Search clinical trials for: BQ 788

Total 657 results

University of Edinburgh
Umeå University

Completed

The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin

Coronary Disease

Sweden
Medical University of Vienna

Completed

Endothelin-Receptor Blockade in Coronary Heart Disease

Vascular Resistance | Coronary Vessels | Endothelins

Austria
University Hospital, Rouen

Completed

Role of Endothelin-1 in Flow-mediated Dilatation (Endothelin)

Healthy Conditions

France
University of Colorado, Boulder
Forest Laboratories

Completed

Nebivolol and the Endothelin (ET)-1 System (NETS)

Hypertension | Prehypertension

United States
The University of Texas at Arlington

Recruiting

The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction

Cardiovascular Diseases | Cardiovascular Risk Factor | Vasoconstriction

United States
BrainQ Technologies Ltd.

Completed

The Efficacy of a Frequency-tuned Electromagnetic Field Treatment in Facilitating the Recovery of Subacute Ischemic Stroke Patients - a Pivotal Study (THE "EMAGINE" STUDY) (BQ5)

Ischemic Stroke

United States
MelCure SA
Universitaire Ziekenhuizen KU Leuven; University of Bern; California Institute...

Terminated

Proof of Concept Study With an Endothelin Receptor B Inhibitor (BQ-788) for Human Melanoma

Melanoma
BrainQ Technologies Ltd.
Sheba Medical Center; The Miami Project to Cure Paralysis; Kessler Institute...

Recruiting

The Use of Electromagnetic Field (EMF) Treatment in Chronic Spinal Cord Injury (SCI) Patients

Incomplete Spinal Cord Injury

Israel, United States
BrainQ Technologies Ltd.

Terminated

Efficacy of EMF BCI Based Device on Acute Stroke

Acute Stroke

India
University of Southern Denmark
The University of Texas at Arlington

Active, not recruiting

Insulin Stimulated Vasodilation in Patients With Type 2 Diabetes

Type2 Diabetes

Denmark
Enanta Pharmaceuticals, Inc

Completed

Evaluation of the Safety and Pharmacokinetics of a Single Oral Dose of EDP-788

Safety in Normal Volunteers

United States
Enanta Pharmaceuticals, Inc

Terminated

Evaluation of the Safety, Tolerability, and Pharmacokinetics of Multiple Oral Doses of EDP-788

Healthy

United States
Millennium Pharmaceuticals, Inc.

Completed

A Study to Evaluate Pharmacokinetics (PK) and Safety of Oral Mobocertinib in Participants With Moderate or Severe Hepatic Impairment (HI) and Normal Hepatic Function

Healthy Volunteers | Hepatic Impairment

United States
Millennium Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Pharmacokinetics (PK), Safety and Tolerability of TAK-788 Followed by Evaluation of the Effects of a Low-Fat Meal on TAK-788 PK and Evaluation of Relative Bioavailability of TAK-788 Capsules in Healthy Participants

Healthy Volunteers

United States
Millennium Pharmaceuticals, Inc.

Completed

A Study of Mobocertinib Capsules in People With Severe Kidney Problems and People With Healthy Kidneys

Renal Impairment | Healthy Volunteers

United States
Takeda

Completed

A Study to Evaluate the Effect of High-Fat Meal on TAK-788 Pharmacokinetics (PK) in Healthy Adult Participants

Healthy Volunteers

United States
National Taiwan University Hospital

Recruiting

Comparison of Vonoprazan-based Versus Lansoprazole-based Triple Therapy, High Dose Dual Therapy, Bismuth and Non-bismuth Quadruple Therapy in the First-line Treatment of Helicobacter Pylori Infection

H. Pylori Infection

Taiwan
Bioquark Inc.
Revita Life Sciences; Anupam Hospital

Completed

Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury

Brain Death

India
Dow University of Health Sciences

Completed

Behavior Changing Intervention for Smokeless Tobacco and Betel Quid Use in Adolescents

Oral Cavity Carcinoma

Pakistan
Millennium Pharmaceuticals, Inc.

Completed

A Study to Assess Absolute Bioavailability (ABA) of Mobocertinib (TAK-788) and to Characterize Mass Balance, Pharmacokinetics (PK), Metabolism, and Excretion of Carbon-14 ([14C])-Mobocertinib in Male Healthy Participants

Healthy Volunteers

United States
Takeda

Active, not recruiting

A Study of TAK-788 in Adults With Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung

United States, Spain, Korea, Republic of, Taiwan, Japan, China, Italy, Germany, United Kingdom, Puerto Rico
Takeda

Withdrawn

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of TAK-988 in Healthy Participants

Healthy Volunteers

United States
Ono Pharmaceutical Co. Ltd

Completed

Single-dose Study to Evaluate the Absolute Bioavailability and Mass Balance of ONO-5788 (ONO-5788-02)

Acromegaly

Netherlands
Brigham and Women's Hospital

Completed

The Role of Endothelin in Pulmonary Hypertension

Pulmonary Hypertension

United States
Eli Lilly and Company
Loxo Oncology, Inc.

Not yet recruiting

A Study of [14C]-LOXO-783 in Healthy Adult Participants

Healthy

United States
Takeda

Withdrawn

A Study to Evaluate the Impact of Management Strategies on Gastrointestinal-Related Adverse Events in Participants With Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations Receiving TAK-788

Non-Small Cell Lung Cancer (NSCLC)
Beijing InnoCare Pharma Tech Co., Ltd.

Recruiting

Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of ICP-488 in Patients With Moderate to Severe Plaque Psoriasis

Moderate to Severe Plaque Psoriasis

China
NeurAxon Inc.

Completed

Study of the Safety and Effectiveness of NXN-188 for the Treatment of Migraine Headache Without Aura

Migraine Without Aura

United States
VA Office of Research and Development
University of Utah

Completed

Contribution of Endothelin-1 to Exercise Intolerance in Heart Failure

Heart Failure

United States
Brigham and Women's Hospital

Completed

The Contribution of Endothelin to Vasomotor Function in Diseased Coronary Arteries

Atherosclerosis, Coronary

United States
Mayo Clinic

Completed

Role of Endothelin in Microvascular Dysfunction Following PCI for NSTEMI (BQ-123)

Myocardial Reperfusion Injury

United States
Blueprint Medicines Corporation

Completed

Safety, Tolerability, Pharmacokinetics, and Food Effect of BLU-782 in Healthy Adults

Healthy Volunteers

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

CBM588 in Improving Clinical Outcomes in Patients Who Have Undergone Donor Hematopoietic Stem Cell Transplant

Hematopoietic and Lymphoid Cell Neoplasm

United States
AbbVie (prior sponsor, Abbott)

Completed

Efficacy and Safety Study for Cognitive Deficits in Adult Subjects With Schizophrenia

Cognitive Deficits in Schizophrenia

United States
Rhythm Pharmaceuticals, Inc.

Recruiting

A Study of RM-718 in Healthy Subjects and in Patients With HO

Hypothalamic Obesity

United States
AbbVie

Recruiting

Study to Evaluate Adverse Events and Movement of Intravenously (IV) Infused ABBV-787 in Adult Participants With Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML)

Acute Myeloid Leukemia

United States, Israel, Japan, Australia, Korea, Republic of
Huashan Hospital

Recruiting

Alterations of Gut Microbiome, Function, and Its Intervention After Defunctioning Ileostomy

Rectal Cancer | Ileostomy - Stoma | Microbial Disease | Intestinal Functional Disorder

China
Kissei Pharmaceutical Co., Ltd.

Completed

A Clinical Study in Patients With Chronic Idiopathic Thrombocytopenic Purpura in R788

Idiopathic Thrombocytopenic Purpura

Japan
GTx

Terminated

Phase II, Dose Finding Study of GTx-758

Prostate Cancer

United States
China Medical University Hospital

Completed

The Effect of Probiotics on Depression Syndrome and Risk Factors of Cardiovascular Disease in Hemodialysis Patients

Cardiovascular Diseases | Depression Mild

Taiwan
Sumitomo Pharma Co., Ltd.

Completed

Study of DSP-7888 in Patients With Myelodysplastic Syndrome (MDS)

Myelodysplastic Syndrome

Japan
Bausch Health Americas, Inc.

Withdrawn

Study Evaluating MOA-728 Administered in Healthy Men

Healthy
Bausch Health Americas, Inc.

Completed

Study Evaluating the Safety and Tolerability of a New Intravenous Formulation of MOA-728 in Healthy Subjects

Healthy

United States
Bausch Health Americas, Inc.

Completed

Bioequivalence Study in Healthy Volunteers

Healthy

United States
Neurocrine Biosciences
Immune Tolerance Network (ITN)

Completed

Evaluation of an Altered Peptide Ligand (NBI-5788) in Patients With Relapsing Multiple Sclerosis (MS)

Multiple Sclerosis
Sumitomo Pharma Co., Ltd.

Completed

A Study of DSP-7888 in Pediatric Patients With Relapsed or Refractory High Grade Gliomas

Glioblastoma | Diffuse Intrinsic Pontine Glioma

Japan
CytomX Therapeutics

Withdrawn

PROCLAIM-CX-188: A Trial to Find Safe and Active Doses of an Investigational Drug CX-188 for Patients With Solid Tumors

Solid Tumor, Adult

United States
Bausch Health Americas, Inc.

Completed

Study Evaluating the Safety of MOA-728 Administered Orally to Healthy Subjects

Postoperative Complications | Constipation

United States
Mast Therapeutics, Inc.
CytRx

Completed

Phase III Randomized Study of Poloxamer 188 for Vaso-Occlusive Crisis of Sickle Cell Disease

Sickle Cell Anemia
PegBio Co., Ltd.

Completed

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of PB-718 Injection in Chinese Obese Subjects.

Obesity

China

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