Example: Heart Attack

Clinical Trials on Urea Cycle Disorders

Total 62 results

NCT04442347

Not yet recruiting

Safety, Tolerability, and Pharmacokinetics of ARCT-810 in Stable Adult Subjects With OTC Deficiency

Conditions: Ornithine Transcarbamylase Deficiency
NCT04416126

Recruiting

Safety, Tolerability and Pharmacokinetics of ARCT-810 in Healthy Adult Subjects

Conditions: Ornithine Transcarbamylase Deficiency
NCT04269122

Completed

A Study to Assess Plasma Ammonia Time-Normalized Area Under the Curve and Rate of Ureagenesis in Healthy Adult Subjects

Conditions: Ornithine Transcarbamylase Deficiency
NCT04248062

Recruiting

Patient and Observer Reported Outcome Measurements in Inborn Errors of Metabolism

Conditions: Inborn Errors of Metabolism; Urea Cycle Disorder; Maple Syrup Urine Disease; Phenylketonurias; Methylmalonicacidemia; OTC Deficiency; Aminoacidopathy; Patient Reported Outcome Measurements
NCT03967795

Not yet recruiting

Citrullinemia for the Prediction of Enteral Nutrition Tolerance Among Critically Ill Patients

Conditions: Enteral Nutrition; Intensive Care Unit; Biomarkers
NCT03933410

Recruiting

UNLOCKED: A Phase 2, Open-label Trial With KB195 in Subjects With a Urea Cycle Disorder

Conditions: Urea Cycle Disorder
NCT03921541

Recruiting

Efficacy and Safety of Pegzilarginase in Patients With Arginase 1 Deficiency

Conditions: Arginase I Deficiency; Hyperargininemia
NCT03911089

Active, not recruiting

A Collection of Case Studies in Infants With UCD to Evaluate Infant Growth and the Safety of a New Medical Food for UCD

Conditions: Urea Cycle Disorder; Inborn Errors of Metabolism
NCT03884959

Recruiting

A Safety and Efficacy Study of Infusions of HepaStem in Urea Cycle Disorders Pediatric Patients

Conditions: Urea Cycle Disorder
NCT03797131

Completed

Clinical Food Study to Evaluate the Effect of KB195 on Gut Nitrogen Metabolism in Patients With Urea Cycle Disorders

Conditions: Urea Cycle Disorders
NCT03767270

Withdrawn

Safety, Tolerability and PK/PD Evaluation of Intravenous Administration of MRT5201 in Patients With OTC Deficiency

Conditions: Ornithine Transcarbamylase Deficiency
NCT03721367

Completed

Chronic Liver Disease in Urea Cycle Disorders

Conditions: Urea Cycle Disorder
NCT03636438

Enrolling by invitation

Long Term Follow Up to Evaluate DTX301 in Adults With Late-Onset OTC Deficiency

Conditions: Ornithine Transcarbamylase (OTC) Deficiency
NCT03409003

Recruiting

Orphan Europe Carbaglu® Surveillance Protocol

Conditions: N-acetylglutamate Synthase (NAGS) Deficiency
NCT03378531

Active, not recruiting

A Study of AEB1102 (Pegzilarginase) in Patients With Arginase I Deficiency

Conditions: Arginase I Deficiency; Hyperargininemia
NCT03343756

Enrolling by invitation

HepaStem Long-Term Safety Registry

Conditions: Urea Cycle Disorder; Crigler-Najjar Syndrome
NCT03335488

Recruiting

Study of Glycerol Phenylbutyrate & Sodium Phenylbutyrate in Phenylbutyrate Naïve Patients With Urea Cycle Disorders

Conditions: Urea Cycle Disorder
NCT03181828

Terminated

Manipulating the Gut Microbiome Study

Conditions: Urea Cycle Disorder
NCT03179878

Completed

Safety and Tolerability of SYNB1020-CP-001

Conditions: Healthy Volunteer; Urea Cycle Disorder
NCT03064048

Recruiting

Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD

Conditions: Argininosuccinate Lyase Deficiency; Urea Cycle Disorder; Urea Cycle Disorders, Inborn; Argininosuccinic Aciduria
NCT02991144

Active, not recruiting

Safety and Dose-Finding Study of DTX301 (scAAV8OTC) in Adults With Late-Onset OTC Deficiency

Conditions: Ornithine Transcarbamylase (OTC) Deficiency
NCT02935283

Recruiting

Neuroimaging and Neuropsychological Outcomes in Urea Cycle Disorders

Conditions: Urea Cycle Disorders
NCT02740153

Active, not recruiting

PCORI Urea Cycle Disorder Study

Conditions: Urea Cycle Disorders
NCT02489292

Unknown status

Study to Evaluate the Efficacy of HepaStem in Urea Cycle Disorders Paediatric Patients (HEP002)

Conditions: Urea Cycle Disorders
NCT02488044

Completed

A Phase 1/2 Study of AEB1102 in Patients With Arginase I Deficiency

Conditions: Arginase I Deficiency; Hyperargininemia
NCT02311283

Completed

Pilot Study: Urea Cycle Disorders Practice Patterns and Outcomes Assessment

Conditions: Urea Cycle Disorders
NCT02252770

Completed

Nitric Oxide Supplementation in Argininosuccinic Aciduria

Conditions: Argininosuccinic Aciduria; Argininosuccinate Lyase Deficiency; Urea Cycle Disorders
NCT02246218

Completed

A Study of the Safety, Efficacy and Pharmacokinetics of Glycerol Phenylbutyrate in Pediatric Subjects Under 2 Years of Age With Urea Cycle Disorders

Conditions: Urea Cycle Disorder
NCT02124330

Completed

Protein Sorbent Properties of Montmorillonite in Vitro and in Vivo Models

Conditions: Urea Cycle Disorders, Inborn; Other Metabolic Diseases
NCT02111200

Completed

Comparative Efficacy of Phenylbutyrate (PBA) vs. Benzoate in Urea Cycle Disorders

Conditions: Urea Cycle Disorders, Inborn
NCT02051049

Completed

Long-term Safety Follow-up Study of Patients Having Received HepaStem (SAF001)

Conditions: Urea Cycle Disorders; Crigler Najjar Syndrome
NCT01948427

Active, not recruiting

Observational Study That Will Collect Information on Patients With Urea Cycle Disorders (UCDs)

Conditions: Urea Cycle Disorder
NCT01780168

Recruiting

The NIH MINI Study: Metabolism, Infection, and Immunity in Inborn Errors of Metabolism

Conditions: MMA; UCD; Acidemias; Fatty Acid Oxidation Defects
NCT01765283

Completed

Safety Study of HepaStem for the Treatment of Urea Cycle Disorders (UCD) and Crigler-Najjar Syndrome (CN)

Conditions: Urea Cycle Disorders,; Crigler Najjar Syndrome
NCT01624311

Completed

Pilot Study For Hypothermia Treatment In Hyperammonemic Encephalopathy In Neonates And Very Young Infants

Conditions: Urea Cycle Disorders; Organic Acidemias
NCT01610089

Completed

Nitric Oxide Flux and Ureagenesis in Argininosuccinate Synthetase Deficiency (ASSD)(Citrullinemia I)

Conditions: Citrullinemia
NCT01599286

Active, not recruiting

Short-Term Outcome of N-Carbamylglutamate in the Treatment of Acute Hyperammonemia

Conditions: Propionic Acidemia, Type I and/or Type II; Methylmalonic Acidemia; Carbamoyl-Phosphate Synthase I Deficiency Disease; Ornithine Carbamoyltransferase Deficiency
NCT01569568

Completed

Investigation of Brain Nitrogen in Partial Ornithine Transcarbamylase Deficiency (OTCD) Using 1 H MRS, DTI, and fMRI

Conditions: Ornithine Transcarbamylase Deficiency
NCT01560897

Unknown status

Investigating Project of the Functional C13 Test "Pilot Study"

Conditions: Disorder of the Urea Cycle
NCT01549015

Completed

Study in Healthy Subjects, Patients With Urea Cycle Disorders (UCD) and Carriers of UCD Mutations to Evaluate Urea Cycle Function

Conditions: Urea Cycle Disorders
NCT01541722

Terminated

Oxidative Stress, Inflammation and Acute Decompensation in Urea Cycle Disorders

Conditions: Urea Cycle Disorders
NCT01421888

Terminated

The NIH UNI Study: Urea Cycle Disorders, Nutrition and Immunity

Conditions: Argininosuccinic Aciduria; Carbamoyl-Phosphate Synthase I Deficiency; Citrullinemia; Ornithine Carbamoyltransferase Deficiency; Hyperargininemia; N-Acetylglutamate Synthase Deficiency
NCT01347073

Completed

Study of the Safety, Pharmacokinetics and Efficacy of HPN-100, in Pediatric Subjects With Urea Cycle Disorders (UCDs)

Conditions: Urea Cycle Disorders
NCT01345578

Suspended

Hepatocyte Transplantation for Liver Based Metabolic Disorders

Conditions: Metabolic Diseases
NCT01341379

Withdrawn

Increasing Ureagenesis in Inborn Errors of Metabolism With N-Carbamylglutamate

Conditions: Urea Cycle Disorders, Inborn; Inborn Errors of Metabolism; Propionic Acidemia; Methylmalonic Acidemia; Carbamyl Phosphate Synthetase Deficiency
NCT01257737

Completed

To Evaluate the Safety of Long-term Use of HPN-100 in the Management of Urea Cycle Disorders (UCDs)

Conditions: Urea Cycle Disorders
NCT01195753

Terminated

Human Heterologous Liver Cells for Infusion in Children With Urea Cycle Disorders

Conditions: Urea Cycle Disorders
NCT01002469

Completed

Study to Evaluate 13 C Isotope Ratio Measurement for Urea Cycle Capacity Assessment

Conditions: Urea Cycle Disorders
NCT00992459

Completed

Efficacy and Safety of HPN-100 for the Treatment of Adults With Urea Cycle Disorders

Conditions: Urea Cycle Disorders
NCT00986895

Completed

A Study of Glyceryl Tri-(4-phenylbutyrate) Administered Orally as a Single Dose, and Twice Daily for Seven Consecutive Days to Subjects With Hepatic Impairment With Cirrhosis and to a Control Group

Conditions: Hepatic Encephalopathy; Urea Cycle Disorders