaired Respiratory Function

Brazil
GlycoMimetics Incorporated

Completed

A Study to Evaluate the Effect of IV Doses of Rivipansel in Subjects With Moderate Hepatic Impairment and in Healthy Subjects With Normal Hepatic Function

Moderate Hepatic Impairment | Normal Hepatic Function

United States
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Investigate the Effect of Severely Diminished Liver Function on the Metabolism, Safety, and Tolerability of a Single Oral Dose of Enzalutamide in Men

Severe Hepatic Impairment | Normal Hepatic Function

Bulgaria
University of Sao Paulo General Hospital

Completed

Effects of THW and rhTSH in Glomerular Filtration Rate During RIT

Other Impaired Renal Function Disorder

Brazil
Genta Incorporated

Terminated

Pharmacokinetics of G3139 in Subjects With Advanced Melanoma, Including Those With Normal Hepatic Function and Those With Moderate Hepatic Impairment

Advanced Melanoma and Normal or Impaired | Hepatic Function
Pfizer's Upjohn has merged with Mylan to form Viatris...

Terminated

An Open Label Pharmacokinetic Study Of Gabapentin In Japanese Subjects With Renal Impairment Including Hemodialysis

PK Properties Of Gabapentin In Subjects With Impaired Renal Function

Japan
Janssen Research & Development, LLC

Completed

A Study to Assess the Effects of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine

Hepatic Impairment | Normal Hepatic Function

United States
Centre Hospitalier Universitaire Dijon

Completed

Study of Subcutaneous Interstitial Pressure During Sepsis (PISEP)

Patients With Septic Shock

France
Meir Medical Center

Unknown

PhysioGlove Versus Clinic Electrocardiogram Comparison (CommwellPG)

Patients With Normal ECG | Patients With Pathological ECG

Israel
University Hospital, Clermont-Ferrand
Diagnostica Stago

Recruiting

Evaluation of the Inter-center Variability of the Measurement of Thrombin Generation by the ST Genesia System (EVIGE)

Patients Without a Medical History of Thrombosis or Hemorrhage | Hemophilic Patient | Patient With FV Leiden Mutation | Patient With Cirrhosis | Patient on Anticoagulant

France
Allergan

Completed

Study of Ulipristal Acetate in Female Patients With Moderately or Severely Impaired Renal Function, Compared With Matched Healthy Female Subjects

Renal Function

United States
Wuhan Union Hospital, China
Yichang Humanwell Pharmaceutical Co., Ltd., China

Recruiting

PK/PD Properties and Safety of Remazolam Besylate for Injection in ICU Patients With Impaired Renal Function

Mechanically Ventilated Patients

China
Duke University

Completed

Vestibular Function After Cochlear Implantation Using Soft Surgery Techniques

Vestibular Function in Cochlear Implant Patients

United States

Clinical Trials on Patients With Impaired Hepatic Function

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