Search clinical trials for: ION 682884

Total 28426 results

Brigham and Women's Hospital

Not yet recruiting

ION-682884 in Patients With TTR Amyloid Cardiomyopathy

Transthyretin Amyloid Cardiopathy

United States
Ionis Pharmaceuticals, Inc.
AstraZeneca

Recruiting

An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM)

Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

United States, Austria, Belgium, Canada, France, Germany, Israel, Italy, Portugal, Spain, Sweden, United Kingdom, Australia, Greece
Ionis Pharmaceuticals, Inc.

Completed

A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Ascending and Multiple Doses of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Healthy Japanese Participants

Healthy Participants

United States
Ionis Pharmaceuticals, Inc.

Recruiting

A Study to Assess the Long-Term Safety and Efficacy of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Patients With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

United States, Italy, Portugal, Spain, Taiwan, Sweden, Canada, Brazil, France, New Zealand, Argentina, Cyprus, Australia, Turkey
Ionis Pharmaceuticals, Inc.

Active, not recruiting

CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

United States, Australia, Spain, Canada, Germany, Japan, Italy, Israel, Argentina, France, Portugal, Austria, Brazil, Greece, United Kingdom, Czechia, Sweden, Belgium, Denmark, Poland, Puerto Rico
Ionis Pharmaceuticals, Inc.

Completed

NEURO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

United States, Spain, Taiwan, Italy, Germany, Argentina, Australia, Brazil, Canada, Cyprus, France, Greece, New Zealand, Portugal, Sweden, Turkey
Ionis Pharmaceuticals, Inc.

Completed

Evaluate the Safety and Tolerability, as Well as the Pharmacokinetic and Pharmacodynamic Profiles of Single and Multiple Doses of Eplontersen Administered Subcutaneously to Healthy Volunteers and Patients With Hereditary Transthyretin-Mediated Amyloidosis (hATTR ).

Healthy Volunteers | hATTR Amyloidosis

Canada
Merck Sharp & Dohme LLC

Completed

[11C]MK-6884 Positron Emission Tomography (PET) Tracer Validation Trial (MK-6884-001)

Alzheimer's Disease
Prim. Prof. Dr. Oliver Findl, MBA

Withdrawn

Performance of a Hydrophilic and a Hydrophobic Intraocular Lens of Similar Design

Cataract

Austria
Vienna Institute for Research in Ocular Surgery

Recruiting

Performance of Two Intraocular Lenses With Extended Depth of Vision

Cataract Senile

Austria
Moorfields Eye Hospital NHS Foundation Trust

Completed

Multifocal-toric IOL Compared to Multifocal IOL Combined With Limbal Relaxing Incisions for Correction of Moderate Astigmatism During Cataract Surgery

Cataract | Astigmatism | Cornea
Cairo University

Completed

Electrical Velocimetry (ICON Cardiometry ) Assessment of Hemodynamic Changes During Pediatric Thoracoscopic Surgery

Hemodynamics

Egypt
German Cancer Research Center
University of Music, Drama, and Media Hannover

Not yet recruiting

Evaluation of Text or Animation-based Narrative and Non-narrative Interventions to Enhance Cancer Literacy: a Pilot Study (CLARO) (CLARO)

Cancer Prevention
Johannes Kepler University of Linz
Medical University of Graz; Mein Hanusch-Krankenhaus; Landesklinikum Sankt Polten

Recruiting

1000 Eyes Lens Biometry Study: Artificial Intelligence for Intraocular Lens Power Calculation

Cataract

Austria
Universidad Rey Juan Carlos

Completed

Dry Needling and Bobath Treatment Clinical Effects Focused on Stroke Patients

Ischemic Stroke | Spasticity

Spain
Carol Henry
Marywood University; Brac; Nutrition International

Unknown

Iron-fortified Lentils to Improve Iron (Fe) Status in Bangladesh

Iron-deficiency | Anemia, Iron-Deficiency | Cognitive Performance

Bangladesh
The Ludwig Boltzmann Institute of Retinology and...

Terminated

Influence of Blue Light Filtering Intraocular Lenses on Daytime Levels of Melatonin (BluMel)

Macular Degeneration

Austria
Zhongshan Ophthalmic Center, Sun Yat-sen University

Recruiting

Incidence of Glaucoma-related Adverse Events in Pediatric Secondary Intraocular Lens Implantation

Lens Implantation, Intraocular

China
Cairo University

Unknown

Postoperative Pain Endodontic Retreatment

Endodontically Treated Teeth
University of Illinois at Chicago
American Cancer Society, Inc.

Completed

Obesity, Iron Regulation and Colorectal Cancer Risk

Obesity | Diet Modification | Iron Malabsorption | Colon Inflammation

United States
Shanghai Proton and Heavy Ion Center

Recruiting

Functional Image-Guided Carbon Ion Irradiation With Simultaneous Integrated Boost for Prostate Cancer

Localized Prostate Cancer

China
Pennington Biomedical Research Center
The Wright Group in Crowley, LA

Completed

Pilot Study of the Effect of Iron Fortified Rice in Iron Deficient Anemic Women

Iron Deficiency Anemia

United States
University of California, Davis

Completed

School-Based Tele-Physiatry Assistance for Rehabilitative and Therapeutic Services (STARS)

Pediatrics | Physical Therapy Modalities | Physical and Rehabilitation Medicine

United States
Associazione Ginco Ticino

Completed

San Rocco Study: Implementation of the Non-pharmacological Therapies for People With Dementia Living in Nursing Home

Dementia | Nursing Home | Staff

Switzerland
University of Utah

Completed

Use Of An In-Home Non-Stress Test Device For Remote Fetal Monitoring

High Risk Pregnancy

United States
Hannover Medical School

Completed

Extracorporeal Membrane Oxygenation (ECMO) in Non-intubated Patients With Acute Respiratory Distress Syndrome (ARDS)

ARDS

Germany
National Center for Tumor Diseases, Heidelberg

Terminated

Sequential FDG-PET (Positron Emission Tomography) and Induction Chemotherapy in Locally Advanced Adenocarcinoma of the Esophagogastric Junction (AEG) (HICON)

Adenocarcinomas of the Esophagogastric Junction

Germany
Chalmers University of Technology
Göteborg University

Completed

Non-heme Iron Absorption From Single Meals of Fava Bean Protein, Beef Protein and Cod Protein

Healthy | Nutrition, Healthy

Sweden
Swiss Federal Institute of Technology
Swiss Tropical & Public Health Institute; Ifakara Health Institute

Completed

Iron Absorption and Utilization During Tuberculosis and After Treatment

Tuberculosis

Tanzania
University of Michigan
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Non-Heme Iron Load Quantification in the Brain - MRI of Patients With Stroke

Stroke

United States
Helena Piccinini
Nova Scotia Health Authority

Withdrawn

Management of Gestational Weight Gain by Family Physicians: Seeking Congruence With Guidelines

Gestational Weight Gain

Canada
University Hospital Heidelberg

Recruiting

Pancreatic Cancer and Carbon Ion Radiotherapy (PACK)

Pancreatic Cancer

Germany
ShiCang Yu

Recruiting

Phase Ⅱ Clinical Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Venous Leg

Venous Leg Ulcer

China
University of Malaya

Completed

Dietary Diversity of Young Children During CoVID-19 Outbreak: A Longitudinal Study (CoDDYC)

Dietary Diversity

Malaysia
Klinikum der Universität Köln

Unknown

Observation of Acute Cardiopulmonary Effects in Healthy Individuals Performing Cardiopulmonary Exercise Test (CPX) During Whole Body Vibration (WBV) (GALILEOhealthy)

Acute Cardiopulmonary Effects

Germany
University of East Anglia
Quadram Institute Bioscience

Completed

Iron & Alginate Study

Iron Deficiency | Anaemia

United Kingdom
Jian Chen

Recruiting

Carbon Ion Radiotherapy for Locally Advanced Lung Cancer in Elderly Patients

Older People | Non-small Cell Lung Cancer | Radiotherapy Side Effect | Carbon Ion Radiotherapy

China
Swiss Federal Institute of Technology

Completed

The Optimization of Bioavailability From Iron Supplements: Study 1

Anemia | Iron Deficiency Anemia | Iron Deficiency

Switzerland
Assiut University

Unknown

Non Invasive Mechanical Ventilation VERSUS Oxygen MASK

Mechanical Ventilation Complication
Pomeranian Medical University Szczecin

Completed

Validation of the Polish Version of CPOT (POL-CPOT)

Pain | ICU Delirium

Poland
University Hospital, Grenoble

Unknown

Validation of Study in Respiratory Physiology and it Interactions (ValApPhI)

Cardiac Function | Respiratory Function | Life Experiences

France
AURA Sante

Unknown

Long Term Physical Activity for Hemodialysis Patients

End Stage Renal Disease on Hemodialysis
Alcon Research

Recruiting

Post Market Clinical Follow-up (PMCF) Study of Clareon Vivity & Clareon PanOptix

Presbyopia | Astigmatism | Aphakia

United States, Puerto Rico
Shanghai Proton and Heavy Ion Center

Recruiting

Carbon Ion Radiotherapy for Recurrent Pancreatic Cancer Post Surgery

Pancreatic Carcinoma

China
Shanghai Proton and Heavy Ion Center

Recruiting

Ablative Carbon Ion Radiotherapy With Pencil Beam Scanning for Locally Advanced Unresectable Pancreatic Cancer

Pancreatic Cancer Non-resectable

China
Shanghai Proton and Heavy Ion Center

Recruiting

12 Fractions Carbon Ion Radiotherapy for Localized Prostate Cancer

Prostate Cancer | Radiotherapy

China
Shanghai Proton and Heavy Ion Center

Recruiting

Carbon Ion Radiotherapy for the Treatment of Localized Prostate Cancer

Prostate Carcinoma

China
Intuitive Surgical

Completed

A Retrospective Multicenter Review to Evaluate the Performance of the Ion Endoluminal System in Sampling Pulmonary Lesions

Lung Cancer | Pulmonary Nodule

United States
Ionis Pharmaceuticals, Inc.

Terminated

A Study to Assess the Safety, Tolerability, and Efficacy of ION-827359 in Participants With Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis (CB)

Chronic Obstructive Pulmonary Disease | Chronic Bronchitis

Germany, Czechia, Hungary, United Kingdom
Intuitive Surgical

Recruiting

Real World Registry for Use of the Ion Endoluminal System

Neoplasms | Respiratory Tract Diseases | Lung Diseases | Neoplasms by Site | Lung Neoplasms | Respiratory Tract Neoplasms | Thoracic Neoplasms | Multiple Pulmonary Nodules | Lung Cancer

United States

Search clinical trials for: ION 682884

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Peru

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations