Search clinical trials for: [13C]-radiolabeled Idasanutlin

Total 1971 results

Hoffmann-La Roche

Completed

A Study to Determine the Excretion Balance, Pharmacokinetics, Metabolism and Absolute Oral Bioavailability of a Single Oral Dose of [14C]-Labeled Idasanutlin and an Intravenous Tracer Dose of [13C]-Labeled Idasanutlin in a Single Cohort of Participants With Solid Tumors (Malignancies)

Solid Tumors

Hungary
Hoffmann-La Roche

Completed

Mass Balance and Absolute Bioavailability Study of RO7049389 in Healthy Volunteers

Healthy Volunteers

United Kingdom
AstraZeneca
Karolinska Institutet, Quintiles IMS

Completed

AZD1390 Administration of a Microdose [11C]AZD1390 to Healthy Volunteers

Healthy Volunteer Male Subjects

Sweden
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Evaluate ACT-132577 in Healthy Male Subjects

Healthy Subjects

Netherlands
Teva Branded Pharmaceutical Products R&D, Inc.
Covance

Terminated

A Study to Investigate the Absorption, Metabolism and Excretion of Talampanel

Healthy

United States
H. Lundbeck A/S

Completed

Study Investigating the Safety and Tolerability of Lu AF88434 in Healthy Young Men

Healthy

Netherlands
Aquinox Pharmaceuticals (Canada) Inc.
Quotient Clinical

Completed

Phase 1 Absorption Distribution Metabolism and Excretion of AQX-1125 (ADME)

Healthy Volunteer

United Kingdom
AB Science

Completed

Mass Balance Recovery, Metabolite Profile and Metabolite Identification of 14C-AB1010 in Healthy Male Subjects

Healthy Volunteers

United Kingdom
Boehringer Ingelheim

Completed

A Study in Healthy Men to Test How BI 1358894 is Taken up and Handled by the Body

Healthy

Netherlands
Trevena Inc.

Completed

A Study to Investigate the Metabolism and Excretion of [14C]-TRV130 in Healthy Male Subjects

Healthy

United States
Edgewise Therapeutics, Inc.

Completed

Absorption, Metabolism, Excretion and Absolute Bioavailability of EDG-5506 in Healthy Volunteers

Nervous System Diseases | Genetic Diseases, Inborn | Musculoskeletal Diseases | Muscular Diseases | Neuromuscular Diseases | Muscular Dystrophies | Muscular Disorders, Atrophic | Healthy Volunteer

United States
Hoffmann-La Roche

Completed

A Study to Investigate the Bioequivalence or Relative Bioavailability of Three New Idasanutlin Tablet Variants Following Oral Administration in Participants With Solid Tumors

Solid Tumors

United States, Canada
University of Zurich

Completed

13C Trioctanoate Breath Test as a Measurement of Gastric Fat Volume Emptying (13CTriOBT)

Healthy

Switzerland
H. Lundbeck A/S

Terminated

Safety and Tolerability of Lu AF95245 in Healthy Young Men

Healthy

Netherlands
Shire

Completed

Adsorption, Metabolism and Excretion (AME) of Single Dose Radiolabeled SPD557 in Volunteers

Healthy Volunteers

United States
Boehringer Ingelheim

Completed

Metabolism and Pharmacokinetics of Oral Solution of [14C]-BI 201335 in Healthy Male Volunteers

Healthy
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

Dysregulation of Glutamine Activity in the Pathogenesis of Multiple Myeloma

Monoclonal Gammopathy of Undetermined Significance | Plasma Cell Myeloma

United States
GlaxoSmithKline

Completed

A Single Dose Of GSK189075 Taken By Mouth Containing Small Amounts Of Radioactivity Studied In Healthy Male Volunteers

Diabetes Mellitus, Type 2 | Type 2 Diabetes Mellitus

United States
University of Lausanne Hospitals

Completed

123I Radiolabeled 3BNC117

Human Immunodeficiency Virus

Switzerland
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Investigate the Absorption, Metabolism, and Excretion of Canagliflozin (JNJ-28431754) in Healthy Male Volunteers

Healthy

Belgium
St. Jude Children's Research Hospital

Withdrawn

Trial of Idasanutlin and Selinexor Therapy for Children With Progressive/Relapsed AT/RT or Extra-CNS Malignant Rhabdoid Tumors

Rhabdoid Tumor | CNS Tumor | Atypical Teratoid/Rhabdoid Tumor | Atypical Teratoid/Rhabdoid Tumor of CNS

United States
Robert Bok, MD, PhD
National Cancer Institute (NCI); National Institute for Biomedical Imaging... and other collaborators

Recruiting

Hyperpolarized 13C Pyruvate as a Biomarker in Advanced Solid Tumors

Advanced Solid Tumor

United States
University of Wisconsin, Madison

Recruiting

In Vivo Metabolic Profiling of CLL (Chronic Lymphocytic Leukemia)

Chronic Lymphocytic Leukemia

United States
Shire

Completed

AME (Absorption, Metabolism, and Excretion) of Radiolabeled SSP-004184

Healthy

United States
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

Parkinson's Disease | Atherosclerosis | Cardiomyopathy | Li-Fraumeni Syndrome | Cardiovascular Capacity

United States
Vanderbilt-Ingram Cancer Center
Genentech, Inc.; Stand Up To Cancer

Terminated

Atezolizumab and Cobimetinib or Idasanutlin in Participants With Stage IV or Unresectable Recurrent Estrogen Receptor Positive Breast Cancer

Stage IV Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IIIC Breast Cancer | HER2/Neu Negative | Stage III Breast Cancer | Estrogen Receptor-positive

United States
SeeCure LLC

Unknown

The Study of Biodistribution and Dosimetry of 99mTc-Glycopeptide(99mTc-GP) in Patients With Breast Cancer

Breast Cancer

United States
Robert Flavell, MD, PhD
U.S. Army Medical Research Acquisition Activity

Recruiting

Magnetic Resonance (MR) Imaging With Hyperpolarized Bicarbonate (13C) to Measure Tissue pH in Prostate Cancer

Prostate Cancer | Localized Prostate Carcinoma

United States
Chang Gung Memorial Hospital
Ministry of Science and Technology, Taiwan

Recruiting

Hyperpolarized 13C Pyruvate MRI for Early Immune Evaluation in Cervical Cancer Patients at Baseline and CCRT Therapy

Cervical Cancer

Taiwan
Mayo Clinic
SFI Research

Completed

Determining Lipid Content in Stool After Alpha-cyclodextrin (FMAT)

Healthy Participants

United States
The Cleveland Clinic

Terminated

TRACER RGD-K5 Carotid Plaque Imaging Study (TRACER)

Carotid Stenosis | Carotid Artery Disease

United States
Y-mAbs Therapeutics

Withdrawn

177Lu-DTPA-Omburtamab Radioimmunotherapy for Leptomeningeal Metastasis From Solid Tumors (Breast, NSCLC, Malignant Melanoma)

Solid Tumor, Adult | Leptomeningeal Metastasis

United States, United Kingdom
GlaxoSmithKline

Terminated

A Validation and Dosimetry Study of GSK2634673F PET Ligand

Idiopathic Pulmonary Fibrosis

United Kingdom
BDD Pharma Ltd
AlgiPharma AS

Completed

A Study to Investigate Lung Deposition of Radiolabelled OligoG

Cystic Fibrosis

United Kingdom
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Terminated

Safety Study to Determine the Appropriate Dose of Antibody Against Tumor Cells to Best Target Patients With Pancreatic Cancer.

Pancreatic Cancer

United States
Dorte Nielsen

Terminated

HER2 PET Imaging in Breast Cancer Patients Using [68GA]ABY-025

HER2-positive Breast Cancer

Denmark
University of Texas Southwestern Medical Center
National Cancer Institute (NCI); Howard Hughes Medical Institute

Recruiting

An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy

Kidney Cancer | Renal Cell Carcinoma | Urothelial Carcinoma | Hereditary Leiomyomatosis and Renal Cell Cancer | Metastatic Urothelial Carcinoma | Chromophobe Renal Cell Carcinoma | Papillary Renal Cell Carcinoma | HLRCC | Clear Cell Carcinoma | Metastatic Kidney Cancer | Fumarate Hydratase Deficiency | Succinate...

United States
Hoffmann-La Roche

Completed

A Study of Venetoclax in Combination With Cobimetinib and Venetoclax in Combination With Idasanutlin in Patients With Relapsed or Refractory Acute Myeloid Leukemia Who Are Not Eligible for Cytotoxic Therapy

Leukemia, Myeloid, Acute

United States, Canada, France, Italy
Johns Hopkins University
amfAR, The Foundation for AIDS Research

Completed

Effect of Seminal Fluid on the Colon Wall; Implications for HIV Transmission

Human Immunodeficiency Virus (HIV)

United States
University of Michigan

Completed

An Exploratory Study of 18F-Labeled Hydroxyphenethylguanidines in Heart Failure Patients

Cardiomyopathy

United States
Loma Linda University

Terminated

Non-invasive Clinical Imaging of Cerebral Metabolism Following Brain Injury Using 13C Magnetic Resonance Spectroscopy.

Traumatic Brain Injury
University Hospital Birmingham NHS Foundation Trust
Pancreatic Cancer UK

Recruiting

The Development of a Metabolomic Test to Diagnose and Quantify Pancreatic Exocrine Insufficiency (The DETECTION Study) (DETECTION)

Pancreatic Exocrine Insufficiency

United Kingdom
Otsuka Pharmaceutical Co., Ltd.

Completed

Safety and Pharmacokinetic Study of C13-URA in Healthy Volunteers

Gastroparesis

United States
Hoffmann-La Roche

Terminated

A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Idasanutlin Monotherapy in Participants With Hydroxyurea-Resistant/Intolerant Polycythemia Vera

Polycythemia Vera

United States, Canada, Italy, Australia
GlaxoSmithKline

Completed

Part A: Radiolabel Study With GW786034 Part B: Single Dose of GW786034

Carcinoma, Renal Cell

United States
Ludwig Institute for Cancer Research
National Cancer Institute (NCI)

Completed

Monoclonal Antibody Therapy in Treating Patients With Advanced Kidney Cancer

Kidney Cancer

United States
Zhen Wang, MD
American Cancer Society, Inc.

Recruiting

Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors

Renal Cell Cancer | Kidney Neoplasm | Benign Kidney Neoplasm

United States
Rutgers, The State University of New Jersey
National Cancer Institute (NCI)

Recruiting

Investigating Targetable Metabolic Pathways Sustaining Pancreatic Cancer

Pancreatic Ductal Adenocarcinoma

United States
Erasmus Medical Center

Completed

Chronic Mesenteric Ischemia Breath Testing

Chronic Mesenteric Ischemia

Netherlands
Gilead Sciences

Completed

Treatment of Non-Hodgkin's Lymphoma With 90Y-hLL2 IgG

Lymphoma, B-Cell | Non-Hodgkin's Lymphoma

Search clinical trials for: [13C]-radiolabeled Idasanutlin

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Macedonia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations