Clinical Trials on Transfusion-dependent Red Blood Cell (RBC) Defect

Total 213 results

Daping Hospital and the Research Institute of Surgery...
Children's Hospital of Chongqing Medical University

Withdrawn

Association of Red Blood Cell Transfusion, Anemia, and Necrotizing Enterocolitis

Anemia | Necrotizing Enterocolitis | Red Blood Cell (RBC) Transfusion

China
Population Health Research Institute

Not yet recruiting

The Effect of Retrograde Autologous Priming on Transfusion Requirements After Cardiac Surgery (TheRAPy)

Red Blood Cell Transfusion
University of California, San Francisco

Terminated

Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation

Myeloid Malignancy | Metabolic Disease | Bone Marrow Failure Syndrome | Transfusion-dependent Red Blood Cell (RBC) Defect | Congenital Immunodeficiency | Severe Immune Dysregulation

United States
Tel-Aviv Sourasky Medical Center

Unknown

Restrictive Versus Liberal Red Cell Transfusion Strategy in Orthopedic-Oncology Patients Undergoing Surgery - a Randomized Controlled Study

Red Blood Cells Transfusion.

Israel
Izmir Katip Celebi University

Completed

Assessment of Oxygen Extraction Rate Changes Following Red Blood Cell Transfusion in the Intensive Care Unit

Oxygen Consumption | Red Blood Cell Transfusion

Turkey
University of Sao Paulo

Completed

Transfusion Requirements in Surgical Oncologic Patient (TRISOP)

Red Blood Cells Transfusion | Oncologic Surgery

Brazil
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR); Canadian Blood Services

Active, not recruiting

An Innovative Trial Assessing Donor Sex on Recipient Mortality (iTADS)

Red Blood Cell Transfusion

Canada
Jordi Gol i Gurina Foundation

Recruiting

Detection of Anemizations in Primary Care. (ANHEMOG)

Anemia | Red Blood Cell Transfusion

Spain
Abdelrady S Ibrahim, MD
Assiut University

Completed

The Effect of Red Blood Cells Storage Duration on Biochemical Changes in Pediatric Patients

Red Blood Cells Transfusion

Egypt
Emory University

Terminated

Physiologic Effects of RBC Transfusion

Red Blood Cell Transfusion

United States
Children's Hospital of Fudan University

Withdrawn

Individualized Strategies of Red Blood Cell Transfusion for Perioperative Pediatric Patients

Clinical Outcome | Individualized Transfusion Strategy | Red Blood Cell | Perioperative Pediatric Patient
Sunnybrook Health Sciences Centre
Princess Margaret Hospital, Canada; Juravinski Cancer Center

Unknown

Red Blood Cell Transfusion Thresholds and QOL in MDS (EnhanceRBC)

Quality of Life | Myelodysplastic Syndromes (MDS) | Red Blood Cell (RBC) Transfusions

Canada
Centre hospitalier de l'Université de Montréal...

Completed

Impact of Tranexamic Acid on Red Blood Cell Transfusion in Spinal Surgery

Orthopedic Surgery | Neurosurgery | Red Blood Cell Transfusion

Canada
Mayo Clinic
Arizona State University

Completed

Red Blood Cell Transfusion in the Ambulatory Setting: Impact on Home Functional Status

Anemia | Oncology | Ambulatory Care | Hematology | Red Blood Cell Transfusions

United States
Johann Wolfgang Goethe University Hospital

Completed

Monitoring the Effect of Red Blood Cell Transfusion on Cerebral Oxygen Saturation With Near Infrared Spectroscopy (NIRS) in Critically Ill Patients

Effect of RBC Transfusions on Cerebral Oxygen Saturation

Germany
University of Chicago

Recruiting

A Trial to Assess the Effect of Transfusion Strategies on Fatigability Levels After Hospital Discharge (EToF)

Fatigue | Anemia | Physical Function | Red Blood Cell Transfusion | Fatigability

United States
Mahidol University
Wolf Schleinzer Stiftung zur Wissenschafts- und Bildungsförderung, Germany

Completed

Immunomodulation Effect of Blood Transfusion

Surgery | Immune Defect | Incompatible Blood Transfusion

Thailand
Boston Children's Hospital

Recruiting

Trial of Indication-Based Transfusion of Red Blood Cells in ECMO (TITRE)

Extracorporeal Membrane Oxygenation | Red Blood Cell Transfusion | Organ Failure, Multiple

United States, Canada
Shire

Terminated

Study for Transfusionally Iron Overloaded Children, Adolescents and Adults Using FBS0701 (SSP-004184)

Iron Overload Due to Repeated Red Blood Cell Transfusions

Canada, United States, Thailand, Italy, United Kingdom
ApoPharma

Completed

Safety and Acceptability of Deferiprone Delayed Release Tablets in Patients With Systemic Iron Overload (TWICE)

Iron Overload Due to Repeated Red Blood Cell Transfusions

United States, Canada, Greece, Italy
Kepler University Hospital

Completed

Prediction of Transfusion-Associated Complications (PRETRACO)

Transfusion-dependent Anemia

Austria
Siriraj Hospital

Completed

An Analysis of Blood Management in Patients Having Hip or Knee Arthroplasty

Transfusion-dependent Anemia

Thailand
Kepler University Hospital

Completed

Machine Learning-Based Prediction of Major Perioperative Allogeneic Blood Requirements in Cardiac Surgery (PREMATRICS)

Transfusion-dependent Anemia

Austria
Siriraj Hospital

Completed

Knowledge and Attitude in Perioperative Erythrocyte Transfusion in Medical Personnel in Siriraj Hospital

Transfusion-dependent Anemia

Thailand
Shire

Terminated

Pharmacokinetics of SSP-004184 in the Treatment of Chronic Iron Overload Requiring Chelation Therapy

Iron Overload Due to Repeated Red Blood Cell Transfusions

United States, Canada, Lebanon, Italy, Egypt
Haemonetics Corporation

Completed

Clinical Investigational Protocol for 2 RBC Single Unit Recovery on MCS®+ 8150 Using LN832 Disposable Sets (US)

Red Blood Cell Donation

United States
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study of Patients With Pure Red Cell Aplasia Associated With Recombinant Human Erythropoietin Treatment

Pure Red-cell Aplasia

United Kingdom, Sweden, South Africa, Brazil, Canada, Germany, Norway, Thailand
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Efficacy of the antiCD38 Monoclonal Antibody Isatuximab in the Treatment of PCRA by Major ABO Mismatch After Allogeneic Hematopoietic Stem Cell Transplantation (ErythroSIM)

Immunological Pure Red Cell Aplasia
Bing Han

Completed

Sirolimus Treatment for Newly Diagnosed Primary Acquired PRCA (PRCA)

Pure Red Cell Aplasia, Acquired

China
Imagine Institute

Recruiting

Pathophysiological Explorations of Red Blood Cells (GR-Ex)

Red Blood Cell Disorder

France
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

The Protection of ACD III on Erythrocytes in Intraoperative Blood Salvage During Cardiopulmonary Bypass

Red Blood Cell Disorder

China
University of British Columbia

Completed

Bioavailability of Folic Acid Fortified Bread

Red Blood Cell Folate

Canada
Heinrich-Heine University, Duesseldorf

Completed

Red Blood Cells as a Reflection of Endothelial Function in Old Age

Endothelial Function | Red Blood Cells | Nitric Oxide Pool in Red Blood Cells and Blood Plasma

Germany
Peking Union Medical College Hospital

Unknown

Tacrolimus Treatment for Refractory PRCA

Pure Red Cell Aplasia

China
Novartis Pharmaceuticals

Completed

Open-label, Multicenter Study Assessing Preference for Deferasirox Film-coated Tablet Compared to Dispersible Tablet (Jupiter)

Non-transfusion-dependent Thalassemia | Transfusion-dependent Thalassemia

Egypt, Turkey, Thailand, Lebanon, Morocco, Saudi Arabia, Vietnam
Heinrich-Heine University, Duesseldorf

Completed

Analysis of Proteome and Pathophysiological Characteristics of Human Blood Cells

Peripheral Blood Mononuclear Cell | Red Blood Cell | Endothelial NO-synthase

Germany
Johann Wolfgang Goethe University Hospital
Wuerzburg University Hospital

Recruiting

Liberal Transfusion Strategy in Elderly Patients (LIBERAL)

Anemia | Surgery | Transfusion-dependent Anemia

Germany
EuroBloodNet Association

Not yet recruiting

Safety and Efficacy of Mitapivat Sulfate in Adult Patients With Erythrocyte Membranopathies (SATISFY)

Hereditary Red Blood Cell Disorder (Disorder)

Denmark, Netherlands
Bing Han

Completed

Sirolimus Treatment for Refractory PRCA

Pure Red Cell Aplasia

China
Institute of Hematology & Blood Diseases Hospital...

Terminated

Bortezomib Plus Dexamethasone for Acquired Pure Red Cell Aplasia Failure or Relapse After First-line Treatment (BID-PERAL)

Acquired Pure Red Cell Aplasia

China
Centre Hospitalier Universitaire, Amiens
Hôpital Necker-Enfants Malades

Recruiting

ERYthrocyte Morphology Using Flow Imaging on ImageSTREAM Cytometer (ERYSTREAM)

Artificial Intelligence | Red Blood Cells | Schistocytes

France
Duke University
Doris Duke Charitable Foundation

Completed

Effect of Broccoli Sprouts Homogenate on SS RBC (BSH)

Oxidative Stress | Fetal Hemoglobin | Sickle Red Blood Cell

United States
Novartis Pharmaceuticals

Completed

Study to Evaluate Treatment Compliance, Efficacy and Safety of an Improved Deferasirox Formulation (Granules) in Pediatric Patients (2-<18 Years Old) With Iron Overload

Transfusion-dependent Anemia

Egypt, Hungary, Turkey, United States, Bulgaria, Italy, Belgium, Russian Federation, Philippines, France, Malaysia, India, Oman, Panama, Lebanon, Thailand, Tunisia
University of Calgary

Recruiting

Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling Donor (Sickle-AID)

Sickle Cell Disease | Pure Red Cell Aplasia | Stem Cell Transplant Complications | Red Blood Cell Disorder

Canada
Agios Pharmaceuticals, Inc.

Active, not recruiting

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-TDT) (ENERGIZE-T)

Transfusion-dependent Alpha-Thalassemia | Transfusion-dependent Beta-Thalassemia

Spain, Taiwan, Thailand, United States, France, Canada, Malaysia, Germany, Netherlands, Bulgaria, United Kingdom, Turkey, Italy, Greece, United Arab Emirates, Brazil, Denmark, Lebanon, Saudi Arabia
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Observe the Number of Patients Who Develop Pure Red Cell Aplasia (PRCA, a Rare Form of Anemia) While Receiving Epoetin Alfa or Other Recombinant Erythropoietins

Red-Cell Aplasia, Pure
Agios Pharmaceuticals, Inc.

Active, not recruiting

A Study Evaluating the Efficacy and Safety of Mitapivat in Participants With Non-Transfusion-Dependent Alpha- or Beta-Thalassemia (α- or β-NTDT) (ENERGIZE)

Non-Transfusion-dependent Alpha-Thalassemia | Non-Transfusion-dependent Beta-Thalassemia

Spain, Taiwan, Thailand, United Kingdom, Malaysia, United States, Netherlands, Bulgaria, Turkey, Italy, Canada, Brazil, France, United Arab Emirates, Denmark, Greece, Lebanon, Saudi Arabia
Johnson & Johnson Pharmaceutical Research & Development...
Janssen-Cilag International NV

Completed

Surveillance Study to Estimate the Incidence of Pure Red Blood Cell Aplasia Among Patients With Chronic Kidney Failure (PRIMS)

Chronic Kidney Failure | Pure Red-Cell Aplasia

Poland, United Kingdom, Belgium, Germany, Spain, Portugal, Australia, Switzerland, Finland, Greece, Sweden, Netherlands, Norway, Ireland, Denmark
IRCCS Policlinico S. Donato

Terminated

ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery (ZEPLAST-PED)

Bleeding | Surgery--Complications | Congenital Heart Disease | Transfusion-Related Acute Lung Injury | Cardiac Defect | Fibrinogenopenia; Acquired | Transfusion-Associated Circulatory Overload

Italy
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study of Risk Factors for Anti-erythropoietin Antibody Positive Pure Red Cell Aplasia Among Patients With Chronic Kidney Disease Receiving Epoetin Alfa

Pure Red-cell Aplasia

United Kingdom, Sweden, South Africa, Brazil, Norway, France, Thailand

Clinical Trials on Transfusion-dependent Red Blood Cell (RBC) Defect

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