Search clinical trials for: Gamma-secretase%2FNotch+signalling+pathway+inhibitor+RO4929097
Total 60 results
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National Cancer Institute (NCI)CompletedStage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal CancerUnited States
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National Cancer Institute (NCI)CompletedAdenocarcinoma of the Pancreas | Recurrent Pancreatic Cancer | Stage IV Pancreatic CancerUnited States
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National Cancer Institute (NCI)TerminatedMale Breast Cancer | Stage IV Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Triple-negative Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer | Estrogen Receptor-negative Breast Cancer | Progesterone Receptor-negative Breast Cancer | HER2-negative Breast CancerCanada
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National Cancer Institute (NCI)TerminatedRecurrent Melanoma | Stage IV Melanoma | Acral Lentiginous Malignant Melanoma | Lentigo Maligna Malignant Melanoma | Nodular Malignant Melanoma | Solar Radiation-related Skin Melanoma | Superficial Spreading Malignant MelanomaUnited States
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National Cancer Institute (NCI)M.D. Anderson Cancer CenterTerminatedStage IIIB Non-small Cell Lung Cancer | Recurrent Non-small Cell Lung Cancer | Stage IV Non-small Cell Lung CancerUnited States
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National Cancer Institute (NCI)TerminatedAdult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain TumorUnited States
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National Cancer Institute (NCI)WithdrawnStage IV Melanoma | Stage IIIB Melanoma | Stage IIIC MelanomaUnited States
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National Cancer Institute (NCI)TerminatedAdult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Recurrent Adult Brain Tumor | Adult Brain Stem GliomaCanada
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National Cancer Institute (NCI)CompletedUnspecified Adult Solid Tumor, Protocol SpecificCanada
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National Cancer Institute (NCI)TerminatedUnspecified Adult Solid Tumor, Protocol Specific | HER2-positive Breast Cancer | Recurrent Melanoma | Male Breast Cancer | Stage IV Breast Cancer | Stage IV Melanoma | Extensive Stage Small Cell Lung Cancer | Recurrent Small Cell Lung Cancer | Recurrent Breast Cancer | Estrogen Receptor-negative Breast... and other conditionsUnited States
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National Cancer Institute (NCI)TerminatedAdenocarcinoma of the Pancreas | Stage IIA Pancreatic Cancer | Stage IIB Pancreatic Cancer | Stage IA Pancreatic Cancer | Stage IB Pancreatic CancerUnited States
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National Cancer Institute (NCI)CompletedExtranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent Adult Diffuse Small Cleaved Cell Lymphoma and other conditionsUnited States, Canada
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National Cancer Institute (NCI)TerminatedRecurrent Prostate Cancer | Adenocarcinoma of the Prostate | Stage IV Prostate CancerUnited States
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National Cancer Institute (NCI)CompletedRecurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Stage IV Fallopian Tube Cancer | Stage IV Ovarian Cancer | Stage IV Primary Peritoneal CancerUnited States, Canada
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National Cancer Institute (NCI)CompletedUnspecified Adult Solid Tumor, Protocol Specific | Adenocarcinoma of the Pancreas | Recurrent Pancreatic Cancer | Stage III Pancreatic Cancer | Stage IV Pancreatic CancerCanada
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National Cancer Institute (NCI)CompletedClear Cell Renal Cell Carcinoma | Recurrent Renal Cell Carcinoma | Stage IV Renal Cell CancerCanada
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National Cancer Institute (NCI)CompletedUnspecified Adult Solid Tumor, Protocol Specific | Stage III Renal Cell Cancer | Recurrent Endometrial Carcinoma | Stage IV Renal Cell Cancer | Recurrent Renal Cell Cancer | Stage IV Endometrial Carcinoma | Stage III Endometrial Carcinoma | Endometrial Papillary Serous CarcinomaCanada
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National Cancer Institute (NCI)TerminatedStage II Breast Cancer | Stage IIIA Breast Cancer | Estrogen Receptor-positive Breast Cancer | Progesterone Receptor-positive Breast Cancer | HER2-negative Breast CancerUnited States
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National Cancer Institute (NCI)TerminatedAdult Anaplastic Astrocytoma | Adult Anaplastic Oligodendroglioma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Recurrent Adult Brain TumorUnited States
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National Cancer Institute (NCI)TerminatedUnspecified Childhood Solid Tumor, Protocol Specific | Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Childhood Atypical Teratoid/Rhabdoid Tumor | Recurrent Childhood Acute Lymphoblastic Leukemia | T-cell Large Granular Lymphocyte Leukemia | T-cell Childhood Acute Lymphoblastic... and other conditionsUnited States, Canada
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National Cancer Institute (NCI)CompletedRecurrent Uterine Corpus Sarcoma | Chondrosarcoma | Recurrent Osteosarcoma | Gastrointestinal Stromal Tumor | Clear Cell Sarcoma of the Kidney | Metastatic Osteosarcoma | Ovarian Sarcoma | Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage III Uterine Sarcoma | Stage IV Adult... and other conditionsUnited States
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National Cancer Institute (NCI)TerminatedStage IV Breast Cancer | Recurrent Breast Carcinoma | Stage IIIB Breast Cancer | Stage IIIC Breast Cancer | Estrogen Receptor Negative | HER2/Neu Negative | Progesterone Receptor Negative | Triple-Negative Breast CarcinomaUnited States
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National Cancer Institute (NCI)CompletedStage IIIA Non-Small Cell Lung Cancer | Stage IIIB Non-Small Cell Lung Cancer | Recurrent Ovarian Carcinoma | Stage IIIA Rectal Cancer | Stage IIIB Rectal Cancer | Stage IIIC Rectal Cancer | Recurrent Renal Cell Carcinoma | Stage III Renal Cell Cancer | Stage IV Skin Melanoma | Recurrent Non-Small Cell... and other conditionsCanada
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National Cancer Institute (NCI)TerminatedStage IV Breast Cancer | Recurrent Breast Carcinoma | Stage IIIB Breast Cancer | Stage IIIC Breast Cancer | Estrogen Receptor Positive | HER2/Neu Negative | Male Breast CarcinomaUnited States
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National Cancer Institute (NCI)TerminatedRecurrent Non-Small Cell Lung Carcinoma | Stage IV Non-Small Cell Lung CancerUnited States
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National Cancer Institute (NCI)WithdrawnRecurrent Colon Cancer | Recurrent Rectal Cancer | Adenocarcinoma of the Rectum | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer | Adenocarcinoma of the ColonUnited States
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PfizerCompletedNeoplasms by Histologic TypeUnited States, Italy
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University of Colorado, DenverSpringWorks Therapeutics, Inc.No longer availableNeoplasm | Desmoid TumorUnited States
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SpringWorks Therapeutics, Inc.AvailableDesmoid Tumor | NOTCH Gene Mutation Positive Tumors
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Bristol-Myers SquibbCompleted
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National Cancer Institute (NCI)TerminatedRecurrent Colon Carcinoma | Recurrent Rectal Carcinoma | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer | Colon Mucinous Adenocarcinoma | Colon Signet Ring Cell Adenocarcinoma | Rectal Mucinous Adenocarcinoma | Rectal Signet Ring Cell AdenocarcinomaUnited States
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CelgeneActive, not recruitingMultiple MyelomaFrance, United States, Canada, Spain, Italy
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Washington University School of MedicineCompletedEnvironmental EnteropathyMalawi
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National Cancer Institute (NCI)TerminatedStage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IIA Breast Cancer | Stage IIB Breast Cancer | Stage IIIC Breast Cancer | Estrogen Receptor Negative | HER2/Neu Negative | Progesterone Receptor Negative | Triple-Negative Breast CarcinomaUnited States
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AIDS Malignancy ConsortiumNational Cancer Institute (NCI); The Emmes Company, LLCWithdrawnHIV Infection | AIDS-related Kaposi Sarcoma | Recurrent Kaposi Sarcoma
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Bristol-Myers SquibbCompletedAlzheimer's Disease
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National Cancer Institute (NCI)CompletedAdult Anaplastic Astrocytoma | Adult Anaplastic Ependymoma | Adult Diffuse Astrocytoma | Adult Ependymoma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Adult Myxopapillary Ependymoma | Adult Oligodendroglioma | Adult Pilocytic Astrocytoma | Adult Pineal Gland... and other conditionsUnited States
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M.D. Anderson Cancer CenterSpringWorks Therapeutics, Inc.Not yet recruiting
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Stanford UniversitySpringWorks Therapeutics, Inc.Recruiting
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SpringWorks Therapeutics, Inc.Active, not recruitingOvarian Cancer | Ovarian Granulosa Cell Tumor | Ovarian Granulosa-Stromal TumorUnited States, Canada, Poland
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National Cancer Institute (NCI)CompletedDesmoid Tumors | Aggressive FibromatosisUnited States
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Cancer Research UKCompletedPancreatic CancerUnited Kingdom
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SpringWorks Therapeutics, Inc.Active, not recruitingDesmoid Tumor | Aggressive FibromatosisUnited States, Belgium, Germany, Canada, Italy, Netherlands, United Kingdom
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National Cancer Institute (NCI)WithdrawnRefractory Plasma Cell Myeloma | DS Stage I Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | DS Stage III Plasma Cell MyelomaUnited States
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Lithuanian University of Health SciencesUniversity of Groningen; Research Council of LithuaniaUnknownExtracellular Matrix Alteration | Allergic Asthma | Airway RemodellingLithuania
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Memorial Sloan Kettering Cancer CenterRecruiting
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Janssen Research & Development, LLCActive, not recruitingMultiple MyelomaUnited States, Belgium, United Kingdom, France, Australia
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Precision BioSciences, Inc.TerminatedRelapsed/Refractory Multiple MyelomaUnited States
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National Cancer Institute (NCI)CompletedStage IV Skin Melanoma | Recurrent MelanomaUnited States
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Allogene TherapeuticsActive, not recruitingRelapsed/Refractory Multiple MyelomaUnited States