Search clinical trials for: Irinotecan

Total 1396 results

Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Oxaliplatin Plus Irinotecan in Treating Patients With Metastatic Gastrointestinal Cancer

Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Esophageal Cancer | Small Intestine Cancer | Anal Cancer | Liver Cancer | Gallbladder Cancer | Extrahepatic Bile Duct Cancer | Gastrointestinal Carcinoid Tumor

United States
National Cancer Center, Korea
Samsung Medical Center; Asan Medical Center; Seoul National University Hospital; Korea University Anam Hospital and other collaborators

Unknown

Irinotecan/Capecitabine Versus Capecitabine in Patients Treated With A/T for HER2 Negative Metastatic Breast Cancer (PROCEED)

Metastatic Breast Cancer

Korea, Republic of
University of California, Davis

Completed

Irinotecan and Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases From Solid Tumors

Unspecified Childhood Solid Tumor, Protocol Specific | Brain and Central Nervous System Tumors | Unspecified Adult Solid Tumor, Protocol Specific | Cognitive/Functional Effects | Long-term Effects Secondary to Cancer Therapy in Children | Long-term Effects Secondary to Cancer Therapy in Adults and other conditions

United States
National Cancer Centre, Singapore

Completed

Irinotecan in Treating Asian Patients With Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific

Singapore
Sanofi
UNC Lineberger Comprehensive Cancer Center

Completed

A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis

Brain Metastases | Estrogen Receptor Negative (ER-Negative) Breast Cancer | Progesterone Receptor Negative (PR-Negative) Breast Cancer | Human Epidermal Growth Factor Receptor 2 Negative (HER2-Negative) Breast Cancer

United States
Duke University
National Cancer Institute (NCI)

Completed

Irinotecan Plus Carmustine in Treating Patients With Recurrent Primary Malignant Glioma

Brain and Central Nervous System Tumors

United States
Zhejiang Cancer Hospital

Recruiting

Genotype-driven Weekly Irinotecan Liposomes in Combination With Capecitabine-based Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer

Rectal Cancer

China
Heinrich-Heine University, Duesseldorf
Servier

Completed

Trifluridine/Tipiracil in Combination With Irinotecan as a Second Line Therapy in Patients With Cholangiocarcinoma (TRITICC)

Cholangiocarcinoma

Germany
Eli Lilly and Company

Completed

A Study of Irinotecan Plus Cetuximab With or Without Enzastaurin in Participants With Colorectal Cancer

Colorectal Cancer | Colorectal Carcinoma | Colorectal Tumor

United States
University of California, San Francisco

Completed

A Phase I Trial of Nanoliposomal CPT-11 (NL CPT-11) in Patients With Recurrent High-Grade Gliomas

Glioblastoma | Gliosarcoma | Anaplastic Astrocytoma | Anaplastic Oligodendroglioma

United States
Pfizer

Completed

Safety And Efficacy Of Irinotecan Plus Capecitabine As First-Line Treatment In Asian Subjects With Hepatocellular Carcinoma

Carcinoma, Hepatocellular

Korea, Republic of, China, Taiwan, Hong Kong
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Withdrawn

Lurbinectedin With or Without Irinotecan in Treating Patients With Relapsed or High Risk Metastatic Ewing Sarcoma

Recurrent Ewing Sarcoma | Metastatic Ewing Sarcoma

United States
Institut du Cancer de Montpellier - Val d'Aurelle
Bayer

Completed

Sorafenib With Irinotecan in Metastatic Colorectal Cancer (mCRC) and K-RAS Mutation (NEXIRI)

Metastatic Colorectal Cancer

France
University of California, San Francisco
National Cancer Institute (NCI)

Completed

Irinotecan and Temozolomide in Treating Patients With Breast Cancer Who Have Received Previous Treatment for Brain Metastases

Breast Cancer | Metastatic Cancer

United States
Fox Chase Cancer Center
National Cancer Institute (NCI)

Terminated

Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Spread to the Liver

Mucinous Adenocarcinoma of the Rectum | Signet Ring Adenocarcinoma of the Rectum | Liver Metastases | Mucinous Adenocarcinoma of the Colon | Signet Ring Adenocarcinoma of the Colon | Recurrent Colon Cancer | Recurrent Rectal Cancer | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer and other conditions

United States
University of Southern California
Sanofi

Completed

Study of Irinotecan and Docetaxel in Patients With Metastatic or Unresectable Gastric or Gastroesophageal Junction Adenocarcinoma

Gastric Cancer | Esophageal Neoplasms

United States
Terumo Europe N.V.
Universitaire Ziekenhuizen KU Leuven; Federation Francophone de Cancerologie...

Completed

LifePearl-Iri Pharmacokinetic Study

Metastatic Colorectal Cancer | mCRC

Belgium, Germany
Barretos Cancer Hospital
University of Campinas, Brazil; AC Camargo Cancer Center

Unknown

Metformin Plus Irinotecan for Refractory Colorectal Cancer

Adenocarcinoma | Colorectal Neoplasms

Brazil
Biotech Pharmaceutical Co., Ltd.

Unknown

Pharmacokinetics Study of Nimotuzumab in Patients With Solid Tumors

Solid Tumors

China
National Cancer Center, Korea

Completed

Phase II Study of Irinotecan/Capecitabine in Patients With Antracycline/Taxane Pretreated MBC

Breast Cancer Metastatic

Korea, Republic of
Nanfang Hospital of Southern Medical University

Recruiting

A Phase II Study of Carelizumab Combined With Irinotecan and Apatinib of Second-line Treatment for Advanced Gastric Cancer

Gastric Cancer

China
First Affiliated Hospital of Zhejiang University

Unknown

mXELOXIRI Combined With Molecular Targeted Drug in mCRC (TRICAP)

Unresectable Metastatic Colorectal Cancer

China
Singapore General Hospital
Singhealth Foundation

Completed

Pilot Study to Assess the Safety and Pharmacokinetics of 70-150μm Drug Eluting Beads Loaded With Irinotecan (DEBIRI).

Colorectal Cancer Metastatic

Singapore
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Docetaxel and Irinotecan in Treating Patients With Advanced Cancer of the Esophagus or Stomach

Gastric Cancer | Esophageal Cancer

United States, Canada
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Irinotecan With Docetaxel in Treating Patients With Recurrent or Metastatic Non-small Cell Lung Cancer

Lung Cancer

United States, Canada
University Health Network, Toronto
National Cancer Institute (NCI)

Completed

Combination Chemotherapy and Imatinib Mesylate in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Lung Cancer

Canada
Federation Francophone de Cancerologie Digestive

Unknown

Irinotecan With or Without Capecitabine as Second-Line Therapy in Treating Older Patients With Progressive, Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

Colorectal Cancer

France
Sun Yat-sen University

Recruiting

Cetuximab Plus Irinotecan in Patients With NeoRAS Wild-type Metastatic Colorectal Cancer In Third-line Therapy

Metastatic Colorectal Cancer

China
Fujian Cancer Hospital

Not yet recruiting

Efficacy and Safety of SBRT Followed by Tislelizumab Plus Cetuximab and Irinotecan in Patients With Previously Treated RAS Wild-type Advanced Refractory Colorectal Cancer

Colorectal Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Completed

Temozolomide Plus Irinotecan in Treating Patients With Recurrent Malignant Glioma

Brain and Central Nervous System Tumors

United States
Kuhnil Pharmaceutical Co., Ltd.
Daiichi Sankyo Co., Ltd.

Terminated

Phase 3 Study of Nimotuzumab and Irinotecan as Second Line With Advanced or Recurrect Gastric and Gastroesophageal Junction Cancer

Gastric Cancer | Gastroesophageal Junction Cancer

Taiwan, Japan, Korea, Republic of
Duke University
National Cancer Institute (NCI)

Completed

Irinotecan Plus Temozolomide in Treating Patients With Recurrent Primary Malignant Glioma

Brain and Central Nervous System Tumors

United States
Montefiore Medical Center
National Cancer Institute (NCI)

Completed

Irinotecan and Capecitabine in Treating Patients With Solid Tumors

Cancer

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Hepatic Arterial Infusion With Floxuridine and Systemic Irinotecan After Surgery in Treating Patients With Hepatic (Liver) Metastases From Colorectal Cancer

Colorectal Cancer | Metastatic Cancer

United States
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

Imatinib Mesylate and Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer

Lung Cancer

United States
Novartis Pharmaceuticals

Recruiting

Study of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.

MSIhi or dMMR Advanced Unresectable or Metastatic Solid Tumors, Including Colorectal Cancers

Japan, Spain, Singapore, Belgium, Germany, Korea, Republic of, Taiwan, France, Israel, United States
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Recruiting

A Clinical Study of TQB3616 Capsules Combined With Anlotinib Hydrochloride Capsules or Standard Chemotherapy Second-line and Above in the Treatment of Advanced Lung Cancer

Advanced Lung Carcinoma

China
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Irinotecan and Docetaxel in Treating Patients With Refractory Metastatic Breast Cancer

Breast Cancer

United States
Yale University
National Cancer Institute (NCI)

Completed

Docetaxel and Irinotecan in Treating Patients With Advanced Solid Tumors

Unspecified Adult Solid Tumor, Protocol Specific

United States
Zhejiang Cancer Hospital

Recruiting

A Phase III Trial of Anus-preservation in Low Rectal Adenocarcinoma Based on MMR/MSI Status

Radiation | Toripalimab

China
The Christie NHS Foundation Trust

Not yet recruiting

Irinotecan Drug-eluting Bead Liver Embolisation Registry (DLivERDEBIRI)

Colorectal Cancer Metastatic | Liver Metastases

United Kingdom
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Sanofi; Pfizer

Completed

Irinotecan, Oxaliplatin, and Capecitabine as First-Line Therapy in Treating Patients With Metastatic or Unresectable Locally Advanced Small Bowel Cancer

Recurrent Small Intestine Cancer | Small Intestine Adenocarcinoma

United States
The University of Texas Health Science Center at...
National Cancer Institute (NCI)

Completed

Olimersen and Irinotecan in Treating Patients With Metastatic or Recurrent Colorectal Cancer

Colorectal Cancer

United States
National Cancer Institute (NCI)

Completed

Monoclonal Antibody Plus Chemotherapy in Treating Patients With Advanced Colorectal Cancer That Overexpresses HER2

Colorectal Cancer

United States
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer

Metastatic Solid Tumor | Advanced Cancer

United States
NCIC Clinical Trials Group
AstraZeneca

Completed

AZD2281 and Irinotecan in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer

Colorectal Cancer

Canada
Washington University School of Medicine
Merck Sharp & Dohme LLC; Ipsen

Withdrawn

Combination Liposomal Irinotecan and Pembrolizumab For Triple-Negative Breast Cancer (TNBC) With Brain Metastases (BM)

Triple Negative Breast Cancer | Brain Metastases

United States
Asan Medical Center

Completed

Efficacy Analysis of Cetuximab Plus Irinotecan in Patients With Wild-type KRAS Without Regard to Epidermal Growth Factor Receptor (EGFR) Expressions

Advanced Colorectal Cancer

Korea, Republic of
St. Jude Children's Research Hospital
National Institutes of Health (NIH)

Completed

Prevention of Diarrhea in Patients Taking IV Irinotecan for Relapsed or Difficult to Treat Pediatric Solid Tumors

Diarrhea | Neoplasm

United States
Peking University

Completed

IPO-NEC Trial:Study on the Efficacy and Safety Using Sequential IP Therapy and Oct Lar in the Treatment of Advanced GI NEC

Progression Free Survival of the Treatment

China

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