Search clinical trials for: 13C-uracil

Total 2406 results

Otsuka Pharmaceutical Co., Ltd.

Completed

Safety and Pharmacokinetic Study of C13-URA in Healthy Volunteers

Gastroparesis

United States
Hoffmann-La Roche

Completed

Mass Balance and Absolute Bioavailability Study of RO7049389 in Healthy Volunteers

Healthy Volunteers

United Kingdom
University of Zurich

Completed

13C Trioctanoate Breath Test as a Measurement of Gastric Fat Volume Emptying (13CTriOBT)

Healthy

Switzerland
Hoffmann-La Roche

Completed

A Study to Determine the Excretion Balance, Pharmacokinetics, Metabolism and Absolute Oral Bioavailability of a Single Oral Dose of [14C]-Labeled Idasanutlin and an Intravenous Tracer Dose of [13C]-Labeled Idasanutlin in a Single Cohort of Participants With Solid Tumors (Malignancies)

Solid Tumors

Hungary
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

Dysregulation of Glutamine Activity in the Pathogenesis of Multiple Myeloma

Monoclonal Gammopathy of Undetermined Significance | Plasma Cell Myeloma

United States
Robert Bok, MD, PhD
National Cancer Institute (NCI); National Institute for Biomedical Imaging... and other collaborators

Recruiting

Hyperpolarized 13C Pyruvate as a Biomarker in Advanced Solid Tumors

Advanced Solid Tumor

United States
University of Wisconsin, Madison

Recruiting

In Vivo Metabolic Profiling of CLL (Chronic Lymphocytic Leukemia)

Chronic Lymphocytic Leukemia

United States
Robert Flavell, MD, PhD
U.S. Army Medical Research Acquisition Activity

Recruiting

Magnetic Resonance (MR) Imaging With Hyperpolarized Bicarbonate (13C) to Measure Tissue pH in Prostate Cancer

Prostate Cancer | Localized Prostate Carcinoma

United States
Chang Gung Memorial Hospital
Ministry of Science and Technology, Taiwan

Recruiting

Hyperpolarized 13C Pyruvate MRI for Early Immune Evaluation in Cervical Cancer Patients at Baseline and CCRT Therapy

Cervical Cancer

Taiwan
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System

Parkinson's Disease | Atherosclerosis | Cardiomyopathy | Li-Fraumeni Syndrome | Cardiovascular Capacity

United States
Otsuka Pharmaceutical Co., Ltd.
Covance

Completed

Phase 2 Study to Evaluate the Preliminary Performance of the C13-URA Breath Test Kit in Dyspeptic Subjects

Dyspeptic Subjects

United States
University of Michigan

Completed

An Exploratory Study of 18F-Labeled Hydroxyphenethylguanidines in Heart Failure Patients

Cardiomyopathy

United States
Loma Linda University

Terminated

Non-invasive Clinical Imaging of Cerebral Metabolism Following Brain Injury Using 13C Magnetic Resonance Spectroscopy.

Traumatic Brain Injury
University of Texas Southwestern Medical Center
National Cancer Institute (NCI); Howard Hughes Medical Institute

Recruiting

An Investigation of Kidney and Urothelial Tumor Metabolism in Patients Undergoing Surgical Resection and/or Biopsy

Kidney Cancer | Renal Cell Carcinoma | Urothelial Carcinoma | Hereditary Leiomyomatosis and Renal Cell Cancer | Metastatic Urothelial Carcinoma | Chromophobe Renal Cell Carcinoma | Papillary Renal Cell Carcinoma | HLRCC | Clear Cell Carcinoma | Metastatic Kidney Cancer | Fumarate Hydratase Deficiency | Succinate...

United States
University Hospital Birmingham NHS Foundation Trust
Pancreatic Cancer UK

Recruiting

The Development of a Metabolomic Test to Diagnose and Quantify Pancreatic Exocrine Insufficiency (The DETECTION Study) (DETECTION)

Pancreatic Exocrine Insufficiency

United Kingdom
Zhen Wang, MD
American Cancer Society, Inc.

Recruiting

Hyperpolarized 13C Pyruvate MRI Scan in Predicting Tumor Aggressiveness in Patients With Renal Tumors

Renal Cell Cancer | Kidney Neoplasm | Benign Kidney Neoplasm

United States
Rutgers, The State University of New Jersey
National Cancer Institute (NCI)

Recruiting

Investigating Targetable Metabolic Pathways Sustaining Pancreatic Cancer

Pancreatic Ductal Adenocarcinoma

United States
Erasmus Medical Center

Completed

Chronic Mesenteric Ischemia Breath Testing

Chronic Mesenteric Ischemia

Netherlands
Centre Oscar Lambret
National Cancer Institute, France

Terminated

Benefit of Chemotherapy Over Best Supportive Care in Metastatic and Squamous Cell-type Esophageal Cancer. (E-DIS)

Squamous Cell Carcinoma of Esophagus

France
Ivan de Kouchkovsky, MD
National Cancer Institute (NCI); American Cancer Society, Inc.; National Institute...

Recruiting

Pilot Study of (MR) Imaging With Pyruvate (13C) to Detect High Grade Prostate Cancer (pyruvate)

Prostate Cancer

United States
KU Leuven

Completed

Determination of the Bioavailability of Short Chain Fatty Acids in Healthy Humans

Short Chain Fatty Acids Bioavailability

Belgium
British Columbia Cancer Agency
University of Victoria; University of Texas Southwestern Medical Center; Van...

Recruiting

13C-Glucose Tracing of Tumour and T Cells in the Ascites of Ovarian Cancer Patients. (iMETABO)

Ovarian Cancer | Ascites

Canada
University of Lausanne

Completed

Fructose-induced Intestinal de Novo Lipogenesis (FIDNL)

Obesity

Switzerland
University of Texas Southwestern Medical Center

Recruiting

UTSW HP [13-C] Pyruvate Injection in HCM (HPHCM)

Duchenne Muscular Dystrophy | Becker Muscular Dystrophy | Dilated Cardiomyopathy | Cardiomyopathy, Hypertrophic | Heart Failure With Reduced Ejection Fraction | Cardiac Sarcoidosis | Heart Failure With Preserved Ejection Fraction

United States
Chang Gung Memorial Hospital
National Science and Technology Council

Not yet recruiting

Hyperpolarized 13C MRI for Cancer Immunotherapy (DNPSPIO)

Cervical Cancer | Gynecologic Cancer | Ovarian Cancer | Endometrial Cancer

Taiwan
University of Texas Southwestern Medical Center

Recruiting

Metabolic Characteristics of Brain Tumors Using Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging (MRSI) (HPCIM)

Brain Tumor Adult

United States
Rahul Aggarwal
National Cancer Institute (NCI)

Terminated

Magnetic Resonance (MR) Imaging With Hyperpolarized Pyruvate (HP) (13C) in Castration-Resistant Prostate Cancer (MR)

Prostate Cancer

United States
Susan Chang
National Cancer Institute (NCI)

Active, not recruiting

Hyperpolarized Carbon-13 (13C) Pyruvate Imaging in Patients With Glioblastoma

Glioblastoma Multiforme (GBM)

United States
University of Florida

Completed

13C-Pyruvate Breath Test (PBT)

Healthy

United States
Université de Sherbrooke
Healthy Aging Research Network

Completed

Metabolism of Omega-3 and Omega-6 During Healthy Aging

Healthy Volunteers
University of Texas Southwestern Medical Center

Enrolling by invitation

Imaging of Traumatic Brain Injury Metabolism Using Hyperpolarized Carbon-13 Pyruvate (HPTBI)

Traumatic Brain Injury

United States
University of Texas Southwestern Medical Center

Enrolling by invitation

Using Hyperpolarized [1-13C]Pyruvate to Detect Cardiotoxicity (HPCardiotox)

Breast Neoplasms

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

An Investigational Scan (hpMRI) for Monitoring Treatment Response in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck Undergoing Radiation Therapy and/or Systemic Therapy

Thyroid Gland Carcinoma

United States
University of California, San Francisco
GE Healthcare

Completed

Hyperpolarized Pyruvate Injection in Subjects With Prostate Cancer

Prostate Cancer

United States
Nanometics (d.b.a. PHD Biosciences)

Completed

Study of 0.1% Uracil Topical Cream (UTC) for the Prevention of Hand-Foot Syndrome

Breast Cancer | Palmar-Plantar Erythrodysesthesia

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors

Primary Brain Neoplasm

United States
Michael Ohliger, MD PhD
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Hyperpolarized Pyruvate (13C) Magnetic Resonance Imaging In Patients With Fatty Liver Disease

NAFLD | Non-Alcoholic Fatty Liver Disease | NASH | Non Alcoholic Fatty Liver | Non Alcoholic Steatohepatitis

United States
Javier Villaneuva-Meyer, MD
National Institute for Biomedical Imaging and Bioengineering (NIBIB); General...

Recruiting

Feasibility of Acquiring Hyperpolarized Imaging in Patients With Meningioma

Meningioma

United States
Mayo Clinic
Takeda Pharmaceuticals International, Inc.

Completed

Biomarkers for Intestinal Permeability in Patients With Constipation

Irritable Bowel Syndrome | Intestinal Diseases | Constipation

United States
Pamela Munster
Novartis

Withdrawn

Alpelisib in Combination With Carboplatin in Patients With Solid Tumors and HPV-Positive Squamous Cell Carcinoma

Locally Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Solid Tumors, Adult | HPV-Related Squamous Cell Carcinoma | Human Papillomavirus-Related Carcinoma | PIK3CA Mutation-Related Tumors | PIK3CA Mutation | Human Papillomavirus-Related Squamous Cell Carcinoma

United States
Rutgers, The State University of New Jersey
Ludwig Institute for Cancer Research

Not yet recruiting

Investigating the Metabolic Pathways in Hormone Receptor Positive/HER2 Negative Breast Cancer

Breast Cancer

United States
Universitaire Ziekenhuizen KU Leuven

Completed

A Dose-finding and Feasibility Study for a Prolonged 13C-octanoate Breath Test for Gastric Emptying (ANTERO-AC-7)

Healthy | Gastric Emptying

Belgium
University of Texas Southwestern Medical Center

Completed

Pediatric Solid Tumor Metabolism [A Prospective Study Exploring Metabolism of Solid Tumors in Pediatrics]

Sarcoma | Neuroblastoma | Pediatric Cancer

United States
Imperial College London

Terminated

A Human In Vivo Feeding Study Of The Blood Monocyte Response To Dietary Lipid Intake (Lipophage14)

Atherosclerosis

United Kingdom
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Hyperpolarized Carbon C 13 Pyruvate Magnetic Resonance Spectroscopic Imaging in Predicting Treatment Response in Patients With Prostate Cancer

Prostate Adenocarcinoma | Stage IV Prostate Cancer AJCC v8 | Stage IIIA Prostate Cancer AJCC v8 | Stage IIIB Prostate Cancer AJCC v8 | Stage III Prostate Cancer AJCC v8 | Stage IIIC Prostate Cancer AJCC v8 | Stage IVA Prostate Cancer AJCC v8 | Stage IVB Prostate Cancer AJCC v8 | Stage IIB Prostate Cancer... and other conditions

United States
Capital Medical University

Completed

The Effects of Lowering Dialysate Sodium in Hypertensive Hemodialysis Patients

Arteriosclerosis | Hypertension | Left Ventricular Hypertrophy

China
Meridian Bioscience, Inc.
Medical University of South Carolina; Northwestern University; Hadassah Medical... and other collaborators

Terminated

Detection of Hepatocellular Carcinoma (HCC) With Octanoate Breath ID Test Compared to MRI (OBT for HCC)

Hepatocellular Carcinoma (HCC) | Chronic Liver Disease

Canada
Meridian Bioscience, Inc.

Completed

BREATHID Octanoate Breath Test With or Without Methacetin Breath Test for Correlation With Biopsy in NASH

Non-Alcoholic Steatohepatitis

United States, France, Belgium, United Kingdom
Cairn Diagnostics
Baylor College of Medicine; Medical College of Wisconsin

Recruiting

Establishing a Pediatric Reference Range for the 13C-Spirulina Gastric Emptying Breath Test (GEBT)

Gastroparesis

United States
Université de Sherbrooke
McMaster University; University of Ottawa

Completed

Effects of Fructose/Glucose-rich Diet on Brown Fat in Healthy Subjects (GB7) (GB7)

Type2 Diabetes

Canada

Search clinical trials for: 13C-uracil

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