Clinical Trials on Pharmacodynamic

Total 89 results

Opiant Pharmaceuticals Inc

Completed

Pharmacodynamic Evaluation of Intranasal Nalmefene

Pharmacodynamic

United States
Guangzhou General Hospital of Guangzhou Military...

Completed

Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia (PIPDIA)

Pharmacodynamic Interaction

China
University of California, San Francisco

Completed

Study of the Ability of Betaine Hydrochloride to Increase Stomach Acid in Healthy Volunteers

Pharmacodynamic

United States
Tarsa Therapeutics, Inc.

Completed

A Study of Oral Calcitonin Given at Night to Healthy Postmenopausal Women

Phase 1 Pharmacodynamic Study

United States
Khon Kaen University

Completed

Comparative Pharmacodynamics and Pharmacokinetics Study of Generic and Reference Clopidogrel Products

Pharmacodynamics

Thailand
Astellas Pharma Inc

Completed

To Evaluate Whether Naproxen and Darexaban (YM150) Interact in Their Effects

Healthy Subjects | Pharmacodynamic Interaction

France
Astellas Pharma Inc

Completed

To Evaluate Whether Acetyl Salicylic Acid (Aspirin), the Combination of Aspirin and Clopidogrel and Darexaban (YM150) Interact in Their Effects

Healthy Subjects | Pharmacodynamic Interaction

France
Radboud University Medical Center

Completed

Eplerenone and Extracellular Adenosine Formation (eplerenone01)

Pharmacodynamics

Netherlands
Teva Branded Pharmaceutical Products R&D, Inc.

Completed

A Phase I Study in Young Healthy Women to Investigate the Effects of Laquinimod on Standard Oral Contraceptive When Both Treatments Are Given Together

Pharmacokinetics | Pharmacodynamics

Germany
Merckle GmbH

Completed

PK, PD, Safety and Tolerability of Lipegfilgrastim in Healthy Japanese and Caucasian Participants

Pharmacokinetics | Pharmacodynamics

United Kingdom
INSYS Therapeutics Inc

Completed

Fentanyl Sublingual Spray and Fentanyl Citrate Intravenous (IV) in Opioid Naive Subjects

Pharmacokinetics and Pharmacodynamics

United States
Dong-A University

Completed

Clopidogrel And Ticagrelor in Healthy Subjects

Pharmacodynamics

Korea, Republic of
Bayer

Completed

Pharmacodynamic Characterization of Dienogest

Pharmacodynamics

Netherlands
HK inno.N Corporation

Completed

To Investigate PK and PD of CJ-12420, Clarithromycin, Amoxicillin After Multiple Dose Administration

Drug Interaction | Pharmacokinetic | Pharmacodynamic

Korea, Republic of
Taipei Veterans General Hospital, Taiwan

Completed

Modeling and Application of Triple Drug Response Surface Models

Pharmacodynamics | Drug Interactions

Taiwan
AstraZeneca

Completed

A Study to Assess the Pharmacodynamic Effect of Single Doses of AZD9977 in Healthy Male Subjects

Healthy Subjects | Pharmacodynamics

United Kingdom
Takeda

Completed

Pharmacokinetics and Pharmacodynamics Study of Alogliptin in Healthy Korean Participants

Pharmacokinetics and Pharmacodynamics

Korea, Republic of
Transdermal Delivery Solutions Corp
Langford Research Institute, Inc.

Completed

Transdermal Insulin Response In Healthy Volunteers

Pharmacodynamic Response to Small Doses of Insulin

United States
Basking Biosciences, Inc.

Completed

Study of DTRI-031 in Healthy Volunteers

Healthy Volunteers | Pharmacokinetics | Pharmacodynamics

Australia
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

Pharmacodynamic Biomarkers to Support Biosimilar Development: Interferon Beta-1A Products

Healthy Subjects | Pharmacokinetics | Pharmacodynamics

United States
Takeda

Terminated

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MLN3126 in Healthy Japanese and Non-Japanese Participants

Pharmacokinetics | Pharmacodynamics | Tolerability | Safety

United States
Il-Yang Pharm. Co., Ltd.

Completed

Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety

Healthy | Pharmacokinetics | Pharmacodynamics | Ilaprazole

Canada
AstraZeneca

Withdrawn

A Drug-Drug Interaction Study Between AZD9668 and Warfarin to Study the Effect of AZD9668 on the Metabolism and Effect of Warfarin

Pharmacokinetics | Pharmacodynamics

Sweden
Turku University Hospital

Completed

Effect of Itraconazole and Ticlopidine on the Pharmacokinetics and Pharmacodynamics of Oral Tramadol

Pharmacokinetics | Pharmacodynamics

Finland
Idorsia Pharmaceuticals Ltd.

Completed

Single-ascending Dose Study to Investigate the Tolerability, Safety, Pharmacokinetics, and Pharmacodynamics of ACT-462206

Pharmacokinetics | Pharmacodynamics | Tolerability | Safety

Netherlands
Ospedale Regionale di Locarno

Completed

ESAs, Reticulocyte Dynamic and Hemoglobin Variability

Erythropoiesis Stimulating Agent Pharmacodynamics

Switzerland
Humanitas Clinical and Research Center

Not yet recruiting

EFFECT OF VASOPRESSORS ON FLUID CHALLENGE PERSISTENCE AN OBSERVATIONAL STUDY IN PATIENTS UNDERGOING LAPAROTOMY. (NORA_FC)

Surgery | Norepinephrine | Fluid Challenge | Pharmakodynamic

Italy
Lee's Pharmaceutical Limited

Completed

A Study to Evaluate the Safety and Tolerability of Tecarfarin in Healthy Chinese Volunteers

Pharmacokinetic and Pharmacodynamic Profile of Tecarfarin

Hong Kong
Astellas Pharma Inc

Completed

To Evaluate Whether Acetyl Salicylic Acid (Aspirin) and Darexaban (YM150) Interact in Their Effects

Healthy Subjects | Pharmacodynamic and Pharmacokinetic Interaction

France
Idorsia Pharmaceuticals Ltd.

Completed

Single-ascending Oral Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT-281959 / ACT-246475 in Healthy Male Subjects

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics

France
HK inno.N Corporation

Unknown

A Phase 1 Study of Tegoprazan on Healthy Male Volunteers

Pharmacokinetics | Pharmacodynamics | Healthy Male Volunteers

Korea, Republic of
Stanford University

Completed

PK/PD Modeling of Magnesium in the Mother and Neonate

Magnesium Sulfate Pharmacokinetics and Pharmacodynamics

United States
Astellas Pharma Inc

Completed

A Study in Healthy Young Men to Look at What Drives the Cardiovascular Effects After Dosing With Mirabegron.

Healthy Volunteers | Pharmacodynamics of Mirabegron

France
Altasciences Company Inc.

Completed

Single Ascending Doses of Kratom in Healthy Nondependent Adults With Opioid Experience

Pharmacokinetics | Pharmacodynamics | Safety

United States
Cui Yimin

Unknown

Impact of Biomarkers on Pharmacokinetics and Pharmacodynamics of Ticagrelor

Pharmacokinetics | Pharmacodynamics | Pharmacogenomics | Accurate Medication | Ticagrelor

China
Astellas Pharma Europe B.V.

Completed

A Study to Assess the Effects of Single Ascending Doses (SAD) of ASP8477, the Effect That Food Has on the Drug, and the Interaction Between ASP8477 and Omeprazole in Healthy Postmenopausal Females and Healthy Young Vasectomized Males

Pharmacokinetics of ASP8477 | Pharmacodynamics of ASP8477

France, Belgium
AstraZeneca

Completed

Study to Assess the Pharmacodynamics/Pharmacokinetics After Repeated Dosing of D961H 10 mg and Omeprazole 10 mg in Japanese Healthy Male Subjects

Pharmacodynamics Study

Japan
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

Pharmacodynamic Biomarkers to Support Biosimilar Development: PCSK9 Inhibitors

Healthy Subjects | Pharmacokinetics | Pharmacodynamics

United States
Food and Drug Administration (FDA)
Spaulding Clinical Research LLC

Completed

Pharmacodynamic Biomarkers to Support Biosimilar Development: Interleukin-5 Antagonists

Healthy Subjects | Pharmacokinetics | Pharmacodynamics

United States
HK inno.N Corporation

Completed

A Study to Evaluate Safety, Tolerability, and PD of Tegoprazan on Healthy Male Volunteers

Pharmacodynamics | Healthy Male Volunteers

Korea, Republic of
Chinese Medical Association

Unknown

Pharmacodynamics and Pharmacokinetics of Dexmedetomidine in Pediatric

Pharmacokinetics | Dexmedetomidine | Pharmacodynamics | Pediatrics

China
Geropharm

Recruiting

Double-blind, Randomized Comparative Cross-sectional Study of Pharmacodynamics and Pharmacokinetics of Drugs GP40141

Pharmacokinetics | Pharmacodynamics | Bioequivalence

Russian Federation
SPARK Biopharma

Completed

SB17170 Phase1 Trial in Healthy Volunteer

Pharmacokinetics | Pharmacodynamics | Safety Issues | Tolerability

Korea, Republic of
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Completed

Behavioral Pharmacology of THC and D-limonene

D-limonene and THC Pharmacodynamics

United States
AstraZeneca

Completed

Single + Multiple Ascending Dose and Food Effect Study of AZD7986 in Healthy Volunteers, PK, PD and Safety Study

Safety, Pharmacokinetics, Pharmacodynamics, Food Effect

United Kingdom
Astellas Pharma Global Development, Inc.
Kyowa Kirin Co., Ltd.

Completed

Bioavailability of ASKP1240 in Healthy Subjects After Intravenous and Subcutaneous Administration of ASKP1240

Healthy Volunteers | Pharmacokinetics of ASKP1240 | Pharmacodynamics of ASKP1240

United States
Astellas Pharma Europe B.V.

Completed

A Study to Investigate the Appearance and Disappearance of ASP3652 in Blood and Spinal Fluid in Healthy Male Subjects

Healthy Subjects | Pharmacokinetics of ASP3652 | Pharmacodynamics of ASP3652

United Kingdom
Astellas Pharma Europe B.V.

Completed

A Study to Evaluate the Safety and Tolerability of YM150 in Healthy Caucasian and Japanese Male and Female Subjects, and to Assess the Effect That Gender May Have on Its Actions in the Body

Healthy Subjects | Pharmacokinetics | Pharmacodynamics | Japanese | Caucasian

Germany
Astellas Pharma Inc

Completed

A Study to Assess the Safety, Tolerability and Pharmacokinetics of ASP015K

Healthy Subjects | Pharmacodynamics | Pharmacokinetics of ASP015K

United States
Centre Hospitalier Universitaire, Amiens

Recruiting

Effect of Oral Water in Healthy Volunteers on Cardiac Output, Regional Flow and Microcirculation in Healthy Volunteers (WATERNAL)

Fluid Therapy | Pharmacodynamics | Fluid Responsiveness | Fluid Challenge | Intravenous Fluids

France

Clinical Trials on Pharmacodynamic

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