Search clinical trials for: Metformin XR plus placebo

Total 1318 results

Merck Sharp & Dohme LLC

Completed

A Pooled Analysis of the Safety and Efficacy of MK-0431A and MK-0431A XR in Pediatric Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Therapy (Alone or in Combination With Insulin) (MK-0431A-170/MK-0431A-289)

Type 2 Diabetes Mellitus
Woman's
Novo Nordisk A/S

Completed

Combined Liraglutide and Metformin Therapy in Women With Previous Gestational Diabetes Mellitus (GDM)

Type 2 Diabetes Mellitus | Metabolic Syndrome | Impaired Glucose Tolerance | Gestational Diabetes Mellitus | Disorder of Glucose Regulation

United States
Bristol-Myers Squibb

Completed

Phase 4: Investigational Study to Evaluate Metformin XR Monotherapy Versus Metformin IR Monotherapy in Subjects With Type 2 Diabetes

Type 2 Diabetes Mellitus

South Africa, United States, Canada, Puerto Rico, Hungary, Germany, Czechia, Poland, Romania, United Kingdom
Dexa Medica Group

Completed

Efficacy and Safety of DLBS3233 in Subjects With Polycystic Ovary Syndrome (PCOS)

Polycystic Ovary Syndrome (PCOS)

Indonesia
Dexa Medica Group

Completed

PCOS Treatment Using DLBS3233, Metformin, and Combination of Both (POSITIF)

Insulin Resistance | Polycystic Ovary Syndrome (PCOS)

Indonesia
Dana-Farber Cancer Institute
National Cancer Institute (NCI)

Recruiting

Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma

United States
The University of Queensland

Recruiting

Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)

Autosomal Dominant Polycystic Kidney Disease

Australia
University of Guadalajara

Recruiting

Effect of Dapagliflozin/Metformin XR vs Monotherapies on Anthropometric Indicators in Obesity

Obesity

Mexico
Shionogi

Completed

Study to Assess Safety and Pharmacokinetics of Double-Blind S-707106 Alone and in Combination With Open-Label Metformin in Patients With Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

United States
Merck KGaA, Darmstadt, Germany

Completed

Metformin Extended Release Versus Metformin Immediate Release in Subjects With Type 2 Diabetes (CONSENT)

Diabetes Mellitus, Type 2

Germany
Boehringer Ingelheim
Eli Lilly and Company

Completed

Relative Bioavailability of 2 Fixed Dose Combinations of Empagliflozin/Metformin Compared With Single Tablets

Healthy

United States
AstraZeneca

Completed

A Study to Assess the Bioequivalence of Fixed Dose Combination of Dapagliflozin/Metformin XR Relative to Co-administration of the Individual Components in Healthy Chinese Subjects.

Healthy Volunteer

China
Sihuan Pharmaceutical Holdings Group Ltd.

Unknown

Janagliflozin Treat Type 2 Diabetes Mellitus (T2DM) Inadequately Controlled With Metformin

Diabetes Mellitus, Type 2

China
Wake Forest University Health Sciences
University of South Florida; National Institute on Aging (NIA)

Recruiting

Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction (Met-PEF)

Heart Failure With Preserved Ejection Fraction

United States
AstraZeneca

Completed

The Purpose of the Study is to Compare Two Fixed Dose Combination Tablets of Dapagliflozin/Metformin XR in Healthy Subjects Under Fasting and Fed Conditions

Healthy Subjects in Fasted and Fed State

Brazil
University of Utah
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Recruiting

Metformin for Fibromyalgia Symptoms (INFORM Trial)

Fibromyalgia Syndrome

United States
Gwendolyn Sowa

Completed

Effects of Metformin on Low Back Pain

Low Back Pain

United States
Handok Inc.

Completed

A Study to Compare MP-513 20mg & Metformin XR 1000mg FDC With Coadministration of the Two Separate Drugs

Healthy Volunteers

Korea, Republic of
James Wang
United States Department of Defense

Recruiting

Managing Chronic Tendon Pain by Metformin

Chronic Pain | Tendinopathy | Achilles Tendinopathy

United States
University Magna Graecia

Completed

Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women

Polycystic Ovary Syndrome | Pregnancy

Italy
NYU Langone Health

Completed

Metformin Prostate Cancer Adjuvant Trial

Prostate Cancer | Prostate Cancer Recurrent

United States
University Magna Graecia

Completed

Metformin and Folate Supplementation in Polycystic Ovary Syndrome (PCOS) Patients

Polycystic Ovary Syndrome | Anovulation

Italy
Duke University

Terminated

Metformin for the Treatment of Nonalcoholic Fatty Liver Disease (NAFLD) (NAFLD)

Fatty Liver

United States
AstraZeneca

Completed

Study To Evaluate 24 Hour Blood Sugar Control (24-hour Mean Weighted Glucose) In Subjects That Are Taking Saxagliptin 5 mg Added Onto Metformin XR 1500 XR mg Compared To Subjects Taking Metformin XR 1500 mg Up-titrated To Metformin XR 2000 mg

Type 2 Diabetes

United States, Argentina, Mexico, Israel
Boehringer Ingelheim
Eli Lilly and Company

Completed

Relative Bioavailability of 2 Fixed Dose Combinations of Empagliflozin/Metformin Extended Release (XR) Compared With Single Tablets

Healthy

United States
Merck KGaA, Darmstadt, Germany

Completed

Glucophage® Extended Release (XR) 750 Milligram (mg) Indonesia Bioequivalence (BE) Study

Healthy

Indonesia
VA Office of Research and Development

Recruiting

Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes (VA-IMPACT)

Atherosclerosis | Prediabetic State | Metformin

United States
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

GXR RM (Glucophage® Extended Release Reduced Mass) 500 Milligram (mg) Korea Bioequivalence (BE) Study

Healthy

Korea, Republic of
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Completed

GXR RM China BE Study (Darmstadt - Jiangsu)

Healthy

Germany
AstraZeneca

Completed

A Study to Assess the Bioequivalence of Dapagliflozin/Metformin XR Fixed-dose Combination Tablets in Healthy Subjects

Bioequivalence | Fixed Dose Combination Tablets | Healthy Male and Female Subjects

United States
Fasa University of Medical Sciences
Shiraz University of Medical Sciences

Completed

Effects of Metformin Plus Simvastatin on Polycystic Ovarian Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study

Polycystic Ovary Syndrome

Iran, Islamic Republic of
Government Dental College and Research Institute...

Completed

Alendronate Compared to Metformin in Chronic Periodontitis

Chronic Periodontitis
National Hepatology & Tropical Medicine Research...

Not yet recruiting

Assessment of Metformin as Adjuvant Therapy in Patients With Ulcerative Colitis

Inflammatory Bowel Diseases | Ulcerative Colitis

Egypt
Bristol-Myers Squibb

Completed

Body Weight Effects on Glucophage's Efficacy in Chinese Diagnosed T2DM Patients

Type 2 Diabetes Mellitus

China
AstraZeneca
Bristol-Myers Squibb

Completed

A Bioequivalence Study of the Fixed Dose Combinations of Saxagliptin/Metformin XR Relative to Co-Administration (SAXA)

Type 2 Diabetes Mellitus(T2DM)

China
Aarhus University Hospital

Completed

Effects of Metformin Treatment on Myocardial Efficiency in Patients With Heart Failure (METRONOME)

Heart Failure, Systolic

Denmark
Woman's
Pfizer; American Cancer Society, Inc.; Our Lady of the Lake Regional Medical...

Withdrawn

Metformin Use to Reduce Disparities in Newly Diagnosed Breast Cancer (METBC)

Insulin Resistance | Breast Cancer Stage | Racial Bias

United States
Dong-A ST Co., Ltd.

Completed

A Clinical Trial to Investigate Safety/Tolerability and Pharmacokinetics of DA-1229_01(Evogliptin/Metformin XR 2.5/500 mg x 2 Tablets) Compared to Co-administration of Evogliptin 5 mg and Metformin XR 1000 mg in Healthy Male Volunteers

Type 2 Diabetes Mellitus

Korea, Republic of
Celon Pharma SA
National Center for Research and Development, Poland

Completed

Safety and Pharmacokinetics Study of CPL207280 Compound in Healthy Volunteers.

Healthy Volunteers

Poland
AstraZeneca

Completed

Bioequivalence Study of Fixed-dose Combinations and Coadministered Individual Tablets of Saxagliptin/Metformin-Brazil

Type 2 Diabetes Mellitus

Brazil
Oregon Health and Science University

Completed

Cortisol Regulation in Polycystic Ovary Syndrome (PCOS)

Polycystic Ovary Syndrome

United States
AstraZeneca

Terminated

Study of Saxagliptin, 5-Hydroxy Saxagliptin, and Metformin Concentrations/Levels in Pediatric Subjects With T2DM

Type 2 Diabetes Mellitus

United States
Jiangsu HengRui Medicine Co., Ltd.

Unknown

Dual Add-on Therapy in Type 2 Diabetes Poorly Controlled With Metformin Monotherapy

Diabetes Mellitus, Type II
Dong-A ST Co., Ltd.

Completed

A Clinical Trial to Investigate Safety/Tolerability and Pharmacokinetics of DA-1229_01 Compared to Co-administration of Evogliptin 5 mg and Metformin XR 1000 mg, and to Evaluate the Effect of Food on the Pharmacokinetics of DA-1229_01 in Healthy Male Volunteers

Type 2 Diabetes Mellitus

Korea, Republic of
Garvan Institute of Medical Research
National Health and Medical Research Council, Australia

Recruiting

Preventing Cognitive Decline With Metformin (MetMemory)

Cognitive Decline

Australia
Woman's
AstraZeneca

Completed

Saxagliptin + Metformin Compared to Saxagliptin or Metformin Monotherapy in PCOS Women With Impaired Glucose Homeostasis (BMS-AZPCOS)

Polycystic Ovary Syndrome | Disorder of Glucose Regulation

United States
Mayo Clinic
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National... and other collaborators

Completed

Effect of Insulin Sensitizer Therapy on Atherothrombotic and Inflammatory Profiles Associated With Insulin Resistance

Metabolic Syndrome | Insulin Resistance | Type 2 Diabetes

United States
Brigham and Women's Hospital
Arthritis Foundation

Not yet recruiting

Preventing Injured Knees From osteoArthritis: Severity Outcomes (PIKASO)

Osteoarthritis, Knee | Post-traumatic Osteoarthritis | ACL Tear

United States
Merck Sharp & Dohme LLC

Completed

A Study to Assess the Pharmacokinetics and the Ability for Pediatric Participants With Type 2 Diabetes to Swallow MK-0431A XR Tablets (MK-0431A-296)

Type 2 Diabetes Mellitus
Laboratorios Silanes S.A. de C.V.

Completed

Tolerability and Pharmacokinetics of Metformin and Metformin Extended Release (ER)

Healthy

Mexico

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