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Search clinical trials for: Alpha 1-Antitrypsin

Total 125 results

NCT04495101

Recruiting

Study to Evaluate the Safety and Efficacy of Prolastin in Hospitalized Participants With Coronavirus Disease (COVID-19)

Conditions: COVID-19
NCT04443192

Not yet recruiting

A Single Ascending and Repeated Dose Study of Oral ZF874 in Healthy Volunteers and PiMZ Subjects

Conditions: Alpha1 Anti-Trypsin Deficiency
NCT04440488

Not yet recruiting

ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study

Conditions: Chronic Obstructive Pulmonary Disease; Alpha1-antitrypsin Deficiency
NCT04385836

Recruiting

Trial of Alpha One Antitrypsin Inhalation in Treating Patient With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

Conditions: Coronavirus
NCT04204252

Recruiting

Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD

Conditions: Alpha 1-Antitrypsin Deficiency
NCT04180319

Recruiting

EARCO REGISTRY. History Of Patients With Alpha-1 Antitrypsin

Conditions: Alpha 1-Antitrypsin Deficiency
NCT04174118

Recruiting

A Study of DCR-A1AT in Healthy Adult Volunteers and Patients With A1ATD-Associated Liver Disease

Conditions: Alpha 1-Antitrypsin Deficiency
NCT04167514

Recruiting

Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids Alone

Conditions: Graft Versus Host Disease (GVHD)
NCT03945292

Recruiting

Safety, Tolerability and Effect on Liver Histologic Parameters of ARO-AAT

Conditions: Alpha 1-Antitrypsin Deficiency
NCT03946449

Recruiting

Assessment of Changes in a Novel Histological Activity Scale in Response to ARO-AAT

Conditions: Alpha 1-Antitrypsin Deficiency
NCT03815396

Recruiting

Phase 1 Study to Assess the Safety, PK and PD of INBRX-101 in Adults With Alpha-1 Antitrypsin Deficiency

Conditions: Alpha-1 Antitrypsin Deficiency; AATD
NCT03805789

Recruiting

The Safety and Efficacy of Alpha-1 Antitrypsin (AAT) for the Prevention of Graft‑Versus-host Disease (GVHD) in Patients Receiving Hematopoietic Cell Transplant

Conditions: Graft Versus Host Disease
NCT03804021

Enrolling by invitation

Long-Term Follow-up Study of ADVM-043

Conditions: Alpha-1 Antitrypsin Deficiency
NCT03802357

Recruiting

Effects of Different Exercise Training Modalities in Alpha-1 Antitrypsin Deficiency Patients

Conditions: Chronic Obstructive Pulmonary Disease; Alpha 1-Antitrypsin Deficiency
NCT03767829

Active, not recruiting

A Study of ALN-AAT02 in Healthy Participants and Participants With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Conditions: ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease
NCT03679598

Recruiting

Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency

Conditions: Alpha-1 Antitrypsin Deficiency (AATD); Pi*ZZ, Pi*SZ, or Pi*Z Null, or Pi*Null Phenotype; Emphysema or COPD
NCT03636347

Recruiting

A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo.

Conditions: Alpha 1-Antitrypsin Deficiency; Emphysema; COPD
NCT03632538

Recruiting

AKI Cardiosurgery Diagnostic Study (AKI-CDS)

Conditions: Acute Kidney Injury; Renal Replacement Therapy
NCT03470857

Recruiting

Oxidoreductive Balance and Lysosomal Activity in Cancer Patients.

Conditions: Neoplasms; Antioxidants; Oxidative Stress; Lipid Peroxidation; Inflammation; Lysosome Alteration
NCT03459040

Active, not recruiting

A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHD

Conditions: Graft-versus-host-disease; GVHD
NCT03385395

Withdrawn

Study Comparing Weekly Intravenous Administration of OctaAlpha1 With a Marketed Preparation Glassia® in Subjects With Alpha-1-antitrypsin Deficiency

Conditions: Alpha 1-Antitrypsin Deficiency
NCT03383939

Completed

Inhaled A1AT in Adult Stable Bronchiectasis

Conditions: Bronchiectasis Adult
NCT03362242

Active, not recruiting

Study of ARO-AAT in Normal Adult Volunteers

Conditions: Alpha 1-Antitrypsin Deficiency
NCT03188601

Unknown status

α1-antitrypsin (AAT) Levels and Functions in Allogeneic Bone Marrow Transplantation and Throughout Progression Into GVHD

Conditions: GVHD; Bone Marrow Transplant Failure; Alpha 1-Antitrypsin
NCT03172455

Available

Early Access Program Using Alpha 1 Antitrypsin Infusion for Patients With Steroid Refractory Acute GvHD After Hematopoietic Stem Cell Transplantation (HSCT)

Conditions: Acute-graft-versus-host Disease; Steroid Refractory Acute Graft Versus Host Disease; Graft-versus-host-disease; Graft Vs Host Disease; Alpha 1-Antitrypsin Deficiency; Alpha-1 Proteinase Inhibitor; Alpha-1 Protease Inhibitor Deficiency; Acute Graft-Versus-Host Reaction Following Bone Marrow Transplant
NCT03114020

Completed

Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency

Conditions: Emphysema; Alpha 1-Antitrypsin Deficiency
NCT03039335

Completed

The Impact of Delayed Diagnosis of Alpha-1 Antitrypsin Deficiency

Conditions: Alpha 1-Antitrypsin Deficiency
NCT03008915

Active, not recruiting

Targeting Pulmonary Perfusion in Alpha-1 Antitrypsin Deficiency

Conditions: Alpha-1 Antitrypsin Deficiency; Emphysema; Chronic Obstructive Pulmonary Disease
NCT02956122

Terminated

A Phase 2/3 Study of GLASSIA for the Treatment of Acute GvHD

Conditions: Graft Versus Host Disease
NCT02947087

Recruiting

Alpha-1 Antitrypsin (AAT) Enhances Islet Autograft Survival in Patients With Chronic Pancreatitis

Conditions: Chronic Pancreatitis
NCT02929940

Recruiting

Liver Disease in Patients With alpha1-antitrypsin Deficiency

Conditions: alpha1-antitrypsin Deficiency
NCT02922751

Suspended

FibroScan™ in Pediatric Cholestatic Liver Disease (FORCE)

Conditions: Biliary Atresia; Alagille Syndrome; Alpha1 Anti-Trypsin Deficiency; Portal Hypertension; Liver Fibrosis; Cholestasis
NCT02915614

Unknown status

Effects of Pulmonary Rehabilitation on Skeletal Muscle in COPD Patients

Conditions: Chronic Obstructive Pulmonary Disease
NCT02900183

Withdrawn

Safety, Tolerability and Effect of ARC-AAT Injection on Circulating and Intrahepatic Alpha-1 Antitrypsin Levels

Conditions: Alpha-1 Antitrypsin Deficiency
NCT02870309

Completed

Safety and Pharmacokinetics of Alpha-1 MP in Patients With Alpha1-Antitrypsin Deficiency

Conditions: Alpha1-Antitrypsin Deficiency
NCT02870348

Active, not recruiting

Long-term Safety of Alpha1-Proteinase Inhibitor (Human) in Japanese Subjects With Alpha1 Antitrypsin Deficiency (GTI1401-OLE)

Conditions: Alpha1-Antitrypsin Deficiency
NCT02841878

Withdrawn

Genetic Determinism of Epithelial Barrier Defects in Irritable Bowel Syndrome

Conditions: Irritable Bowel Syndrome (IBS)
NCT02810327

Completed

Alpha-1 Carrier Genomics Study

Conditions: Alpha-1 Antitrypsin Deficiency; Emphysema; COPD; Smoking
NCT02796937

Enrolling by invitation

Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin Deficiency

Conditions: Pulmonary Emphysema in Alpha-1 Antitrypsin Deficiency
NCT02722304

Terminated

Stage 1 Study of ARALAST NP and GLASSIA in A1PI Deficiency

Conditions: Chronic Obstructive Pulmonary Disease; Alpha1-antitrypsin Deficiency
NCT02719184

Active, not recruiting

Longitudinal Follow up to Assess Biomarkers Predictive of Emphysema Progression in Patients With COPD (Chronic Obstructive Pulmonary Disease)

Conditions: Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema
NCT02713997

Recruiting

Anti-inflammatory Therapy to Improve Outcomes After TPIAT

Conditions: Pancreatitis, Chronic; Diabetes; Transplant
NCT02691611

Active, not recruiting

Epigenetic Regulation of Immunity in Alpha-1 Anti-trypsin Deficiency

Conditions: Alpha 1-Antitrypsin Deficiency
NCT02614872

Active, not recruiting

Study to Evaluate the Safety and Efficacy of Intravenous Glassia® Treatment in Lung Transplantation

Conditions: Transplantation, Lung Rejection
NCT02547532

Completed

Microbioma in Sputa From COPD With Alpha-1 Antitrypsin Deficiency

Conditions: Alpha-1 Antitrypsin Deficiency
NCT02525861

Active, not recruiting

GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study

Conditions: Alpha1-antitrypsin Deficiency
NCT02520076

Completed

Aralast NP in Islet Transplant

Conditions: Type 1 Diabetes Mellitus
NCT02503683

Terminated

A Study of an Investigational Drug, ALN-AAT, in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Conditions: Antitrypsin Deficiency Liver Disease
NCT02502201

Terminated

Environment Effect on Six-Minute Walk Test Performance

Conditions: Chronic Obstructive Pulmonary Disease; Alpha-1 Antitrypsin Deficiency
NCT02498938

Completed

The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders

Conditions: Pulmonary Disease, Chronic Obstructive; Generalized Chronic Periodontitis