Clinical Trials on Rhabdoid Tumor Predisposition Syndrome

Total 792 results

St. Jude Children's Research Hospital
Millennium Pharmaceuticals, Inc.; Takeda Pharmaceuticals U.S.A., Inc.

Active, not recruiting

Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors (SJATRT)

Malignant Rhabdoid Tumor | Atypical Teratoid Rhabdoid Tumor

United States
Australian & New Zealand Children's Haematology...
National Health and Medical Research Council, Australia; Secura Bio, Inc.

Terminated

A Study of Panobinostat in Pediatric Patients With Solid Tumors Including MRT/ATRT (NORTH)

Rhabdoid Tumor | Atypical Teratoid/Rhabdoid Tumor | Malignant Rhabdoid Tumor | Recurrent Brain Tumor, Childhood

Australia, New Zealand, United States
St. Jude Children's Research Hospital

Withdrawn

Trial of Idasanutlin and Selinexor Therapy for Children With Progressive/Relapsed AT/RT or Extra-CNS Malignant Rhabdoid Tumors

Rhabdoid Tumor | CNS Tumor | Atypical Teratoid/Rhabdoid Tumor | Atypical Teratoid/Rhabdoid Tumor of CNS

United States
University Hospital Tuebingen

Recruiting

Diagnostic Value of Exome/ Genome Sequencing, Conventional Methods in Rare Diseases and Familial Tumor Syndromes (EXGEFATU)

Rare Diseases | Genetic Predisposition

Germany
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Combination Chemotherapy, Radiation Therapy, and an Autologous Peripheral Blood Stem Cell Transplant in Treating Young Patients With Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System

Childhood Atypical Teratoid/Rhabdoid Tumor

United States, Canada, Australia
Susan Chi, MD
Bristol-Myers Squibb; Epizyme, Inc.

Recruiting

Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors

Chordoma | Epithelioid Sarcoma | Atypical Teratoid Rhabdoid Tumor | INI1 (SMARCB1)-Deficient Primary CNS Malignant Tumors | SMARCA4-deficient Primary CNS Malignant Tumors | Malignant Rhabdoid Tumor (MRT) | Rhabdoid Tumor of the Kidney (RTK)

United States
Giselle Sholler
K C Pharmaceuticals Inc.; USWM, LLC

Available

An Intermediate Expanded Use Trial of DFMO

Embryonal Tumor With Abundant Neuropil and True Rosettes | Medulloblastoma | Neuroblastoma | Medulloepithelioma | Ependymoblastoma | Typical Teratoid Rhabdoid Tumor

United States
Novartis Pharmaceuticals

Terminated

Study of Safety and Efficacy in Patients With Malignant Rhabdoid Tumors (MRT) and Neuroblastoma

Neuroblastoma | Malignant Rhabdoid Tumors (MRT)

France, Germany, United Kingdom, United States, Australia
National Cancer Institute (NCI)

Recruiting

Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

Malignant Solid Neoplasm | Rhabdoid Tumor | Refractory Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Recurrent Rhabdoid Tumor | Refractory Rhabdoid Tumor | Epithelioid Sarcoma | Kidney Medullary Carcinoma | Atypical Teratoid/Rhabdoid Tumor | Poorly Differentiated Chordoma | Recurrent Atypical... and other conditions

United States, Australia, Canada
Dana-Farber Cancer Institute
Gateway for Cancer Research

Recruiting

Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

Epithelioid Sarcoma | Atypical Teratoid/Rhabdoid Tumor | Malignant Rhabdoid Tumor | Rhabdoid Tumor of the Kidney | Chordoma (Poorly Differentiated or De-differentiated) | Other INI1 Negative Tumors (With PI Approval) | Other SMARCA4-deficient Malignant Tumors (With PI Approval)

United States
Epizyme, Inc.

Active, not recruiting

A Study of Tazemetostat in Adult Participants With Soft Tissue Sarcoma

Synovial Sarcoma | Epithelioid Sarcoma | Renal Medullary Carcinoma | Malignant Rhabdoid Tumors (MRT) | Rhabdoid Tumors of the Kidney (RTK) | Atypical Teratoid Rhabdoid Tumors (ATRT) | Selected Tumors With Rhabdoid Features | INI1-negative Tumors | Malignant Rhabdoid Tumor of Ovary | Poorly Differentiated... and other conditions

France, United States, Australia, Taiwan, Belgium, United Kingdom, Canada, Germany, Italy
Children's Oncology Group
National Cancer Institute (NCI)

Withdrawn

Biomarker Study in Samples From Patients With Malignant Rhabdoid Tumor of the Kidney or Atypical Teratoid Rhabdoid Tumor

Childhood Atypical Teratoid/Rhabdoid Tumor | Rhabdoid Tumor of the Kidney

United States
National Cancer Institute (NCI)

Recruiting

Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

Mesothelioma | Familial Cancer | BRCA1-Associated Protein-1 (BAP1) Mutations | Tumor Predisposition Syndrome (TPDS)

United States
Children's Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Combination Chemotherapy and Surgery in Treating Young Patients With Wilms Tumor

Stage I Kidney Wilms Tumor | Stage II Kidney Wilms Tumor | Stage III Kidney Wilms Tumor | Stage IV Kidney Wilms Tumor | Adult Kidney Wilms Tumor | Beckwith-Wiedemann Syndrome | Childhood Kidney Wilms Tumor | Diffuse Hyperplastic Perilobar Nephroblastomatosis | Rhabdoid Tumor of the Kidney | Stage V Kidney...

United States, Canada, Australia, New Zealand, Puerto Rico, Israel
Burzynski Research Institute

Terminated

Antineoplaston Therapy in Treating Children With Rhabdoid Tumor of the Central Nervous System

Rhabdoid Neoplasm of CNS

United States
Epizyme, Inc.

Completed

A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma

Synovial Sarcoma | INI1-negative Tumors | Malignant Rhabdoid Tumor of Ovary | Rhabdoid Tumors

United States, France, Canada, Italy, Germany, United Kingdom, Australia, Denmark, Netherlands
Seattle Children's Hospital

Active, not recruiting

HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

Glioma | Ependymoma | Medulloblastoma | Pineoblastoma | Central Nervous System Tumor, Pediatric | Germ Cell Tumor | Atypical Teratoid/Rhabdoid Tumor | Primitive Neuroectodermal Tumor | Choroid Plexus Carcinoma

United States
Seattle Children's Hospital

Active, not recruiting

EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors

Glioma | Ependymoma | Medulloblastoma | Pineoblastoma | Central Nervous System Tumor, Pediatric | Germ Cell Tumor | Atypical Teratoid/Rhabdoid Tumor | Primitive Neuroectodermal Tumor | Choroid Plexus Carcinoma

United States
Seattle Children's Hospital

Recruiting

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

Glioma | Ependymoma | Medulloblastoma, Childhood | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma | Central Nervous System Tumor | Germ Cell Tumor | Atypical Teratoid/Rhabdoid Tumor | Primitive Neuroectodermal Tumor | Choroid Plexus Carcinoma | Pineoblastoma, Childhood

United States
University of Pittsburgh

Recruiting

Molecular Basis of Pediatric Liver Cancer

Hepatocellular Carcinoma | Hepatoblastoma | Rhabdoid Tumor of Liver | Childhood Liver Cancer | Liver Malignant Tumors | Embryonal Sarcoma of Liver (Disorder)

United States
Dana-Farber Cancer Institute
National Cancer Institute (NCI)

Completed

Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT

Central Nervous System Tumor, Pediatric

United States
St. Jude Children's Research Hospital

Completed

Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

Brain and Central Nervous System Tumors

United States, Australia, Canada
Sabine Mueller, MD, PhD
Mayo Clinic; Vyriad, Inc.; No More Kids With Cancer; The Matthew Larson Foundation...

Completed

Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT

Medulloblastoma Recurrent | Atypical Teratoid/Rhabdoid Tumor | Medulloblastoma, Childhood, Recurrent

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Biomarkers in Tissue Samples From Patients With High-Risk Wilms Tumor

Clear Cell Sarcoma of the Kidney | Recurrent Wilms Tumor and Other Childhood Kidney Tumors | Stage III Wilms Tumor | Rhabdoid Tumor of the Kidney | Stage IV Wilms Tumor | Stage V Wilms Tumor | Stage I Wilms Tumor | Stage II Wilms Tumor

United States
M.D. Anderson Cancer Center

Withdrawn

Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain Cancer

Malignant Glioma | Medulloblastoma | Anaplastic Ependymoma | Recurrent Malignant Glioma | Recurrent Medulloblastoma | Atypical Teratoid/Rhabdoid Tumor | Primitive Neuroectodermal Tumor | Choroid Plexus Carcinoma | Recurrent Atypical Teratoid/Rhabdoid Tumor | Malignant Brain Neoplasm | Central Nervous System... and other conditions

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

Brain and Central Nervous System Tumors

United States
St. Jude Children's Research Hospital

Recruiting

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

Glioblastoma | Central Nervous System Neoplasms | High Grade Glioma | Ependymoma | Medulloblastoma | Diffuse Midline Glioma, H3 K27M-Mutant | Atypical Teratoid/Rhabdoid Tumor

United States
St. Jude Children's Research Hospital
Pfizer; Ipsen

Recruiting

Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma

Refractory Malignant Solid Neoplasm | Recurrent Ewing Sarcoma | Recurrent Hepatoblastoma | Recurrent Malignant Germ Cell Tumor | Recurrent Malignant Solid Neoplasm | Recurrent Neuroblastoma | Recurrent Osteosarcoma | Recurrent Peripheral Primitive Neuroectodermal Tumor | Recurrent Rhabdoid Tumor | Recurrent... and other conditions

United States, Canada
Nemours Children's Clinic
Alfred I. duPont Hospital for Children

Recruiting

Yttrium-90 (TARE-Y90) in Children, Adolescents, and Young Adults With Liver Tumors

Hepatocellular Carcinoma | Hepatoblastoma | Liver Tumors | Rhabdoid Tumor of Liver | Undifferentiated (Embryonal) Sarcoma of the Liver | Pediatric Liver Cancer

United States
Masonic Cancer Center, University of Minnesota

Completed

Auto Transplant for High Risk or Relapsed Solid or CNS Tumors

Soft Tissue Sarcoma | Medulloblastoma | Retinoblastoma | Rhabdomyosarcoma | Hepatoblastoma | Primary Malignant Brain Neoplasms | CNS Tumors | Germ Cell Tumors | Ewing's Family Tumors | Renal Tumors | Supra-tentorial Primative Neuro-Ectodermal Tumor (PNET) | Atypical Teratoid/Rhabdoid Tumor (AT/RT)

United States
Nicklaus Children's Hospital f/k/a Miami Children...

Terminated

Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors

Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Childhood Atypical Teratoid/Rhabdoid Tumor | Embryonal Tumor With Abundant Neuropil and True Rosettes | Metastatic Malignant Neoplasm to the Leptomeninges

United States
Istari Oncology, Inc.
Duke University; Solving Kids' Cancer; The Andrew McDonough B+ Foundation

Completed

Phase 1b Study PVSRIPO for Recurrent Malignant Glioma in Children

Glioblastoma | Malignant Glioma | Gliosarcoma | Ependymoma | Medulloblastoma | Anaplastic Oligoastrocytoma | Anaplastic Astrocytoma | Anaplastic Oligodendroglioma | Atypical Teratoid/Rhabdoid Tumor of Brain | Pleomorphic Xanthoastrocytoma of Brain | Embryonal Tumor of Brain

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); Memorial Sloan Kettering Cancer Center; American...

Active, not recruiting

Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors

Glioblastoma Multiforme | Medulloblastoma | Low-Grade Astrocytoma, Nos | Anaplastic Astrocytoma | Anaplastic Oligodendroglioma | Pilocytic Astrocytoma | Pineoblastoma | Supratentorial Primitive Neuroectodermal Tumor | Atypical Teratoid/Rhabdoid Tumor | Choroid Plexus Carcinoma | High-grade Astrocytoma NOS | CNS... and other conditions

United States
Emory University
Children's Healthcare of Atlanta

Completed

Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors (Aflac ST0901)

Glioma | Renal Cell Carcinoma | Astrocytoma | Osteosarcoma | Ependymoma | Medulloblastoma | Rhabdoid Tumor | Neuroblastoma | Retinoblastoma | Rhabdomyosarcoma | Wilms Tumor | Hepatoblastoma | Germ Cell Tumor | Atypical Teratoid/Rhabdoid Tumor | Clear Cell Sarcoma | Ewing's Sarcoma

United States
St. Jude Children's Research Hospital

Recruiting

Familial Investigations of Childhood Cancer Predisposition (SJFAMILY)

Pancreatic Cancer | Hodgkin Lymphoma | Lynch Syndrome | Tuberous Sclerosis | Fanconi Anemia | AML | Non Hodgkin Lymphoma | Familial Adenomatous Polyposis | Acute Leukemia | Nevoid Basal Cell Carcinoma Syndrome | Neurofibromatosis Type 1 | Neuroblastoma | Retinoblastoma | MDS | Rhabdomyosarcoma | Von Hippel-Lindau Disease | Adrenocortical Carcinoma and other conditions

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors

Malignant Glioma | Recurrent Childhood Ependymoma | Recurrent Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Recurrent Atypical Teratoid/Rhabdoid Tumor | Refractory Diffuse Intrinsic Pontine Glioma | CNS Embryonal Tumor, Not Otherwise Specified

United States
Rabin Medical Center

Unknown

Prostate Cancer Screening Among Men With High Risk Genetic Predisposition

Lynch Syndrome | BRCA1 Syndrome | BRCA2 Syndrome

Israel
Baylor College of Medicine
Center for Cell and Gene Therapy, Baylor College of Medicine

Recruiting

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

Liposarcoma | Liver Cancer | Rhabdomyosarcoma | Wilms Tumor | Malignant Rhabdoid Tumor | Yolk Sac Tumor

United States
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France; ANSES

Not yet recruiting

Impact of Environmental Exposures on Tumor Risk in Subjects at Risk of Hereditary SDHx Paraganglioma (PGL-EXPO-1)

Environmental Exposure | Genetic Predisposition | SDH Gene Mutation
National Cancer Institute (NCI)

Recruiting

Collection of Blood From Patients With Cancer, Other Tumors, or Tumor Predisposition Syndromes for Genetic Analysis

Lymphoma | Breast Cancer | Ovarian Cancer | Lung Cancer | Prostate Cancer

United States
Baylor College of Medicine
Center for Cell and Gene Therapy, Baylor College of Medicine

Not yet recruiting

Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

Liposarcoma | Liver Cancer | Rhabdomyosarcoma | Wilms Tumor | Malignant Rhabdoid Tumor | Yolk Sac Tumor

United States
National Cancer Institute (NCI)

Active, not recruiting

Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial

Malignant Solid Neoplasm | Recurrent Melanoma | Recurrent Ependymoma | Recurrent Ewing Sarcoma | Recurrent Hepatoblastoma | Recurrent Langerhans Cell Histiocytosis | Recurrent Malignant Germ Cell Tumor | Recurrent Malignant Glioma | Recurrent Medulloblastoma | Recurrent Neuroblastoma | Recurrent Non-Hodgkin... and other conditions

United States, Puerto Rico
Mayo Clinic
National Cancer Institute (NCI)

Completed

Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors

Glioma | Recurrent Childhood Medulloblastoma | Childhood Atypical Teratoid/Rhabdoid Tumor | Diffuse Intrinsic Pontine Glioma | Refractory Brain Neoplasm | Recurrent Childhood Anaplastic Oligodendroglioma | Recurrent Childhood Glioblastoma | Recurrent Primitive Neuroectodermal Tumor | Childhood Astrocytoma and other conditions

United States
Baylor College of Medicine
Center for Cell and Gene Therapy, Baylor College of Medicine

Not yet recruiting

Immunotherapy For Adults With GPC3-Positive Solid Tumors Using IL-15 and IL-21 Armored GPC3-CAR T Cells

Hepatocellular Carcinoma | Liposarcoma | Rhabdomyosarcoma | Wilms Tumor | Hepatoblastoma | Malignant Rhabdoid Tumor | Yolk Sac Tumor | Embryonal Sarcoma of Liver

United States
University Hospital, Clermont-Ferrand

Completed

Analysis of the Postprandial Effects of a Vegetable Protein Mixture Rich in Arginine, Cysteine and Leucine on Endothelial Dysfunction and Inflammation at Low Noise in Elderly People With Cardiometabolic Risk (P-PROBS CM)

Metabolic Syndrome | Predisposition to Cardiovascular Disease

France
Giselle Sholler
Translational Genomics Research Institute; Dell, Inc.

Completed

Molecular-Guided Therapy for Childhood Cancer

Glioma | Renal Cell Carcinoma | Osteosarcoma | Ependymoma | Medulloblastoma | Neuroblastoma | Meningioma | Craniopharyngioma | Choroid Plexus Neoplasms | Rhabdomyosarcoma | Wilms Tumor | Ewings Sarcoma | Malignant Rhabdoid Tumor | Liver Tumors | Germ Cell Tumors | Dysembryoplastic Neuroepithelial Tumor | Clear Cell Sarcoma | ... and other conditions

United States, Lebanon
Emory University

Completed

Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors (AflacST1501)

Diffuse Intrinsic Pontine Glioma | Brain Tumor, Recurrent | Solid Tumor, Recurrent | Neuroblastoma, Recurrent, Refractory | Ewing Sarcoma, Recurrent, Refractory | Rhabdomyosarcoma, Recurrent, Refractory | Osteosarcoma, Recurrent, Refractory | Rhabdoid Tumor, Recurrent, Refractory

United States
Sydney Children's Hospitals Network
Children's Cancer Institute Australia

Recruiting

Cancer Predisposition Testing by Family-based Whole-genome Sequencing (WGS) in Every Child With Newly Diagnosed Cancer (PREDICT)

Cancer | Neoplastic Syndromes, Hereditary | Genetic Predisposition to Disease

Australia
St. Jude Children's Research Hospital

Recruiting

Study of Stored Tumor Samples in Young Patients With Brain Tumors

Brain and Central Nervous System Tumors

United States
Chimerix
National Institutes of Health (NIH)

Recruiting

Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

Glioblastoma | Neuroectodermal Tumors | Neuroectodermal Tumors, Primitive | Central Nervous System Neoplasms | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Pleomorphic Xanthoastrocytoma | Pleomorphic Xanthoastrocytoma | Oligodendroglioma | Choroid Plexus Neoplasms | Diffuse Astrocytoma | Anaplastic... and other conditions

United States

Clinical Trials on Rhabdoid Tumor Predisposition Syndrome

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