Search clinical trials for: L-dopa

Total 2901 results

British Columbia Cancer Agency

No longer available

18F-FDOPA PET in Neuroendocrine Tumours

Thyroid Cancer, Medullary | Neuroblastoma | Pheochromocytoma | Carcinoid Tumor | Paraganglioma | Insulinoma

Canada
Impel Pharmaceuticals

Completed

Therapeutic Potential for Intranasal Levodopa in Parkinson's Disease -Off Reversal (THOR201)

Parkinson's Disease

Australia
Chelsea Therapeutics

Terminated

Study To Assess The Clinical Benefit Of Droxidopa In Subjects With Chronic Fatigue Syndrome (CFS201)

Chronic Fatigue Syndrome | Orthostatic Hypotension | Neurally Mediated Hypotension | Neurogenic Orthostatic Hypotension

United States
Mayo Clinic
Brains Together for the Cure

Active, not recruiting

A Pilot Study Using 18F-DOPA PET-guided Radiotherapy in Gliomas

Malignant Glioma

United States
University Hospital, Toulouse

Completed

Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA (DOPS-AMS)

Multiple System Atrophy

France
Children's Hospital of Philadelphia

Available

18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic Hypoglycemia

Insulinoma | Beckwith-Wiedemann Syndrome | Congenital Hyperinsulinism (CHI)

United States
Chelsea Therapeutics

Completed

Study To Assess The Clinical Benefit Of Droxidopa And Droxidopa/Carbidopa In Subjects With Fibromyalgia (FMS201)

Fibromyalgia

United Kingdom
Chelsea Therapeutics
Chiltern International Inc.

Completed

Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (NOH302)

Primary Autonomic Failure | Dopamine Beta Hydroxylase Deficiency | Symptomatic Neurogenic Orthostatic Hypotension (NOH) | Non-diabetic Neuropathy

United States, Australia, Canada, New Zealand
Vanderbilt University

Approved for marketing

Long Term Treatment With L-DOPS

Dopamine Beta Hydroxylase (DBH) Deficiency

United States
The Methodist Hospital Research Institute
University of California, Los Angeles

Terminated

Response Monitoring Trial in Patients With Suspected Recurrence of Glioblastoma

Glioma | Glioblastoma | Glioblastoma Multiforme

United States
Assistance Publique - Hôpitaux de Paris

Terminated

Clinical Evaluation of 18F-DOPA Positron Emission Tomography in Medullary Thyroid Cancer (DOPMET)

Thyroid Carcinoma | Thyroid Neoplasm | Medullary Carcinoma

France
GlaxoSmithKline

Completed

A Fixed Dose Study of Ropinirole Prolonged Release as Adjunctive Treatment in Patients With Advanced Parkinson's Disease (TANDEM-569)

Parkinson Disease

United States, Korea, Republic of, Estonia, Russian Federation, Slovakia, Argentina, Chile
Chelsea Therapeutics

Terminated

A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy

Parkinson's Disease | Pure Autonomic Failure | Dopamine Beta Hydroxylase Deficiency | Symptomatic Neurogenic Orthostatic Hypotension | Multiple Systems Atrophy

United States
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

An Imaging Agent (Fluorodopa F 18) With Positron Emission Tomography/Magnetic Resonance Imaging for Assessing Treatment Response in Patients With High-Grade Soft Tissue Sarcomas

Soft Tissue Sarcoma | Recurrent Soft Tissue Sarcoma | Resectable Soft Tissue Sarcoma

United States
Molecular NeuroImaging

Completed

An Open-Label Feasibility/Pilot Study With [123I]-IBZM SPECT (DOPA-SYN)

Parkinson's Disease
Children's Hospital of Philadelphia
University of Pennsylvania

Completed

Utility of [F-18] fluoroDOPA for Neonatal Hyperinsulinism

Hyperinsulinism | Congenital Hyperinsulinism | Persistent Hyperinsulinemic Hypoglycemia of Infancy | CHI | PHHI

United States
Chelsea Therapeutics

Withdrawn

Study to Assess Droxidopa in the Treatment of Freezing Of Gait Symptoms in Patients With Parkinson's Disease

Gait Disorders, Neurologic

United States, Canada
Chelsea Therapeutics

Completed

Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304) (NOH304)

Neurogenic Orthostatic Hypotension | Primary Autonomic Failure | Dopamine Beta Hydroxylase Deficiency | Non-Diabetic Neuropathy
Bronx VA Medical Center
Chelsea Therapeutics

Completed

A Dose Titration of Droxidopa in Patients With Spinal Cord Injury

Hypotension | Spinal Cord Injury

United States
Rion Inc.
ProPharma

Active, not recruiting

PEP on a Skin Graft Donor Site Wound

Skin Graft

United States
Pfizer
Vicuron Pharmaceuticals

Completed

The Safety and Effectiveness of Intravenous Anidulafungin as a Treatment for Patients With Invasive Candidiasis.

Candidiasis

United States
Biotie Therapies Inc.

Completed

Safety and Efficacy Study of SYN115 in Parkinson's Patients Using Levodopa to Treat End of Dose Wearing Off

Parkinson's Disease

Ukraine, Argentina, Romania, Canada, United States, Chile
Krzysztof Bankiewicz
National Institute of Neurological Disorders and Stroke (NINDS); University...

Recruiting

A Single-Stage, Adaptive, Open-label, Dose Escalation Safety and Efficacy Study of AADC Deficiency in Pediatric Patients (AADC)

AADC Deficiency

United States
Merck Sharp & Dohme LLC

Completed

Dyskinesia in Parkinson's Disease (Study P04501)

Brain Diseases | Central Nervous System Diseases | Parkinson Disease | Movement Disorders | Neurodegenerative Diseases
Washington University School of Medicine
St. Louis Children's Hospital

Recruiting

Utility of 18FDOPA PET/MRI for Focal Hyperinsulinism (18FDOPA HI)

Hyperinsulinism

United States
University Hospital, Toulouse
French Parkinson Association

Completed

Evaluation of the Role of the Noradrenergic System in Pain Perception in Parkinson's Disease (DOULOX)

Parkinson's Disease

France
University of Alberta
Alberta Health services

Completed

18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety

Parkinson Disease | Neuroendocrine Tumors | Neuroblastoma | Congenital Hyperinsulinism | Brain Glioma

Canada
Bial - Portela C S.A.

Completed

Efficacy and Safety of Opicapone in Clinical Practice (OPTIPARK)

Parkinson's Disease With Wearing-off Motor Fluctuations

Germany
NYU Langone Health

Withdrawn

A Study of Norepinephrine in Patients With Congenital Insensitivity to Pain and Anhidrosis

HSAN Type IV
St. Joseph's Hospital and Medical Center, Phoenix
Arizona State University

Unknown

Effect of L-Dihydoxyphenylserine on Locomotion, Postural Stability, and Fall Risk Reduction in Parkinson Disease

Parkinson Disease

United States
Erik Mittra
National Cancer Institute (NCI)

Terminated

18F-FDOPA PET/CT or PET/MRI in Measuring Tumors in Patients With Newly-Diagnosed or Recurrent Gliomas

Untreated Childhood Brain Stem Glioma | Adult Anaplastic Ependymoma | Adult Anaplastic Oligodendroglioma | Adult Diffuse Astrocytoma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Adult Oligodendroglioma | Adult Pilocytic Astrocytoma | Adult Pineal Gland Astrocytoma and other conditions

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diagnosed High- or Low-Grade Malignant Glioma

Adult Anaplastic Astrocytoma | Adult Anaplastic Ependymoma | Adult Anaplastic Oligodendroglioma | Adult Diffuse Astrocytoma | Adult Ependymoma | Adult Giant Cell Glioblastoma | Adult Glioblastoma | Adult Gliosarcoma | Adult Mixed Glioma | Adult Myxopapillary Ependymoma | Adult Oligodendroglioma | Adult Pilocytic... and other conditions

United States
Baylor College of Medicine

No longer available

Study of the Use of [18F]-DOPA in Hyperinsulinemic Hypoglycemia ([18F]-DOPA)

Congenital Hyperinsulinism | Hyperinsulinemic Hypoglycemia, Persistent | Persistent Hyperinsulinemic Hypoglycemia of Infancy (PHHI)

United States
Shaare Zedek Medical Center

Unknown

Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study

Dystonic Cerebral Palsy

Israel
New York State Psychiatric Institute

Completed

A Study of L-DOPA for Depression and Slowing in Older Adults

Major Depressive Disorder | Dysthymia | Depression Not Otherwise Specified | Decreased Processing Speed | Decreased Gait Speed

United States
Asan Medical Center

Unknown

Effect of Thrombin-containing Collagen-based Hemostatic Matrix (TCM)

Pancreatic Tumor

Korea, Republic of
Beijing Normal University
Yale University

Completed

Oxytocin and Dopamine's Effect on Vicarious Optimism

Oxytocin Group | L-DOPA Group | Placebo Group

China
University of Wisconsin, Madison
National Institute of Mental Health (NIMH)

Recruiting

Improving Therapeutic Learning for PTSD

PTSD | Post Traumatic Stress Disorder

United States
Stanford University
Novartis Pharmaceuticals

Recruiting

Study of PRRT in Metastatic, World Health Organization (WHO) Grade 1 or 2, SSTR Positive, GEP-NET Who Are Candidates for Cytoreductive Surgery

Gastroenteropancreatic Neuroendocrine Tumor

United States
National Institute of Diabetes and Digestive and...

Recruiting

Natural History of Familial Carcinoid Tumor

Carcinoid

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning for a Short Course of Proton Beam Radiation Therapy

Glioblastoma | Malignant Glioma

United States
Chelsea Therapeutics

Completed

A Two Part Study (306A/306B) to Assess Droxidopa in Treatment of NOH in Patients With Parkinson's Disease (306A/306B)

Parkinson's Disease | Orthostatic Hypotension

United States
University of Wisconsin, Madison

Completed

Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753)

Stress Disorder, Post Traumatic

United States
GlaxoSmithKline

Completed

REQUIP (Ropinirole Hydrochloride) IR Long-Term Phase 4 Study

Parkinson's Disease | Parkinson Disease

Japan
National Institute of Mental Health (NIMH)

Recruiting

PET Scanning in Parkinson s Disease

Schizophrenia | Parkinson's Disease

United States
Vanderbilt University
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Treatment of Orthostatic Hypotension

Autonomic Nervous System Diseases | Orthostatic Hypotension | Orthostatic Intolerance | Dopamine Beta-Hydroxylase Deficiency

United States
Assistance Publique - Hôpitaux de Paris

Completed

COMT Polymorphism and Entacapone Efficacy (COMT)

Parkinson's Disease

France
National Taiwan University Hospital

Recruiting

Application of 18F-FDOPA PET and Magnetic Resonance Spectroscopy (MRS) With HCV and PD

Parkinson Disease | Hepatitis B | Hepatitis C

Taiwan
Novartis

Completed

Efficacy and Safety of AFQ056 When Combined With Increased Doses of L-dopa in Parkinson's Disease Patients With Moderate-severe L-dopa Induced Dyskinesia

Parkinson's Disease

United States
Wen-Hann Tan
Baylor College of Medicine; University of California, San Francisco; Vanderbilt... and other collaborators

Completed

A Trial of Levodopa in Angelman Syndrome

Angelman Syndrome

United States

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