Search clinical trials for: Cocktail of CYP450 substrates

Total 105 results

Galapagos NV

Completed

A Drug-drug Interaction Study Between GLPG1205 and a Cocktail of CYP450 Substrates in Healthy Male Subjects

Healthy

Belgium
Sumitomo Pharma America, Inc.

Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Drug Interaction Potential of Napabucasin in Healthy Volunteers

Drug-drug Interactions

United States
Emalex Biosciences Inc.
ICON Early Phase Services; Nuventra

Completed

Drug-Drug Interaction Study to Evaluate the Effects of Ecopipam on the Pharmacokinetics of Multiple Substrates for Drug Metabolism and Transport

Drug Interaction

United States
H. Lundbeck A/S

Completed

Effects of Repeated Doses of Lu AF35700 on Drug Metabolizing Enzymes

Drug Reactions

United Kingdom
CTI BioPharma
PPD

Completed

Drug-Drug Interaction Study of Pacritinib and CYP450,Transporter Substrates, and CYP450 3A4 in Healthy Male Subjects

Drug Interactions

United States
Aristotle University Of Thessaloniki

Not yet recruiting

Metabolic Substrate of Patients With Myocardial Infarction With and Without Modifiable Cardiovascular Risk Factors (Meta-SMuRF)

Cardiovascular Diseases | Acute Coronary Syndrome | Acute Myocardial Infarction | Metabolic Disturbance
Novo Nordisk A/S

Completed

Research Study to Investigate How a Study Medicine (NNC9204- 1177) Affects Blood Levels of Other Medicines in Healthy People

Obesity | Overweight | Healthy Volunteers

United States
Queen Savang Vadhana Memorial Hospital, Thailand

Recruiting

RCT - Epidural Anesthetic Cocktail Following Endoscopic Lumbar Discectomy

Lumbar Disc Herniation

Thailand
University Hospital, Montpellier

Completed

Bacteriophage Effects on Pseudomonas Aeruginosa (MUCOPHAGES)

Cystic Fibrosis

France
Kenneth K. Tanabe, MD
National Cancer Institute (NCI)

Active, not recruiting

rRp450-Phase I Trial in Liver Metastases and Primary Liver Tumors

Liver Metastases | Primary Liver Cancers

United States
AbbVie

Completed

A Study to Evaluate the Effect of Intravenous (IV) Infusions of Risankizumab on Pharmacokinetics of Cytochome P450 Substrates in Adult Participants With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease

Crohn's Disease | Ulcerative Colitis (UC)

United States, Germany, Israel
Pherecydes Pharma

Unknown

Evaluation of Phage Therapy for the Treatment of Escherichia Coli and Pseudomonas Aeruginosa Wound Infections in Burned Patients (PHAGOBURN)

Wound Infection

Belgium, France, Switzerland
Northwell Health
Regeneron Pharmaceuticals

Withdrawn

Transplantation of Deceased Donors With COVID-19 Into COVID-19 Negative Recipients Utilizing Casirivimab and Imdevimab Antibody Cocktail

COVID-19 | Organ Transplant

United States
Federal University of São Paulo

Completed

Stem Cell Therapy for Outer Retinal Degenerations

Age Related Macular Degeneration | Exudative Age-related Macular Degeneration | Stargardt's Disease

Brazil
Amgen

Completed

Safety, Tolerability, Pharmacokinetics, and Efficacy of Acapatamab in Subjects With mCRPC

Prostate Cancer | Metastatic Castration-resistant Prostate Cancer

United States, Belgium, Austria, Singapore, Australia, Netherlands, France, Japan, Taiwan, Canada
Ural State Medical University

Unknown

The Study of the Effectiveness of Tissue Equivalent on the Basis of Cultured Cells to Heal Skin Blemishes (SETES)

Burns | Neurotrophic Ulcers

Russian Federation
Emalex Biosciences Inc.
Syneos Health; Nuventra

Terminated

Drug-Drug Interaction Study to Evaluate the Effects of Ecopipam on the Pharmacokinetics of Multiple Substrates

Drug-Interactions

United States
Kyushu University
Human Genome Center, Institute of Medical Science, University of Tokyo

Completed

Safety Study of Cancer Specific Epitope Peptides Cocktail for Cervical, GI, and Lung Tumors (peptidevac)

Metastatic Tumors

Japan
DeClaire LaMacchia Orthopaedic Institute

Unknown

Effectiveness of Intraoperative Exparel for Postoperative Pain Control in Total Knee Arthroplasty

Osteoarthritis | Pain Management | Total Knee Arthroplasty
VA Office of Research and Development

Completed

Respiratory and Autonomic Plasticity Following Intermittent Hypoxia (RAP-IH)

Sleep Apnea Syndromes

United States
University of Wisconsin, Madison
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

HYPEROXIA Responses and ROS

Cerebrovascular Disorders

United States
Chulalongkorn University
Ramathibodi Hospital; Ministry of Health, Thailand; The Government Pharmaceutical... and other collaborators

Completed

Efficacy and Safety of Nasal Spray Solution Containing Human IgG1 Anti-COVID-19 Antibody Cocktail

SARS-CoV-2 Acute Respiratory Disease | SARS CoV 2 Infection

Thailand
Lobe Sciences Ltd.
Pharmaceutical Research Unit, Jordan

Completed

Evaluation of Safety, Rate and Extent of Absorption of Psilocin Mucate (Psilocin-1)

Side Effect of Drug

Jordan
Eli Lilly and Company

Completed

A Study of Multiple Doses of Lasmiditan in Healthy Participants

Healthy

United States
University of Illinois at Chicago
Oregon State University

Completed

Licorice Botanical Dietary Supplements - Metabolism and Safety in Women

Food-drug Interaction

United States
Pfizer

Completed

Safety, Pharmacokinetics, Bioavailability, Food Effect, Drug-Drug Interaction Study of APX001 Administered Orally

Fungal Infection

Netherlands
Houston Fertility Institute

Completed

Single Injection of Ganirelix in Gonadotropin Intrauterine Insemination (IUI) Cycles

GnRH Antagonist | Compare Pregnancy Rates Between FSH Stimulation and FSH and

United States
Xijing Hospital

Unknown

Cocktail Injection Improves Outcomes of FFR Guided PCI (CocktailII)

Acute Coronary Syndromes

China
University of Nebraska

Withdrawn

Effects of Oral Antioxidant Cocktail in Cardiovascular Disease Patients

Cardiovascular Diseases

United States
Asklepios proresearch
Evangelisches Krankenhaus Düsseldorf; Asklepios Klinik St. Georg

Recruiting

Persistent AF Catheter Ablation: Re-PVI vs. Re-PVI + Continuous Complex Activity Mapping and Ablation - AF-CAM (AF-CAM)

Atrial Fibrillation

Germany
Augusta University
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Estrogen and Diabetes

Diabetes Mellitus, Type 1

United States
Nanyang Technological University
Ministry of Education, Singapore

Completed

Fitness and Fat Oxidation in Overweight Chinese, Indian and Malay Men

Overweight and Obesity

Singapore
Augusta University

Completed

Cystic Fibrosis and Endothelial Function: At Rest and During Exercise

Cystic Fibrosis

United States
Goethe University
German Federal Ministry of Education and Research; Deutsche Leukämie- & Lymphom-Hilfe

Recruiting

Randomized Trial in Adult de Novo Ph Positive ALL With Chemotherapy, Imatinib or Ponatinib, Blinatumomab and SCT (GMALL-EVOLVE)

Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Germany
Assistance Publique - Hôpitaux de Paris

Recruiting

LEVOSIMENDAN to Facilitate Weaning From ECMO in Severe Cardiogenic Shock Patients (LEVOECMO)

Cardiogenic Shock | Extracorporeal Membrane Oxygenation Complication

France
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer

Prostate Cancer | Pharmacokinetics of Dextromethorphan | Pharmacokinetics of Caffeine

Moldova, Republic of
Lahey Clinic

Recruiting

Randomized Controlled Trial for Ankle Fracture Pain Control

Ankle Fractures

United States
Drexel University

Unknown

Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? (MitoASD)

Mitochondrial Diseases | Autism Spectrum Disorders

United States
Assaf-Harofeh Medical Center

Unknown

DMSO Efficacy in IC/PBS Patients During and After Treatment

Cystitis, Interstitial

Israel
EMET Pharmaceuticals, LLC
Eagle Pharmaceuticals, Inc.

Completed

A BE Study Comparing Mesalamine 400 mg to ASACOL® 400 mg in Patients With Mild To Moderately Active Ulcerative Colitis

Mild to Moderate Ulcerative Colitis
AZ Sint-Jan AV

Recruiting

Added Value of Vein of Marshal Ethanol Infusion Compared to Superior Vena Cava Isolation Alone in Patients Undergoing Repeat Ablation for Recurrent Paroxysmal Atrial Fibrillation Despite Durable PV Isolation (VEIN-AF)

Paroxysmal Atrial Fibrillation

Belgium
Augusta University
American Heart Association

Completed

Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

United States
Assaf-Harofeh Medical Center

Unknown

Use of Pharmacogenetics in the Treatment of Children With Autistic Spectrum Disorders

Autism | Neuroleptic Treatment

Israel
University of Utah

Terminated

Multimodal Pain Management Following Primary TKA

Pain

United States
GERCOR - Multidisciplinary Oncology Cooperative...

Unknown

Docetaxel and Epirubicin as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Adenocarcinoma of the Stomach

Gastric Cancer

France
Nova Scotia Health Authority

Terminated

Trial Comparing Intravesical Cocktail With Intravesical Dimethyl Sulfoxide (DMSO) in Painful Bladder Syndrome/Interstitial Cystitis (PBS/IC)

Interstitial Cystitis | Bladder Diseases

Canada
Cephalon

Completed

Armodafinil (CEP-10953) in Treatment of Excessive Sleepiness Associated With Obstructive Sleep Apnea/Hypopnea Syndrome(OSAHS)

Obstructive Sleep Apnea | Hypopnea
University of Eastern Finland
Kuopio University Hospital; Finnish Cultural Foundation; Academy of Finland; Diabetes...

Completed

Effects of LRYGB on Pharmacokinetics of Nine CYP Probe Drugs

Obesity, Morbid | Bariatric Surgery Candidate

Finland
BeiGene

Completed

A Pharmacokinetic Study to Assess Drug-drug Interaction Between Zanubrutinib and a Cocktail of Substrates in Healthy Subjects

Healthy Subjects

United States
James Lewis
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); S...

Completed

Dose Escalation and Remission (DEAR) (DEAR)

Ulcerative Colitis

United States

Search clinical trials for: Cocktail of CYP450 substrates

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