Clinical Trials on Primary Bile Acid Diarrhea

Total 558 results

Imperial College Healthcare NHS Trust

Completed

Obeticholic Acid in Bile Acid Diarrhoea (OBADIAH1)

Primary Bile Acid Malabsorption | Secondary Bile Acid Malabsorption | Chronic Diarrhoea

United Kingdom
University of Manchester

Not yet recruiting

The 8x5 Diet for Bile Acid Diarrhoea: A Feasibility Randomised Controlled Trial

Bile Acid Diarrhea

United Kingdom
Michael Camilleri, MD
NGM Biopharmaceuticals, Inc

Completed

Aldafermin (NGM282) for Chronic Diarrhea Due to Bile Acid Malabsorption (BAM)

Irritable Bowel Syndrome With Diarrhea | Bile Acid Malabsorption | Chronic Diarrhea | Functional Diarrhea | Bile Acid Diarrhea | Bile Acid Malabsorption Syndrome Type II

United States
Novartis Pharmaceuticals

Completed

To Assess Safety, Tolerability and Efficacy of LJN452 in Patients With Primary Bile Acid Diarrhea.

Primary Bile Acid Diarrhea

United States, United Kingdom
Children's Hospital Medical Center, Cincinnati

Completed

GlycoCholic Acid Treatment for Patients With Inborn Errors in Bile Acid Synthesis

Bile Acid Synthesis Defect | Inborn Error of Bile Acid Metabolism | Inborn Error of Bile Acid Conjugation

United States
Mayo Clinic

Recruiting

A Study of Hemp Hull WFI for IBS Diarrhea

Irritable Bowel Syndrome-bile Acid Diarrhea

United States
Lars Kristian Munck
Pierre and Marie Curie University

Completed

Effect of the Sequestrant Colesevelam in Bile Acid Diarrhoea (SINBAD)

Bile Acid Malabsorption | Chronic Diarrhea

Denmark
Mirum Pharmaceuticals, Inc.

Completed

Open Label, Continuation Study of Cholic Acid in Subjects With Inborn Errors of Bile Acid Synthesis

Bile Acid Synthesis Defect

United States
Mayo Clinic
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Trial to Understand Efficacy of Colesevelam in Diarrhea Predominant IBS Patients With Bile Acid Malabsorption

Irritable Bowel Syndrome With Diarrhea | Bile Acid Malabsorption | Chronic Diarrhea

United States
Meir Medical Center

Unknown

A Comparison of Colonic Bile Acid Content Following Right and Left Colectomies

Colectomy | Bile Acid and Salts
Lars Kristian Munck

Completed

Validation of Stimulated ∆FGF19 for Diagnosing Bile Acid Diarrhoea (VABAD)

Bile Acid Malabsorption

Denmark
Mirum Pharmaceuticals, Inc.

Completed

Efficacy of To Be Marketed (TBM) Cholic Acid Capsules Used to Treat Children With Inborn Errors of Bile Acid Synthesis

Inborn Errors of Bile Acid Synthesis

United States
Mirum Pharmaceuticals, Inc.

Active, not recruiting

The REPLACE Registry for Cholbam® (Cholic Acid)

Bile Acid Synthesis Disorders

United States
Filip Krag Knop
University of Copenhagen

Completed

The Impact of Gall Bladder Emptying and Bile Acids on the Human GLP-1-secretion

To Assess the Impact of Bile Acids on Human Glukagon-like-peptide-1 Secretion

Denmark
University of Sao Paulo General Hospital

Completed

Development of Ursodeoxycholic Acid 300 mg at Hospital Das Clinicas of the University of São Paulo School of Medicine

Primary Biliary Cirrhosis | Ursodeoxycholic Acid

Brazil
Filip Krag Knop
Herlev and Gentofte Hospital

Completed

Treatment of Bile Acid Malabsorption With Liraglutide (BAM-LIRA)

Bile Acid Malabsorption

Denmark
Albireo

Completed

Double-blind, Randomised Study of A3384 in BAM/BAD

Bile Acid Malabsorption

Sweden, United Kingdom
University of Aarhus

Recruiting

sCD163 in PBC Patients - Assessment of Treatment Response

Liver Inflammation | Primary Biliary Cirrhosis | Ursodeoxycholic Acid

Denmark
Mayo Clinic
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National...

Completed

A Study of Colesevelam in Fecal Incontinence

Fecal Incontinence | Bile Acid Malabsorption

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

CPI-613 in Treating Patients With Advanced or Metastatic Bile Duct Cancer That Cannot Be Removed By Surgery

Advanced Adult Primary Liver Cancer | Localized Unresectable Adult Primary Liver Cancer | Recurrent Adult Primary Liver Cancer | Recurrent Extrahepatic Bile Duct Cancer | Unresectable Extrahepatic Bile Duct Cancer | Cholangiocarcinoma of the Extrahepatic Bile Duct | Cholangiocarcinoma of the Gallbladder and other conditions

United States
National Cancer Institute (NCI)

Terminated

BMS-247550 in Treating Patients With Liver or Gallbladder Cancer

Advanced Adult Primary Liver Cancer | Localized Extrahepatic Bile Duct Cancer | Localized Gallbladder Cancer | Localized Resectable Adult Primary Liver Cancer | Localized Unresectable Adult Primary Liver Cancer | Recurrent Adult Primary Liver Cancer | Recurrent Extrahepatic Bile Duct Cancer | Recurrent... and other conditions

United States
Universitair Ziekenhuis Brussel

Unknown

Resolving Bile Reflux by Lanreotide in Patients With Roux-en-Y Gastrojejunostomy

Acid Reflux Esophagitis | Non-acid Reflux Esophagitis

Belgium
Florian Beigel

Terminated

Colesevelam for the Treatment of Bile Acid Malabsorption in Patients With Crohn's Disease (COBAM)

Crohns Disease | Bile Acid Malabsorption

Germany
Fox Chase Cancer Center

Completed

PET-CT in Determining the Radioembolization Dose Delivered to Patients With Liver Metastasis, Primary Liver Cancer, or Biliary Cancer

Unspecified Adult Solid Tumor, Protocol Specific | Advanced Adult Primary Liver Cancer | Recurrent Adult Primary Liver Cancer | Recurrent Extrahepatic Bile Duct Cancer | Adult Primary Hepatocellular Carcinoma | Metastatic Extrahepatic Bile Duct Cancer | Stage D Adult Primary Liver Cancer (BCLC)

United States
National Cancer Institute (NCI)

Completed

Erlotinib in Treating Patients With Unresectable Liver, Bile Duct, or Gallbladder Cancer

Advanced Adult Primary Liver Cancer | Localized Unresectable Adult Primary Liver Cancer | Recurrent Adult Primary Liver Cancer | Recurrent Extrahepatic Bile Duct Cancer | Recurrent Gallbladder Cancer | Unresectable Extrahepatic Bile Duct Cancer | Unresectable Gallbladder Cancer | Adult Primary Hepatocellular... and other conditions

United States
Zealand University Hospital

Completed

Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy (BACH)

Cholelithiasis | Bile Acid Malabsorption

Denmark
National Cancer Institute (NCI)

Completed

Lapatinib in Treating Patients With Locally Advanced or Metastatic Biliary Tract or Liver Cancer That Cannot Be Removed By Surgery

Advanced Adult Primary Liver Cancer | Localized Unresectable Adult Primary Liver Cancer | Recurrent Adult Primary Liver Cancer | Recurrent Extrahepatic Bile Duct Cancer | Recurrent Gallbladder Cancer | Unresectable Extrahepatic Bile Duct Cancer | Unresectable Gallbladder Cancer | Adult Primary Hepatocellular...

United States
National Cancer Institute (NCI)

Completed

Lapatinib Ditosylate in Treating Patients With Unresectable Liver or Biliary Tract Cancer

Advanced Adult Primary Liver Cancer | Localized Unresectable Adult Primary Liver Cancer | Recurrent Adult Primary Liver Cancer | Recurrent Extrahepatic Bile Duct Cancer | Recurrent Gallbladder Cancer | Unresectable Extrahepatic Bile Duct Cancer | Unresectable Gallbladder Cancer | Adult Primary Hepatocellular...

United States
National Cancer Institute (NCI)

Terminated

Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary Cancers

Advanced Adult Primary Liver Cancer | Localized Unresectable Adult Primary Liver Cancer | Recurrent Adult Primary Liver Cancer | Recurrent Extrahepatic Bile Duct Cancer | Recurrent Gallbladder Cancer | Unresectable Extrahepatic Bile Duct Cancer | Unresectable Gallbladder Cancer | Cholangiocarcinoma... and other conditions

United States
Fresenius Kabi

Withdrawn

Safety of Omegaven in Pediatric Patients With Parenteral Nutrition-Associated Cholestasis (PNAC)

Malnutrition | Pediatric ALL | Neurocognitive Deficit | Parenteral Nutrition Associated Liver Disease | Essential Fatty Acid Deficiency
National Cancer Institute (NCI)

Terminated

Bortezomib in Treating Patients With Unresectable Locally Advanced or Metastatic Adenocarcinoma of the Bile Duct or Gallbladder

Gastrointestinal Cancer | Advanced Adult Primary Liver Cancer | Localized Unresectable Adult Primary Liver Cancer | Recurrent Adult Primary Liver Cancer | Recurrent Extrahepatic Bile Duct Cancer | Recurrent Gallbladder Cancer | Unresectable Extrahepatic Bile Duct Cancer | Unresectable Gallbladder... and other conditions

United States
Innovative Digestive Health Education and Research...
NinePoint Medical

Unknown

Volumetric Laser Endomicroscopy's (VLE) Diagnostic Accuracy Validation Study: Impact on Clinical Management Study (VLE-IOV)

Cholangiocarcinoma | Bile Duct Cancer | Primary Sclerosing Cholangitis | Bile Duct Diseases | Pancreatic Ductal Adenocarcinoma | Pancreas Cancer | Bile Duct Neoplasms | Biliary Stricture | Bile Duct Obstruction | Bile Duct Obstruction, Extrahepatic | Pancreatic Duct Stricture | Bile Duct Lesions | Bile Duct Neoplasms... and other conditions

United States
National Cancer Institute (NCI)

Withdrawn

Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced Gallbladder or Bile Duct Cancer That Cannot Be Removed By Surgery

Advanced Adult Primary Liver Cancer | Localized Unresectable Adult Primary Liver Cancer | Recurrent Adult Primary Liver Cancer | Recurrent Extrahepatic Bile Duct Cancer | Unresectable Extrahepatic Bile Duct Cancer | Stage II Gallbladder Cancer | Stage IIIA Gallbladder Cancer | Stage IIIB Gallbladder... and other conditions
University of Milano Bicocca
Genetic s.p.a.

Recruiting

Vancomycin in Primary Sclerosing Cholangitis in Italy (VanC-IT)

Primary Sclerosing Cholangitis | IBD | Liver and Intrahepatic Bile Duct Disorder

Italy
Montana State University

Recruiting

Impact of Foods on Bile Acids, Metabolites, and Inflammation

Inflammation | Hyperlipidemias | Hypertriglyceridemia | Metabolic Disease | Bile Acid Malabsorption | Lipid Metabolism Disorder

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Contrast-enhanced MRI in Detecting Benign and Malignant Liver Lesions

Hepatocellular Carcinoma | Liver and Intrahepatic Bile Duct Disorder | Metastatic Malignant Neoplasm in the Liver | Primary Malignant Liver Neoplasm

United States
HighTide Biopharma Pty Ltd

Completed

Open-Label Study of HTD1801 in Adult Subjects With Primary Biliary Cholangitis (PRONTO-PBC)

Biliary Tract Diseases | Cholangitis | Cholestasis | Primary Biliary Cholangitis | Primary Biliary Cirrhosis | Bile Duct Stricture

United States
Makerere University
Radboud University Medical Center; University of Bergen

Active, not recruiting

Early Versus Late BCG Vaccination in HIV-1 Exposed Infants in Uganda in Uganda

Diarrhoea | Septicaemia | Severe Illness | Lower Respiratory Infection

Uganda
National Institute on Alcohol Abuse and Alcoholism...

Completed

Activity of Essential Fatty Acid Elongation/Desaturation Pathway During Early Life in Human Infants, In Vivo

Fatty Acid Metabolism

Chile
Aalborg University Hospital

Recruiting

Radiation-induced Diarrhoea During Curative EBRT of Prostate and Rectal Cancer (PRECANU)

Radiation-induced Diarrhoea in Prostate and Rectal Cancer

Denmark
Medical University of Warsaw
National Science Centre, Poland

Recruiting

S-adenosylmethionine (SAMe) in Patients With Primary Sclerosing Cholangitis (PSC)

Primary Sclerosing Cholangitis (PSC)

Poland
Mayo Clinic

Active, not recruiting

Genomics of Primary Sclerosing Cholangitis (PSC)

Primary Sclerosing Cholangitis (PSC)

United States
Cascade Pharmaceuticals, Inc
Covance

Completed

Study in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of CS0159

Primary Sclerosing Cholangitis (PSC)

United States
HighTide Biopharma Pty Ltd

Completed

A POC and Dose-Ranging Study of HTD1801 in PSC Patients

Primary Sclerosing Cholangitis (PSC)

United States, Canada
Intercept Pharmaceuticals

Completed

Obeticholic Acid (OCA) in Primary Sclerosing Cholangitis (PSC) (AESOP)

Primary Sclerosing Cholangitis (PSC)

United States, Italy
Mirum Pharmaceuticals, Inc.

Completed

Open Label Study to Evaluate Safety and Efficacy of LUM001 in Patients With Primary Sclerosing Cholangitis (CAMEO)

Primary Sclerosing Cholangitis (PSC)

United States, United Kingdom, Canada
Mayo Clinic

Completed

A Pilot Study of Xifaxan to Treat Patients With PSC (PSC)

Primary Sclerosing Cholangitis (PSC)

United States
Institut Pasteur
University of Copenhagen; Institut Cochin

Recruiting

Study on the Association Between Vitamin C Deficiency and Diarrhea in Children (VITAL)

Diarrhea | Infantile

France, Central African Republic, New Caledonia
University of Minnesota

Recruiting

Evaluation of an Oral Microbiota-based Therapeutic as a Treatment Option for PSC

Primary Sclerosing Cholangitis

United States
Galmed Research and Development, Ltd.
Virginia Commonwealth University

Not yet recruiting

A Study Evaluating the Safety, Tolerability, and Efficacy of Aramchol Meglumine in Primary Sclerosing Cholangitis

Primary Sclerosing Cholangitis

Clinical Trials on Primary Bile Acid Diarrhea

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Bahamas

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Drug Interventions

Dietary Supplements

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