Clinical Trials on Severe Covid-19

Total 11490 results

Novartis Pharmaceuticals
Novartis is the Marketing Authorization Holder for Jakavi outside the US.

No longer available

Ruxolitinib Managed Access Program (MAP) for Patients Diagnosed With Severe/Very Severe COVID-19 Illness

Severe/Very Severe COVID-19 Illness
Ministry of Health, Kuwait

Unknown

COVID-19 Convalescent Plasma Treatment in SARS-CoV-2 Infected Patients

Pneumonia, Viral | Moderate COVID-19 Pneumonia, Severe COVID-19 Pneumonia

Kuwait
Hospices Civils de Lyon

Unknown

Senior-COVID-Rea Multicentric Survey (SeniorCOVIDRea)

COVID-19 Disease, Severe Form

France
Centre Hospitalier Universitaire Dijon

Completed

Lipid Metabolism in COVID-19 Severe Pneumonia Compared With Severe Pneumonia Caused by Other Pathogen (COVIDOLIP)

COVID-19 Severe Pneumonia | Severe Pneumonia Due to Other Pathogene

France
60P Australia Pty Ltd

Not yet recruiting

A Clinical Evaluation of the Safety and Efficacy of Randomized Placebo Versus the 8-aminoquinoline Tafenoquine for Early Symptom Resolution in Patients With Mild to Moderate COVID 19 Disease and Low Risk of Disease Progression

Infectious Disease | SARS-CoV-2 | Severe Acute Respiratory Syndrome Coronavirus 2 | COVID 19 Disease | Mild to Moderate COVID 19 Disease
University of Giessen

Completed

GM-CSF Inhalation to Prevent ARDS in COVID-19 Pneumonia (GI-COVID)

COVID-19 Pneumonia | Severe Acute Respiratory Syndrome (SARS) Pneumonia

Germany
ANRS, Emerging Infectious Diseases
University of Bordeaux; PACCI Program

Unknown

Combination Therapies to Reduce Carriage of SARS-Cov-2 and Improve Outcome of COVID-19 in Ivory Coast: a Phase Randomized IIb Trial (INTENSE-COV)

COVID-19 | Severe Acute Respiratory Syndrome Coronavirus 2 | COVID-19 Drug Treatment

Côte D'Ivoire
George Papanicolaou Hospital
General Hospital Of Thessaloniki Ippokratio

Recruiting

Generation of SARS-CoV-2-specific T Lymphocytes From Recovered Donors and Administration to High-risk COVID-19 Patients (CoV-2-STs)

Severe COVID-19

Greece
Brno University Hospital

Recruiting

Corticosteroids in Severe COVID-19(ASAP-C Study) (ASAP-C)

Severe COVID-19

Czechia
Daewoong Pharmaceutical Co. LTD.

Terminated

Efficacy and Safety of DWJ1248 With Remdesivir in Severe COVID-19 Patients

Severe COVID-19

Korea, Republic of
Brno University Hospital
European Society of Intensive Care Medicine; European Society of Anaesthesiology...

Completed

Corticosteroids in Severe COVID-19 (ASAP-ESICM/ESAIC Study) (ASAPESICMESAIC)

Severe COVID-19

Czechia
Hospital San Carlos, Madrid

Completed

Safety and Efficacy of Medications COVID-19

Severe Covid-19

Spain
Assistance Publique - Hôpitaux de Paris

Completed

ANTIcoagulation in Severe COVID-19 Patients (ANTICOVID)

Severe COVID-19 Pneumonia

France
Wuhan Central Hospital

Enrolling by invitation

Risk Identification of Long-term Complications

Severe COVID-19

China
InflaRx GmbH

Completed

Randomized, Controlled Study of IFX-1 in Patients With Severe COVID-19 Pneumonia (PANAMO)

Severe COVID-19 Pneumonia

Belgium, Brazil, France, Germany, Mexico, Netherlands, Peru, Russian Federation, South Africa
Vascular Biogenics Ltd. operating as VBL Therapeutics

Completed

A Study to Evaluate the Efficacy and Safety of VB-201 in Patients With COVID-19

Severe COVID-19

Israel
Hopital of Melun

Completed

Plasma SARS-CoV-2 RNA Levels in Critically Ill COVID-19 Patients (pRNA-COVID-ICU)

COVID-19 Pneumonia | ARDS Due to Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2

France
Xijing Hospital
Massachusetts General Hospital; Fondazione IRCCS Ca' Granda, Ospedale Maggiore...

Withdrawn

Nitric Oxide Gas Inhalation for Severe Acute Respiratory Syndrome in COVID-19. (NOSARSCOVID)

SARS (Severe Acute Respiratory Syndrome) | Coronavirus Covid-19 Infection Variant Omicron
Second Affiliated Hospital, School of Medicine,...

Active, not recruiting

Comparative Analysis of Clinical Parameters and Radiographic Changes of Severe COVID-19

Severe COVID-19

China
University of Erlangen-Nürnberg Medical School

Unknown

Assessment of Efficacy and Safety of Therapy With COVID-19 Convalescent Plasma in Subjects With Severe COVID-19 (IPCO) (IPCO)

Severe COVID-19

Germany
Inovio Pharmaceuticals
Advaccine (Suzhou) Biopharmaceuticals Co., Ltd.

Terminated

Safety, Immunogenicity, and Efficacy of INO-4800 for COVID-19 in Adults at High Risk of SARS-CoV-2 Exposure

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) | Coronavirus Infection | COVID-19 Disease

United States, Mexico, Colombia
National Institute of Allergy and Infectious Diseases...
PPD; University of Washington; Vanderbilt University Medical Center; Implicit Bioscience

Terminated

COVID-19 and Anti-CD14 Treatment Trial (CaTT)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) | Coronavirus Disease 2019 (COVID-19)

United States
Emory University
National Cancer Institute (NCI)

Terminated

Radiation Eliminates Storming Cytokines and Unchecked Edema as a 1-Day Treatment for COVID-19 (RESCUE 1-19)

Pneumonia | Coronavirus Infection in 2019 (COVID-19) | Severe Acute Respiratory Syndrome (SARS) Pneumonia

United States
Asan Medical Center

Suspended

Fluvoxamine for Adults With Mild to Moderate COVID-19

Coronavirus Infection | Severe Acute Respiratory Syndrome Coronavirus 2 | Mild to Moderate COVID-19

Korea, Republic of
Bangabandhu Sheikh Mujib Medical University, Dhaka...
Anwar Khan Mordern Medical College and Hospital, Dhaka; Mugda Medical College...

Unknown

Role of Co-trimoxazole in Severe COVID-19 Patients

Covid19 | Severe COVID-19 Patients

Bangladesh
University Hospital, Lille

Recruiting

COVID-19 and VA-LRTI: Second Versus First Wave of the Pandemic (CoVAPid2)

Severe COVID-19

France
Hospital Central Militar

Completed

Study on the Safety and Efficacy of Convalescent Plasma in Patients With Severe COVID-19 Disease (PC-COVID-HCM)

Severe COVID-19 Disease

Mexico
Hospital Italiano de Buenos Aires

Recruiting

Safety and Effectiveness Study of Tocilizumab in Patients With Severe COVID-19

Tocilizumab | Severe COVID 19 Pneumonia

Argentina
Shanghai Vinnerna Biosciences Co., Ltd.
Sponsor GmbH

Terminated

Efficacy and Safety of JT001 (VV116) Compared With Favipiravir

Moderate to Severe COVID-19

China, Uzbekistan
Noblewell
Medical Research Agency, Poland; Leszek Giec Upper-Silesian Medical Centre...

Terminated

Efficacy of Amantadine Treatment in COVID-19 Patients (TITAN)

Patients With Moderate or Severe COVID-19

Poland
Grand Medical Pty Ltd.
Trium Clinical Consulting

Completed

A Study to Evaluate the Safety and Effect of STC3141 Continuous Infusion in Subjects With Severe Corona Virus Disease 2019（COVID-19）Pneumonia

Severe COVID-19 Pneumonia

Belgium
Federico II University

Completed

COVID-19 Pandemic Burden in Severe Mental Disease Patients (PsyCOVID)

COVID | Psychological Distress | Severe Mental Disorder

Italy
Shahid Beheshti University of Medical Sciences

Unknown

Low Dose Radiotherapy in COVID-19 Pneumonia

COVID | SARS (Severe Acute Respiratory Syndrome)

Iran, Islamic Republic of
Ottawa Hospital Research Institute

Unknown

Supporting Family Members With Severe Grief Reaction During the COVID-19 Pandemic

Bereavement | Severe Grief Reaction

Canada
Professor Dr. Bernd Mühlbauer
Dept. of Statistics and Medical Biometry, University of Bremen; INSERM (Institut... and other collaborators

Unknown

An International Randomized Trial of Additional Treatments for COVID-19 in Hospitalized Patients Who Are All Receiving the Local Standard of Care - WHO-SOLIDARITY-GERMANY

COVID-19 | SARS-CoV-2 Infection | Moderate and Severe COVID-19

Germany
Pfizer

Withdrawn

A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19 (EPIC-HOS)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) | Coronavirus Disease 2019 (COVID-19) | Immunocompromised | Hospitalization | Child, Hospitalized

United States, Bulgaria
ProgenaBiome
Topelia Therapeutics

Active, not recruiting

Trial of Combination Therapy to Treat COVID-19 Infection

Coronavirus Infection | Covid-19 | COVID | Corona Virus Infection | SARS-CoV Infection | SARS-CoV2 | Coronavirus-19

United States
University Hospital, Montpellier

Recruiting

Analysing the French COVID-19 Epidemic Using a National SARS-CoV-2 RT-PCR Database (CovPCR)

Covid-19 | SARS-CoV Infection

France
Democritus University of Thrace

Recruiting

Combination of Inhaled DNase, Baricitinib and Tocilizumab in Severe COVID-19

COVID-19 Severe Respiratory Failure

Greece
Dompé Farmaceutici S.p.A

Recruiting

Reparixin add-on Therapy to Std Care to Limit Progression in Pts With COVID19 & Other Community Acquired Pneumonia

Severe COVID-19 | Infectious Pneumonia

United States, Australia, Turkey, Argentina, Germany, Austria, Italy
University of Zurich

Not yet recruiting

Therapeutic Plasma Exchange as an Adjunctive Strategy to Treat Coagulopathy and Inflammation in Severe Covid-19 (PExCoV)

Severe Covid-19
University of Minnesota
National Institute of Allergy and Infectious Diseases (NIAID); National Institutes... and other collaborators

Completed

Inpatient Treatment of COVID-19 With Anti-Coronavirus Immunoglobulin (ITAC)

COVID-19 | COVID | SARS-CoV-2 | SARS (Severe Acute Respiratory Syndrome)

Spain, United States, Denmark, United Kingdom, Greece, Japan, Nigeria
Johns Hopkins University
Rush University Medical Center; University of California, San Francisco; amfAR...

Completed

COVID-19 Recovery Study: Symptoms and Biomarkers of Long COVID-19 in People Living With and Without HIV

HIV | Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2)

United States
Assistance Publique - Hôpitaux de Paris

Recruiting

Impact of Post-ARDS Covid-19 Sedation on Persistent Neuroinflammation (PET-DEXDOCOVID)

Severe COVID-19

France
Janssen Vaccines & Prevention B.V.

Completed

A Study of Ad26.COV2.S for the Prevention of SARS-CoV-2-mediated COVID-19 in Adults (ENSEMBLE 2)

Participants With or Without Stable Co-morbidities Associated With Progression to Severe COVID-19

United States, United Kingdom, Belgium, Spain, France, Germany, Philippines, Brazil, Colombia, South Africa
Arrowhead Regional Medical Center

Completed

Insulin Regulation and Severity of Severe Acute Respiratory Syndrome COVID-19 Infection

COVID-19 | Diabetes Mellitus | COVID-19 Pneumonia | COVID-19 Respiratory Infection

United States
aTyr Pharma, Inc.

Completed

Study to Evaluate the Safety and Efficacy of ATYR1923 (Efzofitimod) In Participants With Severe Pneumonia Related to COVID-19

SARS-CoV-2 (COVID-19) Severe Pneumonia

United States, Puerto Rico
Rapa Therapeutics LLC
Hackensack Meridian Health

Terminated

RAPA-501-Allo Therapy of COVID-19-ARDS

Severe COVID-19 Disease

United States
Cambridge Health Alliance
The Thoracic Foundation; Alturix

Not yet recruiting

NAC for Attenuation of COVID-19 Symptomatology (NACinCOVID2)

Covid19 | Oxidative Stress | SARS-CoV2 Infection | COVID-19 Pneumonia | SARS-CoV-2 Acute Respiratory Disease | COVID-19 Respiratory Infection | SARS-Associated Coronavirus as Cause of Disease Classified Elsewhere | COVID-19 Lower Respiratory Infection

United States
Azienda Ospedaliera Universitaria Integrata Verona
Charite University, Berlin, Germany; Institut National de la Santé Et de la... and other collaborators

Recruiting

Follow-up of Covid-19 Long Term Sequelae

Coronavirus Infections | Covid19 | Coronavirus Disease 2019 | Corona Virus Infection | Coronavirus | SARS-CoV2 Infection | COVID-19 Pneumonia | SARS-CoV-2 Acute Respiratory Disease | SARS (Severe Acute Respiratory Syndrome) | COVID-19 Respiratory Infection | SARS (Disease) | COVID-19 Acute Respiratory Distress... and other conditions

Italy, Belgium, Congo, France, Netherlands, Spain

Clinical Trials on Severe Covid-19

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mali

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Rare Diseases

Drug Interventions

Dietary Supplements

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