Search clinical trials for: Cilastatin

Total 74 results

Amsterdam UMC, location VUmc
ZonMw: The Netherlands Organisation for Health Research and Development; Fo...

Completed

Short Versus Extended Antibiotic Treatment With a Carbapenem for High-risk Febrile Neutropenia in Hematology Patients With FUO (SHORT)

Febrile Neutropenia | Hematological Malignancy

Netherlands
University Hospital Rijeka
University of Rijeka

Completed

Imipenem Prophylaxis in Patients With Acute Pancreatitis (IMPROWE)

Acute Pancreatitis

Croatia
Merck Sharp & Dohme LLC

Completed

Efficacy and Safety of Imipenem+Cilastatin/Relebactam (MK-7655A) Versus Colistimethate Sodium+Imipenem+Cilastatin in Imipenem-Resistant Bacterial Infection (MK-7655A-013) (RESTORE-IMI 1)

Bacterial Infections
Pfizer

Completed

Complicated Skin and Skin Structure Infections

Abscess | Cellulitis | Skin Infection
Johnson & Johnson Pharmaceutical Research & Development...

Terminated

To Compare Safety and Efficacy of Doripenem Versus Imipenem-Cilastatin in Patients With Ventilator-Associated Pneumonia

Ventilator-Associated Pneumonia

United States, Australia, Germany, France, Spain, Argentina, Mexico, Portugal, India, Romania, Turkey, Ukraine, Canada, Belgium, Brazil, Philippines, Russian Federation, Hungary, Israel, Thailand, Guatemala
Jiangsu HengRui Medicine Co., Ltd.

Not yet recruiting

A Trial of Intravenous HRS-8427 in the Treatment of Adults With Complicate Urinary Tract Infection, Including Acute Pyelonephritis

Patients With Complicated Urinary Tract Infection(cUTI), Including Acute Pyelonephritis(AP)
Evopoint Biosciences Inc.

Recruiting

Evaluation of the Efficacy and Safety of Intravenous Imipenem/Cilastatin/XNW4107 in Comparison With Recarbrio in Adults With HABP /VABP (REITAB-2)

Hospital Acquired Bacterial Pneumonia or Ventilator-Associated Bacterial Pneumonia

United States, Spain, France, Israel
Spero Therapeutics
GlaxoSmithKline

Recruiting

A Study of Oral Tebipenem Pivoxil Hydrobromide (TBP-PI-HBr) Compared to Intravenous Imipenem-cilastatin in Participants With Complicated Urinary Tract Infection (cUTI) or Acute Pyelonephritis (AP) (PIVOT-PO)

Urinary Tract Infection | Acute Pyelonephritis

Moldova, Republic of, Georgia, United States, Serbia, Bulgaria, Romania, South Africa
GlaxoSmithKline

Terminated

GSK2251052 in Complicated Urinary Tract Infection

Infections, Urinary Tract

France, United States, Russian Federation, Spain, Greece, Canada
Spherium Biomed
Hospital Universitario La Paz

Completed

Safety, Tolerability and Pharmacokinetic Profile of an Infusion of Cilastatin in Healthy Volunteers.

Dose Finding Study

Spain
Evopoint Biosciences Inc.

Completed

Pharmacokinetics of XNW4107 in Subjects With Various Degrees of Renal Function

Bacterial Infections

United States
Ruijin Hospital
Pfizer

Unknown

Linezolid Alone or Combined With Carbapenem Against Methicillin-resistant Staphylococcus Aureus (MRSA) in Ventilator-associated Pneumonia

Pneumonia, Ventilator-Associated | Methicillin-resistant Staphylococcus Aureus
Merck Sharp & Dohme LLC

Completed

Efficacy and Safety of Imipenem+Cilastatin/Relebactam (MK-7655A) in Japanese Participants With Complicated Intra-abdominal Infection or Complicated Urinary Tract Infection (MK-7655A-017)

Complicated Intra-abdominal Infection | Complicated Urinary Tract Infection

Japan
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Safety and Tolerability Study of Doripenem in Patients With Abdominal Infections or Pneumonia

Pneumonia | Bacterial Infections | Pneumonia, Bacterial | Abdominal Abscess | Pneumonia, Ventilator-Associated
Entasis Therapeutics

Completed

Evaluation of Safety and Efficacy of Intravenous Sulbactam-ETX2514 in the Treatment of Hospitalized Adults With Complicated Urinary Tract Infections

Acute Pyelonephritis | Complicated Urinary Tract Infection

Bulgaria
Evopoint Biosciences Inc.

Completed

Intrapulmonary Pharmacokinetics of XNW4107, Imipenem and Cilastatin in Healthy Subjects

Bacterial Infections

United States
Evopoint Biosciences Inc.

Completed

To Evaluate the Pharmacokinetics of XNW4107 in Healthy Adult Young Females and in Healthy Adult Elderly Males and Females.

Bacterial Infections

United States
Pfizer

Terminated

Study Evaluating Safety and Efficacy of Tigecycline Versus Imipenem/Cilastatin Subjects With Hospital-Acquired Pneumonia

Pneumonia, Bacterial

Canada, United States, Argentina, Australia, Brazil, Chile, Colombia, Croatia, France, Hungary, Korea, Republic of, Latvia, Russian Federation, Taiwan
Prince of Songkla University

Unknown

PK/PD and Clinial Outcomes of Beta-lactams in ICU Patients

Critical Illness | Bacterial Infections

Thailand
Pfizer

Completed

A Study To Determine The Efficacy And Safety Of Tigecycline Compared With Imipenem/Cliastatin to Treat Complicated Intra-Abdominal Infection

Intra-abdominal Infection

China
University of Illinois at Chicago
Merck Sharp & Dohme LLC

Enrolling by invitation

Impact of Obesity on the Pharmacokinetics of Imipenem-Relebactam in ICU Patients

Obesity | Critical Illness

United States
Shionogi

Completed

A Study of Efficacy and Safety of Intravenous Cefiderocol (S-649266) Versus Imipenem/Cilastatin in Complicated Urinary Tract Infections (APEKS-cUTI)

Urinary Tract Infections
Evopoint Biosciences Inc.

Not yet recruiting

Evaluation of the Efficacy and Safety of Intravenous Imipenem/Cilastatin/XNW4107 in Comparison With Meropenem in Hospitalized Adults With cUTI Including AP (EudraCT no. 2022-000061-40)

Complicated Urinary Tract Infection Including Acute Pyelonephritis

United States
Hartford Hospital
Merck Sharp & Dohme LLC; University of Texas Southwestern Medical Center; University... and other collaborators

Recruiting

Imipenem/Cilastatin/Relebactam Pharmacokinetics, Safety, and Outcomes in Adults and Adolescents With Cystic Fibrosis

Pneumonia, Bacterial | Cystic Fibrosis

United States
Pfizer

Completed

Comparative Study of NXL104/Ceftazidime Versus Comparator in Adults With Complicated Urinary Tract Infections

Complicated Urinary Tract Infection

United States, Lebanon, Jordan
University of Vermont
National Cancer Institute (NCI)

Completed

Dolastatin 10 in Treating Patients With Indolent Lymphoma, Waldenstrom's Macroglobulinemia, or Chronic Lymphocytic Leukemia

Lymphoma | Leukemia

United States
Entasis Therapeutics

Completed

Evaluation of the Safety, Tolerability and Pharmacokinetics of Intravenous ETX2514 Administered in Healthy Subjects

Acinetobacter Baumannii Infection

Australia
University of Chicago
National Cancer Institute (NCI)

Completed

Dolastatin 10 in Treating Patients With Metastatic Or Recurrent Liver, Bile Duct, or Gallbladder Cancer

Liver Cancer | Gallbladder Cancer | Extrahepatic Bile Duct Cancer

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Dolastatin 10 in Treating Patients With Advanced Kidney Cancer

Kidney Cancer

United States
Joseph L. Kuti, PharmD
Merck Sharp & Dohme LLC

Completed

Imipenem/Cilastatin/Relebactam PK in ECMO

Sepsis

United States
National Cancer Institute (NCI)

Completed

Dolastatin 10 in Treating Patients With Recurrent or Metastatic Soft Tissue Sarcoma

Sarcoma | Ovarian Cancer

United States
Merck Sharp & Dohme LLC

Completed

Study of the Safety, Tolerability, and Efficacy of Relebactam (MK-7655) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone to Treat Complicated Intra-Abdominal Infection [cIAI] (MK-7655-004)

Intra-abdominal Infections
Barbara Ann Karmanos Cancer Institute
National Cancer Institute (NCI)

Completed

Dolastatin 10 in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Previous Hormone Therapy

Prostate Cancer

United States
Merck Sharp & Dohme LLC

Completed

A De-Escalating Strategy for Antibiotic Treatment of Pneumonia in The Medical Intensive Care Unit (0787B-092)

Pneumonia | Infection
Geron Corporation

Completed

Open Label Study to Evaluate the Activity of Imetelstat in Patients With Essential Thrombocythemia or Polycythemia Vera (ET/PV)

Polycythemia Vera | Essential Thrombocythemia

United States, Germany, Switzerland
Meiji Seika Pharma Co., Ltd.

Recruiting

Efficacy and Safety of Cefepime/Nacubactam or Aztreonam/Nacubactam Compared to Imipenem/Cilastatin in Subjects With Complicated Urinary Tract Infections or Acute Uncomplicated Pyelonephritis (Integral-1)

Acute Pyelonephritis | Complicated Urinary Tract Infection

Estonia
Entasis Therapeutics

Completed

Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoaceticus Complex (ATTACK)

Bacteremia | Ventilator-associated Bacterial Pneumonia | Acinetobacter Baumannii-calcoaceticus Complex | Hospital-acquired Bacterial Pneumonia | Colistin Resistant ABC

United States, Belarus, Brazil, China, Greece, Hungary, India, Israel, Korea, Republic of, Lithuania, Mexico, Peru, Puerto Rico, Russian Federation, Taiwan, Thailand, Turkey
Ain Shams University

Unknown

Efficacy and Safety of Colistin Based Antibiotic Therapy

Bacterial Infections | Septicemia

Egypt
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating Tigecycline Versus Imipenem/Cilastatin in Hospital-Acquired Pneumonia

Bacterial Pneumonia

United States
Merck Sharp & Dohme LLC

Completed

Safety, Tolerability, and Efficacy of MK-7655 (Relebactam) + Imipenem/Cilastatin Versus Imipenem/Cilastatin Alone for Treating Complicated Urinary Tract Infection (cUTI) (MK-7655-003)

Urinary Tract Infections | Pyelonephritis
Merck Sharp & Dohme LLC

Completed

A Single-Dose Study to Investigate the Pharmacokinetics of MK-7655 in Participants With Impaired Renal Function (MK-7655-005)

Infectious Disease
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Dolastatin 10 in Treating Patients With Metastatic Pancreatic Cancer

Pancreatic Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Dolastatin 10 in Treating Patients With Refractory or Relapsed Acute Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia

Myelodysplastic Syndromes | Leukemia

United States
M.D. Anderson Cancer Center
Merck Sharp & Dohme LLC

Completed

PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONIN

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States
Alissa Gubeli
Spentys

Completed

Overnight and In-house 3D-printed Patient-specific Casts for Non-operative Treatment of Distal Radius Fractures (3D-cast)

Radius Fracture Distal

Switzerland
Merck Sharp & Dohme LLC

Completed

Imipenem/Relebactam/Cilastatin Versus Piperacillin/Tazobactam for Treatment of Participants With Bacterial Pneumonia (MK-7655A-014) (RESTORE-IMI 2)

Bacterial Pneumonia
Jatupon Kongtharvonskul
Police General Hospital

Completed

Comparative Outcomes Between Foot Cast and Short Leg Cast in the Patients With Acute Closed Fracture of Proximal Fifth Metatarsal (Zone II)

Acute Closed Fracture of Proximal Fifth Metatarsal (Zone II)

Thailand
KK Women's and Children's Hospital

Completed

HM vs Fibreglass Casts in Treating Pediatric Supracondylar Humeral Fractures

Pediatric Supracondylar Humeral Fracture

Singapore
Boston Children's Hospital

Completed

Randomized Trial of Casting Techniques for Displaced Forearm Fractures

Displaced Forearm Fractures

United States
George Washington University

Recruiting

Impact of Early ADL Participation on Outcomes Post DRF

Distal Radius Fracture

United States

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