Clinical Trials on Transformation

Total 213 results

Niguarda Hospital

Active, not recruiting

ObinutuzuMab AtezOlizumab and VenetocLax in RichTer transfOrmation (MOLTO)

CLL Transformation

Italy, Switzerland
German CLL Study Group

Recruiting

Efficacy and Safety of Zanubrutinib Plus Tislelizumab Treatment with or Without Sonrotoclax for Patients with Richter Transformation (CLL-RT1)

Richter Transformation

Denmark, Germany, Austria
Institute of Hematology & Blood Diseases Hospital
Xian-Janssen Pharmaceutical Ltd.

Not yet recruiting

R-EPOCH in Combination With Ibrutinib for Patients With Classical RT of CLL (BDHRT001)

Richter Transformation

China
Ono Pharmaceutical Co. Ltd

Recruiting

ONO-4538 Study in Patients With Richter's Transformation

Richter's Transformation

Japan
Karyopharm Therapeutics Inc

Terminated

Selinexor in Initial or Refractory and/or Relapsed Richter's Transformation (SIRRT)

Richter's Transformation

United States, Germany, United Kingdom, Spain, Poland
M.D. Anderson Cancer Center
Amgen

Terminated

Ibrutinib, Nivolumab and Blinatumomab in Richter Transformation

Hematopoietic/Lymphoid Cancer | Richter's Transformation

United States
Children's Hospital of Fudan University

Completed

Implementation Study of Intra-hospital Transfer of Pediatric Inpatients

Implementation Science | Transportation of Patients

China
Sierra Oncology LLC - a GSK company

Terminated

PNT2258 for Treatment of Patients With Richter's Transformation (Brighton)

Richter's Transformation

United States
Transplant Biomedicals, S.L.

Unknown

Prospective, Single-Arm, Study to Assess the Safety and Performance of the TB1-K Device for Organ Preservation in Donor Kidneys for Transplantation (EMERGE)

Kidney Preservation and Transportation

Spain
University Medical Center Groningen

Not yet recruiting

To Evaluate Transport Safety Between Different Scanning Methods for Patients in the Intensive Care Unit (ICU) (CASA)

Intensive Care Medicine | PET / CT | Transportation of Patients

Netherlands
Sun Yat-sen University

Unknown

Cavernous Transformation of Portal Vein： Etiology, Diagnosis, Management and Prognosis

Portal Vein, Cavernous Transformation Of

China
University of Pennsylvania
Lyft, Inc.

Completed

The Impact of Rideshare Transportation Services on Appointment Adherence

Primary Health Care | Social Determinants of Health | Transportation | Appointments and Schedules

United States
Sun Yat-sen University

Unknown

Percutaneous Transhepatic Intrahepatic Portosystemic Shunt for Treatment of Portal Vein Occlusion With Symptomatic Portal Hypertension After Splenectomy

Hypertension, Portal | Portal Vein, Cavernous Transformation Of

China
Sun Yat-sen University

Unknown

Interventional Radiology for the Treatment of Symptomatic Portal Hypertension in Patients With Cavernous Transformation of Portal Vein

Hypertension, Portal | Portal Vein, Cavernous Transformation Of

China
Kochi University

Completed

Prevention for the Development of Liver Tumorigenesis by the Oral Supplementation of Branched-chain Amino Acids

Liver Cancer

Japan
German CLL Study Group

Recruiting

Registry of the German CLL Study Group (CLL-Registry)

CLL | Leukemia, Prolymphocytic, T-Cell | SLL | Leukemia, Prolymphocytic, B-Cell | HCL | T-LGL Leukemia | Richter´s Transformation | NK-LGL Leukemia

Germany
University of Bern
ETH Zurich; University of St.Gallen

Completed

Design and Implementation of a Drunk Driving Detection System (DRIVE)

Alcohol Drinking | Impaired Driving | Transportation Accidents | Drunk Driving

Switzerland
French Society for Intensive Care

Recruiting

Intra-Hospital Transport of Critically Ill Patients in Intensive Care Unit (TIGRHOU)

Critical Illness | Intensive Care Unit | Transportation Accidents

France
Merck Sharp & Dohme LLC

Recruiting

A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)

Follicular Lymphoma | Mantle Cell Lymphoma | Chronic Lymphocytic Leukemia | Richter Transformation Lymphoma

United States, Canada, China, Israel, Italy, Korea, Republic of, Poland, Sweden, Turkey, Brazil, Portugal, Ireland, Germany, Singapore, United Kingdom, Japan, Chile, Czechia, Spain, Peru, Estonia
Nanfang Hospital of Southern Medical University

Recruiting

Decitabine and HQP1351-based Chemotherapy Regimen for the Treatment Advanced CML (Case-Only)

Chronic Myeloid Leukemia in Myeloid Blast Crisis | Chronic Myeloid Leukaemia Transformation | Chronic Myeloid Leukemia - Accelerated Phase | Chronic Myeloid Leukemia in Lymphoid Blast Crisis

China
Beijing University of Chinese Medicine
Harvard Medical School (HMS and HSDM); China Academy of Chinese Medical Sciences and other collaborators

Recruiting

Risk Assessment and Syndrome Evolution Models for Chronic Atrophic Gastritis Malignant Transformation

Risk Assessment of Chronic Atrophic Gastritis Malignant Transformation

China
China Medical University Hospital

Completed

Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke

Stroke | Hemorrhagic Transformation Due to Acute Stroke
The First Affiliated Hospital of Xiamen University
Jiangsu HengRui Medicine Co., Ltd.

Recruiting

Single Arm, Prospective, Multicenter Clinical Study of TACE With Adebrelimab and Bevacizumab for Unresectable Hepatocellular Carcinoma

Hepatocellular Carcinoma | Bevacizumab | TACE | Adebrelimab | Transformation

China
German CLL Study Group
Hoffmann-La Roche

Terminated

Obinutuzumab Containing Conditioning Regimen for Patients With Poor Risk CLL or Richter's Transformation Requiring Allogeneic Stem Cell Transplantation (CLLTX1)

Chronic Lymphocytic Leukemia | Richter's Transformation

Germany
Medical College of Wisconsin

Recruiting

Inhibition of Oral Tumorigenesis by Antitumor B

Squamous Cell Cancer of the Oral Cavity

United States
Lei Li

Unknown

HPV Integration and Tumorigenesis of Uterine Cervical Adenocarcinoma

Cervical Adenocarcinoma | Human Papillomavirus | Metabolome | Prognosis | Whole Exome Sequencing | Tumorigenesis | Transcriptome | Genome-wide Association Study

China
Miltenyi Biomedicine GmbH

Recruiting

DALY II USA/ MB-CART2019.1 for DLBCL

Central Nervous System Lymphoma | Mantle Cell Lymphoma (MCL) | Transformed Lymphoma | Richter Transformation | Refractory Diffuse Large B Cell Lymphoma (DLBCL) | Primary Mediastinal B-cell Lymphoma (PMBCL) | High Grade B-cell Lymphoma (HGBCL) | Relapsed Diffuse Large B Cell Lymphoma

United States, Canada
Kite, A Gilead Company

Terminated

Study of Brexucabtagene Autoleucel in Adults With Rare B-cell Malignancies (ZUMA-25)

Relapsed/Refractory Waldenstrom Macroglobulinemia | Relapsed/Refractory Richter Transformation | Relapsed/Refractory Burkitt Lymphoma | Relapsed/Refractory Hairy Cell Leukemia

United States, Spain, Germany, France, Italy, Switzerland, Netherlands, Austria
University of Los Andes, Columbia
Wellcome Trust; Drexel University; Fundación Santa Fe de Bogota

Active, not recruiting

Urban Transformations and Health: the Case of TransMiCable in Bogotá (TRUST)

Quality of Life | Physical Activity | Respiratory Disease | Social Capital | Transportation | Homicide

Colombia
University of Alberta

Completed

Lixiana Acute Stroke Evaluation Registry (LASER)

Ischemic Stroke | Atrial Fibrillation | Hemorrhagic Transformation Stroke

Canada
TG Therapeutics, Inc.

Terminated

Study of Cosibelimab in Subjects With Relapsed or Refractory Lymphoma

B-cell Non Hodgkin Lymphoma | Richter's Transformation

United States
Instituto de Investigación Hospital Universitario...
Daiichi Sankyo, Inc.; Hospital Universitario La Paz; Fundación Freno al ICTUS

Recruiting

Keeping Oral o Parental AnticoaguLation in the Acute Phase of Cardioembolic Ischemic Stroke (KOALA-IS)

Cardioembolic Stroke | Stroke Recurrence | Anticoagulant Therapy | Haemorrhagic Transformation Stroke

Spain, France
National Taiwan University Hospital

Completed

The Role of Aromatic Hydrocarbon Receptor in the Tumorigenesis of Neuroblastoma and Its Relationship With MYCN Expression

Neuroblastoma
Beijing Tiantan Hospital

Not yet recruiting

Cerebral Autoregulation Guiding Blood Pressure Management After Revascularization (RESCUE-CA)

Ischemic Stroke | Blood Pressure | Cerebral Autoregulation | Revascularization | Cerebrovascular Insufficiency | Individuation | Hemorrhagic Transformation Due to Acute Stroke
Novartis

Completed

STI571 in Treating Patients With Chronic Myelogenous Leukemia in Blast Crisis

Leukemia

United States
Novartis Pharmaceuticals

Approved for marketing

Nilotinib in Adult Patients With Imatinib-resistant or Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase (ENACT)

Chronic Myeloid Leukemia

Mexico
Novartis Pharmaceuticals

Completed

A Study of Nilotinib in Adult Patients With Imatinib Resistant or - Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase (ENACT)

Chronic Myeloid Leukemia

Colombia, Venezuela
M.D. Anderson Cancer Center
Sanofi

Completed

Oxaliplatin, Fludarabine, Cytarabine, and Rituximab in Patients With Richter's Transformation and Leukemias

Leukemia | Richter's Transformation

United States
Newave Pharmaceutical Inc

Recruiting

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

Acute Myeloid Leukemia | Multiple Myeloma | Myelofibrosis | Chronic Lymphocytic Leukemia | Non Hodgkin Lymphoma | Acute Lymphocytic Leukemia | Myelodysplastic/Myeloproliferative Neoplasm | Small Lymphocytic Lymphoma | Chronic Myelomonocytic Leukemia-2 | Richter Transformation | T-cell-prolymphocytic Leukemia and other conditions

United States
Istituto Nazionale di Ricovero e Cura per Anziani

Recruiting

Study on the Predictive Value of High-sensitivity Cardiac Troponin I, N-terminal Pro-B-natriuretic Peptide, and Soluble Suppression of Tumorigenesis-2 for Mortality and the Development of Cardiovascular Events in Patients With Type 2 Diabetes (Diabetes-CV) (Diabetes-CV)

Type 2 Diabetes | Cardiovascular Complication

Italy
University of Rochester

Completed

Cladribine, Cytarabine, and Imatinib Mesylate in Treating Patients With Refractory or Relapsed Acute Myeloid Leukemia or Blastic Phase Chronic Myelogenous Leukemia

Leukemia

United States
Novartis Pharmaceuticals

Completed

Study of Treatment With Nilotinib in Adult Patients With Imatinib - Resistant or - Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase (MACS0439)

Chronic Myeloid Leukemia

Brazil
Novartis Pharmaceuticals

Terminated

Efficacy and Safety of LBH589B in Adult Patients With Refractory Chronic Myeloid Leukemia in Accelerated or Blast Phase

Leukemia, Myeloid, Chronic

United States, Germany
Christine Ryan
Eli Lilly and Company; Genentech, Inc.; Loxo Oncology, Inc.

Recruiting

A Ph2 Study of Glofitamab Alone or With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation

Chronic Lymphocytic Leukemia | Richter's Transformation

United States
Joseph Jurcic
Bristol-Myers Squibb

Terminated

Combination of Fedratinib and Decitabine for Myeloproliferative Neoplasms (MPN)- Accelerated Phase (AP)/Blast Phase (BP)

Myeloproliferative Neoplasm

United States
Bristol-Myers Squibb

Completed

Dasatinib (BMS-354825) in Subjects With Myeloid Blast Phase Chronic Myeloid Leukemia Resistant to or Intolerant of Imatinib Mesylate

Chronic Myeloid Leukemia | Blast Crisis

Netherlands, United States, Italy, Austria, Canada, France, Germany, Singapore, Taiwan, United Kingdom, Australia, Korea, Republic of, Philippines, Sweden, Finland, Israel, Belgium, Denmark, Norway, Switzerland
Fundació Institut de Recerca de l'Hospital de la...
Hospital Clinic of Barcelona; Germans Trias i Pujol Hospital; Hospital Arnau... and other collaborators

Recruiting

Registry of Patients With Remote Posterior cErebral Hemorrhage Following Reperfusion Treatment in Ischemic Stroke (HEROES-CAT)

Ischemic Stroke | Intracranial Hemorrhages | Hemorrhagic Transformation Stroke

Spain
King Faisal Specialist Hospital & Research Center

Completed

An Open-Label, Multicenter, Expanded Access Study of Oral AMN 107 in Adult Patients With Imatinib (Glivec®/Gleevec®_ - Resistant or Intolerant Chronic Myeloid Leukemia in Blast Crisis, Accelerated Phase or Chronic Phase

Leukemia, Myeloid, Chronic
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Chemotherapy in Treating Children With Relapsed Acute Leukemia, Acute Myeloid Leukemia, or Blastic Phase Chronic Myelogenous Leukemia

Leukemia

United States, Australia, Canada
University of Bologna

Completed

Protein-Tyrosine Kinase Inhibitor (STI571) for Treatment of Patients With Ph+ Chronic Myeloid Leukemia in Accelerated and Blastic Phase (CML003)

Chronic Myeloid Leukemia

Italy

Clinical Trials on Transformation

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Liberia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations