Search clinical trials for: Endothelin-1

Total 14877 results

Sohag University

Recruiting

The Role of Endothelin 1 as a Marker of Renal Impairment in Sickle Cell Disease

Sickle Cell Disease

Egypt
Glostrup University Hospital, Copenhagen

Unknown

Endothelin-1 as a Potential Trigger of Migraine Aura

Migraine With Aura

Denmark
University of Alberta

Completed

Physical Activity Measured Through Accelerometers and Its Association With Endothelial Function in Young Patients With Fontan Physiology

Heart Defects

Canada
University of Edinburgh
Umeå University

Completed

The Effects of Diesel Exhaust Inhalation on Vascular Function - the Role of Endothelin

Coronary Disease

Sweden
Janssen Pharmaceutical K.K.

Completed

A Study of Macitentan, in Healthy Japanese Male Participants

Healthy

Japan
Assiut University

Not yet recruiting

Evaluation of Serum Tumor Endothelial Marker1 as a Potential Biomarker for Colorectal Cancer Diagnosis and Cancer Progression

Colorectal Cancer
Benha University

Completed

Assessment of Endocan Serum Levels in Patients With Behcet Disease

Behçet

Egypt
Aswan University Hospital

Not yet recruiting

Developmental Endothelial Locus-1, Platelet Count, and Soluble P-selectin in Overweight and Obese Subjects

Overweight and Obesity

Egypt
Actelion

Terminated

Clinical Study on the Safety and Tolerability of Macitentan in Combination With Dose-dense Temozolomide in Patients With Recurrent Glioblastoma

Glioblastoma

United States
Actelion

Withdrawn

Safety and Tolerability Study of Macitentan in Patients With Idiopathic Pulmonary Fibrosis (MUSIC OL)

Idiopathic Pulmonary Fibrosis
Boston University
Actelion

Terminated

Macitentan in Pulmonary Hypertension of Sickle Cell Disease (MENSCH)

Sickle Cell Disease | Pulmonary Hypertension

United States
Actelion

Completed

REPAIR: Right vEntricular Remodeling in Pulmonary ArterIal hypeRtension (REPAIR)

Pulmonary Arterial Hypertension

United States, Israel, France, Netherlands, Malaysia, Germany, Australia, United Kingdom, Hong Kong, Italy, Russian Federation, Singapore
Actelion

Completed

A Study of Two Different Test Formulations Compared to the Reference Formulation of Macitentan in Healthy Adult Participants

Healthy

Belgium
Actelion

Terminated

A Pulmonary Arterial Hypertension Study With Macitentan to Validate the PAH-SYMPACT™ in France, Italy and Spain (ORCHESTRA)

Pulmonary Arterial Hypertension

Spain, France, Italy
Janssen Pharmaceutical K.K.

Recruiting

A Study of Macitentan in Japanese Pediatric Participants With Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension

Japan
Actelion

Completed

Clinical Study to Assess the Long-term Safety and Tolerability of ACT 064992 in Patients With Symptomatic Pulmonary Arterial Hypertension (SERAPHIN OL)

Pulmonary Arterial Hypertension

United States, United Kingdom, Taiwan, Finland, Canada, Belarus, Belgium, Argentina, Australia, China, Colombia, Croatia, Germany, Hong Kong, India, Israel, Italy, Malaysia, Netherlands, Poland, Russian Federation, South Africa, Tha... and more
University of California, Los Angeles
American Heart Association; Janssen, LP

Completed

Endothelin-1 and Cardiac Allograft Vasculopathy (CAV)

Cardiac Allograft Vasculopathy

United States
Actelion
Henry Ford Health System; Covance; Medidata Solutions; Almac Clinical Technologies and other collaborators

Terminated

An Upcoming Clinical Study to Measure the Safety and Impact of a Drug Called Macitentan in Teenage and Adult Fontan Patients. (RUBATO OL)

Congenital Heart Disease With Fontan Circulation

United Kingdom, Taiwan, France, Poland, China, Australia, Czechia, Canada, United States, Denmark, New Zealand
Actelion

Completed

Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (MERIT-1)

Chronic Thromboembolic Pulmonary Hypertension

United Kingdom, Belgium, Ukraine, Germany, Switzerland, Hungary, China, Korea, Republic of, Mexico, Czechia, France, Lithuania, Poland, Russian Federation, Thailand, Turkey
Franz Rischard, DO
University of Pittsburgh; National Jewish Health

Unknown

CompRehensive Phenotypic Characterization of Patients With Scleroderma-Associated ILD and PH (CRUSADE)

Pulmonary Hypertension | Interstitial Lung Disease | Scleroderma

United States
Actelion

Completed

Clinical Study of Macitentan in Patients With Pulmonary Arterial Hypertension to Psychometrically Validate the PAH-SYMPACT Instrument

Pulmonary Arterial Hypertension

United States
Assistance Publique - Hôpitaux de Paris
Janssen, LP

Recruiting

Initial Dual Oral Combination Therapy Versus Standard-of-care Initial Oral Monotherapy Prior to Balloon Pulmonary Angioplasty in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (IMPACT-CTEPH)

Chronic Disease | Inoperable Disease | Thromboembolic Pulmonary Hypertension

France
Actelion

Completed

A Study of Two Macitentan Pediatric Formulations in Healthy Adult Participants

Healthy

Belgium
Actelion

Terminated

Clinical Study of Macitentan in Patients With PAH to Psychometrically Validate PAH-SYMPACT Instrument (SYMPHONYext)

Pulmonary Arterial Hypertension

United States
University of Giessen
Philipps University Marburg Medical Center

Recruiting

(RIGHT HEART III Study - Right Ventricular Hemodynamic Evaluation and Response to Treatment) (RightHeartIII)

Pulmonary Arterial Hypertension (PAH)

Germany
Actelion

Completed

Study of Macitentan (ACT-064992) on Morbidity and Mortality in Patients With Symptomatic Pulmonary Arterial Hypertension (SERAPHIN)

Pulmonary Arterial Hypertension

United States, United Kingdom, Belarus, Argentina, Australia, Austria, Belgium, Bulgaria, Canada, Chile, China, Colombia, Croatia, France, Germany, Hong Kong, Hungary, India, Israel, Italy, Malaysia, Mexico, Netherlands, Norway, Peru, Poland and more
Actelion

Recruiting

A Study of Macitentan in Healthy Chinese Adult Male Participants

Healthy

China
University of Maryland, Baltimore

Withdrawn

Macitentan to Prevent PRVO (MAC-PRO)

Pulmonary Embolism

United States
Actelion

Completed

Clinical Study Assessing the Efficacy and Safety of Macitentan in Fontan-palliated Subjects (RUBATO)

Congenital Heart Disease

United States, United Kingdom, Taiwan, Germany, France, Poland, China, Australia, Czechia, Canada, Denmark, New Zealand
The George Institute

Not yet recruiting

The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect (CAPTIVATE)

Chronic Kidney Diseases
Actelion

Completed

A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With Preserved Ejection Fraction and Pulmonary Vascular Disease (SERENADE)

Heart Failure With Preserved Ejection Fraction

United States, Spain, United Kingdom, Poland, Germany, Israel, Austria, Czechia, Russian Federation, Denmark, Bulgaria, Hungary, France, Argentina, Brazil, Romania, Sweden
Actelion

Completed

Extension of the Psychometric Validation Study ORCHESTRA in Patients With PAH

Pulmonary Arterial Hypertension

Spain, France, Italy
Actelion

Completed

A Clinical Study to Investigate the Long-term Safety of the Drug Macitentan in Patients With Pulmonary Hypertension Who Were Previously Treated With Macitentan in Clinical Studies. (UMBRELLA)

Pulmonary Arterial Hypertension | Chronic Thromboembolic Pulmonary Hypertension

Belgium, France, Poland, Russian Federation, Belarus, Turkey, Ukraine
University of California, Los Angeles

Withdrawn

Macitentan in the Treatment of Organ Rejection After Lung Transplantation

Lung Transplant Rejection

United States
Actelion

Completed

Clinical Study to Evaluate the Effects of Macitentan on Exercise Capacity in Subjects With Eisenmenger Syndrome (MAESTRO)

Pulmonary Arterial Hypertension

China, Malaysia, United States, Austria, Bulgaria, Chile, France, Germany, Greece, Israel, Mexico, Philippines, Poland, Portugal, Romania, Russian Federation, Serbia, Spain, Turkey, United Kingdom, Vietnam
Actelion

Terminated

A Study to Evaluate Efficacy and Safety of Macitentan 75 mg in Inoperable or Persistent/Recurrent Chronic Thromboembolic Pulmonary Hypertension (MACiTEPH)

Chronic Thromboembolic Pulmonary Hypertension

United States, Germany, Japan, Korea, Republic of, Taiwan, Canada, United Kingdom, China, Austria, Italy, Bulgaria, Turkey, Spain, Thailand, Israel, Ukraine, Hungary, Mexico, Czechia, Russian Federation, France, Saudi Arabia, Singapore and more
Actelion

Completed

OPsumit USers Registry (OPUS)

Pulmonary Arterial Hypertension

United States, Puerto Rico
Actelion

Completed

PORtopulmonary Hypertension Treatment wIth maCitentan - a randOmized Clinical Trial (PORTICO)

Portopulmonary Hypertension

United States, France, Germany, United Kingdom, Brazil, Czechia, Spain
IRCCS Azienda Ospedaliero-Universitaria di Bologna
University of Bologna

Not yet recruiting

Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregnancy (EDIPE)

Preeclampsia | Hypertensive Disorder of Pregnancy

Italy
Actelion

Completed

Clinical Study to Evaluate the Safety and Tolerability of Macitentan in Subjects With Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH) Due to Left Ventricular Dysfunction (MELODY-1)

Pulmonary Hypertension

United States, Austria, Belgium, Canada, Czechia, France, Germany, Israel, Italy, Spain, Switzerland
Actelion

Recruiting

A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH) (TOMORROW)

Pulmonary Arterial Hypertension

United States, Korea, Republic of, Austria, Spain, Malaysia, China, Hungary, Mexico, Poland, Australia, Brazil, Canada, Colombia, France, Israel, Philippines, Portugal, Russian Federation, South Africa, Thailand, Ukraine, Vietnam, F...
Actelion

Completed

Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (MERIT-2)

Chronic Thromboembolic Pulmonary Hypertension

Poland, Ukraine, United Kingdom, China, Russian Federation, Belgium, Germany, Thailand, Hungary, France, Lithuania, Czechia, Mexico, Switzerland, Turkey
Actelion

Completed

A Study of Two Macitentan Formulations in Healthy Adult Participants

Healthy

Belgium
MelCure SA
Universitaire Ziekenhuizen KU Leuven; University of Bern; California Institute...

Terminated

Proof of Concept Study With an Endothelin Receptor B Inhibitor (BQ-788) for Human Melanoma

Melanoma
Actelion

Completed

Macitentan Use in an Idiopathic Pulmonary Fibrosis Clinical Study (MUSIC)

Idiopathic Pulmonary Fibrosis

United States, Israel, Spain, Australia, France, Canada, Turkey, Germany, Italy, South Africa, Slovenia, Sweden
Actelion

Withdrawn

Correlation of LONGterm Wrist ACTigraphy Recorded Physical Performance & 6-minute Walk Distance in Patients With Pulmonary Arterial Hypertension (LONGACT)

Pulmonary Arterial Hypertension
Actelion
EPS Corporation; Imepro Inc.; General Laboratory, BML, Inc.; Mitsubishi Logistics...

Terminated

A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH).

Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Japan
Actelion

Recruiting

A Study of Macitentan in Children Below 2 Years of Age

Arterial Hypertension, Pulmonary

Poland, Germany
Actelion

Terminated

Clinical Study to Assess the Long-term Safety, Tolerability, and Efficacy of Macitentan in Subjects With Eisenmenger Syndrome (MAESTRO-OL)

Pulmonary Arterial Hypertension

China, Malaysia, United States, Austria, Bulgaria, Chile, France, Germany, Greece, Mexico, Philippines, Poland, Portugal, Romania, Russian Federation, Serbia, Spain, United Kingdom, Vietnam
Actelion

Completed

Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients (DUAL-1)

Systemic Sclerosis | Ulcers

Canada, United States, Belarus, Hungary, Croatia, Australia, Denmark, Ukraine, Bulgaria, Chile, Colombia, Czech Republic, Finland, Germany, India, Italy, Poland, Russian Federation

Search clinical trials for: Endothelin-1

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