Search clinical trials for: Optimal medical therapy

Total 26537 results

Clinical Centre of Serbia

Completed

Randomized Comparison of Optimal Medical Therapy and Percutaneous Recanalization for Chronic Total Occlusion (COMET-CTO)

Chronic Total Occlusions of Coronary Arteries

Serbia
Uptake Medical Technology, Inc.
MedPass International

Not yet recruiting

A Randomized Controlled Trial of InterVapor® in France - The TARGET Trial

Emphysema
Aeris Therapeutics

Terminated

Study of the AeriSeal System for HyPerInflation Reduction in Emphysema (ASPIRE) (ASPIRE)

Pulmonary Emphysema

United States, Spain, France, Israel, Netherlands, Greece, Italy
Toad Medical Corporation
University Hospitals Cleveland Medical Center

Unknown

Randomized, Prospective Evaluation of the Toad Brace in Plantar Ulcer Off-loading and Healing

Diabetic Foot | Pedal Ulcers

United States
Ottawa Heart Institute Research Corporation
Canadian Institutes of Health Research (CIHR)

Active, not recruiting

Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients With Permanent Atrial Fibrillation (RAFT-PermAF)

Atrial Fibrillation | Heart Disease | Congestive Heart Failure

Canada
Ottawa Heart Institute Research Corporation
Canadian Institutes of Health Research (CIHR); Medtronic

Completed

Resynchronization/Defibrillation for Ambulatory Heart Failure Trial (RAFT)

Heart Failure, Congestive

Canada, Netherlands, Australia, Turkey, Denmark, Germany, Belgium
Semmelweis University Heart and Vascular Center

Unknown

The Role of Willingness of Participation in Cardiology Trials on the Survival of Patients

Myocardial Infarction | Chronic Heart Failure

Hungary
Centre Hospitalier St Anne
Hôpitaux Universitaires Paris Ile-de-Franc Ouest

Not yet recruiting

" Endarterectomy Combined With Optimal Medical Therapy (OMT) vs OMT Alone in Patients With Asymptomatic Severe Atherosclerotic Carotid Artery Stenosis at Higher-than-average Risk of Ipsilateral Stroke " (ACTRIS)

Asymptomatic Carotid Artery Stenosis

France
Uptake Medical Corp

Completed

Sequential Segmental Treatment of Emphysema With Upper Lobe Predominance (STEP-UP) Study

Emphysema

Australia, Ireland, Germany, Austria, New Zealand, United Kingdom
Medical University of Vienna

Not yet recruiting

Edge-to-edge Mitral Valve Repair in ATTR-CM (MILLENNIAL)

Mitral Regurgitation | ATTR-Cardiomyopathy | Edge-to-Edge Mitral Valve Repair
Guangdong Provincial People's Hospital
The First Affiliated Hospital of Guangzhou Medical University; Shenzhen People... and other collaborators

Recruiting

EndovaScular Versus mediCaL mAnagement of Uncomplicated Type B Intramural heMatoma Trial (ESCLAIM)

Intramural Hematoma

China
Kee-joon Choi
CardioVascular Research Foundation, Korea

Recruiting

Implantable Cardioverter Defibrillator Versus Optimal Medical Therapy In Patients With Variant Angina Manifesting as Aborted Sudden Cardiac Death (VARIANT ICD)

Angina Pectoris, Variant | Sudden Cardiac Death

Korea, Republic of
Kerckhoff Klinik

Completed

Preoperative Excercise Training for Patients Undergoing Coronary Artery Bypass Graft Surgery

Coronary Artery Disease | Physical Activity | Coronary Artery Bypass Graft Surgery

Germany
Aarhus University Hospital Skejby

Recruiting

ISCHEMIA-CTO Trial - Revascularisation or Optimal Medical Therapy of CTO (ISCHEMIA-CTO)

Ischemic Heart Disease | Chronic Total Occlusion of Coronary Artery

Denmark, Sweden, Finland, Spain, Estonia, France, United Kingdom
VA Office of Research and Development

Terminated

Efficacy and Safety of Implantable Cardioverter-Defibrillator (ICD) Implantation in the Elderly (I-70)

Myocardial Infarction | Coronary Artery Disease | Congestive Heart Failure | Cardiomyopathy

United States
University Health Network, Toronto
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Angioplasty and Heart Stents to Treat Individuals With an Occluded Artery Following a Heart Attack (TOSCA-2)

Myocardial Infarction | Heart Diseases | Cardiovascular Diseases | Coronary Disease

Canada
Seung-Jung Park
CardioVascular Research Foundation, Korea

Terminated

Drug-Eluting Stent Implantation Versus Optimal Medical Treatment in Patients With Chronic Total Occlusion (DECISION-CTO)

Coronary Artery Disease

Korea, Republic of, Taiwan, Thailand, Indonesia, India
Impulse Dynamics

Completed

Evaluate Safety and Efficacy of the OPTIMIZER® System in Subjects With Moderate-to-Severe Heart Failure: FIX-HF-5C (FIX-HF-5C)

NYHA Class III Heart Failure | NYHA Class IV Heart Failure

United States, Germany, Czechia
Shanghai Chest Hospital

Not yet recruiting

A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema (BTVA)

Severe Emphysema
The University of Texas Health Science Center,...
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Volcano...

Completed

Combined Pressure and Flow Measurements to Guide Treatment of Coronary Stenoses (DEFINE-FLOW)

Coronary Artery Disease

Denmark, Spain, Netherlands, United Kingdom, Japan, Italy
Memorial Sloan Kettering Cancer Center
Merck Sharp & Dohme LLC

Recruiting

A Study of Vericiguat in People With Breast Cancer and Cancer Therapy-Related Cardiac Dysfunction

Breast Cancer | Cardiac Dysfunction

United States
Charite University, Berlin, Germany
Leipzig Heart Science gGmbH

Recruiting

Prevention Of Sudden Cardiac Death After Myocardial Infarction by Defibrillator Implantation (PROFID EHRA)

Myocardial Infarction | Sudden Cardiac Death

Czechia, Austria, Germany
Respicardia, Inc.

Completed

Respicardia, Inc. Pivotal Trial of the remedē System

Heart Failure | Sleep Disordered Breathing | Sleep Apnea, Central

United States, Poland, Germany
Karolinska Institutet
St. Claraspital AG

Withdrawn

Prevention of Microvascular Complications in Overweight Diabetics With Surgery or Best Medicine (PROMISE)

Diabetic Kidney Disease

Sweden, Switzerland
Edwards Lifesciences

Recruiting

TRISCEND II Pivotal Trial

Cardiovascular Diseases | Heart Failure | Heart Valve Diseases | Tricuspid Valve Regurgitation | Tricuspid Valve Insufficiency | Tricuspid Valve Disease

United States, Germany
Shanghai Zhongshan Hospital

Recruiting

Evaluate Early Invasive Strategy for Patients With STEMI Presenting 24-48 Hours From Symptom Onset

ST-segment Elevation Myocardial Infarction (STEMI)

China
Edwards Lifesciences

Recruiting

Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial (CLASP II TR)

Tricuspid Valve Insufficiency | Tricuspid Regurgitation | Tricuspid Valve Disease

United States, Canada
The First Affiliated Hospital with Nanjing Medical...
West China Hospital; Fujian Medical University Union Hospital; Chinese Academy... and other collaborators

Recruiting

LBBP as Initial Therapy in Patients With Non-ischemic Heart Failure and LBBB (LIT-HF)

Heart Failure | Left Bundle-Branch Block | Non-ischemic Cardiomyopathy

China
University of Maryland, Baltimore
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Electrophysiological Effects of Late PCI After MI

Myocardial Infarction | Heart Diseases | Cardiovascular Diseases | Coronary Disease | Arrhythmia | Ventricular Fibrillation

United States
Montreal Heart Institute

Withdrawn

Evaluation of Outcomes of CRT and MitraClip for Treatment of Low Ejection Fraction and Functional Mitral Regurgitation in HF (EVOLVE-HF)

Heart Failure | Functional Mitral Regurgitation
Columbia University
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH)

Heart Diseases | Cardiovascular Diseases | Heart Failure | Heart Failure, Congestive

United States
Radboud University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Completed

Mindfulness Based Cognitive Therapy and Antidepressant Medication in Recurrent Depression

Depressive Disorder, Major

Netherlands
Pulmonx Corporation

Completed

Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study) (LIBERATE)

Emphysema

United States, Netherlands, United Kingdom, Brazil
Newcastle-upon-Tyne Hospitals NHS Trust
Newcastle University; British Heart Foundation

Active, not recruiting

The British Heart Foundation SENIOR-RITA Trial (SENIOR-RITA)

NSTEMI - Non-ST Segment Elevation MI

United Kingdom
Nuvaira, Inc.

Active, not recruiting

Evaluation of the Safety and Efficacy of TLD in Patients With COPD (AIRFLOW-3)

COPD

United States, France, Netherlands, Austria, Germany, United Kingdom
Nantes University Hospital

Completed

Contribution of Percutaneous Endoscopic Caecostomie in the Management of Severe Constipation Refractory to Medical Treatment (ConstiCAPE)

Constipation

France
Nantes University Hospital

Terminated

Evaluation of Occipital Nerve Stimulation in Intractable Occipital Neuralgias (StimO)

Occipital Neuralgia

France
Leipzig Heart Institute GmbH

Not yet recruiting

Personalised Risk scOre For Implantation of Defibrillators in Patients With Preserved LVEF>35% and a High Risk for Sudden Cardiac Death

Myocardial Infarction | Sudden Cardiac Death
Leipzig Heart Institute GmbH

Not yet recruiting

Personalised Risk scOre For Implantation of Defibrillators in Patients With Reduced LVEF≤35% and a Low Risk for Sudden Cardiac Death (PROFID-Reduced)

Myocardial Infarction | Heart Failure | Sudden Cardiac Death
Nanjing First Hospital, Nanjing Medical University

Recruiting

Transcatheter Self-expandable Valve Implantation for the Treatment of Severe Native Aortic Regurgitation (SEASON-AR)

Aortic Valve Disease

China
Hospices Civils de Lyon

Unknown

Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation (MITRA-FR)

Cardiovascular Diseases

France
Paracor Medical, Inc

Terminated

Prospective Evaluation of Elastic Restraint to LESSen the Effects of Heart Failure (PEERLESS-HF) Trial (PEERLESS-HF)

Heart Failure

United States, Canada
Helios Health Institute GmbH
Heart Center Leipzig - University Hospital; IHF GmbH - Institut für Herzinfarktforschung

Active, not recruiting

Extracorporeal Life Support in Cardiogenic Shock (ECLS-SHOCK)

Acute Myocardial Infarction | Cardiogenic Shock

Germany
MedtronicNeuro

Completed

Spinal Cord Stimulation for Predominant Low Back Pain (PROMISE)

Back Pain | Failed Back Surgery Syndrome | Pain in Leg, Unspecified

United States, Spain, France, Colombia, Belgium, United Kingdom, Canada, Germany, Netherlands
Danish Study Group
Danish Heart Foundation

Completed

Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality (DANISH)

Heart Failure | Dilated Cardiomyopathy | Reduced LVEF

Denmark
Danish Study Group
Danish Heart Foundation

Completed

Danish ICD Study in Patients With Dilated Cardiomyopathy (DANISH)

Heart Failure | Dilated Cardiomyopathy | Reduced LVEF

Denmark
Johns Hopkins University
Leonard & Helen R. Stulman Charitable Foundation; Moveable Feast; Priority Partners... and other collaborators

Completed

Food and Education Effects on Diabetes Study (FEED)

Diabetes Mellitus, Type 2

United States
University Tunis El Manar

Unknown

Allopurinol and Endothelial Function in Diabetic CAD Patients (ALLIENCE)

Coronary Artery Disease | Diabetes Mellitus

Tunisia
Millennium Pain Center

Completed

Trialing of ISS in Patients With CRPS

Causalgia | CRPS I

United States
Meshalkin Research Institute of Pathology of Circulation

Completed

Ganglionated Plexi Ablation vs Renal Denervation in Patients Undergoing Pulmonary Vein Isolation

Hypertension | Atrial Fibrillation

Russian Federation

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