Search clinical trials for: Mepolizumab

Total 283 results

GlaxoSmithKline

Completed

Dose Ranging Efficacy And Safety With Mepolizumab in Severe Asthma (DREAM)

Asthma

United States, Argentina, Australia, Germany, Poland, Romania, Russian Federation, Ukraine, Canada, Chile, France, Korea, Republic of, United Kingdom
Academisch Medisch Centrum - Universiteit van Amsterdam...
GlaxoSmithKline; The Netherlands Asthma Foundation

Unknown

Mepolizumab Treatment for Rhinovirus-induced Asthma Exacerbations (MATERIAL)

Asthma | Viral Infection

Netherlands
King's College Hospital NHS Trust

Active, not recruiting

Study for Children & Adolescent With Severe Asthma With an Eosinophilic Phenotype Treated With Mepolizumab (CASAM)

Asthma in Children

United Kingdom
University Hospital, Montpellier

Completed

Nation-wide Health Resource Consumption and Costs Associated With Mepolizumab (Resala)

Asthma

France
GlaxoSmithKline

No longer available

This Record Contains Information About the Mepolizumab Compassionate Use (CU) Product Activities: 104317: CU and Long-Term Access Study of Mepolizumab in HES. 201956:A Long-term Access Programme for Subjects With Severe Asthma 112562: Expanded Access for Patients With Hypereosinophilic

Hypereosinophilic Syndrome
GlaxoSmithKline

Completed

A Multi-center, Open-label Extension, Safety Study of Mepolizumab in Subjects With Hypereosinophilic Syndrome (HES) From Study 200622

Hypereosinophilic Syndrome

United States, Poland, Spain, France, Belgium, Germany, Argentina, Russian Federation, Mexico, Italy, Brazil, United Kingdom, Romania
University Hospital, Grenoble

Completed

Effect of Mepolizumab on Decrease of Systemic Corticosteroids in Patients With Severe Eosinophilic Asthma (Mepolizumab)

Asthma; Eosinophilic

France
GlaxoSmithKline

Completed

An Evaluation Of Mepolizumab In Therapy Of Eosinophilic Oesophagitis In Adult Patients

Oesophagitis, Eosinophilic

Switzerland
Fondazione Policlinico Universitario Agostino Gemelli...

Not yet recruiting

Mepolizumab in the Treatment of Patients With Severe Uncontrolled CRSwNP: a Multicentric Real Life Observational Study (MEPOREAL)

Chronic Rhinosinusitis With Nasal Polyps

Italy
University Hospital Southampton NHS Foundation...
GlaxoSmithKline

Not yet recruiting

Evaluation of Volatile Organic Compounds in Mepolizumab Therapy (EVOC4M)

Asthma; Eosinophilic

United Kingdom
GlaxoSmithKline

Completed

MEA112997 Open-label Long Term Extension Safety Study of Mepolizumab in Asthmatic Subjects

Asthma

United States, Argentina, Australia, France, Germany, Poland, Romania, Russian Federation, Canada, Chile, Korea, Republic of, Ukraine, United Kingdom
Johns Hopkins University
GlaxoSmithKline

Recruiting

The Role of IL5 in Epithelial Cell Integrity

Chronic Rhinosinusitis (Diagnosis) | Chronic Rhinosinusitis With Nasal Polyps

United States
Istituti Clinici Scientifici Maugeri SpA

Recruiting

Treatment With Mepolizumab on Patients With Severe Refractory Eosinophilic Asthma With or Without CRSwNP.

Asthma | Nasal Polyps | Sinusitis Chronic

Italy
Mayo Clinic
GlaxoSmithKline

Withdrawn

Mepolizumab for Eosinophilic Fasciitis

Eosinophilic Fasciitis
Mayo Clinic
GlaxoSmithKline

Active, not recruiting

Mepolizumab for the Treatment of Chronic Spontaneous Urticaria

Chronic Spontaneous Urticaria

United States
GlaxoSmithKline

Recruiting

Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA) (OCEAN)

Eosinophilic Granulomatosis With Polyangiitis

Canada, France, Italy, Spain, Belgium, Korea, Republic of, United States, Japan, China, Czechia, Hungary, Israel, Portugal, Poland, Netherlands, United Kingdom, Austria, Argentina, Australia, Brazil, Germany, Sweden
GlaxoSmithKline

Completed

Efficacy and Safety Study of Mepolizumab Adjunctive Therapy in Subjects With Severe Uncontrolled Refractory Asthma

Asthma

United States, Argentina, Australia, Canada, France, Germany, Japan, Russian Federation, Spain, Ukraine, Belgium, Chile, Korea, Republic of, Mexico, Italy, United Kingdom
University of Thessaly

Completed

Impulse Oscillometry Measurements in Severe Eosinophilic Asthmatics Before and After Anti-IL-5 Factor Initiation (IMPOSE)

Severe Asthma

Greece
GlaxoSmithKline
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis

Churg-Strauss Syndrome

United States, France, Japan, Spain, Italy, Germany, Canada, Belgium, United Kingdom
Johannes Gutenberg University Mainz
GlaxoSmithKline

Terminated

Effects of Mepolizumab Compared to Placebo on Airway Physiology in Patients With Eosinophilic Asthma: MEMORY Study (MEMORY)

Asthma

Germany
GlaxoSmithKline

Not yet recruiting

REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study (REIMAGINE)

Asthma
St. Paul's Sinus Centre

Not yet recruiting

th2 Modulation CRSwNP

Chronic Rhinosinusitis With Nasal Polyps

Canada
Policlinico Universitario, Catania

Recruiting

Mepolizumab Effectiveness in Severe Eosinophilic Asthma and Bronchiectasis

Bronchiectasis | Bronchial Asthma

Italy
GlaxoSmithKline

Recruiting

Study in Pediatrics With HypEREosinophilic Syndrome (SPHERE) (SPHERE)

Hypereosinophilic Syndrome

United States, Argentina, Spain, Turkey, Israel, Brazil, Mexico, United Kingdom
GlaxoSmithKline

Completed

Intravenous Mepolizumab In Subjects With Hypereosinophilic Syndromes (HES)

Hypereosinophilic Syndrome | Hypereosinophilia

United States, Belgium, Canada, Germany, Italy, France, Switzerland, Australia
GlaxoSmithKline

Completed

Pharmacokinetics and Pharmacodynamics of Mepolizumab Administered Subcutaneously in Children

Asthma

Japan, United States, United Kingdom, Poland
GlaxoSmithKline

Completed

Intravenous Mepolizumab In Children With Eosinophilic Esophagitis

Oesophagitis, Eosinophilic

United States, Canada, United Kingdom, Australia
GlaxoSmithKline

Terminated

Open-Label Extension Of Intravenous Mepolizumab In Patients With Hypereosinophilic Syndrome

Hypereosinophilic Syndrome

United States, Belgium, Canada, Germany, Italy, France, Australia
University Hospital Schleswig-Holstein
GlaxoSmithKline

Completed

Safety and Efficacy Study of Mepolizumab in Churg Strauss Syndrome (MEPOCHUSS)

Churg Strauss Syndrome

Germany
Bio-Thera Solutions

Completed

Evaluate the Pharmacokinetics of BAT2606 Injection in Healthy Chinese Male Subjects

Severe Asthma

China
Brigham and Women's Hospital
GlaxoSmithKline

Completed

Mepolizumab As a Steroid-sparing Treatment Option in the Churg Strauss Syndrome (MATOCSS)

Churg Strauss Syndrome

United States
University of Crete

Recruiting

Role of Epithelial Barrier Integrity in Biologic Treatment Response of Severe Asthmatics With/Out Chronic Rhinosinusitis With Nasal Polyps (CRSwNP).

Severe Eosinophilic Asthma w/wo CRSwNP

Greece
Temple University
GlaxoSmithKline

Not yet recruiting

Immunological Basis for Mepolizumab Activity in COPD

COPD
Hospital Clinico Universitario de Santiago
GlaxoSmithKline

Recruiting

Effect of Mepolizumab on Severe Eosinophilic Asthma (EMESEA)

Asthma | Eosinophilic Asthma

Spain
Instituto de Investigación Marqués de Valdecilla

Not yet recruiting

Mepolizumab and In-office Nasal Polypectomy in Patients With Chronic Rhinosinusitis (CRS). A Three Arm Study. (MELYSA)

Rhinosinusitis Chronic | Polyp, Nasal

Spain
St. Paul's Sinus Centre

Recruiting

Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatment

Asthma | Chronic Rhinosinusitis With Nasal Polyps | Chronic Rhinosinusitis Without Nasal Polyps

Canada
Hospices Civils de Lyon
GlaxoSmithKline

Active, not recruiting

Symptoms Control and adhErenCe Assessment During Treatment With MepolizUmab New pREfilled Devices (SECURE)

Asthma

France
Xijing Hospital

Recruiting

Safety and Efficacy of Meplazumab in Patients With Coronary Artery Disease (REC-SAFECAD)

Coronary Artery Disease

China
GlaxoSmithKline

Completed

Mepolizumab in Nasal Polyposis

Nasal Polyps

Netherlands, Belgium, United Kingdom
GlaxoSmithKline

Completed

A Study to Determine Long-term Safety of Mepolizumab in Asthmatic Subjects

Asthma

United States, Argentina, Australia, Canada, France, Germany, Japan, Netherlands, Poland, Russian Federation, Spain, Ukraine, Belgium, Chile, Korea, Republic of, United Kingdom, Czechia, Mexico, Italy
University of Wisconsin, Madison

Completed

Eosinophilic Airway Inflammation and Mepolizumab

Asthma

United States
GlaxoSmithKline

Terminated

Efficacy and Safety Study of Mepolizumab in Subjects With Moderate to Severe Atopic Dermatitis

Dermatitis, Atopic

United States, Canada
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield

Active, not recruiting

A Pilot Study of the Use of 129Xe and 1H MRI to Measure the Modulation of Eosinophil-Related Inflammation by Mepolizumab In COPD (SUMMER)

COPD

United Kingdom
Medical Centre Leeuwarden
GlaxoSmithKline

Completed

Use of Nucala in Severe Asthma (UNISA)

Asthma Severe Persistent Uncontrolled

Netherlands
KU Leuven

Completed

Effect of Anti-interleukin 5 (IL5) Therapy on Sputum Cells and Cytokines

Asthma
GlaxoSmithKline

Completed

Dose Ranging Pharmacokinetics and Pharmacodynamics Study With Mepolizumab in Asthma Patients With Elevated Eosinophils

Asthma

Germany, France, Estonia, United States
GlaxoSmithKline

Completed

A Study to Compare the Pharmacokinetics of Mepolizumab as a Liquid Drug in a Safety Syringe or an Autoinjector Versus Lyophilised Drug

Asthma

United States, United Kingdom, Germany
National and Kapodistrian University of Athens

Recruiting

Mepolizumab Effectiveness in Patients With Chronic Rhinosinusitis, Nasal Polyps and Comorbid Severe Eosinophilic Asthma (MepoRiNaPAs)

Chronic Rhinosinusitis With Nasal Polyps | Chronic Rhinosinusitis Without Nasal Polyps | Severe Eosinophilic Asthma

Greece
Rigshospitalet, Denmark

Recruiting

A Randomized, Real-world Head-to-head Study of Dupilumab Versus Mepolizumab in Danish CRSwNP Patients (TORNADO)

Eosinophilia | Chronic Rhinosinusitis With Nasal Polyps | Asthma; Eosinophilic

Denmark
National Institute of Allergy and Infectious Diseases...
GlaxoSmithKline; Rho Federal Systems Division, Inc.; Inner-City Asthma Consortium

Completed

A Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children (MUPPITS-2)

Asthma

United States

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