Clinical Trials on Severe Hypercholesterolemia

Total 4903 results

The Hospital for Sick Children

Completed

Flaxseed Compared With Placebo in Patients With Hypercholesterolemia

Familial or Severe Hypercholesterolemia

Canada
Otsuka Beijing Research Institute

Unknown

To Compare the Effect of Concomitant Administration of Probucol and Cilostazol With Probucol Single Treatment on the Atherosclerosis Related Markers (Including the Thickness of the Achilles Tendon) and Evaluate Safety (Based on Atorvastatin Treatment) in Severe Hypercholesterolemia Subject

Severe Hypercholesterolemia

China
Sanofi
Regeneron Pharmaceuticals

Completed

Usability Study of the Commercial Auto-injector Device and the New Auto-injector Device (SYDNEY) in Patients With High or Very High CV Risk With Hypercholesterolemia Not Adequately Controlled With Their Lipid-Modifying Therapy

Hypercholesterolaemia

United States
GlaxoSmithKline

Completed

Acotral® Versus Zetia® Ezetimibe Bioequivalance Study.

Hypercholesterolaemia

India
AstraZeneca

Completed

Registry On Efficacy and Safety Of Rosuvastatin, and Atorvastatin and Simvastatin In Hypercholesterolaemia

Hypercholesterolaemia

Singapore
AstraZeneca

Completed

PULSAR - A Prospective Study to Evaluate the Utility of Low Doses of the Statins Atorvastatin and Rosuvastatin.

Hypercholesterolaemia
Akeso
AD Pharmaceuticals Co., Ltd.

Completed

A Study of PCSK9 Inhibitor AK102 in Healthy Subjects

Hypercholesterolaemia

China
GlaxoSmithKline

Completed

Rosuvastatin Calcium Bioequivalence Study - Fast

Hypercholesterolaemia

Brazil
AstraZeneca

Completed

Evaluation of Patients Treated With HMG-CoA Reductase Inhibitors to Reach Cholesterol Target Values

Hypercholesterolaemia

Bosnia and Herzegovina
AstraZeneca

Completed

Non-interventional Study (NIS) to Assess Reaching of Cholesterol Target Values in Patients Treated With HMG-CoA Reductase Inhibitors

Hypercholesterolaemia

Croatia
AstraZeneca

Completed

Rosuvastatin Efficacy and Safety Evaluation in Hypercholesterolaemic Patients (RESEARCH)

Hypercholesterolaemia

Greece
AstraZeneca

Completed

OLE Study to Evaluate Safety / Efficacy of ZD4522

Hypercholesterolaemia
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Carotid Atorvastatin Study in Hyperlipidemic Post-Menopausal Women

Hypercholesterolaemia

France, Belgium, Netherlands
AstraZeneca

Terminated

Study of Asian Patients With Hypercholesterolaemia in the UK - Rosuvastatin 5mg Versus Atorvastatin 10mg

Hypercholesterolaemia

United Kingdom
Novartis Pharmaceuticals

Recruiting

Specified Drug-use Survey of Leqvio for s.c. Injection.

Hypercholesterolaemia | Familial Hypercholesterolaemia

Japan
Ikaria Bioscience Pty Ltd
SHANGHAI RONA Therapeutics Co.,Ltd.

Not yet recruiting

the Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects in Adult Subjects With Elevated LDL-C

To Reduce the LDL-C Level in Hypercholesteremia Patients
Jiangsu HengRui Medicine Co., Ltd.

Completed

The PK/PD Study of A Single Subcutaneous Injection of SHR-1209 in Healthy Subjects

Hypercholesteremia

China
AstraZeneca

Completed

Pattern of Statins Use in Catalonia

Hypercholesteremia
AstraZeneca

Completed

A Study Measuring Effects on Intima Media Thickness: An Evaluation of Rosuvastatin 40 mg (METEOR)

Hypercholesteremia

United States, France, Norway, Netherlands, Belgium, Germany, Finland, Czech Republic
AstraZeneca

Completed

Direct Statin Comparison of LDL-C Values: an Evaluation of Rosuvastatin Therapy

Hypercholesteremia

Belgium
AstraZeneca

Completed

C-Control: Efficacy and Safety of Therapy With Rosuvastatin in Statin-Naive and in Statin-Switched Patients

Hypercholesteremia
Amgen

Terminated

Study to Evaluate the Safety of Repatha® in Pregnancy

Pregnancy | Hypercholesterolaemia

Belgium, Denmark, Italy, Czechia, United Kingdom, Australia, Austria, Greece, Switzerland, Netherlands, Spain, Sweden, Slovakia, Norway
AstraZeneca

Withdrawn

ORBITAL: Open-Label Primary Care Study: Rosuvastatin Based Compliance Initiatives Linked To Achievement Of LDL Goals

Primary Hypercholesterolaemia
AstraZeneca

Completed

Centralized Pan-South African Survey on the Undertreatment of Hypercholesterolaemia (CEPHEUS)

Undertreatment of Hypercholesterolaemia

South Africa
NeuroBo Pharmaceuticals Inc.

Completed

A 12-Week, Phase 2 Study of Gemcabene in Hypercholesterolemia Patients on Stable Moderate and High-Intensity Statins (ROYAL-1)

Hypercholesteremia

United States
NeuroBo Pharmaceuticals Inc.

Completed

Effect of Gemcabene on the Pharmacokinetics of Atorvastatin in Healthy Volunteers

Hypercholesteremia
The Cooper Institute
Cargill

Completed

Phytosterol Supplementation and Cardiovascular Risk

Hypercholesteremia

United States
Amgen

Completed

Chart Review of Repatha® in Subjects With Hyperlipidaemia (HEYMANS)

Hypercholesterolaemia

Austria, Italy, Belgium, Czechia, Switzerland, Spain, Slovakia, Germany, Portugal, Greece, Bulgaria, Sweden
Novo Nordisk A/S

Completed

A Research Study Investigating How NNC0385-0434 is Tolerated in People With or Without High Cholesterol Levels

Healthy Volunteers | Hypercholesterolaemia

United Kingdom
Organon and Co

Completed

TWICE (Ezetimibe Together With Any Statin Cholesterol Enhancement)(0653-060)

Hypercholesterolaemia | Hyperlipidaemia
Danone Research

Completed

Pilot Study in the Cholesterol Absorption Reduction After Consumption of Low-fat, Drinkable Fermented Milk Enriched With Plant Sterols

Mildly Hypercholesterolemic Subjects

Canada
Danone Research

Completed

Effects of Fermented Milk Product Enriched With Plant Sterols and Policosanols in Mild Hypercholesterolaemic Adults

Mildly Hypercholesterolemic Subjects

United Kingdom
Danone Research

Completed

Effect of the Consumption of a Fermented Milk Enriched With Plant Sterols (Italy)

Mildly Hypercholesterolemic Subjects

Italy
Lescuyer Laboratory
BioFortis

Completed

Dose Effect of Limicol on (LDL)-Cholesterol Levels

Hypercholesterolaemia

France
Integrative Health Technologies, Inc.

Unknown

Study of Changes in Total Cholesterol Levels as a Function of Consuming a Supplement Designed to Improve Cardiovascular Health (AdBiotech)

Hyperlipidemia | Hypercholesteremia | Cholesterol

United States
Shanghai Junshi Bioscience Co., Ltd.

Not yet recruiting

Efficacy and Safety of JS002 as Monotherapy in Patients With Primary Hypercholesterolaemia and Mixed Dyslipidemia

Primary Hypercholesterolaemia and Mixed Dyslipidemia

China
Radboud University Medical Center
Merck Sharp & Dohme LLC

Completed

Pharmacokinetic Drug Interaction Study Between Raltegravir and Atorvastatin. (AVIATOR)

HIV | Hypercholesterolaemia

Netherlands
Universiteit Antwerpen

Completed

The Effect of a Red Rice and Olive Extract Nutrition Supplement on Cholesterol Levels in Patients With Metabolic Syndrome

Hypercholesterolaemia

Belgium
AstraZeneca

Completed

Evaluation of the Efficacy and Safety of Rosuvastatin 5 mg Versus Pravastatin 40 mg and Atorvastatin 10 mg in Type IIa and IIb Hypercholesterolaemic Patients (CAP-Chol)

Type IIa and IIb Hypercholesterolaemia

France
Sanofi
Regeneron Pharmaceuticals

Completed

Efficacy and Safety of Alirocumab Versus Placebo on Top of Maximally Tolerated Lipid Lowering Therapy in Patients With Hypercholesterolemia Who Have Type 1 or Type 2 Diabetes and Are Treated With Insulin (ODYSSEY DM - Insulin)

Hypercholesterolaemia

Belgium, Spain, Germany, Austria, Italy, United States, France, Netherlands, Switzerland, United Kingdom
Juan A. Arnaiz

Completed

Treatment With Rosuvastatin Versus Switching PI (Protease Inhibitor) in Patients HIV With High Cholesterol Levels (SOS)

HIV | Hypercholesterolaemia

Spain
Amgen

Completed

Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders (TAUSSIG)

Severe Familial Hypercholesterolemia

Italy, Czechia, United States, Israel, New Zealand, South Africa, France, Spain, Australia, Belgium, Canada, Netherlands, Hong Kong, Brazil, United Kingdom, Greece, Japan, Lebanon
Lescuyer Laboratory
Aix Marseille Université; CIC Hôpital de la Conception - Marseille

Completed

Effects of Limicol on LDL-cholesterol

Hypercholesteremia

France
Karolinska Institutet

Completed

The Effect of Remote Ischemic Conditioning in Patients With Hypercholesterolemia

Endothelial Dysfunction | Hypercholesteremia

Sweden
AstraZeneca

Completed

Observational to Investigate the Efficacy of CRESTOR 5mg in Reaching LDL-C Target Goals in Patients Who Are at High Risk for a Cardiovascular Event

Hypercholesteremia

Netherlands
Merck Sharp & Dohme LLC

Completed

MK-0616 (Oral PCSK9 Inhibitor) Renal Impairment Study 2 (MK-0616-020)

Hypercholesterolaemia

United States
Sanofi
Regeneron Pharmaceuticals

Completed

An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia

Hypercholesterolaemia

Czechia, France, Denmark, Netherlands, Austria, Mexico, Spain, United States, Argentina, Brazil, Bulgaria, Canada, Finland, Hungary, Italy, Lebanon, Norway, Poland, Russian Federation, Slovenia, South Africa, Sweden, Taiwan, Turkey
Sanofi
Regeneron Pharmaceuticals

Completed

An 8-Week Dose-Finding Study to Evaluate the Efficacy and Safety of Alirocumab in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (ODYSSEY KIDS)

Hypercholesterolaemia

Norway, Russian Federation, Sweden, South Africa, Czechia, United States, Canada, France, Netherlands, Spain
Sanofi
Regeneron Pharmaceuticals

Completed

Efficacy and Safety of Alirocumab (SAR236553/REGN727) Versus Placebo on Top of Lipid-Modifying Therapy in Patients With Heterozygous Familial Hypercholesterolemia (ODYSSEY HIGH FH)

Hypercholesterolaemia

Netherlands, United States, Canada, Russian Federation, South Africa
Institute of Health Information and Statistics...
Centre of Cardiovascular and Transplantation Surgery, Czech Republic; The Central... and other collaborators

Recruiting

Pilot Project of Familial Hypercholesterolemia Screening in Newborns in the Czech Republic (CzeCH-IN)

Familial Hypercholesterolaemia

Czechia

3

Subscribe