Search clinical trials for: Metformin and insulin

Total 269729 results

Novo Nordisk A/S

Completed

Efficacy and Safety of Biphasic Insulin Aspart 30 With Metformin in Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

South Africa
Novo Nordisk A/S

Completed

Comparison of Biphasic Insulin Aspart 70/30, 50/50, and 30/70 in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Poland, United Kingdom, Spain, Denmark, France, Netherlands, Austria, Hungary, Russian Federation, Germany, Turkey, Italy, Bulgaria, Romania, Belgium, Switzerland, Slovenia, Czech Republic
Novo Nordisk A/S

Completed

Comparison of Insulin Glargine Versus Biphasic Insulin Aspart 30/70 or Biphasic Insulin Aspart 30/70 in Combination With Metformin in Subjects With Type 2 Diabetes.

Diabetes Mellitus, Type 2 | Diabetes

Turkey
Novo Nordisk A/S

Completed

Biphasic Insulin Aspart 30 in Type 2 Diabetes Failing OAD Therapy (INITIATE)

Diabetes Mellitus, Type 2 | Diabetes

United States
Novo Nordisk A/S

Completed

Efficacy and Safety of Metformin Plus Biphasic Insulin Aspart 30 in Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Argentina, Brazil
Novo Nordisk A/S

Completed

Comparison of Two NN5401 Formulations Versus Biphasic Insulin Aspart 30, All in Combination With Metformin in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Poland, Spain, Germany, Finland, France
Novo Nordisk A/S

Completed

Comparison of Biphasic Insulin Aspart 70/30 With Anti-Diabetic Drugs in Subjects With Type 2 Diabetes (ACTION)

Diabetes Mellitus, Type 2 | Diabetes

United States
Mount Sinai Hospital, Canada
Canadian Institutes of Health Research (CIHR)

Completed

Early Intermittent Intensive Insulin Therapy as an Effective Treatment of Type 2 Diabetes (RESET-IT Main Trial) (RESET-IT)

Type 2 Diabetes

Canada
Novo Nordisk A/S

Completed

Comparing the Efficacy and Safety of Biphasic Insulin Aspart 30 and Biphasic Human Insulin 30 on Blood Sugar Control in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

China
Novo Nordisk A/S

Completed

Effect of Biphasic Insulin Aspart 30 Combined With Metformin on Blood Glucose Control in Subjects With Type 2 Diabetes Inadequately Controlled With Basal Insulin

Diabetes Mellitus, Type 2 | Diabetes

China
Novo Nordisk A/S

Completed

Effect of Different Insulin Administrations, All in Combination With Metformin, on Glycaemic Control in Subjects With Type 2 Diabetes Inadequately Controlled by Oral Anti-diabetic Drugs

Diabetes Mellitus, Type 2 | Diabetes

Morocco, Tunisia, Algeria, South Africa, Egypt
Novo Nordisk A/S

Completed

Comparison of Biphasic Insulin Aspart 30 Versus Insulin Glargine Both in Combination With Metformin and Glimepiride in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Poland, Spain, Sweden, Malaysia, France, Netherlands, India, Argentina, South Africa, Romania, Former Serbia and Montenegro, Austria, Czech Republic, Philippines, Mexico
Novo Nordisk A/S

Completed

Comparison of Biphasic Insulin Aspart 30 Twice Daily With Two Different Initial Dosage Split Regimens in Subjects With Type 2 Diabetes: An Extension to Trial BIASP-3756

Diabetes Mellitus, Type 2 | Diabetes

China
Novo Nordisk A/S

Completed

Effect of Biphasic Insulin Aspart 50 on Blood Glucose Control in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

China
Mannkind Corporation

Completed

Efficacy and Safety of Prandial Inhalation of Technosphere/Insulin in Combination With Metformin or Technosphere/Insulin Alone Versus 2 Oral Anti-Diabetic Agents in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2

United States, Brazil, Spain, Argentina, Canada, Chile, Mexico, Poland, Russian Federation, Ukraine, Czech Republic
Takeda

Completed

Efficacy of Pioglitazone and Metformin on Cardiovascular Risk in Subjects With Insulin-Treated Type 2 Diabetes Mellitus. (PIOcomb)

Diabetes Mellitus

Germany
University Hospital, Toulouse

Completed

Efficacy of Continuous Subcutaneous Insulin Infusion Versus Basal-bolus Multiple Daily Injections Regimen in Type 2 Diabetes

Type 2 Diabetes Mellitus

France
Novo Nordisk A/S

Completed

Comparison of the Blood Sugar Lowering Effect of Biphasic Insulin Aspart 30 and Insulin Glargine Both Combined With Metformin and Glimepiride in Chinese and Japanese Subjects With Type 2 Diabetes New to Insulin Treatment (EasyMix)

Diabetes Mellitus, Type 2 | Diabetes

Japan, China
University of Texas Southwestern Medical Center

Completed

Preservation of Beta-cell Function in Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

United States
Novo Nordisk A/S

Completed

Comparison of Two NN1250 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

United States, India, South Africa, Canada
University of Jordan

Completed

Dosage Reduction and Acute Glycemic Complications in People With Type 2 Diabetes Who Fast During Ramadan

Diabetes Mellitus, Type 2

Jordan
Fundació Institut de Recerca de l'Hospital de la...

Completed

Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. Systematic Review

Gestational Diabetes Mellitus

Spain
Eli Lilly and Company

Completed

Long-Term Effects of Insulin Plus Metformin Regimens on the Overall and Postprandial Glycemic Control of Patients With Type 2 Diabetes

Diabetes Mellitus, Type 2

United States, Australia, Greece, India, Netherlands, Poland, Puerto Rico
Université de Sherbrooke
Fonds de la Recherche en Santé du Québec

Completed

Gestational Diabetes: Insulin or Oral Hypoglycemic Agents? (DG5)

Gestational Diabetes Mellitus

Canada
Mount Sinai Hospital, Canada
Canadian Institutes of Health Research (CIHR)

Completed

Early Intermittent Intensive Insulin Therapy as an Effective Treatment of Type 2 Diabetes (RESET-IT Pilot Study)

Type 2 Diabetes

Canada
Centre hospitalier de l'Université de Montréal...
Radiological Society of North America; Centre de Recherche du Centre Hospitalier... and other collaborators

Completed

Study of Liraglutide Versus Insulin on Liver Fat Fraction in Patients With Type 2 Diabetes (LIRAINS)

Type 2 Diabetes | Nonalcoholic Fatty Liver Disease | Nonalcoholic Steatohepatitis

Canada
ikfe-CRO GmbH
IKFE Institute for Clinical Research and Development

Completed

Beta-Cell Function of Insulin Glargine Compared to Neutral Protamine Hagedorn (NPH) Insuline and to Insulin Detemir in Combination With Metformin

Type 2 Diabetic Patients | Insufficient Metabolic Control | OAD Treatment

Germany
Novo Nordisk A/S

Completed

Efficacy and Safety of Biphasic Insulin Aspart 30 in Combination With Metformin in Type 2 Diabetes (EUROMIX)

Diabetes Mellitus, Type 2 | Diabetes

Austria, Hungary, Slovenia, Germany, Czech Republic, Poland, Slovakia
Novo Nordisk A/S

Completed

Comparison of Two NN5401 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Germany, Spain, France, Norway, Romania
Ain Shams University

Completed

Adding Metformin to Insulin in Controlling Pregestational and Gestational Diabetes Mellitus

Gestational Diabetes Mellitus in Pregnancy
Sanofi

Completed

Phenotype Evaluation in Insulin Naive Patients Using Lantus (Insulin Glargine) (GALATEE)

Type 2 Diabetes

France
Munich Municipal Hospital
Aventis Pharmaceuticals

Unknown

Can Insulin Glargine Improve Myocardial Function in Patients With T2D and Coronary Artery Disease (CAD)

Coronary Artery Disease | Type 2 Diabetes

Germany
Sanofi

Completed

Insulin Glargine v Rosiglitazone as add-on Therapy in Patients Failing Sulfonylurea and Metformin Combination Therapy

Type 2 Diabetes Mellitus

United States
University of Palermo

Completed

Dulaglutide in Diabetic Patients, Relationship Between Arterial Stiffness, Endothelial Function, Clinical and Laboratory Variables

Diabetes Mellitus

Italy
Novo Nordisk A/S

Terminated

Comparing Efficacy and Safety of Insulin Detemir Plus Insulin Aspart and NPH Insulin Plus Human Soluble Insulin With or Without Metformin in Chinese Patients With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

China
Novo Nordisk A/S

Terminated

Efficacy and Safety of Inhaled Pre-prandial Human Insulin in Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

United Kingdom, Netherlands, Austria, Spain, France, Germany, Ireland, Switzerland, Finland
Centre d'Etudes et de Recherche pour l'Intensification...

Completed

Galvus (Vildagliptin) vs Placebo in Combination With Metformin and Insulin

Type 2 Diabetes

France
Novo Nordisk A/S

Completed

Treatment Intensification With Biphasic Insulin Aspart 30 in Subjects With Type 2 Diabetes Inadequately Controlled on Sitagliptin and Metformin (SIT2MIX)

Diabetes Mellitus, Type 2 | Diabetes

Korea, Republic of, India, Malaysia, Turkey, Argentina, Greece, Australia, Portugal, Thailand, Brazil
Brigham and Women's Hospital
Sanofi

Terminated

The LANCET Trial: A Trial of Long-acting Insulin Injection to Reduce C-reactive Protein in Patients With Type 2 Diabetes

Type 2 Diabetes

United States
Profil Institut für Stoffwechselforschung GmbH
Sanofi

Completed

Adjunctive Therapy of Exenatide or Sitagliptin to Insulin Glargine in Type 2 Diabetes

Type 2 Diabetes

Germany
Sanofi

Completed

ELEONOR STUDY: Insulin Glulisine in Type 2 Diabetes Mellitus.

Diabetes Mellitus, Type 2

Italy
Steno Diabetes Center Copenhagen
Zealand University Hospital; Novo Nordisk A/S; Rigshospitalet, Denmark; Hvidovre... and other collaborators

Completed

The Copenhagen Insulin and Metformin Therapy Trial (CIMT)

Arteriosclerosis | Atherosclerosis | Type 2 Diabetes

Denmark
Xiangya Hospital of Central South University

Recruiting

Efficacy and Safety Of Different Regimens In Patients With Type 2 Diabetes Receiving Intensive Insulin Therapy

Type 2 Diabetes Mellitus

China
Fudan University

Recruiting

Metformin and Insulin to Pancreatic Cancer Related Diabetes (Type 3c)

Diabete Mellitus | Pancretic Cancer

China
Steno Diabetes Center Copenhagen

Completed

Effect of Repaglinide Versus Metformin Treatment in Non-Obese Patients With Type-2-Diabetes

Diabetes Mellitus, Type 2

Denmark
K. Marcinkowski University of Medical Sciences

Completed

Metformin in Gestational Diabetes Mellitus (MetGDM)

Insulin Resistance | Diabetes, Gestational

Poland
Ain Shams University

Completed

Effect of Metformin in Children With Type 1 Diabetes

Effect of Change in T1DM Glycemic Control

Egypt
Dow University of Health Sciences

Unknown

Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country (migdm&t2dm)

Pregnancy | Type 2 Diabetes | Gestational Diabetes
Huazhong University of Science and Technology

Completed

Glycemic Responses to Majia Pomelos in Type 2 Diabetic Patients

Diabetes

China
Sanofi

Completed

Opposing Step-by-step Insulin Reinforcement to Intensified Strategy (OSIRIS)

Diabetes Mellitus, Type 2

France, Korea, Republic of, Russian Federation, Spain, Italy, Belgium, Germany, Hungary, Ireland, Mexico, Poland, Taiwan, Turkey, Netherlands, Greece, Lithuania, Sweden, United Kingdom

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