Clinical Trials on Primary Amyloidosis

Total 59697 results

Pr. Nicolas GIRERD

Recruiting

Prognostic Value of Echocardiographic Parameters Based on Machine Learning Approach (ATTR-AI)

Transthyretin Cardiac Amyloidosis

France
Mayo Clinic

Completed

Long-term Monitoring of Patients With Cardiac Amyloidosis With Implantable Event Monitors

TTR Cardiac Amyloidosis

United States
Poitiers University Hospital
Pfizer

Completed

Imaging for the Evaluation of Transthyretin Cardiac Amyloidosis Prevalence of Patients Over 65 Hospitalized in Cardiology Wards (the IMPACT Study) (IMPACT)

Transthyretin Cardiac Amyloidosis

France
Takeda

Terminated

Study of Dexamethasone Plus IXAZOMIB (MLN9708) or Physicians Choice of Treatment in Relapsed or Refractory Systemic Light Chain (AL) Amyloidosis

Relapsed or Refractory Systemic Light Chain Amyloidosis

United States, Canada, Spain, Israel, France, Australia, Denmark, Germany, Korea, Republic of, Greece, Netherlands, Brazil, Czechia, Italy, United Kingdom
Jian Li
Peking University First Hospital; Tongji Hospital; Nanfang Hospital of Southern... and other collaborators

Completed

BCD With or Without Doxycycline in Mayo Stage II-III Light Chain Amyloidosis Patients

Amyloidosis; Systemic

China
Paolo Milani

Recruiting

NatiOnal Referral cenTEr Study of Transthyretin Amyloid Cardiomyopathy(ATTR) Patients on Tafamidis (NOTE-ATTR)

Amyloidosis | Amyloidosis Cardiac | ATTR Amyloidosis Wild Type

Italy
Columbia University
Attralus, Inc.

Recruiting

Evuzamitide in PET/CT to Measure Potential Therapeutic Response in ATTR

Transthyretin Amyloidosis

United States
Yale University
Alnylam Pharmaceuticals Inc

Not yet recruiting

Evaluation of a Claims-based Algorithm for the Identification of Transthyretin-mediated Amyloidosis (ATTR) Amyloidosis in Medical Records

Transthyretin Amyloidosis

United States
University Hospital, Caen
Pfizer

Recruiting

Quantitative Analysis of Myocardial Uptake of Bone Radiopharmaceuticals in Patients With Cardiac ATTR Amyloidosis (REMOD-TTR)

Amyloidosis Transthyretin

France
Ionis Pharmaceuticals, Inc.

Completed

Evaluate the Safety and Tolerability, as Well as the Pharmacokinetic and Pharmacodynamic Profiles of Single and Multiple Doses of Eplontersen Administered Subcutaneously to Healthy Volunteers and Patients With Hereditary Transthyretin-Mediated Amyloidosis (hATTR ).

Healthy Volunteers | hATTR Amyloidosis

Canada
C.T. Development America, Inc.

Completed

Efficacy and Safety Study of KIACTA in Preventing Renal Function Decline in AA Amyloidosis

Amyloidosis

Spain, United States, Italy, Belgium, Netherlands, India, Tunisia, Latvia, Turkey, France, Germany, Estonia, Lithuania, Poland, Russian Federation, Georgia, United Kingdom, Israel, Egypt, Finland, Peru, Sweden, Ukraine
Alnylam Pharmaceuticals

Completed

A Study of the Safety, Tolerability and Pharmacokinetics of ALN-TTR02 in Japanese Healthy Volunteers

Transthyretin (TTR)-Mediated Amyloidosis

United Kingdom
Nexcella Inc.

Not yet recruiting

Study of NXC-201 CAR-T in Patients With Light Chain (AL) Amyloidosis (NEXICART-2)

Light Chain (AL) Amyloidosis

United States
Assiut University

Not yet recruiting

Validation of Different Diagnostic Modalities in the Detection of Cardiac Amyloidosis Among Patients With "Red Flags"

Cardiac Amyloidosis
Andrew Kolodziej

Recruiting

Cardiac Amyloid Biorepository (CARP)

Cardiac Amyloidosis

United States
Attralus, Inc.
Novotech (Australia) Pty Limited

Recruiting

Study of AT-02 in Healthy Volunteers and Subjects With Systemic Amyloidosis (AT02-001)

Amyloidosis; Systemic

United States, Australia
Saving Lives Matters

Recruiting

Registre HEAR, Healthcare European Amyloidosis Registry

Cardiac Amyloidosis

France
Turkish Society of Cardiology

Recruiting

Prevalence and Prognosis of Cardiac Amiloidosis in Turkey (PAPCAT)

Cardiac Amyloidosis

Turkey
Medical College of Wisconsin

Terminated

Cardiac Uptake of 18F Florbetapir in Patients Undergoing Chemotherapy

Cardiac Amyloidosis

United States
Brigham and Women's Hospital

Terminated

Imaging Cardiac Amyloidosis: A Pilot Study Using F-18 Florbetapir Positron Emission Tomography

Cardiac Amyloidosis

United States
University of Messina
Campisi Mariapaola

Unknown

Morpho-functional Cardiac Modifications in Treated Mutated Transthyretin Cardiac Amyloidosis

Cardiac Amyloidosis

Italy
Tel-Aviv Sourasky Medical Center

Unknown

Diagnosis of Cardiac Amyloidosis With 99mTc-PYP; Comparison Between Planar Imaging, SPECT/CT and Cardiac-dedicated CZT Camera

Cardiac Amyloidosis
Tel-Aviv Sourasky Medical Center

Unknown

The Potential Role of 18F-NaF PET/CT in Diagnosing Cardiac Amyloidosis

Cardiac Amyloidosis

Israel
Seoul National University Hospital
CW pharmaceutical company

Unknown

Thalidomide/Dexamethasone Treatment And PET Evaluation In Organ Involvemenet of Cardiac Amyloidosis (TaPiOCA)

Cardiac Amyloidosis

Korea, Republic of
Jin Lu, MD

Recruiting

Bortezomib, Pomalidomide, Dexamethasone For Systemic AL Amyloidosis

Systemic Amyloidosis

China
Brigham and Women's Hospital
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health... and other collaborators

Recruiting

Molecular Imaging of Primary Amyloid Cardiomyopathy (MICA)

Cardiomyopathy | Amyloidosis, Primary

United States
Virginia Commonwealth University

Not yet recruiting

Southeastern ATTR Amyloidosis Consortium: SEATTRAC Family Registry

Amyloidosis, Hereditary

United States
Oncology Institute of Southern Switzerland
University of Kiel; Ente Ospedaliero Cantonale, Bellinzona

Completed

Prevalence of Wild Type ATTR

Wild-type Transthyretin Amyloidosis

Switzerland
Attralus, Inc.
Novotech (Australia) Pty Limited

Recruiting

A Study of AT-02 in Subjects With Systemic Amyloidosis.

Amyloidosis; Systemic

United States, Australia, United Kingdom
Brigham and Women's Hospital

Recruiting

Ultrasound Therapy In Cardiac Amyloidosis (UTICA)

Amyloidosis Cardiac

United States
University of Tennessee Graduate School of Medicine

Active, not recruiting

Repeat PET/CT Imaging of Patients With Amyloid 124I-AT-01 to Measure Changes in Organ-specific Amyloid Load

Systemic Amyloidosis

United States
The Cleveland Clinic
Avid Radiopharmaceuticals

Terminated

The Role of F-18 Florbetapir in the Early Detection of Cardiac Amyloidosis

Cardiac Amyloidosis

United States
University Hospital Center of Martinique
Pfizer

Unknown

Cardiac Amyloidosis : Diagnostic Using Red Flag Signals (TEAM Red Flags)

Cardiac Amyloidosis

Guadeloupe, Martinique
University of Edinburgh

Unknown

PET/MR Imaging In Patients With Cardiac Amyloidosis

Cardiac Amyloidosis

United Kingdom
Shahid Beheshti University of Medical Sciences

Completed

Q-Switched Nd:YAG in Macular Amyloidosis

Macular Amyloidosis

Iran, Islamic Republic of
Alnylam Pharmaceuticals

Completed

Phase 2 Study to Evaluate ALN-TTRSC (Revusiran) in Patients With Transthyretin (TTR) Cardiac Amyloidosis

TTR-mediated Amyloidosis

United States, United Kingdom
Rennes University Hospital

Recruiting

Myocardial Effects in Patients With ATTRv With Polyneuropathy Treated With Patisiran or Vutrisiran (MyocardON-TTR)

Transthyretin Amyloidosis | Amyloidosis, Hereditary

France
Air Force Military Medical University, China

Not yet recruiting

Probiotic Supplementation Reduces Gastrointestinal Symptoms During the Therapy and Improves Therapeutic Response in AL Amyloidosis

Immunoglobulin Light-chain Amyloidosis
University of Pennsylvania
AstraZeneca; Ionis Pharmaceuticals, Inc.

Active, not recruiting

Early Detection of Neuropathy in ATTRv (EDONA)

Hereditary Amyloidosis, Transthyretin-Related

United States
Ionis Pharmaceuticals, Inc.

Approved for marketing

ATTR Expanded Access Program (EAP) by Ionis

Amyloidosis, Hereditary
Margarida Magalhaes-Silverman
National Cancer Institute (NCI)

Completed

Autologous Stem Cell Transplant Followed By Maintenance Therapy in Treating Elderly Patients With Multiple Myeloma

Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Primary Systemic Amyloidosis | Light Chain Deposition Disease | Extramedullary Plasmacytoma | Isolated Plasmacytoma of Bone

United States
Alnylam Pharmaceuticals

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALN-TTRSC04 in Healthy Subjects

Transthyretin-Mediated Amyloidosis

United Kingdom
IRCCS Policlinico S. Matteo

Completed

A Study of Doxycycline and Tauroursodeoxycholic Acid (Doxy/TUDCA) Plus Standard Supportive Therapy Versus Standard Supportive Therapy Alone in Cardiac Amyloidosis Caused by Transthyretin

TTR Cardiac Amyloidosis

Italy
Alnylam Pharmaceuticals

Completed

Safety and Tolerability of Patisiran (ALN-TTR02) in Transthyretin (TTR) Amyloidosis

TTR-mediated Amyloidosis

Portugal, Spain, Sweden, Brazil, United States, France, Germany
Alnylam Pharmaceuticals

Completed

A Phase 1, Single- and Multi-Dose, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered ALN-TTRSC (Revusiran) in Healthy Volunteers

TTR-mediated Amyloidosis

United Kingdom
Alnylam Pharmaceuticals

Completed

Trial to Evaluate Safety, Tolerability, and Parmacokinetics of ALN-TTR02 in Healthy Volunteer Subjects

TTR-mediated Amyloidosis

United Kingdom
Alnylam Pharmaceuticals

Completed

The Study of ALN-TTR02 (Patisiran) for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Patients Who Have Already Been Treated With ALN-TTR02 (Patisiran)

TTR-mediated Amyloidosis

Portugal, Sweden, Brazil, United States, France, Spain, Germany
Oregon Health and Science University
Attralus, Inc.

Recruiting

Characterizing Iodine-124 Evuzumitide (AT-01) in Systemic Amyloidosis

Amyloidosis | Transthyretin Amyloidosis

United States
GCS Ramsay Santé pour l'Enseignement et la Recherche

Recruiting

Analysis of the Evolution of SUVmax by Quantitative Analysis Method of Bisphosphonate Scintigraphy (QUANTI-SUV)

Cardiac Amyloidosis

France
Wuhan Union Hospital, China

Recruiting

The Diagnostic Value of Hybrid PET/MR for Systemic Amyloidosis

PET/MR | Systemic Amyloidosis

China

Clinical Trials on Primary Amyloidosis

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