Search clinical trials for: dimebon

Total 51 results

Pfizer
Medivation, Inc.

Completed

A Study In Healthy Volunteers To Estimate The Pharmacokinetics Of Four Modified-Release Formulations Of Dimebon (Latrepirdine)

Huntington Disease | Alzheimer's Disease

United States
Medivation, Inc.
Pfizer

Terminated

An Extension of the CONCERT Protocol (DIM18) (CONCERT PLUS)

Alzheimer's Disease
Pfizer
Medivation, Inc.

Completed

A Phase 1 Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF-01913539] In Japanese And Western Healthy Subjects

Alzheimer's Disease | Huntington's Disease

United States
Pfizer
Medivation, Inc.

Completed

A Phase 1, Non-Randomized, Open-Label, Single-Dose Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [PF 01913539] In Subjects With Severely-Impaired And Normal Renal Function

Alzheimer's Disease | Huntington's Disease

United States
Pfizer
Medivation, Inc.

Completed

Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [Pf-01913539] In Subjects With Hepatic Impairment And Normal Hepatic Function

Hepatic Failure

United States
Pfizer
Medivation, Inc.

Completed

A Phase 1 Trial To Assess The Safety And Pharmacokinetics Of Single, Ascending, Oral Doses Of Dimebon In Healthy Adults

Healthy Volunteers

Belgium
Medivation, Inc.
Huntington Study Group

Completed

Safety Study of the Novel Drug Dimebon to Treat Patients With Huntington's Disease

Huntington's Disease

United States
Medivation, Inc.

Completed

A Safety and Efficacy Study of Oral Dimebon in Patients With Mild-To-Moderate Alzheimer's Disease (CONNECTION)

Alzheimer's Disease

United States
Pfizer
Medivation, Inc.

Completed

A Phase 3 Study To Evaluate The Safety And Tolerability Of Dimebon Patients With Mild To Moderate Alzheimer's Disease

Alzheimer's Disease

Canada, United States, Puerto Rico
Medivation, Inc.
Pfizer

Completed

A Safety and Efficacy Study of Dimebon in Patients With Huntington Disease (HORIZON)

Huntington Disease

Germany, Canada, United States, Denmark, United Kingdom, Australia, Sweden
Medivation, Inc.
Pfizer

Terminated

An Extension of the HORIZON Protocol Evaluating the Safety of Dimebon (Latrepirdine) in Subjects With Huntington Disease (HORIZON PLUS)

Huntington Disease
Pfizer
Medivation, Inc.

Completed

A Study Evaluating The Absorption Of Dimebon Into The Body From A Dimebon Solution Applied To The Skin

Alzheimer's Disease | Huntington's Disease

United States
Medivation, Inc.

Completed

Double-blind, Placebo-controlled Study of Oral Dimebon in Subjects With Mild to Moderate Alzheimer's Disease

Alzheimer's Disease

Russian Federation
Medivation, Inc.
Huntington Study Group

Completed

A Study of the Novel Drug Dimebon in Patients With Huntington's Disease (DIMOND)

Huntington's Disease

United States
Pfizer
Medivation, Inc.

Terminated

An Extension To The B1451027 Protocol To Evaluate The Long Term Safety And Tolerability Of Dimebon In Patients With Alzheimer's Disease

Alzheimer's Disease

Canada, United States, Puerto Rico
Medivation, Inc.
Pfizer

Terminated

A Safety and Efficacy Study Evaluating Dimebon (Latrepirdine) in Patients With Moderate to Severe Alzheimer's Disease (CONTACT)

Moderate to Severe Alzheimer

Chile, United Kingdom
Bigespas LTD

Recruiting

DMB-I in the Treatment of Alzheimer Type Dementia

Alzheimer Disease | Dementia of Alzheimer Type

Russian Federation
Pfizer
Medivation, Inc.

Terminated

An Extension To The B1451006 Protocol To Evaluate The Safety and Efficacy of Dimebon In Subjects With Moderate-to-Severe Alzheimer's Disease

Alzheimer's Disease

United States
Medivation, Inc.

Terminated

Study of Combination Therapy With Dimebon and Donepezil (Aricept) in Patients With Alzheimer's Disease

Alzheimer's Disease

United States
Pfizer
Medivation, Inc.

Completed

A Phase 1, Randomized, Open-Label, Two-Way Crossover Study To Evaluate The Steady-State Effect Of Dimebon (PF 01913539) On The Single-Dose Pharmacokinetics And Pharmacodynamics Of Warfarin In Healthy Subjects

Alzheimer's Disease | Huntington's Disease

United States
Medivation, Inc.
Pfizer

Completed

Safety and Efficacy Study Evaluating Dimebon in Patients With Mild to Moderate Alzheimer's Disease on Donepezil (CONCERT)

Alzheimer's Disease

France, United Kingdom, Germany, United States, Australia, Belgium, New Zealand, Italy, Sweden, Finland
Medivation, Inc.

Completed

Safety and Tolerability of Dimebon in Patients on Memantine, and Memantine Plus Donepezil

Alzheimer's Disease

United States
AmpliMed Corporation

Completed

Safety and Efficacy Study of Imexon for Treatment of Multiple Myeloma Patients

Multiple Myeloma

United States
AmpliMed Corporation

Completed

Safety Study of Imexon Treatment of Patients With Metastatic or Disseminated Malignancy

Neoplasm Metastasis

United States
Pfizer
Medivation, Inc.

Completed

A Phase I Study To Estimate The Effect Of Ketoconazole And Omeprazole On The Pharmacokinetics Of Dimebon In Healthy Subjects Who Are Normal Or Poor CYP2D6 Metabolizers

Alzheimer's Disease | Huntington's Disease

United States
Pfizer
Medivation, Inc.

Terminated

A Phase 3 Efficacy Study Of Dimebon In Patients With Moderate To Severe Alzheimer's Disease

Alzheimer Disease

United States, Hungary, Germany, Spain, Turkey, Slovakia, Canada, Portugal
University of Rochester
University of Arizona

Completed

Imexon for Relapsed Follicular and Aggressive Lymphomas (ULYM11011)

Follicular Lymphoma | Mantle Cell Lymphoma | Marginal Zone Lymphoma | Lymphoplasmacytic Lymphoma | Diffuse Large B Cell Lymphoma | Small Lymphocytic Lymphoma | Burkitt's Lymphoma

United States
Vimecon GmbH

Terminated

Vimecon CAI Trial for the Interventional Treatment of Paroxysmal Atrial Fibrillation (AF) (CAI)

Atrial Fibrillation

Czechia, Belgium, Germany
University of Florence

Unknown

Grazoprevir and Elbasvir Without Ribavirin for 12 Weeks in Patients With HCV-related Cryoglobulinemic Nephropathy (CRYOKID)

Hepatitis C | Cryoglobulinaemic Glomerulonephritis
Deutsches Herzzentrum Muenchen

Completed

Iodixanol vs. Iomeprol to Prevent Contrast-Induced Nephropathy After Coronary Intervention (CONTRAST)

Renal Insufficiency, Chronic | Coronary Arteriosclerosis | Angioplasty, Transluminal, Percutaneous Coronary

Germany
Pfizer
Medivation, Inc.

Completed

Dimebon (PF-01913539)-Digoxin Drug-Drug Interaction Study In Healthy Subjects

Alzheimer Disease | Huntington Disease

United States
AmpliMed Corporation

Completed

Safety and Efficacy Trial of Imexon Plus DTIC in Advanced Malignant Melanoma

Malignant Melanoma

United States
Bracco Diagnostics, Inc
Clinipace Worldwide; Bracco International B.V.

Completed

A Multicenter Study of Iomeron®-400 Used With Multi-detector Computed Tomography Angiography (MDCTA) (Iomeron®-400)

Peripheral Artery Disease | Pulmonary Disease | Carotid Disease | Aortic Disorders

China
Pfizer
Medivation, Inc.

Completed

A Phase 1 Study To Evaluate The Effect Of Dimebon On The Pharmacokinetics Of Dextromethorphan

Alzheimer Disease | Huntington Disease

United States
Pfizer
Medivation, Inc.

Completed

A Study To Evaluate The Abuse Potential Of Single Oral Doses Of Dimebon (Latrepirdine) In Healthy Recreational Polydrug Users

Alzheimer's Disease | Huntington's Disease
AmpliMed Corporation

Completed

A Randomized Study of Amplimexon (Imexon) With Gemcitabine in Pancreatic Cancer

Pancreatic Neoplasms

United States
AB-CT - Advanced Breast-CT GmbH
CRO Dr. med. Kottmann GmbH; RQM+ (Germany) GmbH

Recruiting

Comparison of Low-dose Spiral Breast CT With MRI in Major Indications of MRI for Breast Diagnostics

Breast Cancer Diagnosis

Netherlands, Germany
AmpliMed Corporation

Completed

Safety Study of Imexon Plus Docetaxel in Lung, Breast or Prostate Cancer Patients

Breast Cancer | Prostate Cancer | Non-small Cell Lung Cancer

United States
AmpliMed Corporation

Withdrawn

A Safety and Efficacy Trial of Amplimexon Plus Taxotere in Metastatic Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung

United States
National Cancer Institute (NCI)

Active, not recruiting

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

Hyperplasia | Oral Cavity Carcinoma | Oral Leukoplakia | Erythroplakia

United States, Canada
University of Campinas, Brazil

Terminated

Neoadjuvant Metformin in Association to Chemoradiotherapy for Locally Advanced Rectal Cancer (NEOMETRE)

Adenocarcinoma | Carcinoma | Rectal Neoplasms

Brazil
Sidney Kimmel Cancer Center at Thomas Jefferson...

Completed

Metformin Hydrochloride in Mitigating Side Effects of Radioactive Iodine Treatment in Patients With Differentiated Thyroid Cancer

Thyroid

United States
AmpliMed Corporation

Completed

Safety Study of Imexon Plus Gemcitabine in Untreated Pancreatic Adenocarcinoma

Pancreatic Adenocarcinoma

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...

Completed

Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer

Larynx | Oral Cavity | Lip | Pharynx

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...

Active, not recruiting

Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma That Can Be Removed by Surgery

Larynx | Oral Cavity | LIP | Pharynx

United States
Northwestern University
Bristol-Myers Squibb; National Cancer Institute (NCI)

Unknown

Nivolumab and Metformin Hydrochloride in Treating Patients With Stage III-IV Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Stage IIIA Non-Small Cell Lung Cancer | Stage IIIB Non-Small Cell Lung Cancer | Recurrent Non-Small Cell Lung Carcinoma | Stage IV Non-Small Cell Lung Cancer | Stage III Non-Small Cell Lung Cancer

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...

Active, not recruiting

Metformin Hydrochloride and Doxycycline in Treating Patients With Localized Breast or Uterine Cancer

Breast Carcinoma | Endometrial Clear Cell Adenocarcinoma | Endometrial Serous Adenocarcinoma | Uterine Corpus Cancer | Uterine Corpus Carcinosarcoma

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Metformin Hydrochloride and Ritonavir in Treating Patients With Relapsed or Refractory Multiple Myeloma or Chronic Lymphocytic Leukemia

Fatigue | Anemia | Weight Loss | Thrombocytopenia | Fever | Refractory Plasma Cell Myeloma | Lymphadenopathy | Refractory Chronic Lymphocytic Leukemia | Recurrent Plasma Cell Myeloma | Splenomegaly | Recurrent Chronic Lymphocytic Leukemia | Lymphocytosis | Night Sweats

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Metformin, Nelfinavir, and Bortezomib in Treating Patients With Relapsed and/or Refractory Multiple Myeloma

Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma

United States
Gynecologic Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer

Recurrent Uterine Corpus Carcinoma | Endometrial Clear Cell Adenocarcinoma | Endometrial Serous Adenocarcinoma | Endometrial Undifferentiated Carcinoma | Endometrial Adenocarcinoma | Stage III Uterine Corpus Cancer AJCC v7 | Stage IIIA Uterine Corpus Cancer AJCC v7 | Stage IIIB Uterine Corpus Cancer... and other conditions

United States

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