Search clinical trials for: GDC-0973 Oral Capsules

Total 850 results

Genentech, Inc.

Completed

An Absolute Bioavailability Study in Healthy Participants Comparing Oral to Intravenous Administration of GDC-0973 (Cobimetinib)

Healthy Volunteers
Genentech, Inc.

Completed

A Study of the Hedgehog Pathway Inhibitor GDC-0449 in Healthy Female Subjects of Non-Childbearing Potential

Healthy
Genentech, Inc.

Completed

A Pharmacokinetics Study of Radioactive-Labeled GDC-0973 in Healthy Male Volunteers

Healthy Volunteer

United States
Genentech, Inc.

Completed

A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of GDC-0973 in Combination With GDC-0068 When Administered in Participants With Locally Advanced or Metastatic Solid Tumors

Neoplasms

United States, Spain
Genentech, Inc.

Completed

A Study of Relative Bioavailability and Food Effect Study of Cobimetinib in Healthy Participants

Healthy Volunteers
Genentech, Inc.

Completed

A Randomized, Phase I, Cross-Over Study to Assess the Relative Bioavailability of Single-Dose Cobimetinib (GDC-0973) in Tablet vs. Capsule Formulation

Healthy Volunteer

United States
Genentech, Inc.

Completed

A Study of MEHD7945A and Cobimetinib in Patients With Locally Advanced or Metastatic Cancers With Mutant KRAS

Neoplasms

United States, Spain
Hoffmann-La Roche

Completed

Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Participants With Previously Treated Solid Tumors (iMATRIXcobi)

Solid Tumors

United States, Spain, Germany, France, Israel, Italy, United Kingdom
Genentech, Inc.

Terminated

Safety, Tolerability and Pharmacokinetics of Cobimetinib in Combination With Pictilisib in Patients With Locally Advanced or Metastatic Solid Tumors

Solid Tumors

United States
Reata, a wholly owned subsidiary of Biogen

Completed

Safety and PK/PD of RTA 1701 in Healthy Adults

Healthy

Australia
Hoffmann-La Roche

Completed

Study of Atezolizumab in Combination With Cobimetinib in Participants With Locally Advanced or Metastatic Solid Tumors

Solid Tumors

United States, Korea, Republic of, Australia, Canada, Germany, Singapore
Genentech, Inc.

Completed

Ipatasertib (GDC-0068) Study to Evaluate Formulation Change and Food Effect on Bioavailability in Healthy Subjects

Cancer

United States
Massachusetts General Hospital
Center for Microbiome Informatics and Therapeutics

Active, not recruiting

Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy

Hepatic Encephalopathy

United States
Medibiofarma S.L.

Completed

Study to Assess the Safety and Tolerability of MBF-118 in Healthy Volunteers

Cancer

Spain
Genentech, Inc.

Completed

A Study to Evaluate the Effect of Particle Size, Formulation and Food on the Pharmacokinetics of GDC-0032 in Healthy Volunteers

Healthy Volunteer

United States
Genentech, Inc.

Completed

Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-GDC-9545 Following a Single Oral Dose (Part 1) and to Evaluate the Absolute and Relative Bioavailability of Oral Capsule Formulations of GDC-9545 (Part 2) in Healthy Female Subjects of Non-Childbearing Potential

Healthy Volunteers

United Kingdom
Genentech, Inc.

Completed

Evaluation of the Relative Bioavailability and Food Effect of GDC-9545 in Healthy Females of Non-Childbearing Potential

Healthy Volunteers

United States
Psychiatric Hospital of the University of Basel

Terminated

Fecal Microbiota Transplantation in Depression

Major Depressive Disorder

Switzerland
Palobiofarma SL
Clínica Universidad de Navarra

Completed

Study to Assess the Safety and Tolerability of PBF-1650 in Healthy Volunteers. (ADENOIMMUNE)

Psoriasis

Spain
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Cobimetinib and Atezolizumab in Treating Participants With Advanced or Refractory Rare Tumors

Metastatic Skin Squamous Cell Carcinoma | Metastatic Malignant Neoplasm | Unresectable Malignant Neoplasm | Refractory Malignant Neoplasm | Appendix Adenocarcinoma | Locally Advanced Malignant Neoplasm | Skin Squamous Cell Carcinoma | Locally Advanced Skin Squamous Cell Carcinoma | Metastatic Small... and other conditions

United States
Al-Kindy College of Medicine

Completed

The Effect of Cinnamon on Patients With Chronic Prostatitis/Chronic Pelvic Pain Syndrome; a Pilot Study

Chronic Prostatitis | Chronic Pelvic Pain Syndrome

Iraq
Purdue Pharma, Canada

Completed

PRC-063 Classroom Study in Children (6-12 Years of Age) With ADHD

ADHD

United States
Purdue Pharma, Canada

Completed

PRC-063 Adult Laboratory Classroom Study in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)

ADHD

United States
Burnasyan Federal Medical Biophysical Center

Completed

Clinical Study of Medicinal Product Cardionat® Using in Health Athlete Volunteers

Angina Pectoris | Stroke, Not Specified as Hemorrhage or Infarction

Russian Federation
Hoffmann-La Roche

Completed

A Study of Vemurafenib and GDC-0973 (Cobimetinib) in Participants With BRAFV600E Mutation-Positive Metastatic Melanoma

Malignant Melanoma

United States, Australia
University of Calgary
Cumming school of medicine; The W. Garfield Westin Foundation

Recruiting

The Safety and Efficacy of Fecal Microbiota Transplantation in a Population With Major Depressive Disorder

Depression | Treatment Resistant Depression

Canada
Sunnybrook Health Sciences Centre

Active, not recruiting

Study of Neo-adjuvant Use of Vemurafenib Plus Cobimetinib for BRAF Mutant Melanoma With Palpable Lymph Node Metastases

Melanoma

Canada
Garvan Institute of Medical Research

Completed

Alkaline Diet for Insulin Sensitivity (ADIS)

Type 2 Diabetes Mellitus | Dysglycemia

Australia
Hoffmann-La Roche

Terminated

A Study of Cobimetinib Plus Paclitaxel, Cobimetinib Plus Atezolizumab Plus Paclitaxel, or Cobimetinib Plus Atezolizumab Plus Nab-Paclitaxel as Initial Treatment for Participants With Triple-Negative Breast Cancer That Has Spread

Breast Cancer

Israel, Italy, Spain, United States, Belgium, Czechia, Australia, United Kingdom, Korea, Republic of, Romania, France, Taiwan, Latvia
Biota Pharma Europe Limited

Completed

Safety, Efficacy and Pharmacokinetics of BTA-C585 in a RSV Viral Challenge Study

Respiratory Syncytial Virus (RSV) Infection

United Kingdom
Montefiore Medical Center

Completed

Fecal Microbiota Transplantation for the Treatment of Diarrhea-Predominant Irritable Bowel Syndrome

Irritable Bowel Syndrome

United States
Brigham and Women's Hospital

Completed

DAW1033D in Obstructive Sleep Apnea (OSAstimD)

Obstructive Sleep Apnea (OSA)

United States
Aelis Farma
National Institute on Drug Abuse (NIDA)

Completed

Multiple Ascending Dose to Study the Safety, Tolerability, PK and PD Effects of AEF0117

Healthy Volunteers

United States
Brigham and Women's Hospital

Enrolling by invitation

DAW2020 on OSA Endotypic Traits (SedOSA)

Obstructive Sleep Apnea (OSA)

United States
EicOsis Human Health Inc.
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Safety, Tolerability, and Pharmacokinetics of Oral EC5026 in Healthy Subjects

Healthy Adults

United States
Brigham and Women's Hospital

Completed

DAW1033B2 in Obstructive Sleep Apnea (OsaStimB2)

Obstructive Sleep Apnea (OSA)

United States
M.D. Anderson Cancer Center

Active, not recruiting

Atezolizumab, Cobimetinib, and Eribulin in Treating Patients With Chemotherapy Resistant Metastatic Inflammatory Breast Cancer

Recurrent Breast Inflammatory Carcinoma | Stage IV Breast Inflammatory Carcinoma

United States
Yung Shin Pharm. Ind. Co., Ltd.
Changhua Christian Hospital

Completed

A Study to Evaluate the Effects of RCN3028 on Moderate to Severe Vasomotor Symptoms in Women (RDC)

Hot Flashes | PMS

Taiwan
BioCryst Pharmaceuticals

Completed

Study to Evaluate the Efficacy and Safety of BCX7353 as an Oral Treatment for the Prevention of HAE Attacks in Japan (APeX-J)

Hereditary Angioedema, HAE

Japan
Centre Leon Berard

Recruiting

MEK Inhibitor and a PDL1 Inhibitor Patients With Locally Advanced and/or Metastatic Soft Tissue Sarcoma (COTESARC)

Sarcoma,Soft Tissue

France
Yale University
Neurocrine Biosciences

Recruiting

Efficacy of Valbenazine for the Treatment of Trichotillomania in Adults

Trichotillomania (Hair-Pulling Disorder)

United States
Alkermes, Inc.

Terminated

A 28 Day Parallel Group Study to Assess the Effects of RDN-929

Healthy

Netherlands
Genentech, Inc.

Withdrawn

A Study to Assess the Relative Bioavailability And Food Effect of a Tablet Formulation of GDC-0276 in Healthy Participants

Healthy Volunteer

United Kingdom
Melcap Systems Ltd.

Suspended

Safety and Feasibility Assessment of the Bio-electrical One Day Capsule System in Overweight and Class I Obese Participants

Overweight and Obesity

Israel
Sao Thai Duong Joint Stock Company
Big Leap Clinical Research Joint Stock Company

Completed

Safety and Efficacy of KOVIR in the Combination Regimen With Background Treatment in COVID-19 Patients (KOVIR) (KOVIR)

COVID-19

Vietnam
Genentech, Inc.

Completed

A Study to Evaluate the Effect of a Proton-Pump Inhibitor (Rabeprazole) on the Relative Bioavailability of Cobimetinib in Healthy Participants

Healthy Volunteer
Medicines for Malaria Venture
Washington University School of Medicine; Sanaria Inc.; Institute of Tropical... and other collaborators

Completed

Safety, Tolerability and Chemoprotective Activity of P218 in PfSPZ Challenge Model

Malaria

Belgium
Hoffmann-La Roche

Completed

A Study Comparing Vemurafenib Versus Vemurafenib Plus Cobimetinib in Participants With Metastatic Melanoma (coBRIM)

Malignant Melanoma

United States, Spain, Hungary, Israel, United Kingdom, Australia, Austria, Belgium, Czechia, France, Germany, Italy, Netherlands, Russian Federation, Sweden, Switzerland, Canada, New Zealand, Norway
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Not yet recruiting

A Study of HS-10353 in Adult Participants With Major Depressive Disorder

Major Depressive Disorder (MDD)
Pusan National University Hospital

Completed

Efficacy of Fenugreek Seed and Lespedeza Cuneata in TDS

Hypogonadism

Korea, Republic of

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