Clinical Trials on Trypanosomiasis

Total 104 results

Drugs for Neglected Diseases

Completed

ADME Study of Acoziborole in Healthy Subjects

Trypanosomiases, African

United Kingdom
Institut de Recherche pour le Developpement
Institute of Tropical Medicine, Belgium; Institut National de Recherche Biomédicale... and other collaborators

Completed

Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP2 Passive Case Detection (DiTECT-WP2)

Trypanosoma Brucei Gambiense; Infection | Sleeping Sickness; West African | African Trypanosomiases | West African; Trypanosomiasis

Congo, The Democratic Republic of the, Côte D'Ivoire, Guinea
Institut de Recherche pour le Developpement
Institute of Tropical Medicine, Belgium; Institut National de Recherche Biomédicale... and other collaborators

Completed

Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: WP3 Post Elimination Monitoring (DiTECT-HAT-WP3)

Sleeping Sickness | Human African Trypanosomiasis | Trypanosoma Brucei Gambiense; Infection | African Trypanosomiases | West African Sleeping Sickness | Trypanosomiasis; African, Due to Trypanosoma Brucei Gambiense, Gambiense

Congo, The Democratic Republic of the, Côte D'Ivoire, Burkina Faso
Institute of Tropical Medicine, Belgium

Completed

Assessment of Recombinant HAT-RDT Specificity

Human African Trypanosomiasis

Congo, The Democratic Republic of the
Drugs for Neglected Diseases
Institute of Tropical Medicine, Belgium; Institut National de Recherche Biomédicale... and other collaborators

Not yet recruiting

Stop Transmission of Gambiense Human African Trypanosomiasis (STROgHAT) (STROgHAT)

Human African Trypanosomiasis
Drugs for Neglected Diseases
Sanofi

Completed

Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the Fexinidazole

Human African Trypanosomiasis

France
Drugs for Neglected Diseases

Completed

Efficacy and Safety of Fexinidazole in Patients With Stage 1 or Early Stage 2 Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open-label Cohort Study, plug-in to the Pivotal Study

Human African Trypanosomiasis (HAT)

Congo, The Democratic Republic of the
Drugs for Neglected Diseases

Completed

Efficacy and Safety of Fexinidazole in Children at Least 6 Years Old and Weighing Over 20 kg With Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open Study, plug-in to the Pivotal Study

Human African Trypanosomiasis (HAT)

Congo, The Democratic Republic of the
Drugs for Neglected Diseases
Swiss Tropical & Public Health Institute; Ministry of Public Health, Democratic...

Completed

Clinical Study to Assess the Tolerability, Feasibility and Effectiveness of Nifurtimox and Eflornithine (NECT) for the Treatment of Trypanosoma Brucei Gambiense Human African Trypanosomiasis (HAT) in the Meningo-encephalitic Phase (NECT-FIELD)

Human African Trypanosomiasis

Congo
Immtech Pharmaceuticals, Inc
Bill and Melinda Gates Foundation

Completed

Trial of DB289 for the Treatment of Stage I African Trypanosomiasis

African Trypanosomiasis

Congo
Epicentre
Médecins Sans Frontières, France

Terminated

Eflornithine + Nifurtimox Late-Stage Human African Trypanosomiasis (HAT)in West Nile, Uganda (NECS)

Trypanosomiasis, African

Uganda
Drugs for Neglected Diseases

Completed

Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2

Sleeping Sickness | Human African Trypanosomiasis (HAT)

Central African Republic, Congo, The Democratic Republic of the, Congo
Foundation for Innovative New Diagnostics, Switzerland
Makerere University; Ministry of Public Health, Democratic Republic of the...

Withdrawn

Prospective Evaluation of an RDT to Screen for Gambiense HAT and Diagnose P. Falciparum Malaria

Human African Trypanosomiasis
Drugs for Neglected Diseases

Completed

Prospective Study on Efficacy and Safety of Acoziborole (SCYX-7158) in Patients Infected by Human African Trypanosomiasis Due to T.b. Gambiense (OXA002)

Trypanosomiasis, African | Gambiense Trypanosomiasis | Sleeping Sickness

Congo, The Democratic Republic of the, Guinea
Drugs for Neglected Diseases
World Health Organization; Swiss Tropical & Public Health Institute; Epicentre; Medecins Sans Frontieres, Netherlands and other collaborators

Completed

Efficacy - Safety of Eflornithine-Nifurtimox Combination Versus Eflornithine to Treat Human African Trypanosomiasis

Trypanosomiasis, African

Congo, The Democratic Republic of the, Congo
Drugs for Neglected Diseases
European and Developing Countries Clinical Trials Partnership (EDCTP)

Completed

Efficacy and Safety of Fexinidazole in Patients With Human African Trypanosomiasis (HAT) Due to Trypanosoma Brucei Rhodesiense

Trypanosoma Brucei Rhodesiense; Infection

Malawi, Uganda
Institut de Recherche pour le Developpement
Foundation for Innovative New Diagnostics; Programme National de lutte contre... and other collaborators

Completed

Prospective Evaluation of the Specificity of Serological Tests for Human African Trypanosomiasis (SpeSerTryp)

Sleeping Sickness | Human African Trypanosomiasis | Trypanosoma Brucei Gambiense; Infection | West African Sleeping Sickness

Côte D'Ivoire, Guinea
Drugs for Neglected Diseases
Sanofi

Completed

Fexinidazole in Human African Trypanosomiasis Due to T.b. Gambiense at Any Stage

Trypanosomiasis, African | Sleeping Sickness | Trypanosomiasis; Gambian

Congo, The Democratic Republic of the, Guinea
Institut de Recherche pour le Developpement
Institute of Tropical Medicine, Belgium; Institut National de Recherche Biomédicale... and other collaborators

Completed

Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials: Early Test-of-cure (DiTECT-WP4)

Trypanosoma Brucei Gambiense; Infection | African Trypanosomiasis | African; Trypanosomiasis, West | Sleeping Sickness; West African

Congo, The Democratic Republic of the
Drugs for Neglected Diseases

Unknown

Study to Evaluate Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chagas Disease

Chagas Disease | Trypanosomiasis, South American | South American Trypanosomiasis | Disease, Chagas

Bolivia
Drugs for Neglected Diseases

Completed

Bioequivalence Study - Reference Clinical Fexinidazole Tablet Versus Proposed Market Formulation

Trypanosomiasis, African

France
Drugs for Neglected Diseases

Completed

DDI Study of Single Oral Dose of Acoziborole With Sequential Co-administration of Midazolam and Dextromethorphan (OXA-07)

Trypanosomiasis, African

Malaysia
Drugs for Neglected Diseases

Terminated

Multiple Dose Study to Evaluate Security, Tolerance and Pharmacokinetic of Fexinidazole (Drug Candidate for Human African Trypanosomiasis) Administered With a Loading Dose and With Food

Trypanosomiasis, African

France
Drugs for Neglected Diseases

Completed

Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158

Parasitic Diseases | Protozoan Infections | Trypanosomiasis | Trypanosomiasis, African

France
Paxmedica

Completed

A Retrospective Analysis of Suramin Treatment for Stage 1 TBR

Trypanosoma Brucei Rhodesiense; Infection

United States
Immtech Pharmaceuticals, Inc
Bill and Melinda Gates Foundation

Completed

A Trial of DB289 for the Treatment of Stage I African Trypanosomiasis

Trypanosomiasis, African

Angola, Congo
Epicentre
Médecins Sans Frontières, France; Embassy of France in Uganda; National Sleeping...

Terminated

Randomized Clinical Trial of Three Drug Combinations for Late-Stage Gambiense Human African Trypanosomiasis

Trypanosomiasis, African

Uganda
Institute of Tropical Medicine, Belgium
Drugs for Neglected Diseases; Institut National de Recherche Biomédicale. Kinshasa... and other collaborators

Withdrawn

Screen and Treat Implementation for HAT Control

Trypanosomiasis, African | Sleeping Sickness
Drugs for Neglected Diseases

Completed

Safety and Tolerability Study of Acoziborole in g-HAT Seropositive Subjects (OXA004)

Trypanosomiasis, African | Sleeping Sickness | Trypanosoma Brucei Gambiense; Infection

Congo, The Democratic Republic of the, Guinea
Drugs for Neglected Diseases

Recruiting

Pharmacokinetic, Efficacy, Safety and Tolerability Study of a Single Dose of Acoziborole in g-HAT Paediatric Patients (OXA005)

Trypanosomiasis, African | Sleeping Sickness | Trypanosoma Brucei Gambiense; Infection

Congo, The Democratic Republic of the
Drugs for Neglected Diseases
PhinC Development

Completed

Pharmacokinetic Drug-Drug Interaction Study

Chagas Disease

Argentina
Barcelona Centre for International Health Research

Completed

New Tools for the Diagnosis, Prognosis and Treatment Follow-up in Chagas Disease (BIOMARCHA)

Chagas Disease

Spain
Hospital Sao Rafael

Completed

MicroRNAs as Biomarkers in Patients With Chagas Disease

Chagas Disease

Brazil
Abbott Diagnostics Division

Completed

Abbott ESA Chagas Assay Post-Market Study (ESA)

Chagas Disease

United States
Tulane University School of Public Health and Tropical...
University of California, San Diego; Institute for Clinical Effectiveness and...

Recruiting

Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age (BETTY)

Chagas Disease

United States, Argentina
Hospital de Niños R. Gutierrez de Buenos Aires

Active, not recruiting

Nifurtimox Versus Benznidazole Effectiveness and Tolerance for Chagas Disease Treatment

Chagas Disease

Argentina
Universidad Autónoma de Bucaramanga
Fundación Cardioinfantil Instituto de Cardiología; Instituto Nacional de Salud... and other collaborators

Unknown

CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY) (CHICAMOCHA-3)

Chagas Disease

Colombia
Hospital de Niños R. Gutierrez de Buenos Aires
The Hospital for Sick Children; Thrasher Research Fund; Universidad Nacional... and other collaborators

Completed

Population Pharmacokinetics of Benznidazole in Children With Chagas Disease

Chagas Disease

Argentina
Bayer

Completed

Prospective Study of a Pediatric Nifurtimox Formulation for Chagas' Disease

Chagas Disease

Colombia, Argentina, Bolivia
Hospital Sao Rafael

Completed

Assessment of Speckle Tracking Strain Predictive Value for Myocardial Fibrosis in Chagas Disease

Chagas Disease

Brazil
Hospital Sao Rafael

Completed

Galectin-3 as a Biomarker in Patients With Chagas Disease

Chagas Disease

Brazil
Tulane University School of Public Health and Tropical...
Institute for Clinical Effectiveness and Health Policy; Laboratory of Parasitology... and other collaborators

Completed

Congenital Transmission of Lineages I and II of Trypanosoma Cruzi

Chagas Disease

United States, Argentina, Belgium, Honduras, Mexico
Hospital Sao Rafael

Completed

Syndecan-4 as a Biomarker in Patients With Chagas Disease

Chagas Disease

Brazil
Merck Sharp & Dohme LLC

Completed

A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267) (STOP CHAGAS)

Chagas Disease
Drugs for Neglected Diseases

Unknown

BENDITA BEnznidazole New Doses Improved Treatment and Associations (BENDITA)

Chagas Disease

Bolivia
Hospital Universitari Vall d'Hebron Research Institute
Hospital Vall d'Hebron; Tropical Medicine and International Health Unit Drassanes... and other collaborators

Completed

Clinical Trial For The Treatment Of Chronic Chagas Disease With Posaconazole And Benznidazole (CHAGASAZOL)

Chagas Disease

Spain
Hospital de Niños R. Gutierrez de Buenos Aires

Completed

Study of Benznidazole Transfer Into Breastmilk in Lactating Women With Chagas Disease (LACTBENZ)

Chagas Disease | Lactation

Argentina
Hospital de Niños R. Gutierrez de Buenos Aires

Completed

Study Of Nifurtimox Transfer Into Breastmilk In Lactating Women With Chagas Disease (LACTNFX)

Chagas Disease | Lactation

Argentina
Laboratorio Elea Phoenix S.A.
Drugs for Neglected Diseases

Recruiting

Shorter Benznidazole Regimens Compared to the Standard Regimen for Chagas Disease (NuestroBen)

Chagas Disease

Argentina
Drugs for Neglected Diseases
Medecins Sans Frontieres, Netherlands

Completed

Optimization of PCR Technique to Assess Parasitological Response for Patients With Chronic Chagas Disease (PCR)

Chagas Disease

Bolivia

Clinical Trials on Trypanosomiasis

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Armenia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations