Search clinical trials for: Metformin on top of intensive insulin therapy

Total 1004 results

Bethesda General Hospital, Hoogeveen
Novo Nordisk A/S; Merck Sharp & Dohme LLC; Merck KGaA, Darmstadt, Germany; Takeda; LifeSc... and other collaborators

Completed

The HOME Trial: Hyperinsulinaemia: the Outcome of Its Metabolic Effects, a Randomized Controlled Trial

Type 2 Diabetes Mellitus

Netherlands
Mount Sinai Hospital, Canada
Canadian Institutes of Health Research (CIHR)

Completed

Early Intermittent Intensive Insulin Therapy as an Effective Treatment of Type 2 Diabetes (RESET-IT Main Trial) (RESET-IT)

Type 2 Diabetes

Canada
Sun Yat-sen University

Not yet recruiting

Effects of Structured Simplified Short-term Intensive Insulin Therapy on Long-term Glycemic Remission

Newly Diagnosed Type 2 Diabetes | Simplified Short-term Intensive Insulin Therapy | Glycemic Remission

China
Novo Nordisk A/S

Completed

Efficacy and Safety of Biphasic Insulin Aspart 30 With Metformin in Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

South Africa
Becton, Dickinson and Company
Ealing Hospital NHS Trust

Terminated

Treating Diabetic Lipohypertrophy With Intensive Education Versus Standard Care

Insulin Injections and Lipohypertrophy

United Kingdom
Novo Nordisk A/S

Completed

Comparison of Biphasic Insulin Aspart 70/30, 50/50, and 30/70 in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Poland, United Kingdom, Spain, Denmark, France, Netherlands, Austria, Hungary, Russian Federation, Germany, Turkey, Italy, Bulgaria, Romania, Belgium, Switzerland, Slovenia, Czech Republic
Novo Nordisk A/S

Completed

Comparison of Insulin Glargine Versus Biphasic Insulin Aspart 30/70 or Biphasic Insulin Aspart 30/70 in Combination With Metformin in Subjects With Type 2 Diabetes.

Diabetes Mellitus, Type 2 | Diabetes

Turkey
Xijing Hospital

Unknown

Effect of Intensive Insulin Therapy on Clinical Prognosis of Infants Undergoing Cardiac Surgery

Cardiac Surgery

China
Novo Nordisk A/S

Completed

Efficacy and Safety of Metformin Plus Biphasic Insulin Aspart 30 in Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Argentina, Brazil
Novo Nordisk A/S

Completed

Biphasic Insulin Aspart 30 in Type 2 Diabetes Failing OAD Therapy (INITIATE)

Diabetes Mellitus, Type 2 | Diabetes

United States
Shanghai Zhongshan Hospital

Recruiting

Regimen Switch After Intensive Insulin Therapy

Insulin

China
ikfe-CRO GmbH
IKFE Institute for Clinical Research and Development

Completed

Beta-Cell Function of Insulin Glargine Compared to Neutral Protamine Hagedorn (NPH) Insuline and to Insulin Detemir in Combination With Metformin

Type 2 Diabetic Patients | Insufficient Metabolic Control | OAD Treatment

Germany
Hygieia, Inc
TKL Research, Inc.

Completed

Efficacy and Safety of Frequently Modified Intensive Insulin

Diabetes

United States
Novo Nordisk A/S

Completed

Comparison of Two NN5401 Formulations Versus Biphasic Insulin Aspart 30, All in Combination With Metformin in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Poland, Spain, Germany, Finland, France
Novo Nordisk A/S

Completed

Comparison of Biphasic Insulin Aspart 70/30 With Anti-Diabetic Drugs in Subjects With Type 2 Diabetes (ACTION)

Diabetes Mellitus, Type 2 | Diabetes

United States
Policlinico Hospital
Eli Lilly and Company

Completed

Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock

Septic Shock | Severe Sepsis

Italy
University Hospital, Grenoble

Completed

I3LTE4: Intensive Insulin Therapy and Production of LTE4 in Patients With Diabetes

Diabetes Mellitus | Leucotrienes

France
Mount Sinai Hospital, Canada
Canadian Institutes of Health Research (CIHR)

Completed

Early Intermittent Intensive Insulin Therapy as an Effective Treatment of Type 2 Diabetes (RESET-IT Pilot Study)

Type 2 Diabetes

Canada
Novo Nordisk A/S

Completed

Comparing the Efficacy and Safety of Biphasic Insulin Aspart 30 and Biphasic Human Insulin 30 on Blood Sugar Control in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

China
Novo Nordisk A/S

Completed

Effect of Biphasic Insulin Aspart 30 Combined With Metformin on Blood Glucose Control in Subjects With Type 2 Diabetes Inadequately Controlled With Basal Insulin

Diabetes Mellitus, Type 2 | Diabetes

China
Novo Nordisk A/S

Completed

Effect of Different Insulin Administrations, All in Combination With Metformin, on Glycaemic Control in Subjects With Type 2 Diabetes Inadequately Controlled by Oral Anti-diabetic Drugs

Diabetes Mellitus, Type 2 | Diabetes

Morocco, Tunisia, Algeria, South Africa, Egypt
Novo Nordisk A/S

Completed

Comparison of Biphasic Insulin Aspart 30 Versus Insulin Glargine Both in Combination With Metformin and Glimepiride in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Poland, Spain, Sweden, Malaysia, France, Netherlands, India, Argentina, South Africa, Romania, Former Serbia and Montenegro, Austria, Czech Republic, Philippines, Mexico
Novo Nordisk A/S

Completed

Comparison of Biphasic Insulin Aspart 30 Twice Daily With Two Different Initial Dosage Split Regimens in Subjects With Type 2 Diabetes: An Extension to Trial BIASP-3756

Diabetes Mellitus, Type 2 | Diabetes

China
The George Institute
National Health and Medical Research Council, Australia; University of British... and other collaborators

Completed

Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE - SUGAR STUDY)

Hyperglycemia | Critical Illness

Australia
University of Monastir

Completed

Glucose Insulin Potassium With Intensive Insulin Therapy and (GIK2) Versus GIK Alone

Acute Coronary Syndrome

Tunisia
Emory University

Completed

Phase 1 Study of Potential Anti-Inflammatory Effects of Glucose Control During Acute Myocardial Infarction.

Acute Myocardial Infarction

United States
Novo Nordisk A/S

Completed

Effect of Biphasic Insulin Aspart 50 on Blood Glucose Control in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

China
Central Hospital, Nancy, France
Central Hospital, Reims, France; Central Hospital, Toulouse, France; Central... and other collaborators

Unknown

New Insulin Therapy by Multiwave Bolus (EVANEWFIT2)

Type1diabetes

France
Mannkind Corporation

Completed

Efficacy and Safety of Prandial Inhalation of Technosphere/Insulin in Combination With Metformin or Technosphere/Insulin Alone Versus 2 Oral Anti-Diabetic Agents in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2

United States, Brazil, Spain, Argentina, Canada, Chile, Mexico, Poland, Russian Federation, Ukraine, Czech Republic
University Hospital, Toulouse

Completed

Efficacy of Continuous Subcutaneous Insulin Infusion Versus Basal-bolus Multiple Daily Injections Regimen in Type 2 Diabetes

Type 2 Diabetes Mellitus

France
Ohio University
Western University of Health Sciences

Completed

INSPIRE Diabetes Study: Basal Bolus Insulin as Primary Treatment of Type 2 Diabetes (INSPIRE)

Type 2 Diabetes

United States
Charles University, Czech Republic

Completed

Continuous Glucose Monitoring Combined With Computer Algorithm for Intensive Insulin Therapy in Cardiosurgical Patients

Hyperglycemia | Cardiac Surgery

Czech Republic
University of Texas Southwestern Medical Center

Completed

Preservation of Beta-cell Function in Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus

United States
Takeda

Completed

Efficacy of Pioglitazone and Metformin on Cardiovascular Risk in Subjects With Insulin-Treated Type 2 Diabetes Mellitus. (PIOcomb)

Diabetes Mellitus

Germany
Novo Nordisk A/S

Completed

Comparison of the Blood Sugar Lowering Effect of Biphasic Insulin Aspart 30 and Insulin Glargine Both Combined With Metformin and Glimepiride in Chinese and Japanese Subjects With Type 2 Diabetes New to Insulin Treatment (EasyMix)

Diabetes Mellitus, Type 2 | Diabetes

Japan, China
Northwestern University
University of Sao Paulo General Hospital

Withdrawn

Hematopoietic Stem Cell Support Versus Insulin in T1D

Diabetes Mellitus, Type 1
Novo Nordisk A/S

Completed

Comparison of Two NN1250 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

United States, India, South Africa, Canada
Kyunghee University Medical Center
Sanofi; Korea University Guro Hospital; Hanyang University; The Catholic University... and other collaborators

Completed

Study To Evaluate Beta Cell Function and Glycemic Outcome by Intensive Insulin Therapy (KIIT)

Type 2 Diabetes Mellitus | Pancreatic Beta Cell Function | Glucotoxicity

Korea, Republic of
Novo Nordisk A/S

Completed

The Effect of Insulin Detemir in Combination With Liraglutide and Metformin Compared to Liraglutide and Metformin in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

United States, Italy, Puerto Rico, Spain, United Kingdom, Netherlands, Belgium, Germany, France, Canada
Eli Lilly and Company

Completed

Long-Term Effects of Insulin Plus Metformin Regimens on the Overall and Postprandial Glycemic Control of Patients With Type 2 Diabetes

Diabetes Mellitus, Type 2

United States, Australia, Greece, India, Netherlands, Poland, Puerto Rico
Fundació Institut de Recerca de l'Hospital de la...

Completed

Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. Systematic Review

Gestational Diabetes Mellitus

Spain
National Cancer Centre, Singapore
National Medical Research Council (NMRC), Singapore; Ministry of Health, Singapore

Active, not recruiting

ENABLE (Educate, Nurture, Advise, Before Life Ends) Intervention for Heart Failure (HF) Patients and Their Caregivers in Singapore (ENABLE-HF-SG)

Heart Failure

Singapore
Population Health Research Institute
Hamilton Health Sciences Corporation

Completed

Remission Evaluation of Metabolic Interventions in Type 2 Diabetes (REMIT Pilot Trial)

Type 2 Diabetes Mellitus

Canada
Université de Sherbrooke
Fonds de la Recherche en Santé du Québec

Completed

Gestational Diabetes: Insulin or Oral Hypoglycemic Agents? (DG5)

Gestational Diabetes Mellitus

Canada
Novo Nordisk A/S

Completed

Comparison of Two NN5401 Formulations Versus Insulin Glargine, All in Combination With Metformin in Subjects With Type 2 Diabetes

Diabetes Mellitus, Type 2 | Diabetes

Germany, Spain, France, Norway, Romania
Sanofi

Completed

Phenotype Evaluation in Insulin Naive Patients Using Lantus (Insulin Glargine) (GALATEE)

Type 2 Diabetes

France
University of Jordan

Completed

Dosage Reduction and Acute Glycemic Complications in People With Type 2 Diabetes Who Fast During Ramadan

Diabetes Mellitus, Type 2

Jordan
Medical University of Vienna

Completed

Efficiency of Continuous Glucose Monitoring in Critically Ill Patients

Critical Illness

Austria
Centre hospitalier de l'Université de Montréal...
Radiological Society of North America; Centre de Recherche du Centre Hospitalier... and other collaborators

Completed

Study of Liraglutide Versus Insulin on Liver Fat Fraction in Patients With Type 2 Diabetes (LIRAINS)

Type 2 Diabetes | Nonalcoholic Fatty Liver Disease | Nonalcoholic Steatohepatitis

Canada
Ain Shams University

Completed

Adding Metformin to Insulin in Controlling Pregestational and Gestational Diabetes Mellitus

Gestational Diabetes Mellitus in Pregnancy

Search clinical trials for: Metformin on top of intensive insulin therapy

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